hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10279.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLC7A6 | Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2) | 5 | UniProt NCBI |
| TMEM87A | Transmembrane protein 87A (Elkin1) | 5 | UniProt NCBI |
| CERS4 | Ceramide synthase 4 (CerS4) (EC 2.3.1.-) (LAG1 longevity assurance homolog 4) (Sphingosine N-acyltransferase CERS4) (EC 2.3.1.24) | 5 | UniProt NCBI |
| STIM1 | Stromal interaction molecule 1 | 5 | UniProt NCBI |
| MSMO1 | Methylsterol monooxygenase 1 (EC 1.14.18.9) (C-4 methylsterol oxidase) (Sterol-C4-methyl oxidase) | 5 | UniProt NCBI |
| CERS5 | Ceramide synthase 5 (CerS5) (LAG1 longevity assurance homolog 5) (Sphingoid base N-palmitoyltransferase CERS5) (EC 2.3.1.291) (Sphingosine N-acyltransferase CERS5) (EC 2.3.1.24) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5194 | 0.00171766688832 | 0.333333333333 | CERS5 CERS4 | Synthesis of ceramides and 1 deoxyceramides |
| WP:WP4726 | 0.00253948790052 | 0.333333333333 | CERS5 CERS4 | Sphingolipid metabolism integrated pathway |
| WP:WP1422 | 0.00352059040085 | 0.333333333333 | CERS5 CERS4 | Sphingolipid pathway |
| KEGG:00600 | 0.00779476406064 | 0.333333333333 | CERS5 CERS4 | Sphingolipid metabolism |
| REAC:R-HSA-1660661 | 0.0144005758041 | 0.333333333333 | CERS5 CERS4 | Sphingolipid de novo biosynthesis |
| KEGG:04071 | 0.0374918580993 | 0.333333333333 | CERS5 CERS4 | Sphingolipid signaling pathway |
| CORUM:6108 | 0.0499436884912 | 0.166666666667 | STIM1 | STIM1-TRPV4 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TMEM87A | CERS4 | 0.975 | 0.088 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| CERS4 | CERS5 | 0.974 | 0.102 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| TMEM87A | STIM1 | 0.971 | 0.056 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction |
| TMEM87A | MSMO1 | 0.964 | 0.016 | bioplex_WMM bioplex3_WMM WMM_only |
| MSMO1 | CERS5 | 0.959 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only |
| TMEM87A | SLC7A6 | 0.952 | 0.09 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| TMEM87A | CERS5 | 0.931 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only |
| SLC7A6 | CERS5 | 0.928 | 0.178 | bioplex_WMM bioplex3_WMM WMM_only |
| CERS4 | MSMO1 | 0.791 | 0.032 | bioplex_WMM bioplex3_WMM WMM_only |
| SLC7A6 | MSMO1 | 0.661 | 0.036 | bioplex_WMM bioplex3_WMM WMM_only |
| CERS4 | SLC7A6 | 0.168 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only |
| STIM1 | CERS5 | 0.045 | 0.184 | bioplex3_WMM WMM_only |
| CERS4 | STIM1 | 0.02 | 0.044 | youn_WMM gupta_WMM WMM_only |
| STIM1 | MSMO1 | 0.019 | 0.014 | bioplex_WMM bioplex3_WMM WMM_only |
| SLC7A6 | STIM1 | 0.017 | 0.112 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes