hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10383.1
Complex Portal: CPX-19763
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TTN | Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) | 5 | UniProt NCBI |
| AJUBA | LIM domain-containing protein ajuba | 5 | UniProt NCBI |
| MYOZ1 | Myozenin-1 (Calsarcin-2) (Filamin-, actinin- and telethonin-binding protein) (Protein FATZ) | 5 | UniProt NCBI |
| PTPN21 | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | 5 | UniProt NCBI |
| LATS2 | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | 5 | UniProt NCBI |
| MYBPC1 | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | 5 | UniProt NCBI |
| LATS1 | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | 5 | UniProt NCBI |
| MYOM1 | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04392 | 1.37749190626e-05 | 0.375 | LATS2 AJUBA LATS1 | Hippo signaling pathway - multiple species |
| WP:WP383 | 6.37619977677e-05 | 0.375 | MYBPC1 TTN MYOM1 | Striated muscle contraction pathway |
| WP:WP4541 | 0.00137027616359 | 0.375 | LATS2 AJUBA LATS1 | Hippo Merlin signaling dysregulation |
| KEGG:04390 | 0.00260993521755 | 0.375 | LATS2 AJUBA LATS1 | Hippo signaling pathway |
| WP:WP4533 | 0.00364416819939 | 0.25 | LATS2 LATS1 | Transcription co factors SKI and SKIL protein partners |
| WP:WP4537 | 0.00407177869695 | 0.25 | LATS2 LATS1 | Hippo YAP signaling |
| REAC:R-HSA-2028269 | 0.00949504138694 | 0.25 | LATS2 LATS1 | Signaling by Hippo |
| WP:WP4542 | 0.00964105812378 | 0.25 | LATS2 LATS1 | Leukocyte intrinsic Hippo pathway functions |
| GO:0030016 | 0.0197287134506 | 0.5 | MYOM1 MYOZ1 TTN MYBPC1 | myofibril |
| HPA:0440342 | 0.0241638804332 | 0.875 | MYOM1 MYBPC1 MYOZ1 LATS1 LATS2 PTPN21 TTN | skeletal muscle; myocytes[>=Medium] |
| GO:0043292 | 0.0251221694598 | 0.5 | MYOM1 MYOZ1 TTN MYBPC1 | contractile fiber |
| REAC:R-HSA-390522 | 0.02920582473 | 0.25 | MYBPC1 TTN | Striated Muscle Contraction |
| HPA:0440000 | 0.0294872241715 | 1.0 | MYOM1 MYBPC1 AJUBA MYOZ1 LATS1 LATS2 PTPN21 TTN | skeletal muscle |
| HPA:0440341 | 0.0294872241715 | 1.0 | MYOM1 MYBPC1 AJUBA MYOZ1 LATS1 LATS2 PTPN21 TTN | skeletal muscle; myocytes[>=Low] |
| GO:0008307 | 0.0349415747767 | 0.375 | MYBPC1 TTN MYOM1 | structural constituent of muscle |
| CORUM:1987 | 0.0499436884912 | 0.125 | MYOM1 | MYOM1 homodimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| AJUBA | PTPN21 | 0.997 | 0.116 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LATS1 | MYOZ1 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| AJUBA | LATS2 | 0.996 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LATS1 | LATS2 | 0.995 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| LATS1 | AJUBA | 0.991 | 0.226 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LATS1 | TTN | 0.989 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LATS1 | MYBPC1 | 0.985 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LATS1 | MYOM1 | 0.984 | 0.074 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MYOZ1 | MYBPC1 | 0.902 | bioplex3_WMM WMM_only | ||
| MYOZ1 | TTN | 0.902 | bioplex3_WMM WMM_only | ||
| MYOZ1 | MYOM1 | 0.902 | bioplex3_WMM WMM_only | ||
| TTN | MYOM1 | 0.855 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TTN | MYBPC1 | 0.765 | bioplex3_WMM WMM_only | ||
| LATS1 | PTPN21 | 0.762 | 0.2 | bioplex3_WMM WMM_only | |
| PTPN21 | LATS2 | 0.73 | bioplex3_WMM WMM_only | ||
| MYBPC1 | MYOM1 | 0.564 | bioplex3_WMM WMM_only | ||
| MYOZ1 | LATS2 | 0.214 | bioplex3_WMM WMM_only | ||
| LATS2 | MYBPC1 | 0.131 | bioplex3_WMM WMM_only | ||
| LATS2 | MYOM1 | 0.055 | bioplex3_WMM WMM_only | ||
| LATS2 | TTN | 0.043 | bioplex3_WMM WMM_only |
Related Complexes