hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10321.1
Complex Portal: CPX-14855
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PCDHA6 | Protocadherin alpha-6 (PCDH-alpha-6) | 5 | UniProt NCBI |
| PCDHA13 | Protocadherin alpha-13 (PCDH-alpha-13) | 4 | UniProt NCBI |
| KCNT2 | Potassium channel subfamily T member 2 (Sequence like an intermediate conductance potassium channel subunit) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1) | 5 | UniProt NCBI |
| PCDHA11 | Protocadherin alpha-11 (PCDH-alpha-11) | 4 | UniProt NCBI |
| PCDHA3 | Protocadherin alpha-3 (PCDH-alpha-3) | 5 | UniProt NCBI |
| PCDHA8 | Protocadherin alpha-8 (PCDH-alpha-8) | 4 | UniProt NCBI |
| PCDHA1 | Protocadherin alpha-1 (PCDH-alpha-1) | 5 | UniProt NCBI |
| PCDHA12 | Protocadherin alpha-12 (PCDH-alpha-12) | 4 | UniProt NCBI |
| PCDHA2 | Protocadherin alpha-2 (PCDH-alpha-2) | 5 | UniProt NCBI |
| PCDHA4 | Protocadherin alpha-4 (PCDH-alpha-4) | 5 | UniProt NCBI |
| PCDHA7 | Protocadherin alpha-7 (PCDH-alpha-7) | 5 | UniProt NCBI |
| PCDHA10 | Protocadherin alpha-10 (PCDH-alpha-10) | 5 | UniProt NCBI |
| PCDHB14 | Protocadherin beta-14 (PCDH-beta-14) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| TF:M06624 | 2.24822078489e-15 | 0.692307692308 | PCDHA12 PCDHA13 PCDHA2 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA1 PCDHA4 | Factor: ZNF2; motif: NSATCGATCCGA |
| TF:M00162_1 | 1.75418830055e-12 | 0.846153846154 | PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA1 PCDHA10 PCDHA4 | Factor: Oct-1; motif: CWNAWTKWSATRYN; match class: 1 |
| MIRNA:hsa-miR-221-3p | 3.12073929491e-12 | 0.846153846154 | PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA1 PCDHA10 PCDHA4 | hsa-miR-221-3p |
| MIRNA:hsa-miR-181a-5p | 1.21945290445e-10 | 0.846153846154 | PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA1 PCDHA10 PCDHA4 | hsa-miR-181a-5p |
| GO:0007155 | 2.13181056157e-09 | 0.923076923077 | PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA1 PCDHA10 PCDHA4 PCDHB14 | cell adhesion |
| TF:M00162 | 2.14832457509e-06 | 1.0 | KCNT2 PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA1 PCDHA10 PCDHA4 PCDHB14 | Factor: Oct-1; motif: CWNAWTKWSATRYN |
| TF:M07050 | 2.28961385111e-05 | 0.615384615385 | PCDHA12 PCDHA2 PCDHA8 PCDHA7 PCDHA3 PCDHA1 PCDHA10 PCDHA4 | Factor: MITF; motif: NNCACATGNNN |
| TF:M10116 | 0.000160391376238 | 0.769230769231 | KCNT2 PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA10 | Factor: ZID; motif: GGNGMTGGAGCCN |
| TF:M06531 | 0.00020916778873 | 0.461538461538 | PCDHA12 PCDHA2 PCDHA8 PCDHA6 PCDHA11 PCDHA4 | Factor: ZNF555; motif: NCRWGTTTGKCC |
| TF:M10533 | 0.000362927585376 | 0.769230769231 | KCNT2 PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA10 | Factor: ZID; motif: NGGNGCTGGAGCCNS |
| GO:0007399 | 0.000385147263435 | 0.769230769231 | PCDHB14 PCDHA2 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA3 PCDHA1 PCDHA10 PCDHA4 | nervous system development |
| TF:M10758 | 0.00095967864328 | 0.846153846154 | PCDHA12 PCDHA13 PCDHA2 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA1 PCDHA10 PCDHA4 PCDHB14 | Factor: HOXB1; motif: NTCRTTAN |
| TF:M02017 | 0.00118526877441 | 0.923076923077 | KCNT2 PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA1 PCDHA10 PCDHB14 | Factor: HSF1; motif: GAANNTTCTRGNAN |
| TF:M12706 | 0.00192523176882 | 0.769230769231 | PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA10 PCDHA4 | Factor: ZNF450; motif: NNNAGGTCCTGGMAGNK |
| TF:M11633_1 | 0.00202739392642 | 0.846153846154 | PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA1 PCDHA10 PCDHA4 | Factor: Sox-10; motif: AACAATGGNCCATTGTT; match class: 1 |
| TF:M10755 | 0.00226064890735 | 0.846153846154 | PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA1 PCDHA10 PCDHA4 | Factor: hoxd1; motif: NTCRTTAN |
| TF:M05609 | 0.00285289541874 | 0.615384615385 | PCDHA12 PCDHA3 PCDHA8 PCDHA10 PCDHA13 PCDHA11 PCDHA2 PCDHA1 | Factor: SALL3; motif: NMTTTTGRAYN |
| TF:M10991 | 0.00346254115203 | 0.692307692308 | PCDHA12 PCDHA13 PCDHA2 PCDHA7 PCDHA10 PCDHA6 PCDHA11 PCDHA1 PCDHA4 | Factor: lmx1b; motif: CTCGTTAA |
| TF:M11002 | 0.00467591721164 | 0.692307692308 | PCDHA12 PCDHA13 PCDHA2 PCDHA7 PCDHA10 PCDHA6 PCDHA11 PCDHA1 PCDHA4 | Factor: LHX5; motif: NTCGTTAN |
| TF:M07459 | 0.0047207140745 | 0.846153846154 | PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA1 PCDHA10 PCDHA4 | Factor: HSF1; motif: GAANNTTCTNGN |
| TF:M10683 | 0.0053551795627 | 0.692307692308 | PCDHA12 PCDHA13 PCDHA2 PCDHA7 PCDHA10 PCDHA6 PCDHA11 PCDHA1 PCDHA4 | Factor: HOXB7; motif: GTCRTTAN |
| TF:M07259 | 0.00679441573666 | 0.923076923077 | PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA1 PCDHA10 PCDHA4 PCDHB14 | Factor: HSF1; motif: TCYAGAANNTTC |
| TF:M11633 | 0.0103516319994 | 0.846153846154 | PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA1 PCDHA10 PCDHA4 | Factor: Sox-10; motif: AACAATGGNCCATTGTT |
| TF:M00137 | 0.0125354607822 | 1.0 | KCNT2 PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA1 PCDHA10 PCDHA4 PCDHB14 | Factor: Oct-1; motif: NNNRTAATNANNN |
| TF:M10801 | 0.0168820900036 | 0.846153846154 | PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA1 PCDHA10 PCDHA4 | Factor: HOXA10; motif: NRTCGTAAANN |
| TF:M10783 | 0.0186333432918 | 0.692307692308 | PCDHA12 PCDHA13 PCDHA2 PCDHA7 PCDHA10 PCDHA6 PCDHA11 PCDHA1 PCDHA4 | Factor: hoxa9; motif: RTCGTWAANN |
| TF:M10088_1 | 0.0203659933899 | 0.538461538462 | PCDHB14 PCDHA3 PCDHA7 PCDHA10 PCDHA13 PCDHA11 PCDHA4 | Factor: TBP; motif: MTATAAAARS; match class: 1 |
| TF:M10686 | 0.0283041048911 | 0.846153846154 | PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA1 PCDHA10 PCDHA4 | Factor: HOXB7; motif: GTCRTTAN |
| GO:0048731 | 0.0283225360297 | 0.769230769231 | PCDHB14 PCDHA2 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA3 PCDHA1 PCDHA10 PCDHA4 | system development |
| TF:M11571 | 0.0303256217626 | 0.846153846154 | KCNT2 PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA10 PCDHA6 PCDHA11 PCDHA2 PCDHA1 PCDHB14 | Factor: HNF-3alpha; motif: YTRWGTMAATATTTRCWYWN |
| TF:M10632 | 0.0334521780883 | 0.923076923077 | PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA1 PCDHA10 PCDHA4 PCDHB14 | Factor: Nkx2-8; motif: STCGTTGAN |
| TF:M10729 | 0.0412820112464 | 0.846153846154 | PCDHA12 PCDHA13 PCDHA3 PCDHA8 PCDHA7 PCDHA6 PCDHA11 PCDHA2 PCDHA1 PCDHA10 PCDHA4 | Factor: HOXC-8; motif: RTCRTTAN |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| PCDHA11 | PCDHA12 | 1.0 | ||
| PCDHA8 | PCDHA2 | 0.999 |
structurally_consistent (dimer)
|
|
| PCDHA11 | PCDHB14 | 0.998 | ||
| PCDHA8 | PCDHA7 | 0.998 |
mutually_exclusive (Q9Y5H9)
|
|
| PCDHA8 | PCDHA12 | 0.998 |
mutually_exclusive (Q9UN74)
structurally_consistent (dimer) |
|
| PCDHA4 | PCDHA1 | 0.998 | ||
| PCDHA3 | PCDHA1 | 0.998 |
structurally_consistent (dimer)
|
|
| PCDHA6 | PCDHA3 | 0.997 |
mutually_exclusive (Q9Y5H6)
structurally_consistent (dimer) |
|
| PCDHA8 | PCDHA1 | 0.996 |
structurally_consistent (dimer)
|
|
| PCDHA8 | PCDHA10 | 0.996 |
mutually_exclusive (Q9Y5I0)
|
|
| PCDHA7 | PCDHA10 | 0.995 |
structurally_consistent (dimer)
|
|
| PCDHA2 | PCDHA10 | 0.995 |
mutually_exclusive (Q9UN72)
|
|
| PCDHA4 | PCDHA10 | 0.994 | ||
| PCDHA12 | PCDHA10 | 0.994 | ||
| PCDHA6 | PCDHA10 | 0.993 | ||
| PCDHA3 | PCDHA10 | 0.993 | ||
| PCDHA13 | PCDHA10 | 0.993 |
structurally_consistent (dimer)
|
|
| PCDHA2 | PCDHA7 | 0.99 |
structurally_consistent (dimer)
|
|
| PCDHA11 | PCDHA10 | 0.989 | ||
| PCDHA4 | PCDHA7 | 0.989 | ||
| PCDHA7 | PCDHA12 | 0.988 | ||
| PCDHA4 | PCDHA12 | 0.982 |
structurally_consistent (dimer)
|
|
| PCDHA8 | PCDHA3 | 0.978 |
structurally_consistent (dimer)
|
|
| PCDHA13 | PCDHA8 | 0.977 |
structurally_consistent (dimer)
|
|
| PCDHA8 | PCDHA6 | 0.975 |
mutually_exclusive (Q9Y5H8)
structurally_consistent (dimer) |
|
| PCDHA4 | PCDHA8 | 0.975 |
structurally_consistent (dimer)
|
|
| KCNT2 | PCDHA3 | 0.961 | ||
| PCDHA11 | PCDHA1 | 0.961 |
structurally_consistent (dimer)
|
|
| PCDHA3 | PCDHA11 | 0.949 |
mutually_exclusive (Q9Y5I3)
structurally_consistent (dimer) |
|
| PCDHA2 | PCDHA1 | 0.904 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA13 | PCDHA1 | 0.902 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA13 | PCDHA3 | 0.843 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA13 | PCDHA6 | 0.843 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA13 | PCDHA2 | 0.835 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA1 | PCDHA12 | 0.824 | ||
| PCDHA13 | PCDHA7 | 0.823 |
mutually_exclusive (Q9Y5I2)
|
|
| PCDHA13 | PCDHA12 | 0.823 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA4 | PCDHA13 | 0.823 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA4 | PCDHA11 | 0.82 | ||
| PCDHA4 | PCDHA6 | 0.814 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA7 | PCDHA3 | 0.814 | ||
| PCDHA4 | PCDHA2 | 0.814 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA6 | PCDHA12 | 0.814 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA4 | PCDHA3 | 0.814 | ||
| PCDHA7 | PCDHA6 | 0.814 | ||
| PCDHA3 | PCDHA12 | 0.814 | ||
| PCDHA6 | PCDHA1 | 0.814 | ||
| PCDHA2 | PCDHA3 | 0.812 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA2 | PCDHA6 | 0.812 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA2 | PCDHA12 | 0.786 |
mutually_exclusive (Q9Y5H6)
|
|
| PCDHA7 | PCDHA1 | 0.782 | ||
| PCDHA7 | PCDHA11 | 0.775 | ||
| PCDHA13 | PCDHA11 | 0.35 | ||
| PCDHA8 | PCDHA11 | 0.35 | ||
| PCDHA6 | PCDHA11 | 0.335 |
mutually_exclusive (Q9Y5H8)
|
|
| PCDHA2 | PCDHA11 | 0.333 | ||
| PCDHB14 | PCDHA1 | 0.214 | ||
| PCDHA1 | PCDHA10 | 0.214 | ||
| KCNT2 | PCDHA11 | 0.165 | ||
| KCNT2 | PCDHA1 | 0.165 | ||
| PCDHB14 | PCDHA12 | 0.146 | ||
| PCDHA7 | PCDHB14 | 0.146 | ||
| KCNT2 | PCDHA6 | 0.143 |
Related Complexes