hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10381.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HDAC6 | Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Protein deacetylase HDAC6) (EC 3.5.1.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-) | 5 | UniProt NCBI |
| KCNAB2 | Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2) | 5 | UniProt NCBI |
| KCNA6 | Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel HBK2) (Voltage-gated potassium channel subunit Kv1.6) | 5 | UniProt NCBI |
| KCNAB1 | Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K(+) channel subunit beta-1) (Kv-beta-1) | 5 | UniProt NCBI |
| KCNAB3 | Voltage-gated potassium channel subunit beta-3 (EC 1.1.1.-) (K(+) channel subunit beta-3) (Kv-beta-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1296072 | 3.64404491129e-06 | 0.75 | KCNAB2 KCNAB1 KCNAB3 | Voltage gated Potassium channels |
| REAC:R-HSA-1296071 | 6.40033583955e-05 | 0.75 | KCNAB2 KCNAB1 KCNAB3 | Potassium Channels |
| WP:WP702 | 0.000139209137611 | 0.75 | KCNAB2 KCNAB1 KCNAB3 | Metapathway biotransformation Phase I and II |
| GO:0004033 | 0.000777349058504 | 0.75 | KCNAB2 KCNAB1 KCNAB3 | aldo-keto reductase (NADP) activity |
| GO:0015459 | 0.00209449363787 | 0.75 | KCNAB2 KCNAB1 KCNAB3 | potassium channel regulator activity |
| REAC:R-HSA-112316 | 0.00603406960129 | 0.75 | KCNAB2 KCNAB1 KCNAB3 | Neuronal System |
| GO:1901379 | 0.0089837173405 | 0.75 | KCNAB2 KCNAB1 KCNAB3 | regulation of potassium ion transmembrane transport |
| GO:0008076 | 0.00951168180783 | 0.75 | KCNAB2 KCNAB1 KCNAB3 | voltage-gated potassium channel complex |
| GO:0043266 | 0.0118300289699 | 0.75 | KCNAB2 KCNAB1 KCNAB3 | regulation of potassium ion transport |
| GO:0034705 | 0.0137962469792 | 0.75 | KCNAB2 KCNAB1 KCNAB3 | potassium channel complex |
| CORUM:7389 | 0.0249718442456 | 0.25 | KCNAB2 | Potassium channel complex (KCNA1, KCNA2, KCNAB2) |
| HP:0000878 | 0.0259951101914 | 0.5 | HDAC6 KCNAB2 | 11 pairs of ribs |
| HP:0000921 | 0.0476300363671 | 0.5 | HDAC6 KCNAB2 | Missing ribs |
| CORUM:6412 | 0.049938562206 | 0.25 | HDAC6 | AURKA-HDAC6 cilia-disassembly complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| KCNAB2 | KCNAB3 | 0.998 | 0.132 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| HDAC6 | KCNAB3 | 0.994 | 0.07 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KCNAB1 | KCNAB2 | 0.988 | 0.63 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| KCNA6 | KCNAB2 | 0.979 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| KCNAB2 | HDAC6 | 0.91 | 0.052 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes