hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10353.1
Complex Portal: CPX-17226
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SWSAP1 | ATPase SWSAP1 (SWIM-type zinc finger 7-associated protein 1) (SWS1-associated protein 1) (ZSWIM7-associated protein 1) (ZSWIM7AP1) | 5 | UniProt NCBI |
| ZSWIM7 | Zinc finger SWIM domain-containing protein 7 (SWIM domain-containing and Srs2-interacting protein 1 homolog) (SWIM-type zinc finger domain-containing protein 7) | 5 | UniProt NCBI |
| TDP2 | Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase) | 5 | UniProt NCBI |
| CASP2 | Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] | 5 | UniProt NCBI |
| G6PD | Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) | 5 | UniProt NCBI |
| PLA2G10 | Group 10 secretory phospholipase A2 (EC 3.1.1.4) (Group X secretory phospholipase A2) (GX sPLA2) (sPLA2-X) (Phosphatidylcholine 2-acylhydrolase 10) | 5 | UniProt NCBI |
| SPIDR | DNA repair-scaffolding protein (Scaffolding protein involved in DNA repair) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0097196 | 0.00702301080125 | 0.333333333333 | SWSAP1 ZSWIM7 | Shu complex |
| HP:0005625 | 0.00981070246055 | 0.333333333333 | SPIDR ZSWIM7 | Osteoporosis of vertebrae |
| HP:0040161 | 0.011317974846 | 0.333333333333 | SPIDR ZSWIM7 | Localized osteoporosis |
| HP:0011969 | 0.0226111656051 | 0.333333333333 | SPIDR ZSWIM7 | Elevated circulating luteinizing hormone level |
| HP:0010464 | 0.0248677408666 | 0.333333333333 | SPIDR ZSWIM7 | Streak ovary |
| HP:0000133 | 0.0436511011886 | 0.333333333333 | SPIDR ZSWIM7 | Gonadal dysgenesis |
| HP:0008232 | 0.0436511011886 | 0.333333333333 | SPIDR ZSWIM7 | Elevated circulating follicle stimulating hormone level |
| CORUM:129 | 0.0499436884912 | 0.166666666667 | CASP2 | PIDDsome complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SWSAP1 | ZSWIM7 | 1.0 |
mutually_exclusive (Q9H082)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SPIDR | SWSAP1 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ZSWIM7 | PLA2G10 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SPIDR | PLA2G10 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TDP2 | PLA2G10 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SWSAP1 | CASP2 | 0.99 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SPIDR | ZSWIM7 | 0.984 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| SWSAP1 | PLA2G10 | 0.965 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| G6PD | PLA2G10 | 0.958 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ZSWIM7 | CASP2 | 0.401 | bioplex3_WMM WMM_only | ||
| SPIDR | CASP2 | 0.356 | bioplex3_WMM WMM_only | ||
| SPIDR | TDP2 | 0.165 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SWSAP1 | TDP2 | 0.165 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ZSWIM7 | TDP2 | 0.143 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TDP2 | G6PD | 0.03 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZSWIM7 | G6PD | 0.027 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SWSAP1 | G6PD | 0.026 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SPIDR | G6PD | 0.02 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes