hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10252.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GABRQ | Gamma-aminobutyric acid receptor subunit theta (GABA(A) receptor subunit theta) | 5 | UniProt NCBI |
| PON3 | Serum paraoxonase/lactonase 3 (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) | 5 | UniProt NCBI |
| CLEC2B | C-type lectin domain family 2 member B (Activation-induced C-type lectin) (C-type lectin superfamily member 2) (IFN-alpha-2b-inducing-related protein 1) | 4 | UniProt NCBI |
| PON1 | Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP136 | 5.36057998926e-05 | 0.5 | PON3 PON1 | Phase I biotransformations non P450 |
| REAC:R-HSA-2142688 | 0.000215205765992 | 0.5 | PON3 PON1 | Synthesis of 5-eicosatetraenoic acids |
| REAC:R-HSA-9754706 | 0.000286914834749 | 0.5 | PON3 PON1 | Atorvastatin ADME |
| REAC:R-HSA-2142753 | 0.0115164156767 | 0.5 | PON3 PON1 | Arachidonic acid metabolism |
| HP:0009067 | 0.0176079483787 | 0.5 | PON3 PON1 | Progressive spinal muscular atrophy |
| HP:0008955 | 0.0198386649826 | 0.5 | PON3 PON1 | Progressive distal muscular atrophy |
| HP:0025425 | 0.0234332085093 | 0.5 | PON3 PON1 | Laryngospasm |
| HP:0033683 | 0.0234332085093 | 0.5 | PON3 PON1 | Jaw hyperreflexia |
| HP:0030195 | 0.0259951101914 | 0.5 | PON3 PON1 | Fatigable weakness of swallowing muscles |
| HP:0025424 | 0.0315158796726 | 0.5 | PON3 PON1 | Abnormal larynx physiology |
| HP:0012473 | 0.0315158796726 | 0.5 | PON3 PON1 | Tongue atrophy |
| REAC:R-HSA-9748784 | 0.0329793636325 | 0.5 | PON3 PON1 | Drug ADME |
| HP:0007354 | 0.034474601612 | 0.5 | PON3 PON1 | Amyotrophic lateral sclerosis |
| HP:0002145 | 0.0375654511359 | 0.5 | PON3 PON1 | Frontotemporal dementia |
| HP:0000217 | 0.040788355352 | 0.5 | PON3 PON1 | Xerostomia |
| HP:0007269 | 0.040788355352 | 0.5 | PON3 PON1 | Spinal muscular atrophy |
| GO:0004064 | 0.042122686785 | 0.5 | PON3 PON1 | arylesterase activity |
| HP:0030196 | 0.0458701548093 | 0.5 | PON3 PON1 | Fatigable weakness of respiratory muscles |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PON3 | PON1 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GABRQ | CLEC2B | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CLEC2B | PON3 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GABRQ | PON3 | 0.633 | bioplex3_WMM WMM_only |
Related Complexes