List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_10340.1

Confidence: Medium High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
KIF5B	Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC)	5	UniProt   NCBI
TRAK1	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton)	5	UniProt   NCBI
KIF5C	Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1)	5	UniProt   NCBI
KLC4	Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8)	5	UniProt   NCBI
SYNE4	Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4)	5	UniProt   NCBI
KLC3	Kinesin light chain 3 (KLC2-like) (kinesin light chain 2)	5	UniProt   NCBI
TRAK2	Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein)	5	UniProt   NCBI
MYCL	Protein L-Myc (Class E basic helix-loop-helix protein 38) (bHLHe38) (Protein L-Myc-1) (V-myc myelocytomatosis viral oncogene homolog)	5	UniProt   NCBI
KIF5A	Kinesin heavy chain isoform 5A (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC)	5	UniProt   NCBI
CTU2	Cytoplasmic tRNA 2-thiolation protein 2 (Cytosolic thiouridylase subunit 2)	5	UniProt   NCBI
KLC2	Kinesin light chain 2 (KLC 2)	5	UniProt   NCBI
KLC1	Kinesin light chain 1 (KLC 1)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-5625970	4.08361535178e-15	0.545454545455	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4	RHO GTPases activate KTN1
REAC:R-HSA-983189	2.25420126682e-10	0.545454545455	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4	Kinesins
KEGG:04814	2.92539824661e-10	0.636363636364	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4 KIF5C	Motor proteins
GO:0007018	6.04638274669e-10	0.818181818182	KLC2 KIF5A KLC3 KIF5B TRAK1 KLC1 KIF5C TRAK2 KLC4	microtubule-based movement
KEGG:05132	2.88898937854e-09	0.636363636364	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4 KIF5C	Salmonella infection
KEGG:05012	4.42602350944e-09	0.636363636364	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4 KIF5C	Parkinson disease
KEGG:05020	5.42642996561e-09	0.636363636364	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4 KIF5C	Prion disease
REAC:R-HSA-6811434	6.57693145155e-09	0.545454545455	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4	COPI-dependent Golgi-to-ER retrograde traffic
WP:WP5124	7.34762965383e-09	0.636363636364	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4 KIF5C	Alzheimer 39 s disease
WP:WP2059	7.34762965383e-09	0.636363636364	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4 KIF5C	Alzheimer 39 s disease and miRNA effects
KEGG:05016	1.1016012734e-08	0.636363636364	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4 KIF5C	Huntington disease
REAC:R-HSA-2132295	2.67956636612e-08	0.545454545455	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4	MHC class II antigen presentation
KEGG:05014	3.84621445962e-08	0.636363636364	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4 KIF5C	Amyotrophic lateral sclerosis
REAC:R-HSA-8856688	4.20843010097e-08	0.545454545455	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4	Golgi-to-ER retrograde transport
KEGG:05010	5.38538309939e-08	0.636363636364	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4 KIF5C	Alzheimer disease
REAC:R-HSA-983231	1.59882248179e-07	0.545454545455	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4	Factors involved in megakaryocyte development and platelet production
KEGG:05022	2.12251619723e-07	0.636363636364	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4 KIF5C	Pathways of neurodegeneration - multiple diseases
REAC:R-HSA-9716542	5.17684587533e-07	0.727272727273	KLC2 KIF5A KLC3 KIF5B TRAK1 KLC1 KLC4 TRAK2	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
REAC:R-HSA-6811442	5.55935687768e-07	0.545454545455	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4	Intra-Golgi and retrograde Golgi-to-ER traffic
GO:0005871	1.79357540166e-06	0.454545454545	KLC2 KLC1 KIF5B KIF5A KIF5C	kinesin complex
GO:0007017	2.94697780594e-06	0.818181818182	KLC2 KIF5A KLC3 KIF5B TRAK1 KLC1 KIF5C TRAK2 KLC4	microtubule-based process
GO:0008089	3.49422884807e-06	0.454545454545	KIF5C TRAK2 KIF5B KIF5A TRAK1	anterograde axonal transport
GO:0008092	3.61480138266e-06	0.818181818182	KLC2 KIF5A KLC3 KIF5B TRAK1 KLC1 KIF5C TRAK2 KLC4	cytoskeletal protein binding
REAC:R-HSA-195258	7.21222614604e-06	0.545454545455	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4	RHO GTPase Effectors
GO:0098930	1.29370598876e-05	0.454545454545	KIF5C TRAK2 KIF5B KIF5A TRAK1	axonal transport
GO:0008088	2.22957659e-05	0.454545454545	KIF5C TRAK2 KIF5B KIF5A TRAK1	axo-dendritic transport
GO:0098971	6.34131776058e-05	0.272727272727	KIF5B KIF5A KIF5C	anterograde dendritic transport of neurotransmitter receptor complex
CORUM:177	0.000102551658964	0.181818181818	TRAK1 TRAK2	OGT-TRAK1-TRAK2 complex
REAC:R-HSA-264876	0.00010848779128	0.272727272727	KIF5B KIF5A KIF5C	Insulin processing
GO:0019894	0.000204265929084	0.363636363636	KLC3 KLC1 KLC4 KLC2	kinesin binding
REAC:R-HSA-109582	0.000214359188112	0.545454545455	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4	Hemostasis
GO:0098937	0.000316805542726	0.272727272727	KIF5B KIF5A KIF5C	anterograde dendritic transport
GO:0098935	0.000316805542726	0.272727272727	KIF5B KIF5A KIF5C	dendritic transport
REAC:R-HSA-199991	0.000357981895115	0.545454545455	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4	Membrane Trafficking
REAC:R-HSA-5653656	0.000491883025554	0.545454545455	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4	Vesicle-mediated transport
REAC:R-HSA-194315	0.000623030633404	0.545454545455	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4	Signaling by Rho GTPases
KEGG:05223	0.000788862463964	0.272727272727	KIF5B KIF5A KIF5C	Non-small cell lung cancer
REAC:R-HSA-1280218	0.000846293229734	0.545454545455	KLC2 KIF5A KLC3 KIF5B KLC1 KLC4	Adaptive Immune System
GO:0005875	0.000863181324731	0.454545454545	KLC2 KLC1 KIF5B KIF5A KIF5C	microtubule associated complex
GO:0047496	0.000866950933849	0.363636363636	TRAK2 KIF5B KIF5A TRAK1	vesicle transport along microtubule
GO:0099641	0.000886327111509	0.272727272727	KIF5B KIF5A KIF5C	anterograde axonal protein transport
GO:0099640	0.000886327111509	0.272727272727	KIF5B KIF5A KIF5C	axo-dendritic protein transport
REAC:R-HSA-9013425	0.00133260792819	0.181818181818	TRAK1 TRAK2	RHOT1 GTPase cycle
GO:0010970	0.00143147011929	0.454545454545	KIF5C TRAK2 KIF5B KIF5A TRAK1	transport along microtubule
GO:1905383	0.0018977127037	0.272727272727	KIF5B KIF5A KIF5C	protein localization to presynapse
GO:0099118	0.0018977127037	0.272727272727	KIF5B KIF5A KIF5C	microtubule-based protein transport
GO:0098840	0.0018977127037	0.272727272727	KIF5B KIF5A KIF5C	protein transport along microtubule
GO:0099111	0.00258597515393	0.454545454545	KIF5C TRAK2 KIF5B KIF5A TRAK1	microtubule-based transport
REAC:R-HSA-9013419	0.00279617904977	0.181818181818	TRAK1 TRAK2	RHOT2 GTPase cycle
KEGG:04728	0.00324920943997	0.272727272727	KIF5B KIF5A KIF5C	Dopaminergic synapse
REAC:R-HSA-2980736	0.00366420663692	0.272727272727	KIF5B KIF5A KIF5C	Peptide hormone metabolism
REAC:R-HSA-9715370	0.00372670794354	0.181818181818	TRAK1 TRAK2	Miro GTPase Cycle
REAC:R-HSA-162582	0.00386179598205	0.727272727273	KLC2 KIF5A KLC3 KIF5B TRAK1 KLC1 KLC4 TRAK2	Signal Transduction
GO:0051650	0.00413094754083	0.454545454545	KIF5C TRAK2 KIF5B KIF5A TRAK1	establishment of vesicle localization
GO:0030705	0.00478349175664	0.454545454545	KIF5C TRAK2 KIF5B KIF5A TRAK1	cytoskeleton-dependent intracellular transport
GO:0051648	0.00492331576488	0.454545454545	KIF5C TRAK2 KIF5B KIF5A TRAK1	vesicle localization
GO:0099518	0.00505645294141	0.363636363636	TRAK2 KIF5B KIF5A TRAK1	vesicle cytoskeletal trafficking
GO:0008574	0.00574694403184	0.272727272727	KIF5B KIF5A KIF5C	plus-end-directed microtubule motor activity
GO:0072384	0.00822264869622	0.363636363636	TRAK2 KIF5B KIF5A TRAK1	organelle transport along microtubule
GO:0003774	0.0205202050386	0.363636363636	KLC1 KIF5B KIF5A KIF5C	cytoskeletal motor activity
GO:0051640	0.0213116148219	0.545454545455	KLC2 KIF5A KIF5B TRAK1 KIF5C TRAK2	organelle localization
KEGG:04144	0.0298442204102	0.272727272727	KIF5B KIF5A KIF5C	Endocytosis
WP:WP4535	0.0372386402869	0.181818181818	SYNE4 KIF5B	Envelope proteins and their potential roles in EDMD physiopathology
CORUM:5401	0.049976851631	0.0909090909091	KIF5B	PLEKHM2-KIF5B complex



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?
KLC4	KLC3	1.0	0.206
KIF5A	KLC1	1.0	0.136
KLC4	KLC1	1.0	0.274
KIF5B	KLC1	1.0	0.584
KIF5C	KLC1	1.0	0.102
KLC3	KIF5A	1.0	0.094
KIF5B	KLC3	1.0	0.18
KLC3	KLC2	1.0	0.138
KIF5B	KLC2	1.0	0.478
KLC2	KLC1	1.0	0.682
MYCL	KLC4	0.999
MYCL	KLC3	0.999
KIF5C	KLC3	0.999	0.154
KIF5C	SYNE4	0.999
KLC4	KLC2	0.999	0.154
KLC3	KLC1	0.999	0.1
SYNE4	KLC1	0.999
SYNE4	KLC3	0.999
KIF5C	KLC4	0.999	0.126
KIF5B	KLC4	0.998	0.22
KLC4	SYNE4	0.998
TRAK2	KIF5A	0.998	0.078
KIF5C	KLC2	0.998	0.154
KIF5B	SYNE4	0.998
SYNE4	KLC2	0.998
KLC4	KIF5A	0.997	0.322
MYCL	KIF5C	0.997
SYNE4	KIF5A	0.996
MYCL	KIF5B	0.994
TRAK1	KIF5B	0.994
TRAK1	KIF5A	0.992
MYCL	KLC2	0.992
KIF5C	KIF5A	0.99	0.186
TRAK1	KLC1	0.989
TRAK1	TRAK2	0.989
TRAK2	KIF5B	0.989	0.23
TRAK2	KLC2	0.987	0.062
KIF5B	KIF5A	0.985	0.2028
KIF5A	KLC2	0.983	0.14
TRAK2	KLC3	0.982	0.086
CTU2	MYCL	0.98
MYCL	KLC1	0.974
TRAK1	KLC2	0.971
KIF5B	KIF5C	0.97	0.374
MYCL	KIF5A	0.951
TRAK2	KLC1	0.949	0.072
TRAK1	KLC4	0.82
TRAK2	KIF5C	0.661	0.066
TRAK1	KLC3	0.507
TRAK2	KLC4	0.406	0.088
TRAK1	KIF5C	0.25
CTU2	KLC3	0.082	0.056
CTU2	KLC4	0.05	0.038
CTU2	KLC2	0.044	0.048
CTU2	KIF5C	0.018	0.092
CTU2	KIF5A	0.012	0.07
CTU2	KIF5B	0.005	0.058
CTU2	KLC1	0.004	0.048





Related Complexes

Genename	Complexes
KIF5B	huMAP3_04401.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_11266.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14331.1
TRAK1	huMAP3_02950.1 huMAP3_03931.1 huMAP3_05683.1 huMAP3_06314.1 huMAP3_07700.1 huMAP3_09022.1 huMAP3_10340.1 huMAP3_10660.1 huMAP3_10776.1 huMAP3_13949.1 huMAP3_14331.1
KIF5C	huMAP3_04401.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_11266.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14331.1
KLC4	huMAP3_04401.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_11266.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14331.1
SYNE4	huMAP3_04401.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_11266.1 huMAP3_11833.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14331.1
KLC3	huMAP3_04401.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_11266.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14331.1
TRAK2	huMAP3_03939.1 huMAP3_05683.1 huMAP3_10340.1 huMAP3_12367.1 huMAP3_14331.1
MYCL	huMAP3_01125.1 huMAP3_04039.1 huMAP3_06087.1 huMAP3_07843.1 huMAP3_09291.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_10481.1 huMAP3_11266.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14306.1 huMAP3_14331.1
KIF5A	huMAP3_04401.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_11266.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14331.1
CTU2	huMAP3_00416.1 huMAP3_01125.1 huMAP3_03397.1 huMAP3_05662.1 huMAP3_09851.1 huMAP3_10285.1 huMAP3_10340.1 huMAP3_12458.1
KLC2	huMAP3_04401.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_11266.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14331.1
KLC1	huMAP3_04401.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_11266.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14331.1