hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10242.1

Complex Portal: CPX-20441

Confidence: Medium High

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Genename	Protein Name	Uniprot Annotation Score	Links
CAPN1	Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP)	5	UniProt NCBI
CAPN2	Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain)	5	UniProt NCBI
CAPN8	Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain)	4	UniProt NCBI
CAPNS1	Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit)	5	UniProt NCBI
CAST	Calpastatin (Calpain inhibitor) (Sperm BS-17 component)	5	UniProt NCBI
LIX1L	LIX1-like protein	2	UniProt NCBI

Showing 1 to 6 of 6 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-1474228	2.03059825145e-06	0.8	CAPN1 CAST CAPN8 CAPNS1	Degradation of the extracellular matrix
REAC:R-HSA-8862803	4.14297217289e-06	0.6	CAPN1 CAST CAPNS1	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
REAC:R-HSA-8863678	4.14297217289e-06	0.6	CAPN1 CAST CAPNS1	Neurodegenerative Diseases
REAC:R-HSA-9734009	6.30285051125e-06	0.6	CAPN1 CAST CAPNS1	Defective Intrinsic Pathway for Apoptosis
CORUM:6710	1.36501667663e-05	0.4	CAPN1 CAPNS1	Calpain 1
REAC:R-HSA-1474244	4.62662759694e-05	0.8	CAPN1 CAST CAPN8 CAPNS1	Extracellular matrix organization
GO:0004198	0.000158467845213	0.6	CAPN1 CAPN8 CAPNS1	calcium-dependent cysteine-type endopeptidase activity
REAC:R-HSA-9645723	0.000375711265178	0.6	CAPN1 CAST CAPNS1	Diseases of programmed cell death
KEGG:05131	0.00175429069912	0.6	CAPN1 CAST CAPNS1	Shigellosis
WP:WP185	0.020275205407	0.4	CAPN1 CAPNS1	Integrin mediated cell adhesion

Showing 1 to 10 of 13 entries

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Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
CAST	CAPN1	1.0	0.144	mutually_exclusive (P17655)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116
CAPN1	CAPNS1	1.0	0.604		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
CAST	CAPN8	0.998			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CAST	CAPNS1	0.997	0.186	mutually_exclusive (P17655)	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
CAPN8	CAPN1	0.995			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CAPN2	CAPNS1	0.987	0.336	mutually_exclusive (Q96L46) structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
CAPN8	CAPNS1	0.972		mutually_exclusive (Q96L46) structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CAPN2	CAPN1	0.963	0.16	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM
CAST	LIX1L	0.959	0.068		bioplex_WMM bioplex3_WMM WMM_only
CAST	CAPN2	0.707	0.142	structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only

Showing 1 to 10 of 14 entries

Related Complexes

Genename	Complexes
LIX1L	huMAP3_02916.1 huMAP3_05050.1 huMAP3_10242.1 huMAP3_11557.1 huMAP3_12239.1 huMAP3_12453.1 huMAP3_12716.1 huMAP3_12926.1 huMAP3_13615.1 huMAP3_14229.1 huMAP3_15135.1
CAPN8	huMAP3_02916.1 huMAP3_08081.1 huMAP3_08670.1 huMAP3_09127.1 huMAP3_09328.1 huMAP3_10242.1 huMAP3_11557.1 huMAP3_12239.1 huMAP3_12453.1 huMAP3_12716.1 huMAP3_12926.1 huMAP3_13615.1 huMAP3_14229.1 huMAP3_15135.1 huMAP3_15222.1
CAPN2	huMAP3_03420.1 huMAP3_03767.1 huMAP3_08081.1 huMAP3_08670.1 huMAP3_09127.1 huMAP3_09328.1 huMAP3_10029.1 huMAP3_10242.1 huMAP3_11160.1 huMAP3_11557.1 huMAP3_12453.1 huMAP3_12716.1 huMAP3_12926.1 huMAP3_13615.1 huMAP3_14229.1
CAPN1	huMAP3_03767.1 huMAP3_08670.1 huMAP3_09127.1 huMAP3_09328.1 huMAP3_10242.1 huMAP3_11557.1 huMAP3_12716.1 huMAP3_12926.1 huMAP3_13615.1 huMAP3_14229.1
CAPNS1	huMAP3_03767.1 huMAP3_08081.1 huMAP3_08670.1 huMAP3_09127.1 huMAP3_09328.1 huMAP3_10242.1 huMAP3_11557.1 huMAP3_12239.1 huMAP3_12453.1 huMAP3_12716.1 huMAP3_12926.1 huMAP3_13615.1 huMAP3_14229.1 huMAP3_15135.1
CAST	huMAP3_02916.1 huMAP3_05050.1 huMAP3_10242.1 huMAP3_11557.1 huMAP3_12239.1 huMAP3_12453.1 huMAP3_12716.1 huMAP3_12926.1 huMAP3_13615.1 huMAP3_14229.1 huMAP3_15135.1