hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10315.1
Complex Portal: CPX-13619
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PTK2 | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | 5 | UniProt NCBI |
| BSPRY | B box and SPRY domain-containing protein | 4 | UniProt NCBI |
| RNF135 | E3 ubiquitin-protein ligase RNF135 (EC 2.3.2.27) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (RING finger protein leading to RIG-I activation) (Riplet) (RING-type E3 ubiquitin transferase RNF135) | 5 | UniProt NCBI |
| DEAF1 | Deformed epidermal autoregulatory factor 1 homolog (Nuclear DEAF-1-related transcriptional regulator) (NUDR) (Suppressin) (Zinc finger MYND domain-containing protein 5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6310 | 0.0249718442456 | 0.25 | DEAF1 | DEAF1- complex |
| CORUM:7416 | 0.0249718442456 | 0.25 | PTK2 | GJB2-PTK2-NANOG complex |
| CORUM:2896 | 0.049938562206 | 0.25 | PTK2 | ITGA2b-ITGB3-CD47-FAK complex |
| CORUM:5282 | 0.049938562206 | 0.25 | PTK2 | CAS-SRC-FAK complex |
| CORUM:5712 | 0.049938562206 | 0.25 | PTK2 | FAK-beta5 integrin complex, VEGF induced |
| CORUM:6916 | 0.049938562206 | 0.25 | PTK2 | CTTN-FER-PTK2 complex |
| CORUM:6925 | 0.049938562206 | 0.25 | PTK2 | MAPK1-PTK2-PXN complex |
| CORUM:7116 | 0.049938562206 | 0.25 | PTK2 | GRB7-PTK2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| BSPRY | DEAF1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| BSPRY | PTK2 | 0.985 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| BSPRY | RNF135 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| DEAF1 | PTK2 | 0.401 | 0.114 | bioplex3_WMM WMM_only | |
| RNF135 | DEAF1 | 0.35 | 0.032 | bioplex_WMM bioplex3_WMM WMM_only | |
| RNF135 | PTK2 | 0.042 | 0.1 | bioplex3_WMM WMM_only |
Related Complexes