hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10318.1
Complex Portal: CPX-12241
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GDPD2 | Glycerophosphoinositol inositolphosphodiesterase GDPD2 (EC 3.1.4.43) (Glycerophosphodiester phosphodiesterase 3) (Glycerophosphodiester phosphodiesterase domain-containing protein 2) (Osteoblast differentiation promoting factor) | 5 | UniProt NCBI |
| AKR1C2 | Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357) | 5 | UniProt NCBI |
| AKR1C1 | Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.357) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1) (DD1) (High-affinity hepatic bile acid-binding protein) (HBAB) | 5 | UniProt NCBI |
| AKR1C4 | Aldo-keto reductase family 1 member C4 (EC 1.1.1.-) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha-hydroxysteroid dehydrogenase type I) (3-alpha-HSD1) (EC 1.1.1.357) (3alpha-hydroxysteroid 3-dehydrogenase) (Chlordecone reductase) (CDR) (EC 1.1.1.225) (Dihydrodiol dehydrogenase 4) (DD-4) (DD4) (HAKRA) | 5 | UniProt NCBI |
| AKR1D1 | Aldo-keto reductase family 1 member D1 (EC 1.3.1.3) (3-oxo-5-beta-steroid 4-dehydrogenase) (Delta(4)-3-ketosteroid 5-beta-reductase) (Delta(4)-3-oxosteroid 5-beta-reductase) | 5 | UniProt NCBI |
| AKR1C3 | Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5279 | 9.76437070481e-15 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | Mineralocorticoid biosynthesis |
| REAC:R-HSA-193775 | 1.11211677466e-14 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| WP:WP5280 | 1.95276272642e-14 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | Glucocorticoid biosynthesis |
| REAC:R-HSA-193807 | 5.00395448644e-14 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
| GO:0047086 | 5.40263452382e-14 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | ketosteroid monooxygenase activity |
| REAC:R-HSA-193368 | 3.97445658718e-13 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| REAC:R-HSA-192105 | 4.03815729609e-12 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | Synthesis of bile acids and bile salts |
| GO:0004032 | 1.36107562031e-11 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | alditol:NADP+ 1-oxidoreductase activity |
| REAC:R-HSA-194068 | 2.35555725816e-11 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | Bile acid and bile salt metabolism |
| KEGG:00140 | 3.6727533764e-11 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | Steroid hormone biosynthesis |
| WP:WP696 | 3.96214658446e-11 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | Benzo a pyrene metabolism |
| GO:0071395 | 3.94689465137e-10 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | cellular response to jasmonic acid stimulus |
| GO:0009753 | 3.94689465137e-10 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | response to jasmonic acid |
| GO:0008106 | 4.62554486756e-10 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | alcohol dehydrogenase (NADP+) activity |
| GO:0008207 | 1.09837878454e-09 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | C21-steroid hormone metabolic process |
| GO:0016709 | 1.81606603046e-09 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| GO:0004033 | 2.29384716405e-09 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | aldo-keto reductase (NADP) activity |
| GO:0016229 | 2.86714523046e-09 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | steroid dehydrogenase activity |
| GO:0047023 | 5.91904538175e-09 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | androsterone dehydrogenase activity |
| WP:WP702 | 2.66744026378e-08 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | Metapathway biotransformation Phase I and II |
| GO:0042448 | 2.76161616937e-08 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | progesterone metabolic process |
| REAC:R-HSA-8957322 | 4.08980754644e-08 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | Metabolism of steroids |
| GO:0030647 | 4.97036464355e-08 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | aminoglycoside antibiotic metabolic process |
| GO:0032052 | 4.97036464355e-08 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | bile acid binding |
| GO:0044597 | 4.97036464355e-08 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | daunorubicin metabolic process |
| GO:0030638 | 8.28303368884e-08 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | polyketide metabolic process |
| GO:0044598 | 8.28303368884e-08 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | doxorubicin metabolic process |
| GO:0004497 | 3.2038403283e-07 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | monooxygenase activity |
| GO:0071398 | 3.94651622678e-07 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | cellular response to fatty acid |
| GO:1902644 | 9.38024124582e-07 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | tertiary alcohol metabolic process |
| GO:0016137 | 9.38024124582e-07 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | glycoside metabolic process |
| GO:0018636 | 1.92240082153e-06 | 0.5 | AKR1C2 AKR1C1 AKR1C3 | phenanthrene 9,10-monooxygenase activity |
| GO:0070542 | 2.35782092708e-06 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | response to fatty acid |
| GO:0033764 | 3.48770721675e-06 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| GO:0016616 | 4.47504749525e-06 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| GO:0016614 | 6.57276483676e-06 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0016705 | 8.99427202349e-06 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| GO:0006693 | 1.41495482392e-05 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | prostaglandin metabolic process |
| GO:0006692 | 1.60994442835e-05 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | prostanoid metabolic process |
| WP:WP98 | 1.64258598412e-05 | 0.5 | AKR1C2 AKR1C1 AKR1C3 | Prostaglandin synthesis and regulation |
| GO:0042445 | 1.65903354809e-05 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | hormone metabolic process |
| GO:0019748 | 2.31677849716e-05 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | secondary metabolic process |
| GO:1901661 | 2.5973152006e-05 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | quinone metabolic process |
| KEGG:05208 | 2.69173097897e-05 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | Chemical carcinogenesis - reactive oxygen species |
| REAC:R-HSA-975634 | 6.94313281717e-05 | 0.5 | AKR1C4 AKR1C1 AKR1C3 | Retinoid metabolism and transport |
| GO:0008202 | 8.42001762745e-05 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | steroid metabolic process |
| WP:WP4313 | 8.43855364191e-05 | 0.5 | AKR1C2 AKR1C1 AKR1C3 | Ferroptosis |
| REAC:R-HSA-6806667 | 8.6685788479e-05 | 0.5 | AKR1C4 AKR1C1 AKR1C3 | Metabolism of fat-soluble vitamins |
| WP:WP5277 | 0.000100705403036 | 0.333333333333 | AKR1C1 AKR1D1 | Steroid hormone precursor biosynthesis |
| KEGG:00120 | 0.000108973378619 | 0.333333333333 | AKR1C4 AKR1D1 | Primary bile acid biosynthesis |
| REAC:R-HSA-556833 | 0.000134957179754 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | Metabolism of lipids |
| GO:1901657 | 0.000144141211509 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | glycosyl compound metabolic process |
| GO:0016655 | 0.000144141211509 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| GO:0034308 | 0.000155002771391 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | primary alcohol metabolic process |
| GO:0033293 | 0.000155002771391 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | monocarboxylic acid binding |
| GO:0006066 | 0.000218928505637 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | alcohol metabolic process |
| WP:WP4524 | 0.000281820769606 | 0.333333333333 | AKR1C2 AKR1C4 | Alternative pathway of fetal androgen synthesis |
| GO:0016651 | 0.000450665620324 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | oxidoreductase activity, acting on NAD(P)H |
| REAC:R-HSA-2187338 | 0.000531494169007 | 0.5 | AKR1C4 AKR1C1 AKR1C3 | Visual phototransduction |
| GO:0010817 | 0.00059052401487 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | regulation of hormone levels |
| GO:0033559 | 0.000619048899658 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | unsaturated fatty acid metabolic process |
| GO:0006690 | 0.000719028723342 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | icosanoid metabolic process |
| WP:WP5176 | 0.00136659658622 | 0.333333333333 | AKR1C4 AKR1D1 | Disorders of bile acid synthesis and biliary transport |
| GO:1901615 | 0.00141530580053 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | organic hydroxy compound metabolic process |
| GO:0120254 | 0.00147034444981 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | olefinic compound metabolic process |
| KEGG:01100 | 0.00157235036995 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | Metabolic pathways |
| GO:0016628 | 0.00254971303757 | 0.5 | AKR1C2 AKR1C1 AKR1C3 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor |
| GO:0031406 | 0.00269555949443 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | carboxylic acid binding |
| HP:0012245 | 0.00302198579101 | 0.333333333333 | AKR1C2 AKR1C4 | Sex reversal |
| GO:0043177 | 0.00377457359939 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | organic acid binding |
| REAC:R-HSA-196854 | 0.00436661776769 | 0.5 | AKR1C4 AKR1C1 AKR1C3 | Metabolism of vitamins and cofactors |
| WP:WP4545 | 0.00497042421358 | 0.333333333333 | AKR1C4 AKR1D1 | Oxysterols derived from cholesterol |
| GO:0032787 | 0.00521970580151 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | monocarboxylic acid metabolic process |
| HP:0012244 | 0.00593279372985 | 0.333333333333 | AKR1C2 AKR1C4 | Abnormal sex determination |
| GO:0008206 | 0.00627357313526 | 0.5 | AKR1C4 AKR1C1 AKR1D1 | bile acid metabolic process |
| GO:0042180 | 0.00686543980196 | 0.666666666667 | AKR1C2 AKR1C3 AKR1C1 AKR1C4 | cellular ketone metabolic process |
| GO:0047115 | 0.00702301080125 | 0.333333333333 | AKR1C2 AKR1C1 | trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity |
| REAC:R-HSA-9709957 | 0.0101216651073 | 0.5 | AKR1C4 AKR1C1 AKR1C3 | Sensory Perception |
| GO:0016491 | 0.0202240160661 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | oxidoreductase activity |
| GO:0071799 | 0.0210651876021 | 0.333333333333 | AKR1C2 AKR1C3 | cellular response to prostaglandin D stimulus |
| GO:0071798 | 0.0210651876021 | 0.333333333333 | AKR1C2 AKR1C3 | response to prostaglandin D |
| REAC:R-HSA-1430728 | 0.0258573248266 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | Metabolism |
| GO:0016627 | 0.0289892662643 | 0.5 | AKR1C2 AKR1C1 AKR1C3 | oxidoreductase activity, acting on the CH-CH group of donors |
| GO:0019752 | 0.035820867033 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | carboxylic acid metabolic process |
| GO:0043436 | 0.0404352228548 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | oxoacid metabolic process |
| GO:0006082 | 0.0410846453649 | 0.833333333333 | AKR1D1 AKR1C2 AKR1C3 AKR1C1 AKR1C4 | organic acid metabolic process |
| GO:0007586 | 0.0446883661999 | 0.5 | AKR1C2 AKR1C1 AKR1D1 | digestion |
| HP:0000037 | 0.0499762286031 | 0.333333333333 | AKR1C2 AKR1C4 | Male pseudohermaphroditism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| AKR1C3 | AKR1C4 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| AKR1C2 | AKR1C3 | 1.0 | 0.672 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| AKR1C1 | AKR1C2 | 0.999 | 0.196 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AKR1C1 | AKR1D1 | 0.997 | 0.238 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AKR1D1 | AKR1C3 | 0.997 | 0.54 |
structurally_consistent (Q04828)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AKR1C1 | AKR1C3 | 0.997 | 0.348 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM treiber_WMM |
| GDPD2 | AKR1C4 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| AKR1C2 | AKR1C4 | 0.966 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| AKR1D1 | AKR1C4 | 0.924 |
structurally_consistent (P42330)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| AKR1C1 | AKR1C4 | 0.575 | bioplex_WMM bioplex3_WMM WMM_only | ||
| AKR1D1 | AKR1C2 | 0.378 | 0.432 |
structurally_consistent (Q04828)
|
bioplex_WMM bioplex3_WMM WMM_only |
| AKR1C3 | GDPD2 | 0.35 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| GDPD2 | huMAP3_02209.1 huMAP3_10318.1 |
| AKR1C2 | huMAP3_01225.1 huMAP3_10318.1 |
| AKR1C1 | huMAP3_01225.1 huMAP3_08762.1 huMAP3_10318.1 |
| AKR1C4 | huMAP3_02209.1 huMAP3_10318.1 huMAP3_13538.1 |
| AKR1D1 | huMAP3_01225.1 huMAP3_08762.1 huMAP3_10318.1 |
| AKR1C3 | huMAP3_01225.1 huMAP3_08762.1 huMAP3_10318.1 |