hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10284.1
Complex Portal: CPX-23528
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) | 5 | UniProt NCBI |
| RNF25 | E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7) | 5 | UniProt NCBI |
| UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1) | 5 | UniProt NCBI |
| UBE2D2 | Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-168927 | 1.35859604357e-06 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | TICAM1, RIP1-mediated IKK complex recruitment |
| REAC:R-HSA-937041 | 1.59826617962e-06 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | IKK complex recruitment mediated by RIP1 |
| REAC:R-HSA-9705462 | 2.4825378684e-06 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Inactivation of CSF3 (G-CSF) signaling |
| REAC:R-HSA-9674555 | 4.59102468944e-06 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Signaling by CSF3 (G-CSF) |
| REAC:R-HSA-936440 | 7.64413736449e-06 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Negative regulators of DDX58/IFIH1 signaling |
| WP:WP183 | 1.25420427084e-05 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Proteasome degradation |
| REAC:R-HSA-5357905 | 1.85450342998e-05 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Regulation of TNFR1 signaling |
| REAC:R-HSA-9033241 | 2.42139021409e-05 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Peroxisomal protein import |
| REAC:R-HSA-983168 | 2.4769665049e-05 | 1.0 | UBE2D3 UBE2D2 RNF25 UBE2D1 | Antigen processing: Ubiquitination & Proteasome degradation |
| KEGG:03083 | 2.91718888289e-05 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Polycomb repressive complex |
| REAC:R-HSA-75893 | 3.27872895639e-05 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | TNF signaling |
| REAC:R-HSA-8866654 | 3.47141671819e-05 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | E3 ubiquitin ligases ubiquitinate target proteins |
| REAC:R-HSA-1234176 | 5.55513549806e-05 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| REAC:R-HSA-983169 | 5.6357306355e-05 | 1.0 | UBE2D3 UBE2D2 RNF25 UBE2D1 | Class I MHC mediated antigen processing & presentation |
| REAC:R-HSA-1234174 | 7.65476877178e-05 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Cellular response to hypoxia |
| REAC:R-HSA-8852135 | 9.06303437184e-05 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Protein ubiquitination |
| REAC:R-HSA-168928 | 9.44017446448e-05 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| KEGG:04120 | 0.000136723260154 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-168164 | 0.000169699262125 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166166 | 0.000181248084935 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 0.000181248084935 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | TRIF(TICAM1)-mediated TLR4 signaling |
| KEGG:04141 | 0.000211376960202 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-166016 | 0.000422025999557 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-73887 | 0.000464818544718 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Death Receptor Signaling |
| REAC:R-HSA-9609507 | 0.000571445331233 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Protein localization |
| REAC:R-HSA-168898 | 0.000650875640662 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Toll-like Receptor Cascades |
| KEGG:05131 | 0.000652828786911 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Shigellosis |
| REAC:R-HSA-1280218 | 0.000770803233213 | 1.0 | UBE2D3 UBE2D2 RNF25 UBE2D1 | Adaptive Immune System |
| GO:0061631 | 0.00155882617412 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | ubiquitin conjugating enzyme activity |
| GO:0000209 | 0.00236438803028 | 1.0 | UBE2D3 UBE2D2 RNF25 UBE2D1 | protein polyubiquitination |
| GO:0061650 | 0.0025122894873 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | ubiquitin-like protein conjugating enzyme activity |
| REAC:R-HSA-8951664 | 0.00259854618679 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | Neddylation |
| REAC:R-HSA-201451 | 0.00306932002175 | 0.5 | UBE2D3 UBE2D1 | Signaling by BMP |
| REAC:R-HSA-2173795 | 0.00415229579539 | 0.5 | UBE2D3 UBE2D1 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| REAC:R-HSA-8866652 | 0.00444848198459 | 0.5 | UBE2D1 UBE2D2 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes |
| GO:0061630 | 0.00459925423944 | 1.0 | UBE2D3 UBE2D2 RNF25 UBE2D1 | ubiquitin protein ligase activity |
| GO:0061659 | 0.00586958333309 | 1.0 | UBE2D3 UBE2D2 RNF25 UBE2D1 | ubiquitin-like protein ligase activity |
| REAC:R-HSA-2173793 | 0.012504459305 | 0.5 | UBE2D3 UBE2D1 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| GO:0004842 | 0.0150864160861 | 1.0 | UBE2D3 UBE2D2 RNF25 UBE2D1 | ubiquitin-protein transferase activity |
| GO:0019787 | 0.0206584614239 | 1.0 | UBE2D3 UBE2D2 RNF25 UBE2D1 | ubiquitin-like protein transferase activity |
| GO:0070936 | 0.0228491864842 | 0.75 | UBE2D3 UBE2D1 UBE2D2 | protein K48-linked ubiquitination |
| GO:0016755 | 0.0237141260813 | 1.0 | UBE2D3 UBE2D2 RNF25 UBE2D1 | aminoacyltransferase activity |
| REAC:R-HSA-2871837 | 0.0282617295192 | 0.5 | UBE2D1 UBE2D2 | FCERI mediated NF-kB activation |
| REAC:R-HSA-168256 | 0.032293648674 | 1.0 | UBE2D3 UBE2D2 RNF25 UBE2D1 | Immune System |
| REAC:R-HSA-170834 | 0.0380580405855 | 0.5 | UBE2D3 UBE2D1 | Signaling by TGF-beta Receptor Complex |
| REAC:R-HSA-202424 | 0.0398310607487 | 0.5 | UBE2D1 UBE2D2 | Downstream TCR signaling |
| REAC:R-HSA-5607764 | 0.0407325822829 | 0.5 | UBE2D1 UBE2D2 | CLEC7A (Dectin-1) signaling |
| CORUM:6037 | 0.049938562206 | 0.25 | UBE2D2 | CHIP-HSC70-TAU-UBCH5B complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RNF25 | UBE2D2 | 0.999 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RNF25 | UBE2D3 | 0.998 | 0.064 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2D1 | 0.997 | 0.144 |
mutually_exclusive (Q969T4)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| UBE2D3 | UBE2D1 | 0.975 | 0.369636363636 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UBE2D3 | UBE2D2 | 0.975 | 0.22 | bioplex_WMM bioplex3_WMM WMM_only | |
| UBE2D2 | UBE2D1 | 0.388 | 0.308 | bioplex3_WMM youn_WMM WMM_only |
Related Complexes