hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10293.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PITPNM1 | Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) | 5 | UniProt NCBI |
| OSBP | Oxysterol-binding protein 1 | 5 | UniProt NCBI |
| OSBPL9 | Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9) | 5 | UniProt NCBI |
| SLC22A15 | Solute carrier family 22 member 15 (Fly-like putative transporter 1) (Flipt 1) | 5 | UniProt NCBI |
| VAPA | Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33) | 5 | UniProt NCBI |
| OSBPL11 | Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005319 | 0.00269555949443 | 0.666666666667 | OSBPL9 OSBPL11 PITPNM1 OSBP | lipid transporter activity |
| GO:0015248 | 0.00498056162807 | 0.5 | OSBPL9 OSBP OSBPL11 | sterol transporter activity |
| REAC:R-HSA-192105 | 0.00540340354533 | 0.333333333333 | OSBPL9 OSBP | Synthesis of bile acids and bile salts |
| REAC:R-HSA-556833 | 0.00784925061173 | 0.666666666667 | OSBPL9 PITPNM1 VAPA OSBP | Metabolism of lipids |
| REAC:R-HSA-194068 | 0.0104313293282 | 0.333333333333 | OSBPL9 OSBP | Bile acid and bile salt metabolism |
| REAC:R-HSA-1660661 | 0.0144005758041 | 0.333333333333 | OSBP VAPA | Sphingolipid de novo biosynthesis |
| GO:0032934 | 0.0309610298034 | 0.5 | OSBPL9 OSBP OSBPL11 | sterol binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| VAPA | OSBPL9 | 0.998 | 0.106 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| OSBPL9 | OSBPL11 | 0.997 | 0.428 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| VAPA | OSBPL11 | 0.997 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| VAPA | OSBP | 0.992 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| VAPA | PITPNM1 | 0.983 | 0.11 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SLC22A15 | VAPA | 0.957 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SLC22A15 | PITPNM1 | 0.902 | bioplex3_WMM WMM_only | |
| OSBP | OSBPL9 | 0.821 | 0.104 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| PITPNM1 | OSBPL11 | 0.772 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only |
| PITPNM1 | OSBPL9 | 0.772 | 0.056 | bioplex_WMM bioplex3_WMM WMM_only |
| OSBP | OSBPL11 | 0.769 | 0.088 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| SLC22A15 | OSBPL11 | 0.768 | bioplex3_WMM WMM_only | |
| PITPNM1 | OSBP | 0.731 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only |
| SLC22A15 | OSBPL9 | 0.697 | bioplex3_WMM WMM_only | |
| SLC22A15 | OSBP | 0.323 | bioplex3_WMM WMM_only |
Related Complexes