hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10253.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TMEM94 | Transmembrane protein 94 | 3 | UniProt NCBI |
| CCNI | Cyclin-I | 4 | UniProt NCBI |
| C2CD5 | C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa) | 5 | UniProt NCBI |
| FIBP | Acidic fibroblast growth factor intracellular-binding protein (aFGF intracellular-binding protein) (FGF-1 intracellular-binding protein) | 5 | UniProt NCBI |
| CABLES1 | CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) | 5 | UniProt NCBI |
| CDK5 | Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) | 5 | UniProt NCBI |
| CABLES2 | CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2) | 3 | UniProt NCBI |
| CNPPD1 | Protein CNPPD1 (Cyclin Pas1/PHO80 domain-containing protein 1) | 3 | UniProt NCBI |
| CDK5R1 | Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9032845 | 0.000798060792831 | 0.222222222222 | CDK5R1 CDK5 | Activated NTRK2 signals through CDK5 |
| GO:0000307 | 0.00111503328238 | 0.444444444444 | CDK5R1 CCNI CDK5 CNPPD1 | cyclin-dependent protein kinase holoenzyme complex |
| REAC:R-HSA-399956 | 0.00835291407054 | 0.222222222222 | CDK5R1 CDK5 | CRMPs in Sema3A signaling |
| REAC:R-HSA-9768919 | 0.0121597301349 | 0.222222222222 | CDK5R1 CDK5 | NPAS4 regulates expression of target genes |
| REAC:R-HSA-9006115 | 0.0121597301349 | 0.222222222222 | CDK5R1 CDK5 | Signaling by NTRK2 (TRKB) |
| KEGG:05030 | 0.0138019713376 | 0.222222222222 | CDK5R1 CDK5 | Cocaine addiction |
| REAC:R-HSA-8862803 | 0.0166738379974 | 0.222222222222 | CDK5R1 CDK5 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 0.0166738379974 | 0.222222222222 | CDK5R1 CDK5 | Neurodegenerative Diseases |
| GO:0016533 | 0.016855225923 | 0.222222222222 | CDK5R1 CDK5 | protein kinase 5 complex |
| REAC:R-HSA-9734009 | 0.0218931941247 | 0.222222222222 | CDK5R1 CDK5 | Defective Intrinsic Pathway for Apoptosis |
| REAC:R-HSA-983231 | 0.0230866683473 | 0.333333333333 | CABLES2 CABLES1 CDK5 | Factors involved in megakaryocyte development and platelet production |
| WP:WP3878 | 0.0249090322132 | 0.222222222222 | CDK5R1 CDK5 | ATM signaling in development and disease |
| REAC:R-HSA-9634815 | 0.0299458635385 | 0.222222222222 | CDK5R1 CDK5 | Transcriptional Regulation by NPAS4 |
| GO:1902554 | 0.0320910249908 | 0.444444444444 | CDK5R1 CCNI CDK5 CNPPD1 | serine/threonine protein kinase complex |
| REAC:R-HSA-9031628 | 0.0392438573551 | 0.222222222222 | CDK5R1 CDK5 | NGF-stimulated transcription |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| C2CD5 | FIBP | 1.0 | 0.62 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| FIBP | CABLES1 | 1.0 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| FIBP | CABLES2 | 0.999 | 0.146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| FIBP | CDK5 | 0.999 | 0.056 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| CDK5 | CDK5R1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TMEM94 | FIBP | 0.998 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| C2CD5 | CDK5 | 0.995 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| CDK5 | CCNI | 0.993 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| C2CD5 | CABLES1 | 0.992 | 0.084 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CNPPD1 | CDK5 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CABLES1 | CDK5 | 0.987 | 0.086 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| TMEM94 | C2CD5 | 0.967 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only |
| TMEM94 | CABLES2 | 0.95 | 0.058 | bioplex_WMM bioplex3_WMM WMM_only |
| TMEM94 | CABLES1 | 0.931 | 0.132 | bioplex_WMM bioplex3_WMM WMM_only |
| C2CD5 | CABLES2 | 0.923 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only |
| CABLES1 | CABLES2 | 0.899 | 0.058 | bioplex_WMM bioplex3_WMM WMM_only |
| CABLES2 | CDK5 | 0.805 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only |
| TMEM94 | CDK5 | 0.397 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only |
| CABLES1 | CDK5R1 | 0.146 | bioplex3_WMM WMM_only | |
| C2CD5 | CDK5R1 | 0.043 | bioplex3_WMM WMM_only | |
| FIBP | CDK5R1 | 0.043 | bioplex3_WMM WMM_only |
Related Complexes