hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10292.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CDK12 | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | 5 | UniProt NCBI |
| CDK13 | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | 5 | UniProt NCBI |
| CCNK | Cyclin-K | 5 | UniProt NCBI |
| MAGEB2 | Melanoma-associated antigen B2 (Cancer/testis antigen 3.2) (CT3.2) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2 antigen) (MAGE-B2 antigen) | 5 | UniProt NCBI |
| GTF2F2 | General transcription factor IIF subunit 2 (General transcription factor IIF 30 kDa subunit) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0008024 | 2.15253635486e-05 | 0.75 | CDK13 CDK12 CCNK | cyclin/CDK positive transcription elongation factor complex |
| GO:0008353 | 3.22863876272e-05 | 0.75 | CDK13 CDK12 CCNK | RNA polymerase II CTD heptapeptide repeat kinase activity |
| REAC:R-HSA-6796648 | 5.03512663474e-05 | 0.75 | CDK13 CDK12 CCNK | TP53 Regulates Transcription of DNA Repair Genes |
| GO:0140994 | 0.000215165225046 | 0.75 | CDK13 CDK12 CCNK | RNA polymerase II CTD heptapeptide repeat modifying activity |
| GO:0019908 | 0.000261258639543 | 0.75 | CDK13 CDK12 CCNK | nuclear cyclin-dependent protein kinase holoenzyme complex |
| GO:0032806 | 0.000437924933217 | 0.75 | CDK13 CDK12 CCNK | carboxy-terminal domain protein kinase complex |
| GO:0002944 | 0.0028092043205 | 0.5 | CCNK CDK12 | cyclin K-CDK12 complex |
| GO:0002945 | 0.0028092043205 | 0.5 | CDK13 CCNK | cyclin K-CDK13 complex |
| GO:0008023 | 0.00622026610693 | 0.75 | CDK13 CDK12 CCNK | transcription elongation factor complex |
| GO:0032968 | 0.00622026610693 | 0.75 | CDK13 CDK12 CCNK | positive regulation of transcription elongation by RNA polymerase II |
| REAC:R-HSA-3700989 | 0.00879681508035 | 0.75 | CDK13 CDK12 CCNK | Transcriptional Regulation by TP53 |
| GO:0000307 | 0.0100599149475 | 0.75 | CDK13 CDK12 CCNK | cyclin-dependent protein kinase holoenzyme complex |
| GO:0032786 | 0.0118300289699 | 0.75 | CDK13 CDK12 CCNK | positive regulation of DNA-templated transcription, elongation |
| GO:0034243 | 0.0291371139957 | 0.75 | CDK13 CDK12 CCNK | regulation of transcription elongation by RNA polymerase II |
| CORUM:1083 | 0.049938562206 | 0.25 | CCNK | P-TEFb.4 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CDK12 | CCNK | 0.996 | 0.59 | hein_WMM bioplex_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction |
| CDK12 | CDK13 | 0.99 | 0.392 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| CDK12 | MAGEB2 | 0.986 | 0.086 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| CDK13 | CCNK | 0.983 | 0.38 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| CDK12 | GTF2F2 | 0.961 | 0.102 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| CDK13 | MAGEB2 | 0.814 | 0.114 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| CCNK | MAGEB2 | 0.313 | 0.056 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| CCNK | GTF2F2 | 0.067 | 0.45 | bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| GTF2F2 | MAGEB2 | 0.012 | 0.0907057971014 | bioplex3_WMM WMM_only |
| CDK13 | GTF2F2 | 0.008 | 0.154 | youn_WMM WMM_only |
Related Complexes