hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10360.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
THY1	Thy-1 membrane glycoprotein (CDw90) (Thy-1 antigen) (CD antigen CD90)	5	UniProt NCBI
PIGS	GPI transamidase component PIG-S (Phosphatidylinositol-glycan biosynthesis class S protein)	5	UniProt NCBI
LYPD3	Ly6/PLAUR domain-containing protein 3 (GPI-anchored metastasis-associated protein C4.4A homolog) (Matrigel-induced gene C4 protein) (MIG-C4)	5	UniProt NCBI
DNAJC22	DnaJ homolog subfamily C member 22	2	UniProt NCBI
ULBP2	UL16-binding protein 2 (ALCAN-alpha) (NKG2D ligand 2) (N2DL-2) (NKG2DL2) (Retinoic acid early transcript 1H)	5	UniProt NCBI
GPAA1	Glycosylphosphatidylinositol anchor attachment 1 protein (GPI anchor attachment protein 1) (GAA1 protein homolog) (hGAA1)	5	UniProt NCBI
PIGK	GPI-anchor transamidase (GPI transamidase) (EC 3.-.-.-) (GPI8 homolog) (hGPI8) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K)	5	UniProt NCBI
PIGU	Phosphatidylinositol glycan anchor biosynthesis class U protein (Cell division cycle protein 91-like 1) (Protein CDC91-like 1) (GPI transamidase component PIG-U)	5	UniProt NCBI
TMC4	Transmembrane channel-like protein 4	3	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-163125	2.09005758712e-13	0.777777777778	ULBP2 GPAA1 PIGK PIGS LYPD3 PIGU THY1	Post-translational modification: synthesis of GPI-anchored proteins
CORUM:994	2.69032781214e-11	0.444444444444	PIGK PIGS PIGU GPAA1	GAA1-GPI8-PIGT-PIG-PIGS complex
REAC:R-HSA-162791	5.49494891089e-10	0.444444444444	PIGK PIGS PIGU GPAA1	Attachment of GPI anchor to uPAR
GO:0042765	1.65724193228e-08	0.444444444444	PIGK PIGS PIGU GPAA1	GPI-anchor transamidase complex
KEGG:00563	1.99701096891e-08	0.444444444444	PIGK PIGS PIGU GPAA1	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
GO:0016255	4.97036464355e-08	0.444444444444	PIGK PIGS PIGU GPAA1	attachment of GPI anchor to protein
GO:0034235	2.31823352537e-07	0.444444444444	PIGK THY1 PIGU GPAA1	GPI anchor binding
GO:0008303	4.17167775941e-07	0.444444444444	PIGK PIGS PIGU GPAA1	caspase complex
GO:0051861	1.59928316967e-05	0.444444444444	PIGK THY1 PIGU GPAA1	glycolipid binding
GO:0006506	3.50368755955e-05	0.444444444444	PIGK PIGS PIGU GPAA1	GPI anchor biosynthetic process
GO:0006505	4.16991368105e-05	0.444444444444	PIGK PIGS PIGU GPAA1	GPI anchor metabolic process
HP:0003155	8.42571852059e-05	0.444444444444	PIGK PIGS PIGU GPAA1	Elevated circulating alkaline phosphatase concentration
HP:0004379	0.000131156149322	0.444444444444	PIGK PIGS PIGU GPAA1	Abnormality of alkaline phosphatase level
REAC:R-HSA-597592	0.000218137300916	0.777777777778	ULBP2 GPAA1 PIGK PIGS LYPD3 PIGU THY1	Post-translational protein modification
GO:0009247	0.00148634035373	0.444444444444	PIGK PIGS PIGU GPAA1	glycolipid biosynthetic process
REAC:R-HSA-392499	0.00202692701529	0.777777777778	ULBP2 GPAA1 PIGK PIGS LYPD3 PIGU THY1	Metabolism of proteins
GO:0006497	0.00220742322002	0.444444444444	PIGK PIGS PIGU GPAA1	protein lipidation
GO:0042158	0.00234919252133	0.444444444444	PIGK PIGS PIGU GPAA1	lipoprotein biosynthetic process
GO:1905369	0.00316270648564	0.444444444444	PIGK PIGS PIGU GPAA1	endopeptidase complex
GO:0042157	0.0051353875679	0.444444444444	PIGK PIGS PIGU GPAA1	lipoprotein metabolic process
GO:1903509	0.00596183262373	0.444444444444	PIGK PIGS PIGU GPAA1	liposaccharide metabolic process
GO:0006664	0.00596183262373	0.444444444444	PIGK PIGS PIGU GPAA1	glycolipid metabolic process
HP:0003282	0.0110078716337	0.222222222222	PIGS PIGK	Low alkaline phosphatase
GO:1905368	0.0126624076937	0.444444444444	PIGK PIGS PIGU GPAA1	peptidase complex
GO:0140534	0.0154150912184	0.444444444444	PIGK PIGS PIGU GPAA1	endoplasmic reticulum protein-containing complex
GO:0006661	0.0166325722167	0.444444444444	PIGK PIGS PIGU GPAA1	phosphatidylinositol biosynthetic process
GO:0003923	0.016855225923	0.222222222222	GPAA1 PIGK	GPI-anchor transamidase activity
GO:0046467	0.0238286102078	0.444444444444	PIGK PIGS PIGU GPAA1	membrane lipid biosynthetic process
GO:0046488	0.0310808183133	0.444444444444	PIGK PIGS PIGU GPAA1	phosphatidylinositol metabolic process

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
LYPD3	DNAJC22	0.999		bioplex3_WMM bioplex3_HCT116 WMM_only
PIGS	PIGK	0.999	0.986	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM boldt_WMM
PIGS	GPAA1	0.999	0.486	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () gupta_WMM boldt_WMM
GPAA1	PIGU	0.998	0.07	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM
PIGS	PIGU	0.998	0.36	hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM
THY1	GPAA1	0.995	0.078	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
LYPD3	GPAA1	0.993	0.084	bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116
TMC4	LYPD3	0.993		bioplex3_WMM bioplex3_HCT116 WMM_only
GPAA1	PIGK	0.992	0.386	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM boldt_WMM
PIGK	PIGU	0.992	0.138	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM boldt_WMM
LYPD3	PIGS	0.992	0.072	bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116
THY1	PIGU	0.984	0.022	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
THY1	PIGK	0.98	0.082	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
THY1	PIGS	0.979	0.06	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
ULBP2	LYPD3	0.975	0.104	bioplex3_WMM bioplex3_HCT116 WMM_only
LYPD3	PIGU	0.97	0.088	bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116
TMC4	GPAA1	0.955		bioplex3_HEK293 bioplex3_WMM WMM_only
TMC4	DNAJC22	0.902		bioplex3_WMM WMM_only
TMC4	PIGS	0.769		bioplex3_HEK293 bioplex3_WMM WMM_only
TMC4	PIGK	0.683		bioplex3_HEK293 bioplex3_WMM WMM_only
LYPD3	PIGK	0.613	0.078	bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116
TMC4	PIGU	0.597		bioplex3_WMM WMM_only
ULBP2	DNAJC22	0.355		bioplex3_WMM WMM_only
TMC4	ULBP2	0.243		bioplex3_WMM WMM_only
DNAJC22	GPAA1	0.156		bioplex3_HEK293 bioplex3_WMM WMM_only
DNAJC22	PIGS	0.154		bioplex3_WMM WMM_only
DNAJC22	PIGU	0.129		bioplex3_WMM WMM_only
DNAJC22	PIGK	0.081		bioplex3_WMM WMM_only
ULBP2	PIGS	0.077	0.068	bioplex_WMM bioplex3_WMM WMM_only
ULBP2	PIGU	0.043	0.1	bioplex3_WMM WMM_only
ULBP2	GPAA1	0.028	0.052	bioplex3_WMM WMM_only
ULBP2	PIGK	0.005	0.078	bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
THY1	huMAP3_01184.1 huMAP3_04873.1 huMAP3_10360.1 huMAP3_12209.1 huMAP3_12837.1
PIGS	huMAP3_01184.1 huMAP3_04873.1 huMAP3_06250.1 huMAP3_10360.1 huMAP3_12209.1
LYPD3	huMAP3_00985.1 huMAP3_01186.1 huMAP3_04991.1 huMAP3_06250.1 huMAP3_06348.1 huMAP3_10360.1 huMAP3_10536.1 huMAP3_11660.1
DNAJC22	huMAP3_00985.1 huMAP3_01186.1 huMAP3_04991.1 huMAP3_06250.1 huMAP3_06348.1 huMAP3_10360.1 huMAP3_10536.1 huMAP3_13114.1 huMAP3_13549.1 huMAP3_14788.1
ULBP2	huMAP3_00985.1 huMAP3_01186.1 huMAP3_02282.1 huMAP3_03921.1 huMAP3_04991.1 huMAP3_05754.1 huMAP3_06250.1 huMAP3_06624.1 huMAP3_09768.1 huMAP3_10360.1 huMAP3_10536.1 huMAP3_10566.1 huMAP3_14140.1
GPAA1	huMAP3_01184.1 huMAP3_04496.1 huMAP3_10360.1 huMAP3_10536.1 huMAP3_12209.1
PIGK	huMAP3_01184.1 huMAP3_04873.1 huMAP3_06138.1 huMAP3_10360.1
PIGU	huMAP3_01184.1 huMAP3_04475.1 huMAP3_04496.1 huMAP3_06250.1 huMAP3_08648.1 huMAP3_09592.1 huMAP3_10360.1
TMC4	huMAP3_00985.1 huMAP3_01186.1 huMAP3_03691.1 huMAP3_04991.1 huMAP3_06250.1 huMAP3_06348.1 huMAP3_08310.1 huMAP3_10360.1 huMAP3_10536.1 huMAP3_12006.1 huMAP3_13549.1 huMAP3_14350.1 huMAP3_14788.1 huMAP3_15126.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10360.1