hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10312.1
Complex Portal: CPX-16715
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GPC1 | Glypican-1 [Cleaved into: Secreted glypican-1] | 5 | UniProt NCBI |
| JCAD | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | 5 | UniProt NCBI |
| GPC6 | Glypican-6 [Cleaved into: Secreted glypican-6] | 5 | UniProt NCBI |
| CAMKV | CaM kinase-like vesicle-associated protein | 5 | UniProt NCBI |
| CEACAM7 | Carcinoembryonic antigen-related cell adhesion molecule 7 (CEA cell adhesion molecule 7) (Carcinoembryonic antigen CGM2) | 5 | UniProt NCBI |
| GPC4 | Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4] | 5 | UniProt NCBI |
| HBEGF | Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R)] | 5 | UniProt NCBI |
| FGF1 | Fibroblast growth factor 1 (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (HBGF-1) | 5 | UniProt NCBI |
| TGFBR3 | Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III) | 5 | UniProt NCBI |
| SDC4 | Syndecan-4 (SYND4) (Amphiglycan) (Ryudocan core protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3656253 | 2.66329974158e-08 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS |
| REAC:R-HSA-3656237 | 2.66329974158e-08 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Defective EXT2 causes exostoses 2 |
| REAC:R-HSA-9694614 | 6.32607926503e-08 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Attachment and Entry |
| REAC:R-HSA-4420332 | 8.13085695349e-08 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Defective B3GALT6 causes EDSP2 and SEMDJL1 |
| REAC:R-HSA-3560801 | 8.13085695349e-08 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Defective B3GAT3 causes JDSSDHD |
| REAC:R-HSA-3560783 | 8.13085695349e-08 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Defective B4GALT7 causes EDS, progeroid type |
| REAC:R-HSA-2024096 | 1.94114532425e-07 | 0.4 | GPC4 GPC1 SDC4 GPC6 | HS-GAG degradation |
| REAC:R-HSA-1971475 | 2.8179151173e-07 | 0.4 | GPC4 GPC1 SDC4 GPC6 | A tetrasaccharide linker sequence is required for GAG synthesis |
| REAC:R-HSA-2022928 | 5.42263887023e-07 | 0.4 | GPC4 GPC1 SDC4 GPC6 | HS-GAG biosynthesis |
| REAC:R-HSA-9772572 | 1.081952275e-06 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Early SARS-CoV-2 Infection Events |
| REAC:R-HSA-3560782 | 1.94851007479e-06 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Diseases associated with glycosaminoglycan metabolism |
| REAC:R-HSA-975634 | 2.41085386609e-06 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 3.25232382974e-06 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Metabolism of fat-soluble vitamins |
| REAC:R-HSA-1793185 | 4.29630226864e-06 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Chondroitin sulfate/dermatan sulfate metabolism |
| REAC:R-HSA-1638091 | 6.05531392235e-06 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Heparan sulfate/heparin (HS-GAG) metabolism |
| REAC:R-HSA-2187338 | 3.71608649487e-05 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Visual phototransduction |
| REAC:R-HSA-1630316 | 0.000148822389646 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Glycosaminoglycan metabolism |
| REAC:R-HSA-3781865 | 0.000159998174048 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Diseases of glycosylation |
| GO:0009986 | 0.000379271297098 | 0.7 | GPC6 TGFBR3 GPC4 HBEGF GPC1 SDC4 CEACAM7 | cell surface |
| GO:0016477 | 0.000579801539494 | 0.8 | FGF1 TGFBR3 JCAD HBEGF GPC1 GPC4 SDC4 GPC6 | cell migration |
| REAC:R-HSA-196854 | 0.000618263826346 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Metabolism of vitamins and cofactors |
| REAC:R-HSA-5668914 | 0.0012397358363 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Diseases of metabolism |
| GO:0048870 | 0.0013666341845 | 0.8 | FGF1 TGFBR3 JCAD HBEGF GPC1 GPC4 SDC4 GPC6 | cell motility |
| REAC:R-HSA-9709957 | 0.00189067986721 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Sensory Perception |
| REAC:R-HSA-71387 | 0.00429319177604 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Metabolism of carbohydrates |
| REAC:R-HSA-9694516 | 0.00552913474634 | 0.4 | GPC4 GPC1 SDC4 GPC6 | SARS-CoV-2 Infection |
| GO:0005796 | 0.00692327695124 | 0.4 | GPC4 GPC1 SDC4 GPC6 | Golgi lumen |
| GO:0043202 | 0.0103846818546 | 0.4 | GPC4 GPC1 SDC4 GPC6 | lysosomal lumen |
| KEGG:05205 | 0.0107622950615 | 0.3 | HBEGF GPC1 SDC4 | Proteoglycans in cancer |
| REAC:R-HSA-9679506 | 0.0193414541774 | 0.4 | GPC4 GPC1 SDC4 GPC6 | SARS-CoV Infections |
| REAC:R-HSA-5663205 | 0.0338429281772 | 0.5 | GPC4 HBEGF GPC1 SDC4 GPC6 | Infectious disease |
| REAC:R-HSA-1643685 | 0.0385148593027 | 0.6 | FGF1 GPC4 HBEGF GPC1 SDC4 GPC6 | Disease |
| CORUM:6909 | 0.0499436884912 | 0.1 | FGF1 | FGF1-FGFR1-ITGB3 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CAMKV | TGFBR3 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CAMKV | JCAD | 0.997 | 0.056 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TGFBR3 | FGF1 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| FGF1 | SDC4 | 0.991 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GPC4 | GPC1 | 0.99 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GPC1 | FGF1 | 0.989 | 0.172 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAMKV | GPC1 | 0.987 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HBEGF | GPC1 | 0.986 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GPC4 | CAMKV | 0.985 | 0.158 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GPC1 | CEACAM7 | 0.984 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CAMKV | SDC4 | 0.982 | 0.084 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GPC4 | HBEGF | 0.973 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GPC6 | GPC4 | 0.97 | 0.146 |
mutually_exclusive (P05230)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| GPC1 | SDC4 | 0.969 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only | |
| TGFBR3 | SDC4 | 0.967 | 0.148 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| GPC1 | TGFBR3 | 0.967 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only | |
| GPC4 | FGF1 | 0.957 | 0.076 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GPC4 | SDC4 | 0.951 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only | |
| GPC4 | TGFBR3 | 0.926 | 0.116 | bioplex_WMM bioplex3_WMM WMM_only | |
| JCAD | TGFBR3 | 0.675 | 0.146 | bioplex3_WMM WMM_only | |
| GPC6 | TGFBR3 | 0.543 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | |
| JCAD | SDC4 | 0.418 | 0.06 | bioplex3_WMM WMM_only | |
| GPC6 | GPC1 | 0.347 | 0.228 | bioplex_WMM bioplex3_WMM WMM_only | |
| JCAD | GPC1 | 0.334 | 0.112 | bioplex3_WMM WMM_only | |
| GPC6 | SDC4 | 0.333 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only | |
| GPC4 | JCAD | 0.32 | 0.082 | bioplex3_WMM WMM_only | |
| GPC6 | FGF1 | 0.199 | 0.144 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| GPC6 | CAMKV | 0.158 | 0.072 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GPC6 | JCAD | 0.043 | 0.084 | bioplex3_WMM WMM_only |
Related Complexes