hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10371.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
ATG16L2	Protein Atg16l2 (APG16-like 2) (Autophagy-related protein 16-2) (WD repeat-containing protein 80)	4	UniProt NCBI
NR4A1	Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3)	5	UniProt NCBI
RAB33A	Ras-related protein Rab-33A (Small GTP-binding protein S10)	5	UniProt NCBI
ATG16L1	Autophagy-related protein 16-1 (APG16-like 1)	5	UniProt NCBI
RAB33B	Ras-related protein Rab-33B	5	UniProt NCBI
ATG12	Ubiquitin-like protein ATG12 (Autophagy-related protein 12) (APG12-like)	5	UniProt NCBI
TECPR1	Tectonin beta-propeller repeat-containing protein 1	5	UniProt NCBI
ATG5	Autophagy protein 5 (APG5-like) (Apoptosis-specific protein)	5	UniProt NCBI
ATRIP	ATR-interacting protein (ATM and Rad3-related-interacting protein)	5	UniProt NCBI
RAB19	Ras-related protein Rab-19	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP4863	1.84421026031e-08	0.444444444444	ATG16L2 ATG12 ATG5 ATG16L1	Host pathogen interaction of human coronaviruses autophagy
GO:0034274	4.97036464355e-08	0.444444444444	ATG16L2 ATG12 ATG5 ATG16L1	Atg12-Atg5-Atg16 complex
KEGG:04140	7.99718004853e-07	0.555555555556	ATG5 ATG16L2 ATG12 RAB33B ATG16L1	Autophagy - animal
GO:0034045	4.51189669214e-06	0.444444444444	ATG16L2 ATG12 ATG5 ATG16L1	phagophore assembly site membrane
GO:0005776	2.06232346045e-05	0.555555555556	ATG16L2 ATG12 ATG5 TECPR1 ATG16L1	autophagosome
WP:WP2509	2.25575023346e-05	0.333333333333	ATG16L1 ATG5 ATG12	Nanoparticle triggered autophagic cell death
KEGG:04136	3.28707503917e-05	0.333333333333	ATG16L1 ATG5 ATG12	Autophagy - other
WP:WP4923	4.78972943695e-05	0.333333333333	ATG16L1 ATG5 ATG12	Autophagy
GO:0000045	6.79200533087e-05	0.555555555556	ATG16L2 ATG12 RAB19 ATG5 ATG16L1	autophagosome assembly
GO:1905037	8.35815609902e-05	0.555555555556	ATG16L2 ATG12 RAB19 ATG5 ATG16L1	autophagosome organization
GO:0000407	0.000118310401973	0.444444444444	ATG16L2 ATG12 ATG5 ATG16L1	phagophore assembly site
WP:WP4577	0.000143918669646	0.333333333333	ATG16L1 ATG5 ATG12	Neurodegeneration with brain iron accumulation NBIA subtypes pathway
GO:0016236	0.000161171267427	0.666666666667	ATG16L2 ATG16L1 ATG5 TECPR1 RAB19 ATG12	macroautophagy
KEGG:05131	0.000339656530832	0.444444444444	ATG16L1 ATG5 TECPR1 ATG12	Shigellosis
WP:WP5205	0.000723743379875	0.333333333333	ATG16L1 ATG5 ATG12	Clock controlled autophagy in bone metabolism
REAC:R-HSA-8873719	0.00142112451214	0.333333333333	RAB33A RAB33B RAB19	RAB geranylgeranylation
GO:0007033	0.00166847558555	0.555555555556	ATG16L2 ATG12 RAB19 ATG5 ATG16L1	vacuole organization
REAC:R-HSA-8934903	0.00223242997382	0.222222222222	ATG12 ATG5	Receptor Mediated Mitophagy
GO:0006914	0.00307592279137	0.666666666667	ATG16L2 ATG16L1 ATG5 TECPR1 RAB19 ATG12	autophagy
GO:0061919	0.00307592279137	0.666666666667	ATG16L2 ATG16L1 ATG5 TECPR1 RAB19 ATG12	process utilizing autophagic mechanism
KEGG:04621	0.00396874980186	0.333333333333	ATG16L1 ATG5 ATG12	NOD-like receptor signaling pathway
GO:1901096	0.00450341440411	0.333333333333	ATG12 ATG5 TECPR1	regulation of autophagosome maturation
REAC:R-HSA-1632852	0.0119915115759	0.333333333333	ATG16L1 ATG5 ATG12	Macroautophagy
REAC:R-HSA-5205685	0.0166738379974	0.222222222222	ATG12 ATG5	PINK1-PRKN Mediated Mitophagy
REAC:R-HSA-9612973	0.0167694259816	0.333333333333	ATG16L1 ATG5 ATG12	Autophagy
GO:0039689	0.016855225923	0.222222222222	ATG16L2 ATG16L1	negative stranded viral RNA replication
REAC:R-HSA-5205647	0.0257635620293	0.222222222222	ATG12 ATG5	Mitophagy
KEGG:04622	0.0347423807791	0.222222222222	ATG12 ATG5	RIG-I-like receptor signaling pathway
WP:WP5420	0.0398484415758	0.333333333333	ATG16L1 ATG5 ATG12	ADHD and autism ASD linked metabolic pathways and SNP
REAC:R-HSA-936440	0.0417623735111	0.222222222222	ATG12 ATG5	Negative regulators of DDX58/IFIH1 signaling
WP:WP3865	0.0432890882108	0.222222222222	ATG12 ATG5	Novel intracellular components of RIG I like receptor pathway
GO:0000421	0.0436468140298	0.333333333333	ATG16L2 TECPR1 ATG16L1	autophagosome membrane

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
ATG5	ATG16L1	1.0	0.128	bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM Malo bioplex3_HCT116 fraction
ATG5	RAB33A	0.999	0.178	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
ATG5	TECPR1	0.999	0.09	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
ATG5	ATG12	0.999	0.442	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction
RAB33B	ATG5	0.999	0.14	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
RAB33A	ATG16L1	0.999	0.064	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
RAB33B	RAB33A	0.998	0.106	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
ATG12	RAB33A	0.998	0.144	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
ATG16L2	ATG5	0.998		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
RAB33B	ATG16L1	0.998	0.0448888888889	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
RAB33B	ATG12	0.998	0.118	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
RAB33A	NR4A1	0.989		bioplex3_HEK293 bioplex3_WMM WMM_only
RAB33A	RAB19	0.988	0.044	bioplex3_HEK293 bioplex3_WMM WMM_only
ATG12	ATG16L1	0.986	0.162761904762	bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
ATRIP	ATG16L1	0.972	0.082	bioplex3_WMM bioplex3_HCT116 WMM_only
ATG16L2	TECPR1	0.946		bioplex3_WMM WMM_only
ATG16L2	ATG16L1	0.916		bioplex3_WMM WMM_only
TECPR1	ATG16L1	0.916	0.056	bioplex3_WMM WMM_only
ATG16L2	ATG12	0.779		bioplex3_WMM WMM_only
ATG12	TECPR1	0.779	0.134	bioplex3_WMM WMM_only
NR4A1	RAB19	0.415		bioplex3_WMM WMM_only
ATG12	RAB19	0.278	0.17	bioplex3_WMM WMM_only
ATG5	ATRIP	0.261	0.118	bioplex3_WMM WMM_only
ATG16L1	RAB19	0.25	0.066	bioplex3_WMM WMM_only
RAB33B	RAB19	0.25	0.12	bioplex3_WMM WMM_only
ATG5	RAB19	0.25	0.124	bioplex3_WMM WMM_only
ATG12	ATRIP	0.248	0.164	bioplex3_WMM WMM_only
ATG12	NR4A1	0.113		bioplex3_WMM WMM_only
RAB33B	NR4A1	0.078		bioplex3_WMM WMM_only
ATG16L1	NR4A1	0.078		bioplex3_WMM WMM_only
ATG5	NR4A1	0.078		bioplex3_WMM WMM_only
RAB33B	ATRIP	0.026	0.152	bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
ATG16L2	huMAP3_00694.1 huMAP3_04208.1 huMAP3_04382.1 huMAP3_09496.1 huMAP3_10371.1 huMAP3_11658.1 huMAP3_12491.1 huMAP3_14274.1 huMAP3_14329.1
NR4A1	huMAP3_03511.1 huMAP3_10371.1 huMAP3_11843.1 huMAP3_12806.1 huMAP3_12911.1
RAB33A	huMAP3_01895.1 huMAP3_03511.1 huMAP3_06994.1 huMAP3_08773.1 huMAP3_10371.1 huMAP3_11094.1 huMAP3_11860.1 huMAP3_12491.1 huMAP3_14274.1 huMAP3_14329.1
ATG16L1	huMAP3_03157.1 huMAP3_09496.1 huMAP3_10371.1 huMAP3_11658.1 huMAP3_12491.1 huMAP3_14274.1 huMAP3_14329.1
RAB33B	huMAP3_00694.1 huMAP3_01895.1 huMAP3_06994.1 huMAP3_08941.1 huMAP3_09217.1 huMAP3_09496.1 huMAP3_10371.1 huMAP3_11094.1 huMAP3_11860.1 huMAP3_12491.1 huMAP3_14274.1 huMAP3_14329.1
ATG12	huMAP3_00694.1 huMAP3_04382.1 huMAP3_09496.1 huMAP3_10371.1 huMAP3_11658.1 huMAP3_12353.1 huMAP3_12491.1 huMAP3_14274.1 huMAP3_14329.1
TECPR1	huMAP3_00694.1 huMAP3_04208.1 huMAP3_04382.1 huMAP3_09496.1 huMAP3_10371.1 huMAP3_11658.1 huMAP3_12491.1 huMAP3_14274.1 huMAP3_14329.1
ATG5	huMAP3_00694.1 huMAP3_04208.1 huMAP3_04382.1 huMAP3_09496.1 huMAP3_10371.1 huMAP3_11658.1 huMAP3_12491.1 huMAP3_14274.1 huMAP3_14329.1
ATRIP	huMAP3_02159.1 huMAP3_03157.1 huMAP3_09496.1 huMAP3_10371.1 huMAP3_14697.1
RAB19	huMAP3_03511.1 huMAP3_08773.1 huMAP3_10371.1 huMAP3_11860.1 huMAP3_12491.1 huMAP3_14274.1 huMAP3_14329.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10371.1