hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10343.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLC25A28 | Mitoferrin-2 (Mitochondrial RNA-splicing protein 3/4 homolog) (MRS3/4) (hMRS3/4) (Mitochondrial iron transporter 2) (Solute carrier family 25 member 28) | 4 | UniProt NCBI |
| ORMDL3 | ORM1-like protein 3 | 5 | UniProt NCBI |
| CHST11 | Carbohydrate sulfotransferase 11 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 1) (Chondroitin 4-sulfotransferase 1) (C4S-1) (C4ST-1) (C4ST1) | 5 | UniProt NCBI |
| ORMDL2 | ORM1-like protein 2 (Adoplin-2) | 5 | UniProt NCBI |
| SLC2A12 | Solute carrier family 2, facilitated glucose transporter member 12 (Glucose transporter type 12) (GLUT-12) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1660661 | 0.00849065158197 | 0.4 | ORMDL2 ORMDL3 | Sphingolipid de novo biosynthesis |
| GO:0035339 | 0.0280843539964 | 0.4 | ORMDL2 ORMDL3 | SPOTS complex |
| GO:0090156 | 0.0280843539964 | 0.4 | ORMDL2 ORMDL3 | intracellular sphingolipid homeostasis |
| REAC:R-HSA-428157 | 0.0395622673154 | 0.4 | ORMDL2 ORMDL3 | Sphingolipid metabolism |
| GO:1900060 | 0.0468008499735 | 0.4 | ORMDL2 ORMDL3 | negative regulation of ceramide biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ORMDL2 | ORMDL3 | 0.988 | 0.262 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| SLC25A28 | SLC2A12 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ORMDL3 | SLC2A12 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ORMDL2 | SLC2A12 | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CHST11 | SLC2A12 | 0.975 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SLC25A28 | ORMDL3 | 0.279 | 0.124 | bioplex_WMM bioplex3_WMM WMM_only |
| CHST11 | ORMDL3 | 0.213 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only |
| SLC25A28 | ORMDL2 | 0.165 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only |
| CHST11 | ORMDL2 | 0.165 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only |
| SLC25A28 | CHST11 | 0.164 | 0.1 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes