hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10235.1
Complex Portal: CPX-13235
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TEAD4 | Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) | 5 | UniProt NCBI |
| WWTR1 | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) | 5 | UniProt NCBI |
| AMOTL2 | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | 5 | UniProt NCBI |
| TEAD2 | Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) | 5 | UniProt NCBI |
| TEAD3 | Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3) | 5 | UniProt NCBI |
| TEAD1 | Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) | 5 | UniProt NCBI |
| VGLL4 | Transcription cofactor vestigial-like protein 4 (Vgl-4) | 5 | UniProt NCBI |
| YAP1 | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8951671 | 1.23339345898e-17 | 0.75 | TEAD4 TEAD1 YAP1 TEAD3 TEAD2 WWTR1 | RUNX3 regulates YAP1-mediated transcription |
| GO:0035329 | 1.14531576605e-16 | 1.0 | TEAD4 YAP1 TEAD1 AMOTL2 VGLL4 WWTR1 TEAD3 TEAD2 | hippo signaling |
| REAC:R-HSA-2032785 | 4.06828790531e-16 | 0.75 | TEAD4 TEAD1 YAP1 TEAD3 TEAD2 WWTR1 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| WP:WP4537 | 5.11860811141e-15 | 0.75 | TEAD4 TEAD1 YAP1 TEAD3 TEAD2 WWTR1 | Hippo YAP signaling |
| KEGG:04392 | 2.35469188303e-14 | 0.75 | TEAD4 TEAD1 YAP1 TEAD3 TEAD2 WWTR1 | Hippo signaling pathway - multiple species |
| WP:WP4541 | 3.06667516691e-13 | 0.875 | TEAD4 YAP1 TEAD1 VGLL4 WWTR1 TEAD3 TEAD2 | Hippo Merlin signaling dysregulation |
| WP:WP4534 | 7.2234780509e-13 | 0.75 | TEAD4 TEAD1 YAP1 TEAD3 TEAD2 WWTR1 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| WP:WP3967 | 4.0116837281e-12 | 0.625 | TEAD4 TEAD1 TEAD2 YAP1 TEAD3 | miR 509 3p alteration of YAP1 ECM axis |
| WP:WP4540 | 6.55722240887e-11 | 0.75 | TEAD4 TEAD1 YAP1 TEAD3 TEAD2 WWTR1 | Hippo signaling regulation pathways |
| WP:WP4542 | 1.08825057348e-10 | 0.625 | TEAD4 TEAD1 TEAD2 YAP1 TEAD3 | Leukocyte intrinsic Hippo pathway functions |
| REAC:R-HSA-8878159 | 2.36483496392e-10 | 0.75 | TEAD4 TEAD1 YAP1 TEAD3 TEAD2 WWTR1 | Transcriptional regulation by RUNX3 |
| KEGG:04390 | 1.22242614927e-09 | 0.75 | TEAD4 TEAD1 YAP1 TEAD3 TEAD2 WWTR1 | Hippo signaling pathway |
| WP:WP5087 | 4.67575129557e-09 | 0.875 | TEAD4 YAP1 TEAD1 VGLL4 WWTR1 TEAD3 TEAD2 | Pleural mesothelioma |
| WP:WP4533 | 1.02534731012e-08 | 0.5 | TEAD4 TEAD1 TEAD2 TEAD3 | Transcription co factors SKI and SKIL protein partners |
| REAC:R-HSA-9796292 | 1.92107583885e-06 | 0.375 | TEAD4 TEAD2 YAP1 | Formation of axial mesoderm |
| GO:0140552 | 5.38272230028e-06 | 0.375 | TEAD1 TEAD2 YAP1 | TEAD-YAP complex |
| REAC:R-HSA-2028269 | 2.21041516255e-05 | 0.375 | WWTR1 AMOTL2 YAP1 | Signaling by Hippo |
| CORUM:6651 | 2.39226645298e-05 | 0.25 | WWTR1 YAP1 | WWTR1-YAP1 complex |
| REAC:R-HSA-9619665 | 3.03234516525e-05 | 0.375 | WWTR1 YAP1 TEAD1 | EGR2 and SOX10-mediated initiation of Schwann cell myelination |
| REAC:R-HSA-9758941 | 0.000176426072101 | 0.375 | TEAD4 TEAD2 YAP1 | Gastrulation |
| REAC:R-HSA-212436 | 0.000618267964089 | 0.75 | TEAD4 TEAD1 YAP1 TEAD3 TEAD2 WWTR1 | Generic Transcription Pathway |
| REAC:R-HSA-73857 | 0.00117920251092 | 0.75 | TEAD4 TEAD1 YAP1 TEAD3 TEAD2 WWTR1 | RNA Polymerase II Transcription |
| REAC:R-HSA-74160 | 0.0024601668809 | 0.75 | TEAD4 TEAD1 YAP1 TEAD3 TEAD2 WWTR1 | Gene expression (Transcription) |
| GO:0035556 | 0.00268170503809 | 1.0 | TEAD4 YAP1 TEAD1 AMOTL2 VGLL4 WWTR1 TEAD3 TEAD2 | intracellular signal transduction |
| WP:WP2857 | 0.00317175791745 | 0.375 | TEAD1 TEAD2 YAP1 | Mesodermal commitment pathway |
| REAC:R-HSA-1266738 | 0.00691845604305 | 0.625 | TEAD4 TEAD1 TEAD2 YAP1 WWTR1 | Developmental Biology |
| REAC:R-HSA-8940973 | 0.0105471572959 | 0.25 | WWTR1 YAP1 | RUNX2 regulates osteoblast differentiation |
| REAC:R-HSA-8941326 | 0.0166306183768 | 0.25 | WWTR1 YAP1 | RUNX2 regulates bone development |
| GO:0005667 | 0.0229204338906 | 0.625 | TEAD4 TEAD1 TEAD2 YAP1 TEAD3 | transcription regulator complex |
| CORUM:6652 | 0.0499436884912 | 0.125 | WWTR1 | WWTR1 homodimer |
| CORUM:7062 | 0.0499436884912 | 0.125 | WWTR1 | NFAT5-WWTR1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TEAD2 | TEAD1 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WWTR1 | TEAD1 | 1.0 | 0.15 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| VGLL4 | TEAD3 | 1.0 | 0.066 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| WWTR1 | TEAD4 | 0.999 | 0.078 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| WWTR1 | TEAD2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TEAD4 | TEAD1 | 0.999 | 0.38 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TEAD2 | YAP1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TEAD2 | TEAD4 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| AMOTL2 | YAP1 | 0.997 | 0.068 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| TEAD3 | WWTR1 | 0.997 | 0.136 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| YAP1 | TEAD4 | 0.994 | 0.132 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| VGLL4 | TEAD1 | 0.991 | 0.136 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| VGLL4 | TEAD4 | 0.99 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| WWTR1 | AMOTL2 | 0.975 | 0.104 | hein_WMM bioplex3_WMM WMM_only | |
| WWTR1 | YAP1 | 0.974 | 0.114 |
mutually_exclusive (Q15561)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| AMOTL2 | TEAD1 | 0.956 | 0.126 | hein_WMM bioplex3_WMM WMM_only | |
| TEAD3 | TEAD1 | 0.925 | 0.254 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| YAP1 | TEAD1 | 0.923 | 0.074 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| TEAD3 | TEAD2 | 0.902 | bioplex3_WMM WMM_only | ||
| TEAD3 | TEAD4 | 0.829 | 0.21 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| TEAD3 | YAP1 | 0.813 | 0.094 | hein_WMM hein () | |
| VGLL4 | TEAD2 | 0.378 |
mutually_exclusive (P28347)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| AMOTL2 | TEAD4 | 0.248 | 0.068 | hein_WMM WMM_only | |
| TEAD3 | AMOTL2 | 0.248 | 0.11 | hein_WMM WMM_only | |
| VGLL4 | WWTR1 | 0.215 | 0.094 |
mutually_exclusive (Q99594)
|
bioplex_WMM bioplex3_WMM WMM_only |
| VGLL4 | YAP1 | 0.196 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes