hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10362.1

Complex Portal: CPX-17812

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
GORASP2	Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59)	5	UniProt NCBI
TMED4	Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (GMP25iso) (Putative NF-kappa-B-activating protein 156) (p24 family protein alpha-3) (p24alpha3)	5	UniProt NCBI
TMED3	Transmembrane emp24 domain-containing protein 3 (Membrane protein p24B) (p24 family protein gamma-4) (p24gamma4) (p26)	5	UniProt NCBI
GOLGB1	Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin)	5	UniProt NCBI
FGF3	Fibroblast growth factor 3 (FGF-3) (Heparin-binding growth factor 3) (HBGF-3) (Proto-oncogene Int-2)	5	UniProt NCBI
TMED10	Transmembrane emp24 domain-containing protein 10 (Protein TMED10) (21 kDa transmembrane-trafficking protein) (S31I125) (S31III125) (Tmp-21-I) (Transmembrane protein Tmp21) (p23) (p24 family protein delta-1) (p24delta1) (p24delta)	5	UniProt NCBI
TMED2	Transmembrane emp24 domain-containing protein 2 (Membrane protein p24A) (p24) (p24 family protein beta-1) (p24beta1)	5	UniProt NCBI
CDK5RAP3	CDK5 regulatory subunit-associated protein 3 (CDK5 activator-binding protein C53) (LXXLL/leucine-zipper-containing ARF-binding protein) (Protein HSF-27)	5	UniProt NCBI
TMED1	Transmembrane emp24 domain-containing protein 1 (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor-binding protein) (p24 family protein gamma-1) (Tp24) (p24gamma1)	5	UniProt NCBI
TMED9	Transmembrane emp24 domain-containing protein 9 (GMP25) (Glycoprotein 25L2) (p24 family protein alpha-2) (p24alpha2) (p25)	5	UniProt NCBI
TMED5	Transmembrane emp24 domain-containing protein 5 (p24 family protein gamma-2) (p24gamma2) (p28)	5	UniProt NCBI
KIF14	Kinesin-like protein KIF14	5	UniProt NCBI
BLZF1	Golgin-45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor)	5	UniProt NCBI
TMED7	Transmembrane emp24 domain-containing protein 7 (p24 family protein gamma-3) (p24gamma3) (p27)	5	UniProt NCBI
CTXN1	Cortexin-1	2	UniProt NCBI
ETNPPL	Ethanolamine-phosphate phospho-lyase (EC 4.2.3.2) (Alanine--glyoxylate aminotransferase 2-like 1)	5	UniProt NCBI
CHST8	Carbohydrate sulfotransferase 8 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 1) (GalNAc-4-ST1) (GalNAc4ST-1) (N-acetylgalactosamine-4-O-sulfotransferase 1)	5	UniProt NCBI
LIPG	Endothelial lipase (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL) (EL) (Phospholipase A1) (EC 3.1.1.32)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0007030	4.24988356328e-15	0.647058823529	TMED10 GORASP2 TMED4 GOLGB1 TMED5 BLZF1 TMED7 TMED1 TMED9 TMED2 TMED3	Golgi organization
GO:0005793	1.21193862031e-11	0.529411764706	TMED10 TMED4 GOLGB1 TMED5 TMED7 TMED1 TMED9 TMED2 TMED3	endoplasmic reticulum-Golgi intermediate compartment
GO:0030134	3.05980020711e-10	0.470588235294	TMED4 TMED1 TMED5 TMED7 TMED10 TMED2 TMED9 TMED3	COPII-coated ER to Golgi transport vesicle
GO:0010256	7.9430957118e-09	0.647058823529	TMED10 GORASP2 TMED4 GOLGB1 TMED5 BLZF1 TMED7 TMED1 TMED9 TMED2 TMED3	endomembrane system organization
GO:0006888	1.62440727421e-08	0.470588235294	TMED4 TMED1 TMED5 TMED7 TMED10 TMED2 TMED9 TMED3	endoplasmic reticulum to Golgi vesicle-mediated transport
REAC:R-HSA-948021	1.57189238551e-07	0.411764705882	TMED10 CHST8 GOLGB1 TMED7 TMED2 TMED9 TMED3	Transport to the Golgi and subsequent modification
GO:0048193	2.34464178628e-07	0.529411764706	TMED4 TMED1 TMED5 BLZF1 TMED7 TMED10 TMED2 TMED9 TMED3	Golgi vesicle transport
REAC:R-HSA-6807878	2.58237771439e-07	0.352941176471	TMED10 GOLGB1 TMED7 TMED2 TMED9 TMED3	COPI-mediated anterograde transport
GO:0005794	2.86854977471e-07	0.764705882353	TMED10 GORASP2 TMED4 GOLGB1 TMED5 BLZF1 TMED7 LIPG TMED1 TMED9 TMED2 TMED3 CHST8	Golgi apparatus
GO:0030135	2.7991671624e-06	0.470588235294	TMED4 TMED1 TMED5 TMED7 TMED10 TMED2 TMED9 TMED3	coated vesicle
REAC:R-HSA-199977	2.88538047356e-06	0.352941176471	TMED10 GOLGB1 TMED7 TMED2 TMED9 TMED3	ER to Golgi Anterograde Transport
REAC:R-HSA-446203	5.03784647972e-06	0.411764705882	TMED10 CHST8 GOLGB1 TMED7 TMED2 TMED9 TMED3	Asparagine N-linked glycosylation
GO:0000139	8.62070374854e-06	0.529411764706	TMED10 GORASP2 BLZF1 GOLGB1 TMED7 TMED2 TMED9 TMED3 CHST8	Golgi membrane
GO:0033036	1.21061706561e-05	0.823529411765	TMED10 GORASP2 TMED4 BLZF1 GOLGB1 TMED5 KIF14 TMED7 LIPG TMED1 TMED9 TMED2 TMED3 CDK5RAP3	macromolecule localization
REAC:R-HSA-6811434	1.75883148379e-05	0.294117647059	TMED10 TMED9 TMED3 TMED7 TMED2	COPI-dependent Golgi-to-ER retrograde traffic
GO:0008104	3.61416883421e-05	0.764705882353	TMED10 GORASP2 TMED4 BLZF1 GOLGB1 TMED5 KIF14 TMED7 TMED1 TMED9 TMED2 TMED3 CDK5RAP3	protein localization
GO:0070727	3.72580019588e-05	0.764705882353	TMED10 GORASP2 TMED4 BLZF1 GOLGB1 TMED5 KIF14 TMED7 TMED1 TMED9 TMED2 TMED3 CDK5RAP3	cellular macromolecule localization
GO:0045184	6.29286884019e-05	0.647058823529	TMED10 GORASP2 TMED4 BLZF1 TMED5 KIF14 TMED7 TMED1 TMED9 TMED2 TMED3	establishment of protein localization
GO:0033116	7.42613550103e-05	0.294117647059	TMED10 TMED9 TMED3 TMED7 TMED2	endoplasmic reticulum-Golgi intermediate compartment membrane
REAC:R-HSA-8856688	8.07967755936e-05	0.294117647059	TMED10 TMED9 TMED3 TMED7 TMED2	Golgi-to-ER retrograde transport
GO:0005801	8.30450212052e-05	0.294117647059	BLZF1 GOLGB1 GORASP2 TMED5 TMED10	cis-Golgi network
GO:0030137	0.00029997578462	0.235294117647	TMED10 TMED3 TMED7 TMED2	COPI-coated vesicle
GO:0005798	0.000599320348887	0.294117647059	TMED10 TMED9 TMED3 TMED7 TMED2	Golgi-associated vesicle
REAC:R-HSA-6811442	0.000669100671413	0.294117647059	TMED10 TMED9 TMED3 TMED7 TMED2	Intra-Golgi and retrograde Golgi-to-ER traffic
HPA:0420053	0.000977525287233	0.529411764706	TMED10 GORASP2 TMED4 GOLGB1 TMED5 TMED9 TMED2 TMED3 ETNPPL	salivary gland; glandular cells[High]
GO:0006886	0.00129699792981	0.470588235294	TMED4 TMED1 TMED5 TMED7 TMED10 TMED2 TMED9 TMED3	intracellular protein transport
GO:0048200	0.00130441648129	0.176470588235	TMED10 TMED9 TMED2	Golgi transport vesicle coating
GO:0035964	0.00130441648129	0.176470588235	TMED10 TMED9 TMED2	COPI-coated vesicle budding
GO:0048205	0.00130441648129	0.176470588235	TMED10 TMED9 TMED2	COPI coating of Golgi vesicle
GO:0015031	0.00236867756237	0.529411764706	TMED4 TMED1 TMED5 BLZF1 TMED7 TMED10 TMED2 TMED9 TMED3	protein transport
GO:0051641	0.00350717209124	0.764705882353	TMED10 GORASP2 TMED4 BLZF1 GOLGB1 TMED5 KIF14 TMED7 TMED1 TMED9 TMED2 TMED3 CDK5RAP3	cellular localization
GO:0048194	0.00546674693619	0.176470588235	TMED10 TMED9 TMED2	Golgi vesicle budding
HPA:0180053	0.00549289467009	0.529411764706	TMED10 GORASP2 TMED4 GOLGB1 TMED7 TMED9 TMED2 TMED3 CDK5RAP3	epididymis; glandular cells[High]
REAC:R-HSA-199991	0.0097570165014	0.352941176471	TMED10 GOLGB1 TMED7 TMED2 TMED9 TMED3	Membrane Trafficking
REAC:R-HSA-5653656	0.0132528700542	0.352941176471	TMED10 GOLGB1 TMED7 TMED2 TMED9 TMED3	Vesicle-mediated transport
GO:0071702	0.0183980208119	0.588235294118	TMED4 TMED1 TMED5 BLZF1 TMED7 LIPG TMED10 TMED2 TMED9 TMED3	organic substance transport
WP:WP5380	0.0198517773563	0.176470588235	TMED10 TMED9 TMED2	5q35 copy number variation
REAC:R-HSA-162658	0.0318027124492	0.117647058824	BLZF1 GORASP2	Golgi Cisternae Pericentriolar Stack Reorganization
GO:0051179	0.0364346961143	0.823529411765	TMED10 GORASP2 TMED4 BLZF1 GOLGB1 TMED5 KIF14 TMED7 LIPG TMED1 TMED9 TMED2 TMED3 CDK5RAP3	localization
GO:0071705	0.0435173109341	0.529411764706	TMED4 TMED1 TMED5 BLZF1 TMED7 TMED10 TMED2 TMED9 TMED3	nitrogen compound transport

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
TMED2	TMED9	1.0	0.92	structurally_consistent (dimer)
TMED2	TMED1	1.0	0.676	mutually_exclusive (P49755) structurally_consistent (dimer)
TMED4	TMED2	1.0	0.922
TMED9	TMED5	1.0	0.386
TMED2	TMED5	1.0	0.654	mutually_exclusive (P49755)
BLZF1	GORASP2	1.0	0.074
TMED3	TMED2	1.0	0.356	mutually_exclusive (P49755)
TMED2	TMED10	1.0	0.858	mutually_exclusive (Q13445) structurally_consistent (dimer)
TMED9	TMED10	1.0	0.928
TMED10	TMED1	1.0	0.508	mutually_exclusive (Q15363) structurally_consistent (dimer)
TMED3	TMED10	1.0	0.238	structurally_consistent (dimer)
TMED9	TMED1	1.0	0.656	mutually_exclusive (Q15363) structurally_consistent (dimer)
TMED10	TMED5	0.999	0.676	structurally_consistent (dimer)
TMED7	TMED2	0.999	0.954
TMED7	TMED10	0.999	0.866
TMED4	TMED5	0.999	0.554
LIPG	TMED5	0.999
TMED3	TMED9	0.999	0.212	structurally_consistent (dimer)
TMED4	TMED1	0.999	0.578
TMED7	TMED4	0.998	0.804	mutually_exclusive (Q9Y3Q3) structurally_consistent (dimer)
KIF14	GORASP2	0.998	0.413926332288
TMED3	TMED1	0.998	0.208
TMED7	GORASP2	0.998	0.136
TMED4	TMED10	0.998	0.928
TMED7	TMED9	0.997	0.692	mutually_exclusive (Q9Y3Q3)
TMED4	TMED9	0.997	0.734
TMED4	TMED3	0.997	0.236	mutually_exclusive (Q9Y3B3) structurally_consistent (dimer)
TMED7	BLZF1	0.996	0.08
TMED1	TMED5	0.996	0.272	mutually_exclusive (P49755)
LIPG	TMED10	0.996
TMED3	TMED5	0.996	0.14	mutually_exclusive (P49755)
CDK5RAP3	TMED1	0.996	0.164
CHST8	TMED5	0.995
LIPG	TMED2	0.995
CDK5RAP3	TMED5	0.995	0.104
CTXN1	TMED2	0.994
LIPG	TMED9	0.994
GOLGB1	TMED2	0.994	0.132
GORASP2	TMED5	0.994	0.086
BLZF1	TMED10	0.993	0.188
TMED7	TMED3	0.993	0.176	structurally_consistent (dimer)
GOLGB1	TMED9	0.992	0.2
TMED2	CHST8	0.992
GOLGB1	TMED10	0.992	0.16
CDK5RAP3	TMED9	0.99	0.174
TMED9	CHST8	0.988		structurally_consistent (dimer)
TMED4	CHST8	0.985
CDK5RAP3	TMED2	0.985	0.252
GOLGB1	TMED5	0.981	0.072
ETNPPL	LIPG	0.981
LIPG	TMED4	0.98
TMED2	GORASP2	0.978	0.232
FGF3	TMED1	0.977
FGF3	TMED2	0.977
CDK5RAP3	TMED10	0.976	0.254
CHST8	TMED10	0.973
CHST8	TMED1	0.972		mutually_exclusive (Q9BVK6)
CDK5RAP3	TMED4	0.967	0.26
CTXN1	TMED10	0.965
TMED7	KIF14	0.962	0.276
TMED4	GORASP2	0.959	0.278
GORASP2	TMED10	0.949	0.286
FGF3	TMED9	0.949
CTXN1	TMED9	0.949
TMED3	CHST8	0.943
BLZF1	TMED3	0.932	0.064
FGF3	TMED4	0.93
BLZF1	TMED2	0.924	0.095
LIPG	TMED1	0.918
TMED7	CTXN1	0.915
GOLGB1	TMED1	0.894	0.1
TMED9	GORASP2	0.893	0.242
TMED4	GOLGB1	0.89	0.178
TMED7	TMED1	0.875	0.22
FGF3	TMED10	0.862
CTXN1	TMED3	0.857
TMED7	GOLGB1	0.851	0.19
TMED7	TMED5	0.845	0.394
TMED3	GOLGB1	0.844	0.138
CTXN1	TMED4	0.759
BLZF1	TMED1	0.753	0.064
BLZF1	KIF14	0.726	0.242
BLZF1	TMED5	0.721	0.046
TMED7	CHST8	0.685
BLZF1	TMED9	0.676	0.134
FGF3	TMED5	0.619
CTXN1	TMED1	0.604
BLZF1	TMED4	0.526	0.098
CTXN1	CDK5RAP3	0.356
TMED3	GORASP2	0.351	0.114
CTXN1	TMED5	0.32
CTXN1	GOLGB1	0.306
GORASP2	TMED1	0.304	0.086
GOLGB1	GORASP2	0.294	0.19
KIF14	TMED4	0.284	0.237919047619
CDK5RAP3	GOLGB1	0.25	0.172
TMED7	CDK5RAP3	0.233	0.106
BLZF1	GOLGB1	0.227	0.126
KIF14	GOLGB1	0.212	0.158
KIF14	TMED2	0.177	0.194
KIF14	TMED5	0.137	0.128
CDK5RAP3	GORASP2	0.124	0.248
CDK5RAP3	TMED3	0.111	0.192
KIF14	CDK5RAP3	0.076	0.588
KIF14	TMED9	0.061	0.311677948718
CTXN1	GORASP2	0.055
BLZF1	CDK5RAP3	0.051	0.132
KIF14	TMED3	0.025	0.064
KIF14	TMED1	0.02	0.064
FGF3	GORASP2	0.014
ETNPPL	GORASP2	0.005
KIF14	TMED10	0.004	0.453349112426

Related Complexes

Genename	Complexes
GORASP2	huMAP3_05535.1 huMAP3_05844.1 huMAP3_06703.1 huMAP3_07831.1 huMAP3_10362.1 huMAP3_10786.1 huMAP3_11421.1 huMAP3_11596.1
TMED4	huMAP3_04392.1 huMAP3_07118.1 huMAP3_08461.1 huMAP3_09886.1 huMAP3_10362.1 huMAP3_11421.1
TMED3	huMAP3_04392.1 huMAP3_07118.1 huMAP3_08461.1 huMAP3_09886.1 huMAP3_10362.1 huMAP3_11421.1
GOLGB1	huMAP3_04392.1 huMAP3_07118.1 huMAP3_08461.1 huMAP3_09886.1 huMAP3_10362.1 huMAP3_11421.1 huMAP3_12566.1
FGF3	huMAP3_00579.1 huMAP3_04392.1 huMAP3_07118.1 huMAP3_08461.1 huMAP3_09886.1 huMAP3_10362.1 huMAP3_11421.1
TMED10	huMAP3_07118.1 huMAP3_08461.1 huMAP3_09886.1 huMAP3_10362.1 huMAP3_11421.1
TMED2	huMAP3_04392.1 huMAP3_07118.1 huMAP3_08461.1 huMAP3_09886.1 huMAP3_10362.1 huMAP3_11421.1
CDK5RAP3	huMAP3_03937.1 huMAP3_09886.1 huMAP3_10362.1 huMAP3_12534.1 huMAP3_14075.1
TMED1	huMAP3_07118.1 huMAP3_08461.1 huMAP3_09886.1 huMAP3_10362.1 huMAP3_11421.1
TMED9	huMAP3_04392.1 huMAP3_07118.1 huMAP3_08461.1 huMAP3_09886.1 huMAP3_10362.1 huMAP3_11421.1
TMED5	huMAP3_07118.1 huMAP3_08461.1 huMAP3_09886.1 huMAP3_10362.1 huMAP3_11421.1
KIF14	huMAP3_02010.1 huMAP3_04501.1 huMAP3_07831.1 huMAP3_08742.1 huMAP3_10337.1 huMAP3_10362.1 huMAP3_10528.1 huMAP3_11596.1
BLZF1	huMAP3_00577.1 huMAP3_02010.1 huMAP3_05535.1 huMAP3_05844.1 huMAP3_06703.1 huMAP3_07831.1 huMAP3_10362.1 huMAP3_10786.1 huMAP3_11421.1 huMAP3_11596.1
TMED7	huMAP3_00577.1 huMAP3_02010.1 huMAP3_05535.1 huMAP3_05844.1 huMAP3_06703.1 huMAP3_07831.1 huMAP3_10362.1 huMAP3_10786.1 huMAP3_11420.1 huMAP3_11421.1 huMAP3_11596.1 huMAP3_15126.1
CTXN1	huMAP3_02725.1 huMAP3_02910.1 huMAP3_04392.1 huMAP3_07118.1 huMAP3_08297.1 huMAP3_08461.1 huMAP3_09886.1 huMAP3_10362.1 huMAP3_11421.1 huMAP3_11499.1 huMAP3_12583.1 huMAP3_12602.1 huMAP3_13991.1 huMAP3_15224.1
ETNPPL	huMAP3_00602.1 huMAP3_01397.1 huMAP3_03588.1 huMAP3_05567.1 huMAP3_05679.1 huMAP3_10362.1 huMAP3_10636.1 huMAP3_11411.1 huMAP3_14984.1
CHST8	huMAP3_06399.1 huMAP3_07118.1 huMAP3_08461.1 huMAP3_09886.1 huMAP3_10362.1 huMAP3_10825.1 huMAP3_11421.1 huMAP3_14260.1
LIPG	huMAP3_00602.1 huMAP3_01397.1 huMAP3_05567.1 huMAP3_07118.1 huMAP3_10362.1 huMAP3_10636.1 huMAP3_11421.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10362.1

Complex Portal: CPX-17812