hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10380.1
Complex Portal: CPX-23292
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RNF151 | RING finger protein 151 | 5 | UniProt NCBI |
| TAF1A | TATA box-binding protein-associated factor RNA polymerase I subunit A (RNA polymerase I-specific TBP-associated factor 48 kDa) (TAFI48) (TATA box-binding protein-associated factor 1A) (TBP-associated factor 1A) (Transcription factor SL1) (Transcription initiation factor SL1/TIF-IB subunit A) | 5 | UniProt NCBI |
| TAF1C | TATA box-binding protein-associated factor RNA polymerase I subunit C (RNA polymerase I-specific TBP-associated factor 110 kDa) (TAFI110) (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (Transcription initiation factor SL1/TIF-IB subunit C) | 5 | UniProt NCBI |
| TAF1D | TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) | 5 | UniProt NCBI |
| TAF1B | TATA box-binding protein-associated factor RNA polymerase I subunit B (RNA polymerase I-specific TBP-associated factor 63 kDa) (TAFI63) (TATA box-binding protein-associated factor 1B) (TBP-associated factor 1B) (Transcription initiation factor SL1/TIF-IB subunit B) | 5 | UniProt NCBI |
| ZNF616 | Zinc finger protein 616 | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5727 | 1.87066161015e-08 | 0.5 | TAF1A TAF1B TAF1C | TBP-TAF complex |
| REAC:R-HSA-73863 | 4.55228403166e-08 | 0.666666666667 | TAF1A TAF1B TAF1D TAF1C | RNA Polymerase I Transcription Termination |
| REAC:R-HSA-73762 | 2.57601805302e-07 | 0.666666666667 | TAF1A TAF1B TAF1D TAF1C | RNA Polymerase I Transcription Initiation |
| REAC:R-HSA-427359 | 5.29930924667e-07 | 0.666666666667 | TAF1A TAF1B TAF1D TAF1C | SIRT1 negatively regulates rRNA expression |
| REAC:R-HSA-5250924 | 2.05309631721e-06 | 0.666666666667 | TAF1A TAF1B TAF1D TAF1C | B-WICH complex positively regulates rRNA expression |
| REAC:R-HSA-73772 | 2.16235704625e-06 | 0.666666666667 | TAF1A TAF1B TAF1D TAF1C | RNA Polymerase I Promoter Escape |
| REAC:R-HSA-5250913 | 4.19553514217e-06 | 0.666666666667 | TAF1A TAF1B TAF1D TAF1C | Positive epigenetic regulation of rRNA expression |
| REAC:R-HSA-427413 | 4.38152126179e-06 | 0.666666666667 | TAF1A TAF1B TAF1D TAF1C | NoRC negatively regulates rRNA expression |
| REAC:R-HSA-5250941 | 4.97663696861e-06 | 0.666666666667 | TAF1A TAF1B TAF1D TAF1C | Negative epigenetic regulation of rRNA expression |
| REAC:R-HSA-73854 | 5.18783780436e-06 | 0.666666666667 | TAF1A TAF1B TAF1D TAF1C | RNA Polymerase I Promoter Clearance |
| REAC:R-HSA-73864 | 5.40567812429e-06 | 0.666666666667 | TAF1A TAF1B TAF1D TAF1C | RNA Polymerase I Transcription |
| REAC:R-HSA-212165 | 4.89935586914e-05 | 0.666666666667 | TAF1A TAF1B TAF1D TAF1C | Epigenetic regulation of gene expression |
| REAC:R-HSA-74160 | 0.00558415609329 | 0.833333333333 | ZNF616 TAF1A TAF1B TAF1D TAF1C | Gene expression (Transcription) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TAF1A | TAF1C | 0.998 | 0.178 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM |
| TAF1D | TAF1B | 0.998 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TAF1A | TAF1B | 0.997 | 0.178 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM |
| TAF1A | TAF1D | 0.997 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM | ||
| TAF1C | TAF1B | 0.996 | 0.15 |
mutually_exclusive (Q15573)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM |
| TAF1C | TAF1D | 0.995 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| TAF1A | RNF151 | 0.99 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TAF1D | RNF151 | 0.987 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TAF1C | RNF151 | 0.966 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RNF151 | ZNF616 | 0.959 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TAF1C | ZNF616 | 0.479 | bioplex3_WMM WMM_only | ||
| TAF1D | ZNF616 | 0.238 | bioplex3_WMM WMM_only | ||
| TAF1A | ZNF616 | 0.133 | bioplex3_WMM WMM_only | ||
| TAF1B | ZNF616 | 0.121 | bioplex3_WMM WMM_only | ||
| TAF1B | RNF151 | 0.031 | bioplex3_HCT116 WMM_only |
Related Complexes