hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10248.1
Complex Portal: CPX-19484
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SIX5 | Homeobox protein SIX5 (DM locus-associated homeodomain protein) (Sine oculis homeobox homolog 5) | 5 | UniProt NCBI |
| SIX2 | Homeobox protein SIX2 (Sine oculis homeobox homolog 2) | 5 | UniProt NCBI |
| EYA4 | Eyes absent homolog 4 (EC 3.1.3.48) | 5 | UniProt NCBI |
| EYA2 | Eyes absent homolog 2 (EC 3.1.3.48) | 5 | UniProt NCBI |
| EYA3 | Eyes absent homolog 3 (EC 3.1.3.48) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5693565 | 0.000177125385704 | 0.6 | EYA4 EYA2 EYA3 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 0.00018480745401 | 0.6 | EYA4 EYA2 EYA3 | DNA Double Strand Break Response |
| GO:1901099 | 0.00109385703544 | 0.6 | EYA4 EYA2 EYA3 | negative regulation of signal transduction in absence of ligand |
| GO:2001240 | 0.00109385703544 | 0.6 | EYA4 EYA2 EYA3 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| REAC:R-HSA-5693532 | 0.0019808748776 | 0.6 | EYA4 EYA2 EYA3 | DNA Double-Strand Break Repair |
| GO:2001239 | 0.00220577099344 | 0.6 | EYA4 EYA2 EYA3 | regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| GO:0038034 | 0.00807957978043 | 0.6 | EYA4 EYA2 EYA3 | signal transduction in absence of ligand |
| GO:0097192 | 0.00807957978043 | 0.6 | EYA4 EYA2 EYA3 | extrinsic apoptotic signaling pathway in absence of ligand |
| GO:0140789 | 0.0140440992017 | 0.4 | EYA3 EYA2 | histone phosphatase activity |
| GO:0140793 | 0.0140440992017 | 0.4 | EYA3 EYA2 | histone H2AXY142 phosphatase activity |
| REAC:R-HSA-73894 | 0.014302073064 | 0.6 | EYA4 EYA2 EYA3 | DNA Repair |
| GO:2001237 | 0.036132773595 | 0.6 | EYA4 EYA2 EYA3 | negative regulation of extrinsic apoptotic signaling pathway |
| GO:0007501 | 0.0468008499735 | 0.4 | SIX2 EYA2 | mesodermal cell fate specification |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EYA2 | SIX2 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SIX2 | EYA4 | 0.99 | 0.25 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EYA4 | SIX5 | 0.975 | 0.154 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| EYA3 | SIX2 | 0.973 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EYA3 | SIX5 | 0.935 | 0.078 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| EYA2 | EYA4 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| EYA3 | EYA2 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | ||
| EYA3 | EYA4 | 0.315 | 0.166 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes