hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10270.1

Complex Portal: CPX-16749

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
PTGR3	Prostaglandin reductase 3 (PRG-3) (EC 1.3.1.48) (Zinc-binding alcohol dehydrogenase domain-containing protein 2)	4	UniProt NCBI
MYH14	Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C)	5	UniProt NCBI
FBXO40	F-box only protein 40 (Muscle disease-related protein)	4	UniProt NCBI
MYH10	Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB)	5	UniProt NCBI
MYH9	Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)	5	UniProt NCBI
SYNPO	Synaptopodin	5	UniProt NCBI
MYL6	Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6)	5	UniProt NCBI
JMY	Junction-mediating and -regulatory protein	5	UniProt NCBI
MYL12B	Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)	5	UniProt NCBI
MYL3	Myosin light chain 3 (Cardiac myosin light chain 1) (CMLC1) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin alkali light chain) (Ventricular myosin light chain 1) (VLCl) (Ventricular/slow twitch myosin alkali light chain) (MLC-lV/sb)	5	UniProt NCBI
IQGAP2	Ras GTPase-activating-like protein IQGAP2	5	UniProt NCBI
IQGAP1	Ras GTPase-activating-like protein IQGAP1 (p195)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-5627117	4.48164941267e-10	0.416666666667	MYL6 MYH14 MYL12B MYH10 MYH9	RHO GTPases Activate ROCKs
REAC:R-HSA-416572	4.48164941267e-10	0.416666666667	MYL6 MYH14 MYL12B MYH10 MYH9	Sema4D induced cell migration and growth-cone collapse
REAC:R-HSA-5625900	4.48164941267e-10	0.416666666667	MYL6 MYH14 MYL12B MYH10 MYH9	RHO GTPases activate CIT
REAC:R-HSA-5627123	5.97314512092e-10	0.416666666667	MYL6 MYH14 MYL12B MYH10 MYH9	RHO GTPases activate PAKs
REAC:R-HSA-400685	1.29482408489e-09	0.416666666667	MYL6 MYH14 MYL12B MYH10 MYH9	Sema4D in semaphorin signaling
REAC:R-HSA-3928663	2.52820160423e-09	0.416666666667	MYL6 MYH14 MYL12B MYH10 MYH9	EPHA-mediated growth cone collapse
KEGG:04530	3.04301041155e-08	0.5	MYL12B MYH14 SYNPO MYL6 MYH9 MYH10	Tight junction
GO:0015629	4.61603524673e-08	0.75	MYL12B IQGAP1 MYH14 SYNPO MYL6 IQGAP2 MYH9 MYH10 MYL3	actin cytoskeleton
KEGG:04814	7.68391335435e-08	0.5	MYL12B MYH14 MYL6 MYH9 MYH10 MYL3	Motor proteins
REAC:R-HSA-373755	1.89892922681e-07	0.416666666667	MYL6 MYH14 MYL12B MYH10 MYH9	Semaphorin interactions
KEGG:04810	2.34723989078e-07	0.5	MYL12B IQGAP1 MYH14 MYH9 IQGAP2 MYH10	Regulation of actin cytoskeleton
GO:0016460	2.3824763162e-07	0.416666666667	MYL6 MYH14 MYH10 MYL3 MYH9	myosin II complex
REAC:R-HSA-195258	2.57045599412e-07	0.583333333333	MYL12B IQGAP1 MYH14 MYL6 MYH9 IQGAP2 MYH10	RHO GTPase Effectors
REAC:R-HSA-5625740	9.6330407271e-07	0.416666666667	MYL6 MYH14 MYL12B MYH10 MYH9	RHO GTPases activate PKNs
REAC:R-HSA-2682334	1.02544521764e-06	0.416666666667	MYL6 MYH14 MYL12B MYH10 MYH9	EPH-Ephrin signaling
GO:0016459	1.42069743999e-06	0.416666666667	MYL6 MYH14 MYH10 MYL3 MYH9	myosin complex
GO:0097513	2.11464090368e-05	0.25	MYH14 MYH10 MYH9	myosin II filament
GO:0003779	2.90085093994e-05	0.583333333333	MYL3 IQGAP1 SYNPO MYH14 MYH9 IQGAP2 MYH10	actin binding
GO:0031032	3.78150391615e-05	0.5	IQGAP1 SYNPO MYH14 MYH9 IQGAP2 MYH10	actomyosin structure organization
GO:0042641	3.81014307417e-05	0.416666666667	MYH14 MYL12B SYNPO MYH10 MYH9	actomyosin
KEGG:04270	4.31969130907e-05	0.333333333333	MYL6 MYH14 MYH10 MYH9	Vascular smooth muscle contraction
REAC:R-HSA-194315	4.76736012089e-05	0.583333333333	MYL12B IQGAP1 MYH14 MYL6 MYH9 IQGAP2 MYH10	Signaling by Rho GTPases
REAC:R-HSA-9716542	5.54018658177e-05	0.583333333333	MYL12B IQGAP1 MYH14 MYL6 MYH9 IQGAP2 MYH10	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
GO:0099512	9.16079638887e-05	0.666666666667	MYL12B IQGAP1 MYL3 SYNPO MYH14 IQGAP2 MYH9 MYH10	supramolecular fiber
GO:0099081	0.000101119084683	0.666666666667	MYL12B IQGAP1 MYL3 SYNPO MYH14 IQGAP2 MYH9 MYH10	supramolecular polymer
GO:0030029	0.000148299709923	0.666666666667	IQGAP2 IQGAP1 MYH14 SYNPO MYL6 JMY MYH9 MYH10	actin filament-based process
CORUM:486	0.000225350794349	0.166666666667	MYH9 MYL6	WIP-WASp-actin-myosin-IIa complex
GO:0000146	0.000462656529812	0.333333333333	MYL6 MYH14 MYH10 MYH9	microfilament motor activity
GO:0008092	0.00062102810733	0.666666666667	IQGAP2 MYL3 IQGAP1 JMY MYH14 SYNPO MYH9 MYH10	cytoskeletal protein binding
GO:0030036	0.00271618387292	0.583333333333	IQGAP1 JMY MYH14 SYNPO IQGAP2 MYH10 MYH9	actin cytoskeleton organization
GO:0099080	0.00310763574538	0.666666666667	MYL12B IQGAP1 MYL3 SYNPO MYH14 IQGAP2 MYH9 MYH10	supramolecular complex
GO:0097517	0.00402975500401	0.333333333333	MYH9 MYL12B MYH10 SYNPO	contractile actin filament bundle
GO:0001725	0.00402975500401	0.333333333333	MYH9 MYL12B MYH10 SYNPO	stress fiber
GO:0032432	0.00578662173363	0.333333333333	MYH9 MYL12B MYH10 SYNPO	actin filament bundle
REAC:R-HSA-422475	0.0067875022035	0.416666666667	MYL6 MYH14 MYL12B MYH10 MYH9	Axon guidance
GO:0051015	0.00722685728433	0.416666666667	IQGAP2 MYH14 IQGAP1 MYH10 MYH9	actin filament binding
REAC:R-HSA-9675108	0.00809947326709	0.416666666667	MYL6 MYH14 MYL12B MYH10 MYH9	Nervous system development
GO:0005938	0.00835872057838	0.416666666667	IQGAP2 MYH9 IQGAP1 MYH10 MYL12B	cell cortex
GO:0005856	0.0117703736413	0.75	MYL12B IQGAP1 MYH14 SYNPO MYL6 IQGAP2 MYH9 MYH10 MYL3	cytoskeleton
GO:0032982	0.0142868257683	0.25	MYH14 MYH10 MYH9	myosin filament
KEGG:05130	0.0149918612825	0.25	MYH14 MYH10 MYH9	Pathogenic Escherichia coli infection
WP:WP51	0.0159186203537	0.25	MYL3 MYH10 IQGAP1	Regulation of actin cytoskeleton
GO:0003774	0.0306371941249	0.333333333333	MYL6 MYH14 MYH10 MYH9	cytoskeletal motor activity
WP:WP524	0.0375857505732	0.166666666667	IQGAP2 IQGAP1	G13 signaling pathway
WP:WP4758	0.0473228596265	0.166666666667	MYH9 SYNPO	Nephrotic syndrome
CORUM:1844	0.0499436884912	0.0833333333333	IQGAP1	APC-IQGAP1 complex
CORUM:6729	0.0499436884912	0.0833333333333	IQGAP1	IQGAP1-CXCR2 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
MYH9	MYL6	0.999	0.428674157303
MYL12B	MYH10	0.998	0.124
MYH9	MYL3	0.998	0.564	structurally_consistent (dimer)
MYL3	MYH10	0.998	0.044
MYL6	MYH10	0.996	0.176307692308
MYH9	MYL12B	0.996	0.916
MYH14	MYL6	0.995
IQGAP2	MYL6	0.995	0.128
MYL6	MYL12B	0.993	0.146
MYL3	IQGAP1	0.992	0.174	structurally_consistent (dimer)
MYL6	IQGAP1	0.991	0.252624
MYH14	MYL12B	0.99
MYL12B	IQGAP1	0.984	0.544
FBXO40	MYH10	0.983
MYH9	JMY	0.982	0.222
JMY	MYL12B	0.979	0.042
JMY	MYL6	0.979	0.058
PTGR3	JMY	0.976	0.036
MYL6	MYL3	0.975	0.09
MYH9	MYH10	0.973	0.507
JMY	MYH10	0.973	0.072
MYH9	FBXO40	0.972
MYH9	SYNPO	0.969
FBXO40	MYH14	0.963
MYH14	MYL3	0.947
IQGAP1	MYH10	0.936	0.198
MYH9	IQGAP1	0.895	0.776	mutually_exclusive (P08590)
MYL12B	MYL3	0.869	0.676
IQGAP2	MYL12B	0.806	0.124
SYNPO	MYL12B	0.796
SYNPO	MYL6	0.693
IQGAP2	MYH14	0.687
MYH9	MYH14	0.518
IQGAP2	IQGAP1	0.503	0.262
MYH14	IQGAP1	0.469
SYNPO	IQGAP1	0.38
JMY	MYH14	0.315
IQGAP2	MYH10	0.231	0.144
SYNPO	MYH10	0.15
MYH14	MYH10	0.077
SYNPO	JMY	0.063
JMY	IQGAP1	0.063	0.212
IQGAP2	MYH9	0.026	0.350547619048
FBXO40	MYL6	0.012
IQGAP2	MYL3	0.008	0.106
FBXO40	MYL12B	0.007
FBXO40	IQGAP1	0.006
PTGR3	IQGAP1	0.005	0.048
PTGR3	MYL12B	0.003	0.006
PTGR3	MYL6	0.003	0.036
MYH9	PTGR3	0.001	0.0663571428571

Related Complexes

Genename	Complexes
PTGR3	huMAP3_02015.1 huMAP3_03395.1 huMAP3_03551.1 huMAP3_05056.1 huMAP3_06026.1 huMAP3_09870.1 huMAP3_10244.1 huMAP3_10270.1 huMAP3_12775.1
MYH14	huMAP3_02178.1 huMAP3_03169.1 huMAP3_03184.1 huMAP3_05543.1 huMAP3_07968.1 huMAP3_08039.1 huMAP3_09441.1 huMAP3_10270.1 huMAP3_15295.1
FBXO40	huMAP3_02178.1 huMAP3_08039.1 huMAP3_10270.1 huMAP3_15295.1
MYH10	huMAP3_05057.1 huMAP3_06017.1 huMAP3_07666.1 huMAP3_09789.1 huMAP3_10270.1
MYH9	huMAP3_01606.1 huMAP3_05057.1 huMAP3_06017.1 huMAP3_07666.1 huMAP3_09789.1 huMAP3_10270.1 huMAP3_15295.1
SYNPO	huMAP3_01606.1 huMAP3_03689.1 huMAP3_04826.1 huMAP3_05057.1 huMAP3_05614.1 huMAP3_06017.1 huMAP3_07776.1 huMAP3_09555.1 huMAP3_09579.1 huMAP3_10270.1 huMAP3_10784.1 huMAP3_11076.1 huMAP3_12531.1 huMAP3_15295.1
MYL6	huMAP3_02370.1 huMAP3_03169.1 huMAP3_05350.1 huMAP3_05543.1 huMAP3_06098.1 huMAP3_06531.1 huMAP3_07968.1 huMAP3_08039.1 huMAP3_09441.1 huMAP3_10270.1
JMY	huMAP3_02015.1 huMAP3_03395.1 huMAP3_05056.1 huMAP3_06017.1 huMAP3_06026.1 huMAP3_06531.1 huMAP3_09870.1 huMAP3_10270.1
MYL12B	huMAP3_02370.1 huMAP3_06098.1 huMAP3_06531.1 huMAP3_08039.1 huMAP3_09542.1 huMAP3_10270.1
MYL3	huMAP3_02370.1 huMAP3_03169.1 huMAP3_05350.1 huMAP3_05543.1 huMAP3_06098.1 huMAP3_06531.1 huMAP3_08039.1 huMAP3_09789.1 huMAP3_10270.1 huMAP3_15295.1
IQGAP2	huMAP3_00809.1 huMAP3_02370.1 huMAP3_02834.1 huMAP3_05543.1 huMAP3_06531.1 huMAP3_08039.1 huMAP3_08200.1 huMAP3_09441.1 huMAP3_10270.1 huMAP3_10273.1 huMAP3_10665.1 huMAP3_12336.1 huMAP3_13036.1
IQGAP1	huMAP3_02370.1 huMAP3_05543.1 huMAP3_06098.1 huMAP3_06445.1 huMAP3_06531.1 huMAP3_08039.1 huMAP3_10270.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10270.1

Complex Portal: CPX-16749