hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10303.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
TBP	TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)	5	UniProt NCBI
GTF2A1	Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)]	5	UniProt NCBI
TAF7L	Transcription initiation factor TFIID subunit 7-like (Cancer/testis antigen 40) (CT40) (RNA polymerase II TBP-associated factor subunit Q) (TATA box-binding protein-associated factor 50 kDa) (Transcription initiation factor TFIID 50 kDa subunit)	5	UniProt NCBI
GTF2A2	Transcription initiation factor IIA subunit 2 (General transcription factor IIA subunit 2) (TFIIA p12 subunit) (TFIIA-12) (TFIIAS) (Transcription initiation factor IIA gamma chain) (TFIIA-gamma)	5	UniProt NCBI
TBPL1	TATA box-binding protein-like 1 (TBP-like 1) (21 kDa TBP-like protein) (Second TBP of unique DNA protein) (STUD) (TATA box-binding protein-related factor 2) (TBP-related factor 2) (TBP-like factor) (TBP-related protein)	5	UniProt NCBI
TAF8	Transcription initiation factor TFIID subunit 8 (Protein taube nuss) (TBP-associated factor 43 kDa) (TBP-associated factor 8) (Transcription initiation factor TFIID 43 kDa subunit) (TAFII-43) (TAFII43) (hTAFII43)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:03022	1.72124236649e-14	1.0	TBPL1 TAF7L TBP TAF8 GTF2A2 GTF2A1	Basal transcription factors
GO:0016251	8.59682292869e-12	1.0	TBPL1 TAF7L TBP TAF8 GTF2A2 GTF2A1	RNA polymerase II general transcription initiation factor activity
GO:0140223	4.53788462633e-11	1.0	TBPL1 TAF7L TBP TAF8 GTF2A2 GTF2A1	general transcription initiation factor activity
GO:0005669	9.1660568716e-09	0.833333333333	TBP GTF2A2 TAF8 GTF2A1 TAF7L	transcription factor TFIID complex
GO:0006352	4.12070666059e-08	1.0	TBPL1 TAF7L TBP TAF8 GTF2A2 GTF2A1	DNA-templated transcription initiation
GO:0051123	1.40035891182e-07	0.833333333333	TBP GTF2A2 TAF8 GTF2A1 TAF7L	RNA polymerase II preinitiation complex assembly
GO:0070897	1.7038132548e-07	0.833333333333	TBP GTF2A2 TAF8 GTF2A1 TAF7L	transcription preinitiation complex assembly
REAC:R-HSA-167161	2.15231725589e-07	0.666666666667	TBP GTF2A2 GTF2A1 TAF7L	HIV Transcription Initiation
REAC:R-HSA-73776	2.15231725589e-07	0.666666666667	TBP GTF2A2 GTF2A1 TAF7L	RNA Polymerase II Promoter Escape
REAC:R-HSA-75953	2.15231725589e-07	0.666666666667	TBP GTF2A2 GTF2A1 TAF7L	RNA Polymerase II Transcription Initiation
REAC:R-HSA-76042	2.15231725589e-07	0.666666666667	TBP GTF2A2 GTF2A1 TAF7L	RNA Polymerase II Transcription Initiation And Promoter Clearance
REAC:R-HSA-73779	2.15231725589e-07	0.666666666667	TBP GTF2A2 GTF2A1 TAF7L	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
REAC:R-HSA-167162	2.15231725589e-07	0.666666666667	TBP GTF2A2 GTF2A1 TAF7L	RNA Polymerase II HIV Promoter Escape
GO:0016591	5.61153799548e-07	0.833333333333	TBP GTF2A2 TAF8 GTF2A1 TAF7L	RNA polymerase II, holoenzyme
REAC:R-HSA-167172	1.17345778452e-06	0.666666666667	TBP GTF2A2 GTF2A1 TAF7L	Transcription of the HIV genome
REAC:R-HSA-6807505	1.48174523696e-06	0.666666666667	TBP TAF8 GTF2A1 GTF2A2	RNA polymerase II transcribes snRNA genes
GO:0005672	1.92240082153e-06	0.5	TBP GTF2A1 GTF2A2	transcription factor TFIIA complex
CORUM:492	2.12427516715e-06	0.5	TBP GTF2A1 GTF2A2	DA complex
REAC:R-HSA-674695	2.16235704625e-06	0.666666666667	TBP GTF2A2 GTF2A1 TAF7L	RNA Polymerase II Pre-transcription Events
CORUM:493	2.61408971096e-06	0.5	TBP GTF2A1 GTF2A2	DAB complex
GO:0055029	2.64367621138e-06	0.833333333333	TBP GTF2A2 TAF8 GTF2A1 TAF7L	nuclear DNA-directed RNA polymerase complex
GO:0000428	2.79372493311e-06	0.833333333333	TBP GTF2A2 TAF8 GTF2A1 TAF7L	DNA-directed RNA polymerase complex
GO:0030880	3.28516911608e-06	0.833333333333	TBP GTF2A2 TAF8 GTF2A1 TAF7L	RNA polymerase complex
GO:0006367	8.610395678e-06	0.833333333333	TBP GTF2A2 TAF8 GTF2A1 TAF7L	transcription initiation at RNA polymerase II promoter
REAC:R-HSA-162599	1.62558528405e-05	0.666666666667	TBP GTF2A2 GTF2A1 TAF7L	Late Phase of HIV Life Cycle
CORUM:489	1.70876175213e-05	0.333333333333	GTF2A2 GTF2A1	TFIIA complex
CORUM:490	1.70876175213e-05	0.333333333333	GTF2A2 GTF2A1	TFIIA complex
KEGG:05203	1.93340728016e-05	0.666666666667	TBPL1 TBP GTF2A1 GTF2A2	Viral carcinogenesis
REAC:R-HSA-162587	2.32027043518e-05	0.666666666667	TBP GTF2A2 GTF2A1 TAF7L	HIV Life Cycle
GO:0065004	4.97691274505e-05	0.833333333333	TBP GTF2A2 TAF8 GTF2A1 TAF7L	protein-DNA complex assembly
CORUM:1221	5.12534978153e-05	0.333333333333	GTF2A2 GTF2A1	TFIIA-TRF2 complex
GO:0060261	0.000124138457674	0.666666666667	TBP TAF8 GTF2A1 GTF2A2	positive regulation of transcription initiation by RNA polymerase II
REAC:R-HSA-162906	0.000137028646463	0.666666666667	TBP GTF2A2 GTF2A1 TAF7L	HIV Infection
GO:0090575	0.000153415434737	0.833333333333	TBP GTF2A2 TAF8 GTF2A1 TAF7L	RNA polymerase II transcription regulator complex
GO:2000144	0.000191285986513	0.666666666667	TBP TAF8 GTF2A1 GTF2A2	positive regulation of DNA-templated transcription initiation
GO:0060260	0.000204687081424	0.666666666667	TBP TAF8 GTF2A1 GTF2A2	regulation of transcription initiation by RNA polymerase II
GO:2000142	0.000300438201885	0.666666666667	TBP TAF8 GTF2A1 GTF2A2	regulation of DNA-templated transcription initiation
GO:0061695	0.000684514612873	0.833333333333	TBP GTF2A2 TAF8 GTF2A1 TAF7L	transferase complex, transferring phosphorus-containing groups
GO:0000979	0.000698569295426	0.5	TBP GTF2A1 TBPL1	RNA polymerase II core promoter sequence-specific DNA binding
GO:0001091	0.00218580514948	0.5	TBP GTF2A1 GTF2A2	RNA polymerase II general transcription initiation factor binding
REAC:R-HSA-9018519	0.00231149151162	0.5	TBP GTF2A1 GTF2A2	Estrogen-dependent gene expression
GO:0005667	0.0025579351051	0.833333333333	TBP GTF2A2 TAF8 GTF2A1 TAF7L	transcription regulator complex
REAC:R-HSA-73857	0.00300615431734	0.833333333333	TBP GTF2A2 TAF8 GTF2A1 TAF7L	RNA Polymerase II Transcription
REAC:R-HSA-74160	0.00558415609329	0.833333333333	TBP GTF2A2 TAF8 GTF2A1 TAF7L	Gene expression (Transcription)
REAC:R-HSA-8939211	0.00713416614811	0.5	TBP GTF2A1 GTF2A2	ESR-mediated signaling
WP:WP405	0.00780497827062	0.333333333333	TBP GTF2A2	Eukaryotic transcription initiation
GO:0001046	0.00949259421943	0.5	TBP GTF2A1 TBPL1	core promoter sequence-specific DNA binding
REAC:R-HSA-9824446	0.013543022596	0.666666666667	TBP GTF2A2 GTF2A1 TAF7L	Viral Infection Pathways
REAC:R-HSA-9006931	0.0168855312186	0.5	TBP GTF2A1 GTF2A2	Signaling by Nuclear Receptors
GO:0071824	0.0174215115702	0.833333333333	TBP GTF2A2 TAF8 GTF2A1 TAF7L	protein-DNA complex organization
GO:0140296	0.0188853212627	0.5	TBP GTF2A1 GTF2A2	general transcription initiation factor binding
REAC:R-HSA-5663205	0.0303849890339	0.666666666667	TBP GTF2A2 GTF2A1 TAF7L	Infectious disease
GO:0001099	0.0421653429605	0.5	TBP GTF2A1 GTF2A2	basal RNA polymerase II transcription machinery binding
GO:0001098	0.0421653429605	0.5	TBP GTF2A1 GTF2A2	basal transcription machinery binding
CORUM:721	0.0499436884912	0.166666666667	TBP	PU.1-TBP complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
GTF2A1	GTF2A2	1.0	0.224	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
GTF2A1	TBPL1	1.0	0.12	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
TBP	GTF2A1	0.999	0.094	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM
TAF7L	TAF8	0.998		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TBPL1	GTF2A2	0.997	0.09	bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
TAF7L	TBP	0.997		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TBP	GTF2A2	0.995	0.204	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only
TAF8	GTF2A1	0.994	0.224	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
TAF7L	GTF2A1	0.986		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TAF8	TBP	0.983	0.126	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TBP	TBPL1	0.881	0.124	bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
TAF8	TBPL1	0.016	0.252	youn_WMM WMM_only
TAF8	GTF2A2	0.015	0.174	youn_WMM WMM_only

Related Complexes

Genename	Complexes
TBP	huMAP3_00597.1 huMAP3_04057.1 huMAP3_04722.1 huMAP3_06625.1 huMAP3_10303.1 huMAP3_10806.1 huMAP3_13329.1 huMAP3_14501.1
GTF2A1	huMAP3_04057.1 huMAP3_04119.1 huMAP3_04134.1 huMAP3_04356.1 huMAP3_04722.1 huMAP3_10303.1 huMAP3_13329.1 huMAP3_14501.1 huMAP3_14957.1
TAF7L	huMAP3_00288.1 huMAP3_04356.1 huMAP3_04720.1 huMAP3_08438.1 huMAP3_09451.1 huMAP3_10303.1 huMAP3_10385.1 huMAP3_14501.1 huMAP3_14957.1
GTF2A2	huMAP3_04057.1 huMAP3_04119.1 huMAP3_04134.1 huMAP3_04356.1 huMAP3_04722.1 huMAP3_10303.1 huMAP3_13329.1 huMAP3_14501.1 huMAP3_15044.1
TBPL1	huMAP3_04057.1 huMAP3_04119.1 huMAP3_04134.1 huMAP3_04356.1 huMAP3_04722.1 huMAP3_10303.1 huMAP3_13329.1 huMAP3_14501.1 huMAP3_15044.1
TAF8	huMAP3_00288.1 huMAP3_04356.1 huMAP3_04720.1 huMAP3_08438.1 huMAP3_09451.1 huMAP3_10303.1 huMAP3_10385.1 huMAP3_14501.1 huMAP3_14957.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10303.1