hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10370.1
Complex Portal: CPX-16844
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DUSP4 | Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) | 5 | UniProt NCBI |
| GADD45G | Growth arrest and DNA damage-inducible protein GADD45 gamma (Cytokine-responsive protein CR6) (DNA damage-inducible transcript 2 protein) (DDIT-2) | 5 | UniProt NCBI |
| MAP3K4 | Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4872 | 0.000103023242897 | 0.666666666667 | GADD45G MAP3K4 | MAP3K1 role in promoting and blocking gonadal determination |
| KEGG:04010 | 0.000123391020622 | 1.0 | DUSP4 MAP3K4 GADD45G | MAPK signaling pathway |
| WP:WP382 | 0.0225614433222 | 0.666666666667 | DUSP4 MAP3K4 | MAPK signaling pathway |
| CORUM:5546 | 0.0499402709677 | 0.333333333333 | GADD45G | CDC2-PCNA-CCNB1-GADD45G complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAP3K4 | GADD45G | 1.0 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| DUSP4 | GADD45G | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MAP3K4 | DUSP4 | 0.401 | 0.054 | bioplex3_WMM WMM_only |
Related Complexes