hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10366.1
Complex Portal: CPX-16423
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) | 5 | UniProt NCBI |
| PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | 5 | UniProt NCBI |
| PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | 5 | UniProt NCBI |
| AHCYL1 | S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) | 5 | UniProt NCBI |
| CHD9 | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.12) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | 5 | UniProt NCBI |
| PLCD3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8847453 | 2.8266247124e-08 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | Synthesis of PIPs in the nucleus |
| WP:WP5411 | 6.3119012747e-08 | 0.666666666667 | PLCD3 PIP4K2C PIP4K2A PIP4K2B | Phosphatidyl inositol phosphate pathway |
| WP:WP4971 | 6.3119012747e-08 | 0.666666666667 | PLCD3 PIP4K2C PIP4K2A PIP4K2B | Phosphoinositides metabolism |
| KEGG:00562 | 2.74781163208e-07 | 0.666666666667 | PLCD3 PIP4K2C PIP4K2A PIP4K2B | Inositol phosphate metabolism |
| REAC:R-HSA-6811555 | 5.93134254527e-07 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | PI5P Regulates TP53 Acetylation |
| KEGG:04070 | 8.19967802532e-07 | 0.666666666667 | PLCD3 PIP4K2C PIP4K2A PIP4K2B | Phosphatidylinositol signaling system |
| GO:1902633 | 1.92240082153e-06 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process |
| GO:1902635 | 1.92240082153e-06 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process |
| GO:0016309 | 1.92240082153e-06 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| REAC:R-HSA-6804758 | 2.85755298292e-05 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | Regulation of TP53 Activity through Acetylation |
| GO:0016308 | 0.00010757157937 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| REAC:R-HSA-1660499 | 0.000113827315454 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | Synthesis of PIPs at the plasma membrane |
| REAC:R-HSA-9006925 | 0.000283193622385 | 0.666666666667 | AHCYL1 PIP4K2C PIP4K2A PIP4K2B | Intracellular signaling by second messengers |
| REAC:R-HSA-1483255 | 0.000417052782963 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | PI Metabolism |
| REAC:R-HSA-6811558 | 0.000453163624664 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-1430728 | 0.000579637081746 | 1.0 | PLCD3 CHD9 PIP4K2B AHCYL1 PIP4K2C PIP4K2A | Metabolism |
| REAC:R-HSA-199418 | 0.000595799814657 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | Negative regulation of the PI3K/AKT network |
| WP:WP51 | 0.000923551537994 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | Regulation of actin cytoskeleton |
| GO:2000786 | 0.00130441648129 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | positive regulation of autophagosome assembly |
| KEGG:01100 | 0.00157235036995 | 0.833333333333 | PLCD3 AHCYL1 PIP4K2C PIP4K2A PIP4K2B | Metabolic pathways |
| KEGG:04810 | 0.00235078889433 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | Regulation of actin cytoskeleton |
| GO:0044090 | 0.00295184433846 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | positive regulation of vacuole organization |
| GO:0052742 | 0.00339409783315 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | phosphatidylinositol kinase activity |
| REAC:R-HSA-5633007 | 0.00396312414269 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | Regulation of TP53 Activity |
| GO:0046627 | 0.00440656064028 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | negative regulation of insulin receptor signaling pathway |
| GO:1900077 | 0.00498056162807 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | negative regulation of cellular response to insulin stimulus |
| REAC:R-HSA-1483257 | 0.00614623588272 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | Phospholipid metabolism |
| REAC:R-HSA-556833 | 0.00784925061173 | 0.666666666667 | CHD9 PIP4K2C PIP4K2A PIP4K2B | Metabolism of lipids |
| GO:0001727 | 0.0136563164499 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | lipid kinase activity |
| REAC:R-HSA-1257604 | 0.0136572631243 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | PIP3 activates AKT signaling |
| GO:0071375 | 0.0153056641383 | 0.666666666667 | AHCYL1 PIP4K2C PIP4K2A PIP4K2B | cellular response to peptide hormone stimulus |
| GO:2000785 | 0.017471616814 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | regulation of autophagosome assembly |
| GO:0046626 | 0.0203731249082 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | regulation of insulin receptor signaling pathway |
| GO:1900076 | 0.0219369042126 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | regulation of cellular response to insulin stimulus |
| GO:0043434 | 0.0292377969225 | 0.666666666667 | AHCYL1 PIP4K2C PIP4K2A PIP4K2B | response to peptide hormone |
| GO:0046854 | 0.0309610298034 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | phosphatidylinositol phosphate biosynthetic process |
| GO:1901653 | 0.0309639973592 | 0.666666666667 | AHCYL1 PIP4K2C PIP4K2A PIP4K2B | cellular response to peptide |
| GO:0044088 | 0.0330200031842 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | regulation of vacuole organization |
| REAC:R-HSA-3700989 | 0.0427993747798 | 0.5 | PIP4K2C PIP4K2A PIP4K2B | Transcriptional Regulation by TP53 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PIP4K2B | PIP4K2C | 1.0 | 0.014 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM | |
| PIP4K2A | PIP4K2C | 1.0 | 0.0883043478261 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM | |
| PIP4K2A | PIP4K2B | 1.0 | 0.318 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| PIP4K2A | PLCD3 | 0.999 | 0.068 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PLCD3 | PIP4K2C | 0.994 | 0.15 |
structurally_consistent (O43865)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PIP4K2A | AHCYL1 | 0.974 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| CHD9 | PIP4K2A | 0.972 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| AHCYL1 | PLCD3 | 0.951 | 0.082 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| PIP4K2B | PLCD3 | 0.95 | 0.068 |
structurally_consistent (O43865)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| CHD9 | PLCD3 | 0.754 | 0.134 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| PIP4K2B | AHCYL1 | 0.552 | 0.042 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| AHCYL1 | PIP4K2C | 0.347 | 0.046 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| CHD9 | AHCYL1 | 0.262 | 0.158 | bioplex_WMM bioplex3_WMM fraction | |
| CHD9 | PIP4K2C | 0.162 | 0.04 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CHD9 | PIP4K2B | 0.127 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes