hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10304.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EDRF1 | Erythroid differentiation-related factor 1 | 5 | UniProt NCBI |
| HSP90AB1 | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) | 5 | UniProt NCBI |
| TSSK6 | Testis-specific serine/threonine-protein kinase 6 (TSK-6) (TSSK-6) (Testis-specific kinase 6) (EC 2.7.11.1) (Cancer/testis antigen 72) (CT72) (Serine/threonine-protein kinase SSTK) (Small serine/threonine kinase) | 5 | UniProt NCBI |
| CTDSPL2 | CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-) | 4 | UniProt NCBI |
| CDC37L1 | Hsp90 co-chaperone Cdc37-like 1 (Hsp90-associating relative of Cdc37) | 5 | UniProt NCBI |
| HSP90AA1 | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | 5 | UniProt NCBI |
| STK35 | Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase 1) (CLIK-1) (PDLIM1-interacting kinase 1) (Serine/threonine-protein kinase 35 L1) | 5 | UniProt NCBI |
| UNC45B | Protein unc-45 homolog B (Unc-45B) (SMUNC45) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2112 | 7.17483486175e-05 | 0.25 | HSP90AB1 HSP90AA1 | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex |
| CORUM:5234 | 0.000239030245992 | 0.25 | HSP90AB1 HSP90AA1 | IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex |
| CORUM:5269 | 0.000358447219737 | 0.25 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 8 |
| CORUM:5268 | 0.000668735194034 | 0.25 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 7 |
| CORUM:5212 | 0.000668735194034 | 0.25 | HSP90AB1 HSP90AA1 | Kinase maturation complex 2 |
| REAC:R-HSA-5336415 | 0.000835868410279 | 0.25 | HSP90AB1 HSP90AA1 | Uptake and function of diphtheria toxin |
| CORUM:5286 | 0.00107416462378 | 0.25 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 10 |
| CORUM:5266 | 0.00186035657619 | 0.25 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 6 |
| CORUM:5199 | 0.00285973689486 | 0.25 | HSP90AB1 HSP90AA1 | Kinase maturation complex 1 |
| REAC:R-HSA-3371511 | 0.00367178411278 | 0.25 | HSP90AB1 HSP90AA1 | HSF1 activation |
| REAC:R-HSA-3371568 | 0.00433819320746 | 0.25 | HSP90AB1 HSP90AA1 | Attenuation phase |
| REAC:R-HSA-399954 | 0.00583667819665 | 0.25 | HSP90AB1 HSP90AA1 | Sema3A PAK dependent Axon repulsion |
| REAC:R-HSA-5339562 | 0.00949504138694 | 0.25 | HSP90AB1 HSP90AA1 | Uptake and actions of bacterial toxins |
| REAC:R-HSA-9613829 | 0.0116541924374 | 0.25 | HSP90AB1 HSP90AA1 | Chaperone Mediated Autophagy |
| GO:1902949 | 0.0131096201623 | 0.25 | HSP90AB1 HSP90AA1 | positive regulation of tau-protein kinase activity |
| REAC:R-HSA-3371571 | 0.0140328389809 | 0.25 | HSP90AB1 HSP90AA1 | HSF1-dependent transactivation |
| REAC:R-HSA-9013418 | 0.0140328389809 | 0.25 | HSP90AB1 HSP90AA1 | RHOBTB2 GTPase cycle |
| KEGG:04612 | 0.0233723051135 | 0.25 | HSP90AB1 HSP90AA1 | Antigen processing and presentation |
| REAC:R-HSA-9706574 | 0.0328938418336 | 0.25 | HSP90AB1 HSP90AA1 | RHOBTB GTPase Cycle |
| KEGG:04657 | 0.0372066280408 | 0.25 | HSP90AB1 HSP90AA1 | IL-17 signaling pathway |
| KEGG:04914 | 0.0421715550792 | 0.25 | HSP90AB1 HSP90AA1 | Progesterone-mediated oocyte maturation |
| CORUM:5716 | 0.0499436884912 | 0.125 | HSP90AA1 | NOS3-HSP90 complex, VEGF induced |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HSP90AB1 | HSP90AA1 | 1.0 | 0.954 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt hein () Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| STK35 | CTDSPL2 | 0.999 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CDC37L1 | STK35 | 0.999 | 0.056 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| EDRF1 | HSP90AB1 | 0.995 | 0.32305 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| HSP90AA1 | STK35 | 0.994 | 0.334152808277 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| HSP90AB1 | STK35 | 0.993 | 0.25618165364 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CDC37L1 | HSP90AB1 | 0.986 | 0.351110091582 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| EDRF1 | HSP90AA1 | 0.983 | 0.474 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only |
| TSSK6 | HSP90AA1 | 0.98 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TSSK6 | HSP90AB1 | 0.978 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CDC37L1 | HSP90AA1 | 0.966 | 0.479316479401 | hein_WMM bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| HSP90AB1 | UNC45B | 0.963 | 0.144 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| HSP90AA1 | UNC45B | 0.952 | 0.207431818182 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| CDC37L1 | EDRF1 | 0.667 | 0.082 | bioplex3_WMM WMM_only |
| CDC37L1 | CTDSPL2 | 0.625 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only |
| HSP90AA1 | CTDSPL2 | 0.164 | 0.163065589526 | bioplex_WMM bioplex3_WMM WMM_only |
| HSP90AB1 | CTDSPL2 | 0.164 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only |
| EDRF1 | STK35 | 0.023 | 0.09 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| EDRF1 | CTDSPL2 | 0.016 | 0.06 | bioplex3_WMM WMM_only |
Related Complexes