hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10260.1

Complex Portal: CPX-10868

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
CTSG	Cathepsin G (CG) (EC 3.4.21.20) [Cleaved into: Cathepsin G, C-terminal truncated form]	5	UniProt NCBI
CYP3A43	Cytochrome P450 3A43 (EC 1.14.14.1)	5	UniProt NCBI
SMIM8	Small integral membrane protein 8	2	UniProt NCBI
ANXA3	Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III)	5	UniProt NCBI
MMP8	Neutrophil collagenase (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL)	5	UniProt NCBI
BPI	Bactericidal permeability-increasing protein (BPI) (CAP 57)	5	UniProt NCBI
PRTN3	Myeloblastin (EC 3.4.21.76) (AGP7) (C-ANCA antigen) (Leukocyte proteinase 3) (PR-3) (PR3) (Neutrophil proteinase 4) (NP-4) (P29) (Wegener autoantigen)	5	UniProt NCBI
ARHGDIB	Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (Ly-GDI) (Rho-GDI beta)	5	UniProt NCBI
EGFL8	Epidermal growth factor-like protein 8 (EGF-like protein 8) (Vascular endothelial statin-2) (VE-statin-2)	5	UniProt NCBI
ELANE	Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase)	5	UniProt NCBI
MPO	Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain]	5	UniProt NCBI
ITGAM	Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)	5	UniProt NCBI
MNDA	Myeloid cell nuclear differentiation antigen	5	UniProt NCBI
GNG8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 (Gamma-9)	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-6798695	6.52650609645e-05	0.545454545455	MPO ELANE MMP8 MNDA CTSG PRTN3	Neutrophil degranulation
GO:0035578	0.000149449757499	0.454545454545	CTSG MPO MNDA PRTN3 ELANE	azurophil granule lumen
REAC:R-HSA-1592389	0.000164893810838	0.272727272727	CTSG MMP8 ELANE	Activation of Matrix Metalloproteinases
GO:0034774	0.00120678376762	0.545454545455	MPO ELANE MMP8 MNDA CTSG PRTN3	secretory granule lumen
GO:0060205	0.00125747239864	0.545454545455	MPO ELANE MMP8 MNDA CTSG PRTN3	cytoplasmic vesicle lumen
GO:0031983	0.00128347045579	0.545454545455	MPO ELANE MMP8 MNDA CTSG PRTN3	vesicle lumen
HPA:0040083	0.00149022613417	0.636363636364	MPO ELANE ARHGDIB MMP8 MNDA CTSG PRTN3	bone marrow; hematopoietic cells[High]
GO:0005766	0.00197517902501	0.454545454545	CTSG MPO MNDA PRTN3 ELANE	primary lysosome
GO:0042582	0.00197517902501	0.454545454545	CTSG MPO MNDA PRTN3 ELANE	azurophil granule
REAC:R-HSA-6803157	0.00235166852176	0.272727272727	CTSG PRTN3 ELANE	Antimicrobial peptides
GO:0005775	0.00294309287827	0.454545454545	CTSG MPO MNDA PRTN3 ELANE	vacuolar lumen
REAC:R-HSA-168249	0.00454683274465	0.545454545455	MPO ELANE MMP8 MNDA CTSG PRTN3	Innate Immune System
KEGG:04613	0.00822526724793	0.272727272727	CTSG MPO ELANE	Neutrophil extracellular trap formation
REAC:R-HSA-1474228	0.014771707923	0.272727272727	CTSG MMP8 ELANE	Degradation of the extracellular matrix
GO:0004252	0.0234558852507	0.363636363636	CTSG ELANE MMP8 PRTN3	serine-type endopeptidase activity
CORUM:7177	0.049976851631	0.0909090909091	GNG8	GNAS-L-GNB3-GNG8 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
BPI	EGFL8	0.997
CYP3A43	BPI	0.996
MMP8	SMIM8	0.994
EGFL8	MNDA	0.994
ITGAM	CYP3A43	0.992
CYP3A43	ARHGDIB	0.992
EGFL8	ELANE	0.992
ARHGDIB	EGFL8	0.992
EGFL8	PRTN3	0.991		structurally_consistent (dimer)
SMIM8	MNDA	0.99		mutually_exclusive (P24158)
CTSG	EGFL8	0.987
GNG8	BPI	0.986
CYP3A43	MNDA	0.983
CYP3A43	ELANE	0.982
GNG8	ELANE	0.98		mutually_exclusive (P24158)
GNG8	MNDA	0.977
GNG8	PRTN3	0.977		structurally_consistent (P08311) structurally_consistent (dimer)
ELANE	SMIM8	0.977
MPO	EGFL8	0.975
CYP3A43	CTSG	0.974
MMP8	GNG8	0.973
ITGAM	GNG8	0.971
ANXA3	GNG8	0.971
CYP3A43	PRTN3	0.968		structurally_consistent (dimer)
CTSG	SMIM8	0.962		mutually_exclusive (P24158)
CYP3A43	MPO	0.958
GNG8	CTSG	0.956		structurally_consistent (dimer)
MPO	CTSG	0.956	0.328
MPO	SMIM8	0.953
GNG8	MPO	0.924
CTSG	ELANE	0.868	0.254	structurally_consistent (dimer)
MPO	ELANE	0.868	0.304
BPI	MNDA	0.822	0.082
CTSG	MNDA	0.805	0.354	structurally_consistent (dimer)
ELANE	MNDA	0.805	0.242	structurally_consistent (dimer)
MPO	MNDA	0.805	0.328
BPI	ELANE	0.792	0.282
ITGAM	MMP8	0.785
BPI	PRTN3	0.779
BPI	CTSG	0.779	0.268
PRTN3	MNDA	0.779	0.214	structurally_consistent (P08311) structurally_consistent (dimer)
MMP8	BPI	0.777
BPI	MPO	0.77	0.224
ARHGDIB	MNDA	0.766	0.156
ITGAM	BPI	0.766	0.212
MPO	ARHGDIB	0.765	0.118
ITGAM	MNDA	0.753	0.176
ITGAM	ELANE	0.753	0.232
GNG8	ARHGDIB	0.742
ARHGDIB	PRTN3	0.732	0.13
BPI	ARHGDIB	0.709	0.056
ITGAM	MPO	0.709	0.23
ARHGDIB	ELANE	0.709	0.164
ITGAM	PRTN3	0.709	0.284
ITGAM	CTSG	0.709	0.192
CTSG	ARHGDIB	0.686	0.114
MMP8	MPO	0.667
MMP8	ELANE	0.667
MMP8	MNDA	0.667
ITGAM	ARHGDIB	0.667	0.108
MMP8	CTSG	0.667
PRTN3	ELANE	0.638	0.356	structurally_consistent (dimer)
MMP8	PRTN3	0.625
MPO	PRTN3	0.583	0.254
CTSG	PRTN3	0.579	0.222	structurally_consistent (dimer)
MMP8	ARHGDIB	0.433
ANXA3	MPO	0.379	0.082
ANXA3	ARHGDIB	0.079	0.12
ANXA3	BPI	0.079	0.07
ANXA3	MNDA	0.079	0.116
ANXA3	MMP8	0.065
ITGAM	ANXA3	0.063	0.112
ANXA3	ELANE	0.058	0.112
ANXA3	PRTN3	0.051	0.134
PRTN3	SMIM8	0.033		structurally_consistent (dimer)
ANXA3	CTSG	0.01	0.174
ANXA3	EGFL8	0.002
ANXA3	SMIM8	0.002	0.03
CYP3A43	ANXA3	0.002

Related Complexes

Genename	Complexes
CTSG	huMAP3_03846.1 huMAP3_10260.1 huMAP3_11343.1 huMAP3_13546.1
CYP3A43	huMAP3_02125.1 huMAP3_05837.1 huMAP3_06009.1 huMAP3_09846.1 huMAP3_10260.1 huMAP3_11343.1 huMAP3_14556.1 huMAP3_14585.1
SMIM8	huMAP3_07991.1 huMAP3_09846.1 huMAP3_10260.1 huMAP3_11343.1 huMAP3_13546.1
ANXA3	huMAP3_02768.1 huMAP3_04465.1 huMAP3_06454.1 huMAP3_07446.1 huMAP3_08049.1 huMAP3_08139.1 huMAP3_09846.1 huMAP3_10260.1 huMAP3_11819.1 huMAP3_12898.1 huMAP3_13279.1 huMAP3_14481.1
MMP8	huMAP3_02768.1 huMAP3_06454.1 huMAP3_07446.1 huMAP3_07991.1 huMAP3_08139.1 huMAP3_09846.1 huMAP3_10260.1 huMAP3_14295.1
BPI	huMAP3_02938.1 huMAP3_10260.1 huMAP3_14295.1 huMAP3_14556.1
PRTN3	huMAP3_07914.1 huMAP3_10260.1 huMAP3_12334.1 huMAP3_12535.1 huMAP3_13103.1
ARHGDIB	huMAP3_05837.1 huMAP3_06009.1 huMAP3_07915.1 huMAP3_09846.1 huMAP3_10260.1 huMAP3_15228.1
EGFL8	huMAP3_06009.1 huMAP3_07915.1 huMAP3_09846.1 huMAP3_10260.1 huMAP3_11343.1 huMAP3_15040.1
ELANE	huMAP3_07914.1 huMAP3_10260.1 huMAP3_11343.1 huMAP3_13546.1
MPO	huMAP3_03846.1 huMAP3_10260.1 huMAP3_11343.1 huMAP3_13546.1
ITGAM	huMAP3_02125.1 huMAP3_02768.1 huMAP3_05837.1 huMAP3_07446.1 huMAP3_08139.1 huMAP3_08988.1 huMAP3_09846.1 huMAP3_10260.1 huMAP3_14295.1
MNDA	huMAP3_10260.1 huMAP3_11343.1 huMAP3_13546.1
GNG8	huMAP3_02768.1 huMAP3_04465.1 huMAP3_06454.1 huMAP3_07446.1 huMAP3_08049.1 huMAP3_08139.1 huMAP3_09846.1 huMAP3_10260.1 huMAP3_11819.1 huMAP3_15040.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10260.1

Complex Portal: CPX-10868