hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10401.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WTAP | Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein) | 5 | UniProt NCBI |
| VIRMA | Protein virilizer homolog | 5 | UniProt NCBI |
| CBLL1 | E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai) | 5 | UniProt NCBI |
| METTL14 | N6-adenosine-methyltransferase non-catalytic subunit (Methyltransferase-like protein 14) (hMETTL14) | 5 | UniProt NCBI |
| METTL3 | N6-adenosine-methyltransferase catalytic subunit (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N6-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | 5 | UniProt NCBI |
| ZC3H13 | Zinc finger CCCH domain-containing protein 13 | 5 | UniProt NCBI |
| CBLL2 | E3 ubiquitin-protein ligase CBLL2 (EC 2.3.2.27) (Cbl proto-oncogene-like protein 2) (RING-type E3 ubiquitin transferase ZNF645) (Zinc finger protein 645) (c-Cbl-like protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0036396 | 7.24703702028e-16 | 0.857142857143 | METTL3 VIRMA ZC3H13 CBLL1 METTL14 WTAP | RNA N6-methyladenosine methyltransferase complex |
| GO:0045293 | 4.4400953154e-14 | 0.857142857143 | METTL3 VIRMA ZC3H13 CBLL1 METTL14 WTAP | mRNA editing complex |
| GO:0080009 | 3.20149871907e-13 | 0.857142857143 | METTL3 VIRMA ZC3H13 CBLL1 METTL14 WTAP | mRNA methylation |
| GO:0016556 | 9.7394448374e-12 | 0.857142857143 | METTL3 VIRMA ZC3H13 CBLL1 METTL14 WTAP | mRNA modification |
| GO:0001510 | 6.6205971092e-09 | 0.857142857143 | METTL3 VIRMA ZC3H13 CBLL1 METTL14 WTAP | RNA methylation |
| GO:0034708 | 1.71681656462e-08 | 0.857142857143 | METTL3 VIRMA ZC3H13 CBLL1 METTL14 WTAP | methyltransferase complex |
| GO:0043414 | 1.39386944178e-07 | 0.857142857143 | METTL3 VIRMA ZC3H13 CBLL1 METTL14 WTAP | macromolecule methylation |
| GO:0032259 | 1.76162152851e-07 | 0.857142857143 | METTL3 VIRMA ZC3H13 CBLL1 METTL14 WTAP | methylation |
| GO:0009451 | 4.30768035466e-07 | 0.857142857143 | METTL3 VIRMA ZC3H13 CBLL1 METTL14 WTAP | RNA modification |
| CORUM:929 | 4.17611021312e-05 | 0.428571428571 | VIRMA WTAP ZC3H13 | CEN complex |
| GO:0016071 | 0.000979013104412 | 0.857142857143 | METTL3 VIRMA ZC3H13 CBLL1 METTL14 WTAP | mRNA metabolic process |
| GO:0016607 | 0.00329094508646 | 0.714285714286 | METTL3 VIRMA ZC3H13 WTAP CBLL1 | nuclear speck |
| GO:1990234 | 0.0074086488747 | 0.857142857143 | METTL3 VIRMA ZC3H13 CBLL1 METTL14 WTAP | transferase complex |
| GO:0021861 | 0.0294899169624 | 0.285714285714 | METTL14 METTL3 | forebrain radial glial cell differentiation |
| REAC:R-HSA-72203 | 0.0418111738628 | 0.428571428571 | METTL14 WTAP METTL3 | Processing of Capped Intron-Containing Pre-mRNA |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| METTL14 | METTL3 | 1.0 | 0.214 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () Malo fraction |
| WTAP | VIRMA | 1.0 | 0.606 | hein_WMM youn () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo fraction |
| CBLL2 | VIRMA | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WTAP | CBLL2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WTAP | METTL3 | 0.999 | 0.196 | hein_WMM bioplex_WMM youn_WMM hein () |
| CBLL2 | ZC3H13 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| VIRMA | ZC3H13 | 0.999 | 0.294 | bioplex_WMM Guru bioplex3_WMM youn_WMM Malo fraction |
| WTAP | ZC3H13 | 0.995 | 0.242 | bioplex_WMM Guru bioplex3_WMM youn_WMM Malo fraction |
| CBLL1 | VIRMA | 0.987 | 0.1 | youn () youn_WMM Malo fraction |
| WTAP | METTL14 | 0.986 | 0.238 | hein_WMM youn_WMM WMM_only |
| METTL3 | VIRMA | 0.907 | 0.168 | youn () youn_WMM WMM_only |
| WTAP | CBLL1 | 0.868 | 0.594 | youn_WMM Malo fraction |
| METTL14 | VIRMA | 0.595 | 0.194 | youn () youn_WMM WMM_only |
| CBLL1 | ZC3H13 | 0.423 | 0.286 | hein_WMM WMM_only |
| METTL3 | CBLL1 | 0.287 | 0.142 | youn_WMM WMM_only |
| METTL14 | CBLL1 | 0.271 | 0.21 | youn_WMM WMM_only |
| METTL3 | ZC3H13 | 0.011 | 0.186 | youn_WMM WMM_only |
Related Complexes