hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10258.1
Complex Portal: CPX-16070
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZMYM4 | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | 5 | UniProt NCBI |
| RCOR3 | REST corepressor 3 | 5 | UniProt NCBI |
| GSE1 | Genetic suppressor element 1 | 5 | UniProt NCBI |
| OVOL2 | Transcription factor Ovo-like 2 (hOvo2) (Zinc finger protein 339) | 5 | UniProt NCBI |
| ZMYM3 | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | 5 | UniProt NCBI |
| PWWP2A | PWWP domain-containing protein 2A | 5 | UniProt NCBI |
| RERE | Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) | 5 | UniProt NCBI |
| HMG20B | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (SMARCE1-related protein) (BRCA2-associated factor 35) (HMG box-containing protein 20B) (HMG domain-containing protein 2) (HMG domain-containing protein HMGX2) (Sox-like transcriptional factor) (Structural DNA-binding protein BRAF35) | 5 | UniProt NCBI |
| PHF12 | PHD finger protein 12 (PHD factor 1) (Pf1) | 5 | UniProt NCBI |
| PHF21A | PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80) | 5 | UniProt NCBI |
| EEF1AKMT4-ECE2 | EEF1AKMT4-ECE2 readthrough transcript protein (EC 3.4.24.71) [Includes: Methyltransferase-like region (EC 2.1.1.-); Endothelin-converting enzyme 2 region (EC 3.4.24.71)] | 5 | UniProt NCBI |
| RCOR1 | REST corepressor 1 (Protein CoREST) | 5 | UniProt NCBI |
| KDM1A | Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A) | 5 | UniProt NCBI |
| TRERF1 | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | 5 | UniProt NCBI |
| ADNP | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | 5 | UniProt NCBI |
| DNTTIP1 | Deoxynucleotidyltransferase terminal-interacting protein 1 (Terminal deoxynucleotidyltransferase-interacting factor 1) (TdIF1) (TdT-interacting factor 1) | 5 | UniProt NCBI |
| ZSCAN5A | Zinc finger and SCAN domain-containing protein 5A (Zinc finger protein 495) | 4 | UniProt NCBI |
| ZMYM2 | Zinc finger MYM-type protein 2 (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein) (Zinc finger protein 198) | 5 | UniProt NCBI |
| RCOR2 | REST corepressor 2 | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:633 | 2.24260864342e-17 | 0.368421052632 | RCOR1 GSE1 ZMYM3 KDM1A HMG20B PHF21A ZMYM2 | anti-BHC110 complex |
| CORUM:632 | 1.3159525735e-15 | 0.368421052632 | RCOR1 GSE1 ZMYM3 KDM1A HMG20B PHF21A ZMYM2 | Anti-HDAC2 complex |
| CORUM:1492 | 1.6034653305e-14 | 0.315789473684 | HMG20B PHF21A ZMYM2 RCOR1 GSE1 KDM1A | BHC110 complex |
| CORUM:626 | 1.30726370872e-13 | 0.315789473684 | RCOR1 RCOR3 ZMYM2 HMG20B PHF21A KDM1A | LSD1 complex |
| CORUM:636 | 1.16588129528e-09 | 0.210526315789 | HMG20B KDM1A PHF21A RCOR1 | BHC complex |
| CORUM:871 | 2.71815533384e-09 | 0.210526315789 | HMG20B KDM1A PHF21A RCOR1 | BRAF53-BRCA2 complex |
| CORUM:620 | 2.71815533384e-09 | 0.210526315789 | HMG20B KDM1A PHF21A RCOR1 | CoREST-HDAC complex |
| GO:0000118 | 5.32326883509e-08 | 0.368421052632 | DNTTIP1 RCOR2 RCOR1 PHF12 RCOR3 TRERF1 PHF21A | histone deacetylase complex |
| TF:M10112_1 | 1.73972532135e-05 | 0.894736842105 | DNTTIP1 ZMYM2 PWWP2A ZMYM3 OVOL2 PHF12 PHF21A RCOR3 ZMYM4 TRERF1 ADNP EEF1AKMT4-ECE2 HMG20B RCOR1 GSE1 RCOR2 KDM1A | Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR; match class: 1 |
| CORUM:642 | 4.77947327477e-05 | 0.157894736842 | RCOR3 KDM1A RCOR1 | CtBP complex |
| TF:M01118_1 | 5.27967518385e-05 | 0.789473684211 | PWWP2A ZMYM3 OVOL2 PHF12 PHF21A RCOR3 ZMYM4 TRERF1 ADNP KDM1A HMG20B RCOR1 GSE1 RCOR2 ZMYM2 | Factor: WT1; motif: SMCNCCNSC; match class: 1 |
| CORUM:624 | 6.11162772017e-05 | 0.105263157895 | RCOR1 KDM1A | LSD1-CoREST complex |
| CORUM:648 | 0.000183206632644 | 0.105263157895 | RCOR1 KDM1A | HDAC1-associated core complex cI |
| TF:M12464_1 | 0.000265109144545 | 0.736842105263 | PWWP2A ZMYM3 HMG20B PHF12 PHF21A RCOR3 ZMYM4 TRERF1 ADNP EEF1AKMT4-ECE2 RCOR1 GSE1 RCOR2 ZMYM2 | Factor: ZNF148; motif: NNCCCCTCCCCC; match class: 1 |
| TF:M01175_1 | 0.000472828808891 | 0.736842105263 | ZMYM2 RCOR2 ZMYM3 HMG20B PHF12 PHF21A RCOR3 ZMYM4 TRERF1 ADNP EEF1AKMT4-ECE2 RCOR1 GSE1 KDM1A | Factor: CKROX; motif: SCCCTCCCC; match class: 1 |
| CORUM:634 | 0.000609741949881 | 0.105263157895 | ZMYM3 KDM1A | XFIM complex |
| REAC:R-HSA-3214815 | 0.00090736193322 | 0.210526315789 | HMG20B KDM1A PHF21A RCOR1 | HDACs deacetylate histones |
| REAC:R-HSA-9679191 | 0.00115686058502 | 0.210526315789 | HMG20B KDM1A PHF21A RCOR1 | Potential therapeutics for SARS |
| GO:0003714 | 0.00182039196661 | 0.315789473684 | RERE RCOR1 PHF12 RCOR3 TRERF1 RCOR2 | transcription corepressor activity |
| HPA:0170252 | 0.00190527229325 | 0.526315789474 | ZMYM3 HMG20B PHF12 RCOR3 ZMYM4 TRERF1 ADNP KDM1A RCOR1 ZMYM2 | endometrium 2; cells in endometrial stroma[>=Medium] |
| CORUM:646 | 0.00218827065477 | 0.105263157895 | RCOR1 KDM1A | HDAC1-associated protein complex |
| CORUM:643 | 0.00218827065477 | 0.105263157895 | RCOR1 KDM1A | CtBP core complex |
| TF:M07436_1 | 0.00571531903459 | 0.684210526316 | PWWP2A ZMYM3 OVOL2 PHF12 PHF21A RCOR3 ZMYM4 TRERF1 ADNP ZMYM2 RCOR1 GSE1 RCOR2 | Factor: WT1; motif: NNGGGNGGGSGN; match class: 1 |
| GO:0005667 | 0.00994377494074 | 0.368421052632 | RCOR2 TRERF1 PHF12 RCOR3 KDM1A ADNP RCOR1 | transcription regulator complex |
| REAC:R-HSA-983231 | 0.013116233271 | 0.210526315789 | HMG20B KDM1A PHF21A RCOR1 | Factors involved in megakaryocyte development and platelet production |
| TF:M12057_1 | 0.0147753805588 | 0.526315789474 | RCOR2 ZMYM3 RCOR1 ADNP RCOR3 ZMYM4 KDM1A TRERF1 GSE1 ZMYM2 | Factor: ZBP99; motif: GCCCMTCCCCCR; match class: 1 |
| HP:0001182 | 0.017487036475 | 0.210526315789 | ADNP ZMYM2 PHF21A KDM1A | Tapered finger |
| TF:M09834_1 | 0.0229802976739 | 0.684210526316 | RCOR2 ZMYM3 HMG20B PHF12 PHF21A RCOR3 ZMYM4 TRERF1 ADNP ZMYM2 OVOL2 RCOR1 GSE1 | Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN; match class: 1 |
| GO:0045892 | 0.02304919751 | 0.473684210526 | RCOR2 RCOR1 PHF12 RCOR3 TRERF1 KDM1A OVOL2 PHF21A ZMYM2 | negative regulation of DNA-templated transcription |
| GO:1902679 | 0.0254085658836 | 0.473684210526 | RCOR2 RCOR1 PHF12 RCOR3 TRERF1 KDM1A OVOL2 PHF21A ZMYM2 | negative regulation of RNA biosynthetic process |
| GO:0003712 | 0.0274132472444 | 0.368421052632 | RERE RCOR1 PHF12 RCOR3 KDM1A TRERF1 RCOR2 | transcription coregulator activity |
| TF:M10432_1 | 0.0328763033098 | 0.789473684211 | PWWP2A ZMYM3 OVOL2 ZSCAN5A PHF12 PHF21A RCOR3 ZMYM4 TRERF1 ADNP ZMYM2 HMG20B RCOR1 GSE1 RCOR2 | Factor: MAZ; motif: GGGMGGGGS; match class: 1 |
| CORUM:2160 | 0.0496196263904 | 0.0526315789474 | KDM1A | AOF2-AR complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| HMG20B | GSE1 | 1.0 | 0.058 | |
| GSE1 | RCOR1 | 1.0 | 0.066 | |
| HMG20B | RCOR1 | 1.0 | 0.082 | |
| HMG20B | KDM1A | 1.0 | 0.236 |
structurally_consistent (dimer)
|
| HMG20B | RCOR3 | 1.0 | 0.152 | |
| RCOR1 | KDM1A | 1.0 | 0.496 |
structurally_consistent (dimer)
|
| RCOR3 | KDM1A | 1.0 | 0.724 |
structurally_consistent (dimer)
|
| HMG20B | PHF21A | 1.0 | 0.252 | |
| ZSCAN5A | ZMYM2 | 1.0 | ||
| GSE1 | RCOR3 | 0.999 | 0.104 | |
| RCOR3 | RCOR1 | 0.999 | 0.32 | |
| GSE1 | KDM1A | 0.999 | 0.289164179104 | |
| ZMYM2 | RCOR3 | 0.999 | 0.17 | |
| PHF21A | RCOR1 | 0.999 | 0.076 | |
| ZMYM2 | ZMYM3 | 0.999 | 0.182 | |
| ZMYM4 | ZMYM2 | 0.999 | 0.148 | |
| ZMYM4 | ZSCAN5A | 0.999 | ||
| PHF21A | RCOR3 | 0.999 | 0.084 |
mutually_exclusive (O60341)
|
| ZMYM2 | RCOR1 | 0.998 | 0.116 | |
| HMG20B | RCOR2 | 0.998 | 0.102 | |
| ZMYM3 | RCOR3 | 0.998 | 0.15 | |
| HMG20B | OVOL2 | 0.997 | ||
| ZMYM3 | RCOR1 | 0.996 | 0.098 | |
| ADNP | ZMYM3 | 0.996 | 0.55 | |
| EEF1AKMT4-ECE2 | RCOR3 | 0.996 | 0.066 | |
| ZSCAN5A | RCOR2 | 0.996 | ||
| EEF1AKMT4-ECE2 | RCOR2 | 0.995 | 0.044 | |
| ZMYM4 | ZMYM3 | 0.995 | 0.234 | |
| TRERF1 | DNTTIP1 | 0.994 | ||
| PHF21A | GSE1 | 0.994 | 0.1 |
mutually_exclusive (Q13547)
|
| ZMYM2 | KDM1A | 0.993 | 0.4 | |
| PHF21A | KDM1A | 0.993 | 0.18 |
structurally_consistent (dimer)
|
| ZSCAN5A | ZMYM3 | 0.992 | ||
| ZSCAN5A | KDM1A | 0.992 | ||
| ZSCAN5A | RCOR3 | 0.991 | ||
| EEF1AKMT4-ECE2 | KDM1A | 0.989 | 0.216 | |
| TRERF1 | PWWP2A | 0.987 | ||
| ZMYM2 | RCOR2 | 0.986 | 0.228 | |
| RCOR2 | KDM1A | 0.985 | 0.102 |
structurally_consistent (dimer)
|
| PWWP2A | DNTTIP1 | 0.984 | 0.212 | |
| ZSCAN5A | RCOR1 | 0.98 | ||
| ZMYM3 | KDM1A | 0.978 | 0.474 | |
| PHF12 | RCOR1 | 0.978 | 0.104 | |
| ZMYM4 | RCOR1 | 0.976 | 0.1 | |
| ZMYM2 | HMG20B | 0.974 | 0.076 | |
| RCOR2 | RCOR3 | 0.974 | 0.07 | |
| PWWP2A | RCOR3 | 0.972 | 0.104 | |
| ZMYM2 | TRERF1 | 0.969 |
mutually_exclusive (Q13547)
|
|
| PHF12 | TRERF1 | 0.968 | ||
| ADNP | ZMYM2 | 0.967 | 0.34 | |
| HMG20B | PWWP2A | 0.967 | 0.12 | |
| PHF12 | RCOR3 | 0.966 | 0.112 | |
| PWWP2A | RCOR1 | 0.965 | 0.17 | |
| RERE | PWWP2A | 0.965 | 0.108 | |
| ADNP | RCOR3 | 0.964 | 0.25 | |
| PHF12 | GSE1 | 0.964 | 0.172 | |
| GSE1 | RCOR2 | 0.961 | 0.144 | |
| PHF21A | RCOR2 | 0.961 | 0.08 | |
| OVOL2 | KDM1A | 0.96 | ||
| RERE | ZMYM2 | 0.96 | 0.132 | |
| RCOR2 | RCOR1 | 0.958 | 0.066 | |
| GSE1 | PWWP2A | 0.957 | 0.058 | |
| PHF12 | HMG20B | 0.956 | 0.238 | |
| RERE | PHF12 | 0.956 | 0.276 | |
| ZMYM3 | TRERF1 | 0.939 | ||
| ZMYM3 | HMG20B | 0.906 | 0.162 | |
| EEF1AKMT4-ECE2 | RCOR1 | 0.899 | 0.092 | |
| ZMYM4 | RCOR3 | 0.891 | 0.12 | |
| RERE | HMG20B | 0.878 | 0.116 | |
| ZMYM3 | DNTTIP1 | 0.877 | 0.07 | |
| PWWP2A | KDM1A | 0.871 | 0.16 | |
| RERE | TRERF1 | 0.87 | ||
| ZMYM3 | PWWP2A | 0.863 | 0.142 | |
| PHF12 | ZMYM2 | 0.857 | 0.362 | |
| TRERF1 | KDM1A | 0.856 | ||
| PHF12 | KDM1A | 0.856 | 0.372 | |
| ADNP | ZMYM4 | 0.855 | 0.46 | |
| RERE | KDM1A | 0.85 | 0.378 | |
| ADNP | RCOR1 | 0.847 | 0.096 | |
| RERE | ZMYM3 | 0.841 | 0.13 | |
| TRERF1 | RCOR3 | 0.841 |
mutually_exclusive (Q13547)
|
|
| TRERF1 | RCOR1 | 0.841 | ||
| PHF12 | PWWP2A | 0.835 | 0.108 | |
| HMG20B | TRERF1 | 0.832 | ||
| ZMYM3 | RCOR2 | 0.825 | 0.146 | |
| GSE1 | TRERF1 | 0.806 | ||
| RERE | GSE1 | 0.793 | 0.096 | |
| ZMYM3 | GSE1 | 0.763 | 0.096 | |
| RERE | RCOR3 | 0.758 | 0.106 | |
| ADNP | KDM1A | 0.75 | 0.282 | |
| OVOL2 | RCOR1 | 0.749 | ||
| RERE | RCOR1 | 0.735 | 0.17 | |
| TRERF1 | RCOR2 | 0.73 |
mutually_exclusive (Q13547)
|
|
| ZMYM2 | PWWP2A | 0.725 | 0.066 | |
| HMG20B | DNTTIP1 | 0.71 | 0.09 | |
| RERE | DNTTIP1 | 0.71 | 0.07 | |
| ZMYM4 | KDM1A | 0.686 | 0.386 | |
| OVOL2 | RCOR3 | 0.672 | ||
| RERE | PHF21A | 0.658 | 0.23 | |
| PHF21A | TRERF1 | 0.637 |
mutually_exclusive (Q13547)
|
|
| DNTTIP1 | RCOR2 | 0.605 | 0.028 | |
| DNTTIP1 | RCOR1 | 0.604 | 0.062 |
mutually_exclusive (Q92769)
|
| GSE1 | DNTTIP1 | 0.594 | 0.096 | |
| RERE | RCOR2 | 0.567 | 0.092 | |
| DNTTIP1 | RCOR3 | 0.55 | 0.07 |
mutually_exclusive (Q92769)
|
| PHF12 | ZMYM3 | 0.479 | 0.11 | |
| ZMYM2 | PHF21A | 0.468 | 0.15 | |
| ADNP | RCOR2 | 0.447 | 0.084 | |
| PHF21A | DNTTIP1 | 0.443 | 0.072 | |
| PHF12 | PHF21A | 0.44 | 0.222 | |
| RERE | ADNP | 0.436 | 0.146 | |
| ZMYM2 | DNTTIP1 | 0.417 | 0.062 | |
| PHF12 | DNTTIP1 | 0.412 | 0.134 | |
| PHF21A | PWWP2A | 0.396 | 0.118 | |
| ZMYM2 | GSE1 | 0.367 | 0.094 | |
| ZMYM4 | RCOR2 | 0.346 | 0.044 | |
| ZMYM3 | PHF21A | 0.312 | 0.122 | |
| DNTTIP1 | KDM1A | 0.201 | 0.146 | |
| PHF12 | RCOR2 | 0.19 | 0.092 | |
| PWWP2A | RCOR2 | 0.143 | 0.06 | |
| ADNP | ZSCAN5A | 0.079 | ||
| ADNP | TRERF1 | 0.063 | ||
| ADNP | HMG20B | 0.063 | 0.104 | |
| RERE | ZMYM4 | 0.043 | 0.164 | |
| ADNP | PHF12 | 0.042 | 0.33 | |
| ADNP | PHF21A | 0.041 | 0.086 | |
| ADNP | PWWP2A | 0.039 | 0.116 | |
| ZMYM4 | HMG20B | 0.036 | 0.168 | |
| ADNP | GSE1 | 0.03 | 0.1 | |
| ZMYM4 | GSE1 | 0.02 | 0.162 | |
| ADNP | DNTTIP1 | 0.018 | 0.096 | |
| ZMYM4 | PHF21A | 0.017 | 0.084 | |
| OVOL2 | GSE1 | 0.015 | ||
| PHF12 | ZMYM4 | 0.014 | 0.134 | |
| ZMYM4 | DNTTIP1 | 0.006 | 0.072 |
Related Complexes