hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10314.1
Complex Portal: CPX-25217
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TMEM164 | Transmembrane protein 164 | 3 | UniProt NCBI |
| TSPAN15 | Tetraspanin-15 (Tspan-15) (Tetraspan NET-7) (Transmembrane 4 superfamily member 15) | 5 | UniProt NCBI |
| EXTL3 | Exostosin-like 3 (EC 2.4.1.223) (EXT-related protein 1) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Hereditary multiple exostoses gene isolog) (Multiple exostosis-like protein 3) (Putative tumor suppressor protein EXTL3) | 5 | UniProt NCBI |
| HRH1 | Histamine H1 receptor (H1R) (HH1R) | 5 | UniProt NCBI |
| DMAC1 | Distal membrane-arm assembly complex protein 1 (Transmembrane protein 261) | 4 | UniProt NCBI |
| B3GAT3 | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 3) (Glucuronosyltransferase I) (GlcAT-I) (UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase) (GlcUAT-I) | 5 | UniProt NCBI |
| TM7SF2 | Delta(14)-sterol reductase TM7SF2 (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (Another new gene 1 protein) (C-14 sterol reductase) (C14SR) (Putative sterol reductase SR-1) (Sterol C14-reductase) (Transmembrane 7 superfamily member 2) | 5 | UniProt NCBI |
| SYPL2 | Synaptophysin-like protein 2 | 4 | UniProt NCBI |
| MFSD12 | Major facilitator superfamily domain-containing protein 12 | 5 | UniProt NCBI |
| TMEM54 | Transmembrane protein 54 (Beta-casein-like protein) (Protein CAC-1) | 5 | UniProt NCBI |
| PIGG | GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (GPI7 homolog) (hGPI7) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0003051 | 0.00476283944706 | 0.181818181818 | EXTL3 B3GAT3 | Enlarged metaphyses |
| KEGG:00534 | 0.00546960937724 | 0.181818181818 | EXTL3 B3GAT3 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
| WP:WP4784 | 0.00817141007079 | 0.181818181818 | EXTL3 B3GAT3 | Proteoglycan biosynthesis |
| WP:WP5395 | 0.0372386402869 | 0.181818181818 | EXTL3 B3GAT3 | Glycosaminoglycan synthesis in fibroblasts |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TSPAN15 | MFSD12 | 0.994 | 0.07 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TSPAN15 | TMEM54 | 0.99 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| EXTL3 | B3GAT3 | 0.988 | 0.1 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TSPAN15 | PIGG | 0.985 | 0.134 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TSPAN15 | HRH1 | 0.982 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TSPAN15 | TM7SF2 | 0.981 | 0.08 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| TSPAN15 | B3GAT3 | 0.972 | 0.068 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| TMEM164 | TSPAN15 | 0.971 | 0.118 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| TSPAN15 | DMAC1 | 0.964 | 0.154 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EXTL3 | PIGG | 0.96 | 0.186 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| SYPL2 | MFSD12 | 0.955 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| B3GAT3 | PIGG | 0.952 | 0.052 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HRH1 | DMAC1 | 0.902 | bioplex3_WMM WMM_only | ||
| DMAC1 | TMEM54 | 0.902 | bioplex3_WMM WMM_only | ||
| HRH1 | TMEM54 | 0.902 | bioplex3_WMM WMM_only | ||
| TM7SF2 | TMEM54 | 0.869 | bioplex3_WMM WMM_only | ||
| HRH1 | TM7SF2 | 0.869 | bioplex3_WMM WMM_only | ||
| B3GAT3 | MFSD12 | 0.863 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only | |
| PIGG | MFSD12 | 0.835 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| TM7SF2 | MFSD12 | 0.811 | 0.064 | bioplex3_WMM WMM_only | |
| DMAC1 | TM7SF2 | 0.796 | 0.082 | bioplex3_WMM WMM_only | |
| TMEM54 | MFSD12 | 0.768 | bioplex3_WMM WMM_only | ||
| HRH1 | MFSD12 | 0.768 | bioplex3_WMM WMM_only | ||
| TMEM164 | PIGG | 0.698 | 0.1 | bioplex_WMM bioplex3_WMM WMM_only | |
| DMAC1 | MFSD12 | 0.675 | 0.074 | bioplex3_WMM WMM_only | |
| EXTL3 | MFSD12 | 0.625 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only | |
| TMEM164 | TM7SF2 | 0.568 | 0.09 |
structurally_consistent (O95858)
|
bioplex_WMM bioplex3_WMM WMM_only |
| TM7SF2 | PIGG | 0.509 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only | |
| EXTL3 | TMEM164 | 0.468 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only | |
| TSPAN15 | SYPL2 | 0.365 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| EXTL3 | TSPAN15 | 0.347 | 0.082 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TMEM164 | MFSD12 | 0.324 | 0.132 | bioplex_WMM bioplex3_WMM WMM_only | |
| TM7SF2 | B3GAT3 | 0.224 | 0.09 |
structurally_consistent (O95858)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EXTL3 | TM7SF2 | 0.19 | 0.078 | bioplex3_WMM WMM_only | |
| DMAC1 | PIGG | 0.179 | 0.054 | bioplex3_WMM WMM_only | |
| EXTL3 | TMEM54 | 0.162 | bioplex3_WMM WMM_only | ||
| EXTL3 | HRH1 | 0.162 | bioplex3_WMM WMM_only | ||
| TMEM54 | PIGG | 0.147 | bioplex3_WMM WMM_only | ||
| HRH1 | PIGG | 0.147 | bioplex3_WMM WMM_only | ||
| TMEM164 | B3GAT3 | 0.132 | 0.032 | bioplex_WMM bioplex3_WMM WMM_only | |
| TMEM54 | B3GAT3 | 0.12 | bioplex3_WMM WMM_only | ||
| HRH1 | B3GAT3 | 0.12 | bioplex3_WMM WMM_only | ||
| EXTL3 | DMAC1 | 0.099 | 0.054 | bioplex3_WMM WMM_only | |
| DMAC1 | B3GAT3 | 0.086 | 0.034 | bioplex3_WMM WMM_only | |
| TMEM164 | HRH1 | 0.042 | bioplex3_WMM WMM_only | ||
| TMEM164 | TMEM54 | 0.042 | bioplex3_WMM WMM_only | ||
| TMEM164 | DMAC1 | 0.041 | 0.068 | bioplex3_WMM WMM_only |
Related Complexes