hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10341.1
Complex Portal: CPX-23084
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | 5 | UniProt NCBI |
| CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | 5 | UniProt NCBI |
| PUSL1 | tRNA pseudouridine synthase-like 1 (EC 5.4.99.-) (tRNA pseudouridylate synthase-like 1) (tRNA-uridine isomerase-like 1) | 4 | UniProt NCBI |
| UNG | Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) | 5 | UniProt NCBI |
| CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | 5 | UniProt NCBI |
| SNRK | SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-111932 | 2.61984124802e-07 | 0.6 | CAMK2B CAMK2A CAMK2D | CaMK IV-mediated phosphorylation of CREB |
| REAC:R-HSA-442982 | 1.13468173222e-06 | 0.6 | CAMK2B CAMK2A CAMK2D | Ras activation upon Ca2+ influx through NMDA receptor |
| REAC:R-HSA-438066 | 2.11908198931e-06 | 0.6 | CAMK2B CAMK2A CAMK2D | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-9617324 | 2.11908198931e-06 | 0.6 | CAMK2B CAMK2A CAMK2D | Negative regulation of NMDA receptor-mediated neuronal transmission |
| REAC:R-HSA-9620244 | 2.54263716986e-06 | 0.6 | CAMK2B CAMK2A CAMK2D | Long-term potentiation |
| WP:WP4875 | 2.77106908724e-06 | 0.6 | CAMK2B CAMK2A CAMK2D | Disruption of postsynaptic signaling by CNV |
| GO:0005954 | 3.84440695359e-06 | 0.6 | CAMK2B CAMK2A CAMK2D | calcium- and calmodulin-dependent protein kinase complex |
| REAC:R-HSA-442742 | 4.79663279828e-06 | 0.6 | CAMK2B CAMK2A CAMK2D | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| REAC:R-HSA-3371571 | 5.51556094215e-06 | 0.6 | CAMK2B CAMK2A CAMK2D | HSF1-dependent transactivation |
| REAC:R-HSA-5576892 | 6.30285051125e-06 | 0.6 | CAMK2B CAMK2A CAMK2D | Phase 0 - rapid depolarisation |
| REAC:R-HSA-399721 | 7.16159413456e-06 | 0.6 | CAMK2B CAMK2A CAMK2D | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| REAC:R-HSA-399719 | 7.16159413456e-06 | 0.6 | CAMK2B CAMK2A CAMK2D | Trafficking of AMPA receptors |
| WP:WP4756 | 7.20293237755e-06 | 0.6 | CAMK2B CAMK2A CAMK2D | Renin angiotensin aldosterone system RAAS |
| WP:WP4008 | 9.34985361286e-06 | 0.6 | CAMK2B CAMK2A CAMK2D | NO cGMP PKG mediated neuroprotection |
| REAC:R-HSA-9022692 | 1.13729170368e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Regulation of MECP2 expression and activity |
| REAC:R-HSA-111933 | 1.26352756558e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Calmodulin induced events |
| REAC:R-HSA-111997 | 1.26352756558e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | CaM pathway |
| REAC:R-HSA-5673000 | 1.26352756558e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | RAF activation |
| REAC:R-HSA-111996 | 1.54330255969e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Ca-dependent events |
| REAC:R-HSA-9656223 | 2.03584684634e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Signaling by RAF1 mutants |
| KEGG:04971 | 2.17491853578e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Gastric acid secretion |
| REAC:R-HSA-1489509 | 2.22069549267e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | DAG and IP3 signaling |
| KEGG:04720 | 2.30261795237e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Long-term potentiation |
| REAC:R-HSA-9609736 | 2.62324018845e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Assembly and cell surface presentation of NMDA receptors |
| REAC:R-HSA-6802949 | 2.62324018845e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Signaling by RAS mutants |
| REAC:R-HSA-9649948 | 2.62324018845e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Signaling downstream of RAS mutants |
| REAC:R-HSA-6802955 | 2.62324018845e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802946 | 2.62324018845e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Signaling by moderate kinase activity BRAF mutants |
| REAC:R-HSA-936837 | 2.62324018845e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Ion transport by P-type ATPases |
| KEGG:05031 | 2.71544115994e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Amphetamine addiction |
| REAC:R-HSA-5578775 | 3.31378787787e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Ion homeostasis |
| REAC:R-HSA-112043 | 3.5683276241e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | PLC beta mediated events |
| KEGG:04911 | 4.05033588721e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Insulin secretion |
| KEGG:05214 | 4.64569454207e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Glioma |
| KEGG:04912 | 4.64569454207e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | GnRH signaling pathway |
| WP:WP4341 | 4.76576715509e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Non genomic actions of 1 25 dihydroxyvitamin D3 |
| KEGG:04750 | 4.85636233593e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Inflammatory mediator regulation of TRP channels |
| REAC:R-HSA-112040 | 5.03751582702e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | G-protein mediated events |
| KEGG:04713 | 5.76252819292e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Circadian entrainment |
| KEGG:04925 | 6.00539667617e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Aldosterone synthesis and secretion |
| KEGG:04012 | 6.51136022216e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | ErbB signaling pathway |
| REAC:R-HSA-8986944 | 7.27326653199e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Transcriptional Regulation by MECP2 |
| KEGG:04740 | 8.19757737363e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Olfactory transduction |
| KEGG:04916 | 8.50411012707e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Melanogenesis |
| REAC:R-HSA-6802952 | 8.60380398164e-05 | 0.6 | CAMK2B CAMK2A CAMK2D | Signaling by BRAF and RAF1 fusions |
| WP:WP673 | 0.000102203948036 | 0.6 | CAMK2B CAMK2A CAMK2D | ErbB signaling pathway |
| KEGG:04725 | 0.000105044972713 | 0.6 | CAMK2B CAMK2A CAMK2D | Cholinergic synapse |
| KEGG:04922 | 0.000116123670778 | 0.6 | CAMK2B CAMK2A CAMK2D | Glucagon signaling pathway |
| KEGG:04066 | 0.00014493342506 | 0.6 | CAMK2B CAMK2A CAMK2D | HIF-1 signaling pathway |
| KEGG:04722 | 0.000149400492944 | 0.6 | CAMK2B CAMK2A CAMK2D | Neurotrophin signaling pathway |
| REAC:R-HSA-438064 | 0.00015535926553 | 0.6 | CAMK2B CAMK2A CAMK2D | Post NMDA receptor activation events |
| KEGG:04114 | 0.000168183083601 | 0.6 | CAMK2B CAMK2A CAMK2D | Oocyte meiosis |
| REAC:R-HSA-6802957 | 0.000177125385704 | 0.6 | CAMK2B CAMK2A CAMK2D | Oncogenic MAPK signaling |
| KEGG:04728 | 0.000193785633278 | 0.6 | CAMK2B CAMK2A CAMK2D | Dopaminergic synapse |
| WP:WP428 | 0.000199217136091 | 0.6 | CAMK2B CAMK2A CAMK2D | Wnt signaling |
| REAC:R-HSA-877300 | 0.000217750033404 | 0.6 | CAMK2B CAMK2A CAMK2D | Interferon gamma signaling |
| REAC:R-HSA-111885 | 0.000235592298974 | 0.6 | CAMK2B CAMK2A CAMK2D | Opioid Signalling |
| KEGG:04921 | 0.000246155766644 | 0.6 | CAMK2B CAMK2A CAMK2D | Oxytocin signaling pathway |
| KEGG:04261 | 0.0002524957978 | 0.6 | CAMK2B CAMK2A CAMK2D | Adrenergic signaling in cardiomyocytes |
| REAC:R-HSA-442755 | 0.000254380816813 | 0.6 | CAMK2B CAMK2A CAMK2D | Activation of NMDA receptors and postsynaptic events |
| WP:WP5083 | 0.000264889191211 | 0.6 | CAMK2B CAMK2A CAMK2D | Neuroinflammation and glutamatergic signaling |
| WP:WP536 | 0.000272151633458 | 0.6 | CAMK2B CAMK2A CAMK2D | Calcium regulation in cardiac cells |
| KEGG:04148 | 0.00028582601872 | 0.6 | CAMK2B CAMK2A CAMK2D | Efferocytosis |
| KEGG:04934 | 0.0002928242891 | 0.6 | CAMK2B CAMK2A CAMK2D | Cushing syndrome |
| REAC:R-HSA-3371556 | 0.000305650569508 | 0.6 | CAMK2B CAMK2A CAMK2D | Cellular response to heat stress |
| REAC:R-HSA-5576891 | 0.000305650569508 | 0.6 | CAMK2B CAMK2A CAMK2D | Cardiac conduction |
| KEGG:04217 | 0.00038585597196 | 0.6 | CAMK2B CAMK2A CAMK2D | Necroptosis |
| WP:WP289 | 0.00043634468393 | 0.6 | CAMK2B CAMK2A CAMK2D | Myometrial relaxation and contraction pathways |
| KEGG:05152 | 0.000467209213785 | 0.6 | CAMK2B CAMK2A CAMK2D | Tuberculosis |
| KEGG:04310 | 0.000506742943047 | 0.6 | CAMK2B CAMK2A CAMK2D | Wnt signaling pathway |
| KEGG:04360 | 0.000548434275739 | 0.6 | CAMK2B CAMK2A CAMK2D | Axon guidance |
| KEGG:04024 | 0.000592339283786 | 0.6 | CAMK2B CAMK2A CAMK2D | cAMP signaling pathway |
| KEGG:04020 | 0.000764246790836 | 0.6 | CAMK2B CAMK2A CAMK2D | Calcium signaling pathway |
| KEGG:05417 | 0.000875882872118 | 0.6 | CAMK2B CAMK2A CAMK2D | Lipid and atherosclerosis |
| KEGG:05415 | 0.000905384445946 | 0.6 | CAMK2B CAMK2A CAMK2D | Diabetic cardiomyopathy |
| KEGG:05205 | 0.000905384445946 | 0.6 | CAMK2B CAMK2A CAMK2D | Proteoglycans in cancer |
| REAC:R-HSA-983712 | 0.000955846750913 | 0.6 | CAMK2B CAMK2A CAMK2D | Ion channel transport |
| WP:WP5231 | 0.00100346979189 | 0.4 | CAMK2B CAMK2A | Hippocampal synaptogenesis and neurogenesis |
| GO:0004683 | 0.00147736290187 | 0.6 | CAMK2B CAMK2A CAMK2D | calmodulin-dependent protein kinase activity |
| REAC:R-HSA-397014 | 0.00169462737448 | 0.6 | CAMK2B CAMK2A CAMK2D | Muscle contraction |
| REAC:R-HSA-112314 | 0.0019808748776 | 0.6 | CAMK2B CAMK2A CAMK2D | Neurotransmitter receptors and postsynaptic signal transmission |
| KEGG:05012 | 0.00202081325994 | 0.6 | CAMK2B CAMK2A CAMK2D | Parkinson disease |
| REAC:R-HSA-913531 | 0.00269181495124 | 0.6 | CAMK2B CAMK2A CAMK2D | Interferon Signaling |
| REAC:R-HSA-418594 | 0.0032316154136 | 0.6 | CAMK2B CAMK2A CAMK2D | G alpha (i) signalling events |
| REAC:R-HSA-112315 | 0.0041994817849 | 0.6 | CAMK2B CAMK2A CAMK2D | Transmission across Chemical Synapses |
| REAC:R-HSA-5673001 | 0.00484953278503 | 0.6 | CAMK2B CAMK2A CAMK2D | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.00512712329405 | 0.6 | CAMK2B CAMK2A CAMK2D | MAPK1/MAPK3 signaling |
| REAC:R-HSA-5683057 | 0.00773441075999 | 0.6 | CAMK2B CAMK2A CAMK2D | MAPK family signaling cascades |
| REAC:R-HSA-9006925 | 0.00931456721467 | 0.6 | CAMK2B CAMK2A CAMK2D | Intracellular signaling by second messengers |
| KEGG:05022 | 0.0104994491245 | 0.6 | CAMK2B CAMK2A CAMK2D | Pathways of neurodegeneration - multiple diseases |
| KEGG:05200 | 0.0130900202546 | 0.6 | CAMK2B CAMK2A CAMK2D | Pathways in cancer |
| REAC:R-HSA-112316 | 0.0132169246876 | 0.6 | CAMK2B CAMK2A CAMK2D | Neuronal System |
| GO:0010663 | 0.0140440992017 | 0.4 | CAMK2A CAMK2D | positive regulation of striated muscle cell apoptotic process |
| GO:0010666 | 0.0140440992017 | 0.4 | CAMK2A CAMK2D | positive regulation of cardiac muscle cell apoptotic process |
| REAC:R-HSA-388396 | 0.024557290195 | 0.6 | CAMK2B CAMK2A CAMK2D | GPCR downstream signalling |
| REAC:R-HSA-5663202 | 0.0253606811944 | 0.6 | CAMK2B CAMK2A CAMK2D | Diseases of signal transduction by growth factor receptors and second messengers |
| WP:WP4549 | 0.0347437372246 | 0.4 | CAMK2B CAMK2A | Fragile X syndrome |
| REAC:R-HSA-372790 | 0.0361267714165 | 0.6 | CAMK2B CAMK2A CAMK2D | Signaling by GPCR |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CAMK2B | CAMK2D | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | ||
| CAMK2D | CAMK2A | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | ||
| SNRK | CAMK2A | 0.997 | 0.138 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CAMK2B | CAMK2A | 0.994 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| CAMK2D | PUSL1 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| UNG | CAMK2D | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CAMK2A | PUSL1 | 0.889 | 0.066 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| UNG | CAMK2B | 0.284 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CAMK2B | PUSL1 | 0.17 | bioplex_WMM bioplex3_WMM WMM_only | ||
| UNG | PUSL1 | 0.165 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only | |
| UNG | CAMK2A | 0.164 | 0.034 | bioplex_WMM bioplex3_WMM WMM_only | |
| SNRK | PUSL1 | 0.079 | 0.09 | bioplex3_WMM WMM_only | |
| SNRK | CAMK2B | 0.076 | bioplex3_WMM WMM_only | ||
| SNRK | CAMK2D | 0.065 | bioplex3_HEK293 bioplex () bioplex3_WMM |
Related Complexes