hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10366.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha)	5	UniProt NCBI
PIP4K2B	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta)	5	UniProt NCBI
PIP4K2C	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)	5	UniProt NCBI
AHCYL1	S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2)	5	UniProt NCBI
CHD9	Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.12) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein)	5	UniProt NCBI
PLCD3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-8847453	2.8266247124e-08	0.5	PIP4K2C PIP4K2A PIP4K2B	Synthesis of PIPs in the nucleus
WP:WP5411	6.3119012747e-08	0.666666666667	PLCD3 PIP4K2C PIP4K2A PIP4K2B	Phosphatidyl inositol phosphate pathway
WP:WP4971	6.3119012747e-08	0.666666666667	PLCD3 PIP4K2C PIP4K2A PIP4K2B	Phosphoinositides metabolism
KEGG:00562	2.74781163208e-07	0.666666666667	PLCD3 PIP4K2C PIP4K2A PIP4K2B	Inositol phosphate metabolism
REAC:R-HSA-6811555	5.93134254527e-07	0.5	PIP4K2C PIP4K2A PIP4K2B	PI5P Regulates TP53 Acetylation
KEGG:04070	8.19967802532e-07	0.666666666667	PLCD3 PIP4K2C PIP4K2A PIP4K2B	Phosphatidylinositol signaling system
GO:1902633	1.92240082153e-06	0.5	PIP4K2C PIP4K2A PIP4K2B	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process
GO:1902635	1.92240082153e-06	0.5	PIP4K2C PIP4K2A PIP4K2B	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
GO:0016309	1.92240082153e-06	0.5	PIP4K2C PIP4K2A PIP4K2B	1-phosphatidylinositol-5-phosphate 4-kinase activity
REAC:R-HSA-6804758	2.85755298292e-05	0.5	PIP4K2C PIP4K2A PIP4K2B	Regulation of TP53 Activity through Acetylation
GO:0016308	0.00010757157937	0.5	PIP4K2C PIP4K2A PIP4K2B	1-phosphatidylinositol-4-phosphate 5-kinase activity
REAC:R-HSA-1660499	0.000113827315454	0.5	PIP4K2C PIP4K2A PIP4K2B	Synthesis of PIPs at the plasma membrane
REAC:R-HSA-9006925	0.000283193622385	0.666666666667	AHCYL1 PIP4K2C PIP4K2A PIP4K2B	Intracellular signaling by second messengers
REAC:R-HSA-1483255	0.000417052782963	0.5	PIP4K2C PIP4K2A PIP4K2B	PI Metabolism
REAC:R-HSA-6811558	0.000453163624664	0.5	PIP4K2C PIP4K2A PIP4K2B	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
REAC:R-HSA-1430728	0.000579637081746	1.0	AHCYL1 PLCD3 CHD9 PIP4K2A PIP4K2B PIP4K2C	Metabolism
REAC:R-HSA-199418	0.000595799814657	0.5	PIP4K2C PIP4K2A PIP4K2B	Negative regulation of the PI3K/AKT network
WP:WP51	0.000923551537994	0.5	PIP4K2C PIP4K2A PIP4K2B	Regulation of actin cytoskeleton
GO:2000786	0.00130441648129	0.5	PIP4K2C PIP4K2A PIP4K2B	positive regulation of autophagosome assembly
KEGG:01100	0.00157235036995	0.833333333333	PLCD3 AHCYL1 PIP4K2C PIP4K2A PIP4K2B	Metabolic pathways
KEGG:04810	0.00235078889433	0.5	PIP4K2C PIP4K2A PIP4K2B	Regulation of actin cytoskeleton
GO:0044090	0.00295184433846	0.5	PIP4K2C PIP4K2A PIP4K2B	positive regulation of vacuole organization
GO:0052742	0.00339409783315	0.5	PIP4K2C PIP4K2A PIP4K2B	phosphatidylinositol kinase activity
REAC:R-HSA-5633007	0.00396312414269	0.5	PIP4K2C PIP4K2A PIP4K2B	Regulation of TP53 Activity
GO:0046627	0.00440656064028	0.5	PIP4K2C PIP4K2A PIP4K2B	negative regulation of insulin receptor signaling pathway
GO:1900077	0.00498056162807	0.5	PIP4K2C PIP4K2A PIP4K2B	negative regulation of cellular response to insulin stimulus
REAC:R-HSA-1483257	0.00614623588272	0.5	PIP4K2C PIP4K2A PIP4K2B	Phospholipid metabolism
REAC:R-HSA-556833	0.00784925061173	0.666666666667	CHD9 PIP4K2C PIP4K2A PIP4K2B	Metabolism of lipids
GO:0001727	0.0136563164499	0.5	PIP4K2C PIP4K2A PIP4K2B	lipid kinase activity
REAC:R-HSA-1257604	0.0136572631243	0.5	PIP4K2C PIP4K2A PIP4K2B	PIP3 activates AKT signaling
GO:0071375	0.0153056641383	0.666666666667	AHCYL1 PIP4K2C PIP4K2A PIP4K2B	cellular response to peptide hormone stimulus
GO:2000785	0.017471616814	0.5	PIP4K2C PIP4K2A PIP4K2B	regulation of autophagosome assembly
GO:0046626	0.0203731249082	0.5	PIP4K2C PIP4K2A PIP4K2B	regulation of insulin receptor signaling pathway
GO:1900076	0.0219369042126	0.5	PIP4K2C PIP4K2A PIP4K2B	regulation of cellular response to insulin stimulus
GO:0043434	0.0292377969225	0.666666666667	AHCYL1 PIP4K2C PIP4K2A PIP4K2B	response to peptide hormone
GO:0046854	0.0309610298034	0.5	PIP4K2C PIP4K2A PIP4K2B	phosphatidylinositol phosphate biosynthetic process
GO:1901653	0.0309639973592	0.666666666667	AHCYL1 PIP4K2C PIP4K2A PIP4K2B	cellular response to peptide
GO:0044088	0.0330200031842	0.5	PIP4K2C PIP4K2A PIP4K2B	regulation of vacuole organization
REAC:R-HSA-3700989	0.0427993747798	0.5	PIP4K2C PIP4K2A PIP4K2B	Transcriptional Regulation by TP53

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
PIP4K2B	PIP4K2C	1.0	0.014	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM
PIP4K2A	PIP4K2C	1.0	0.0883043478261	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM
PIP4K2A	PIP4K2B	1.0	0.318	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM
PIP4K2A	PLCD3	0.999	0.068	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PLCD3	PIP4K2C	0.994	0.15	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
PIP4K2A	AHCYL1	0.974	0.048	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
CHD9	PIP4K2A	0.972	0.088	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
AHCYL1	PLCD3	0.951	0.082	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
PIP4K2B	PLCD3	0.95	0.068	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
CHD9	PLCD3	0.754	0.134	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
PIP4K2B	AHCYL1	0.552	0.042	bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only
AHCYL1	PIP4K2C	0.347	0.046	bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
CHD9	AHCYL1	0.262	0.158	bioplex_WMM bioplex3_WMM fraction
CHD9	PIP4K2C	0.162	0.04	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
CHD9	PIP4K2B	0.127	0.096	bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
PIP4K2A	huMAP3_00550.1 huMAP3_00708.1 huMAP3_02291.1 huMAP3_02922.1 huMAP3_03481.1 huMAP3_05647.1 huMAP3_06847.1 huMAP3_07416.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13786.1 huMAP3_13857.1 huMAP3_14693.1
PIP4K2B	huMAP3_00550.1 huMAP3_00708.1 huMAP3_02291.1 huMAP3_03481.1 huMAP3_04301.1 huMAP3_06847.1 huMAP3_07416.1 huMAP3_07859.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10753.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13786.1 huMAP3_13857.1
PIP4K2C	huMAP3_01275.1 huMAP3_04301.1 huMAP3_05601.1 huMAP3_05855.1 huMAP3_07416.1 huMAP3_07859.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10753.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13786.1 huMAP3_13857.1
AHCYL1	huMAP3_00550.1 huMAP3_02291.1 huMAP3_03410.1 huMAP3_03481.1 huMAP3_06847.1 huMAP3_07110.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08739.1 huMAP3_08874.1 huMAP3_09163.1 huMAP3_09280.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10844.1 huMAP3_10957.1 huMAP3_13428.1 huMAP3_13742.1 huMAP3_14337.1
CHD9	huMAP3_00526.1 huMAP3_00550.1 huMAP3_04960.1 huMAP3_08289.1 huMAP3_08914.1 huMAP3_09657.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_11590.1 huMAP3_12211.1 huMAP3_13428.1 huMAP3_13786.1
PLCD3	huMAP3_00550.1 huMAP3_02291.1 huMAP3_03481.1 huMAP3_04301.1 huMAP3_06847.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08739.1 huMAP3_08874.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10753.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10366.1