hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10266.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CFAP74 | Cilia- and flagella-associated protein 74 | 5 | UniProt NCBI |
| RNF34 | E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34) | 5 | UniProt NCBI |
| PDE9A | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35) | 5 | UniProt NCBI |
| PALD1 | Paladin | 4 | UniProt NCBI |
| MACIR | Macrophage immunometabolism regulator | 5 | UniProt NCBI |
| UNC119 | Protein unc-119 homolog A (Retinal protein 4) (hRG4) | 5 | UniProt NCBI |
| AVPI1 | Arginine vasopressin-induced protein 1 (AVP-induced protein 1) | 5 | UniProt NCBI |
| UNC119B | Protein unc-119 homolog B | 5 | UniProt NCBI |
| PRDM16 | Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) | 5 | UniProt NCBI |
| SPDEF | SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor) | 5 | UniProt NCBI |
| PRKG2 | cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) | 5 | UniProt NCBI |
| DENND4C | DENN domain-containing protein 4C | 5 | UniProt NCBI |
| RSPRY1 | RING finger and SPRY domain-containing protein 1 | 4 | UniProt NCBI |
| CYS1 | Cystin-1 (Cilia-associated protein) | 4 | UniProt NCBI |
| PSKH2 | Serine/threonine-protein kinase H2 (EC 2.7.11.1) (Protein serine kinase H2) (PSK-H2) | 5 | UniProt NCBI |
| LZTS1 | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5624138 | 0.00327932770653 | 0.125 | UNC119B CYS1 | Trafficking of myristoylated proteins to the cilium |
| HP:0004592 | 0.0182741382889 | 0.125 | PRKG2 RSPRY1 | Thoracic platyspondyly |
| REAC:R-HSA-418457 | 0.021546998337 | 0.125 | PDE9A PRKG2 | cGMP effects |
| REAC:R-HSA-392154 | 0.0442583139424 | 0.125 | PDE9A PRKG2 | Nitric oxide stimulates guanylate cyclase |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| UNC119 | UNC119B | 1.0 | 0.32 |
| UNC119 | MACIR | 0.999 | 0.092 |
| PALD1 | UNC119 | 0.999 | 0.066 |
| UNC119 | AVPI1 | 0.999 | |
| PDE9A | UNC119 | 0.999 | |
| UNC119 | LZTS1 | 0.998 | 0.036 |
| UNC119 | PSKH2 | 0.998 | |
| PALD1 | UNC119B | 0.997 | 0.014 |
| PSKH2 | UNC119B | 0.997 | |
| UNC119 | SPDEF | 0.996 | |
| RNF34 | UNC119 | 0.996 | 0.072 |
| AVPI1 | MACIR | 0.995 | |
| AVPI1 | UNC119B | 0.995 | |
| SPDEF | MACIR | 0.995 | |
| RNF34 | UNC119B | 0.995 | 0.038 |
| SPDEF | PRDM16 | 0.994 | |
| CYS1 | UNC119B | 0.994 | |
| UNC119B | MACIR | 0.994 | 0.056 |
| UNC119 | CYS1 | 0.985 | |
| MACIR | DENND4C | 0.978 | 0.064 |
| UNC119 | RSPRY1 | 0.977 | 0.122 |
| RSPRY1 | UNC119B | 0.977 | 0.068 |
| SPDEF | UNC119B | 0.976 | |
| PALD1 | MACIR | 0.972 | 0.05 |
| RSPRY1 | MACIR | 0.971 | 0.084 |
| UNC119 | PRKG2 | 0.966 | |
| UNC119B | LZTS1 | 0.955 | 0.04 |
| PDE9A | PALD1 | 0.918 | |
| PDE9A | LZTS1 | 0.916 | |
| PDE9A | MACIR | 0.789 | |
| PDE9A | RSPRY1 | 0.693 | |
| PDE9A | PRKG2 | 0.65 | |
| PDE9A | UNC119B | 0.605 | |
| PALD1 | LZTS1 | 0.582 | 0.072 |
| PRKG2 | LZTS1 | 0.572 | |
| PDE9A | AVPI1 | 0.557 | |
| AVPI1 | PRKG2 | 0.557 | |
| AVPI1 | LZTS1 | 0.53 | |
| PALD1 | PRKG2 | 0.495 | |
| PALD1 | RSPRY1 | 0.468 | 0.036 |
| RNF34 | PDE9A | 0.46 | |
| RNF34 | PRKG2 | 0.45 | |
| LZTS1 | MACIR | 0.448 | 0.09 |
| RSPRY1 | LZTS1 | 0.408 | 0.118 |
| PALD1 | AVPI1 | 0.336 | |
| RNF34 | AVPI1 | 0.333 | |
| UNC119 | PRDM16 | 0.268 | |
| PRKG2 | MACIR | 0.267 | |
| AVPI1 | RSPRY1 | 0.218 | |
| RNF34 | PALD1 | 0.216 | 0.042 |
| PRDM16 | MACIR | 0.215 | |
| PRKG2 | RSPRY1 | 0.201 | |
| UNC119B | PRDM16 | 0.189 | |
| RNF34 | MACIR | 0.186 | 0.074 |
| RNF34 | LZTS1 | 0.172 | 0.074 |
| PRKG2 | UNC119B | 0.165 | |
| RNF34 | DENND4C | 0.076 | 0.088 |
| RSPRY1 | CFAP74 | 0.063 | |
| RNF34 | RSPRY1 | 0.051 | 0.128 |
| PALD1 | DENND4C | 0.017 | 0.038 |
| LZTS1 | DENND4C | 0.014 | 0.074 |
| UNC119B | DENND4C | 0.014 | 0.056 |
| PALD1 | PRDM16 | 0.008 |
Related Complexes