hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10405.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NPRL2 | GATOR1 complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4) | 5 | UniProt NCBI |
| KPTN | KICSTOR complex protein kaptin (Actin-associated protein 2E4) | 5 | UniProt NCBI |
| ITFG2 | KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2) | 5 | UniProt NCBI |
| NPRL3 | GATOR1 complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA) | 5 | UniProt NCBI |
| OGA | Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT) | 5 | UniProt NCBI |
| KICS2 | KICSTOR subunit 2 (KICSTOR complex protein C12orf66) | 5 | UniProt NCBI |
| TMCO4 | Transmembrane and coiled-coil domain-containing protein 4 | 3 | UniProt NCBI |
| BMT2 | S-adenosylmethionine sensor upstream of mTORC1 (Probable methyltransferase BMT2 homolog) (EC 2.1.1.-) | 5 | UniProt NCBI |
| SZT2 | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | 5 | UniProt NCBI |
| DEPDC5 | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9639288 | 1.85944932109e-16 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | Amino acids regulate mTORC1 |
| GO:1904262 | 5.13261546639e-15 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | negative regulation of TORC1 signaling |
| GO:0034198 | 6.30501568494e-15 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | cellular response to amino acid starvation |
| GO:1990928 | 9.37003451641e-15 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | response to amino acid starvation |
| GO:0032007 | 9.6228291146e-14 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | negative regulation of TOR signaling |
| REAC:R-HSA-9711097 | 1.2813776358e-12 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | Cellular response to starvation |
| GO:1903432 | 2.08176381103e-12 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | regulation of TORC1 signaling |
| GO:0038202 | 3.05360385507e-12 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | TORC1 signaling |
| CORUM:6754 | 8.06664600281e-12 | 0.4 | ITFG2 SZT2 KPTN KICS2 | KICSTOR complex |
| GO:0009267 | 3.37838530978e-11 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | cellular response to starvation |
| GO:0032006 | 4.7395724853e-11 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | regulation of TOR signaling |
| GO:0042594 | 1.01167150074e-10 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | response to starvation |
| GO:0031929 | 1.14024864325e-10 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | TOR signaling |
| GO:0031669 | 4.02138948626e-10 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | cellular response to nutrient levels |
| GO:0031668 | 6.26619623191e-10 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | cellular response to extracellular stimulus |
| GO:0071496 | 2.75988205034e-09 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | cellular response to external stimulus |
| GO:0031667 | 4.90660956734e-09 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | response to nutrient levels |
| GO:0140007 | 5.52565251192e-09 | 0.4 | ITFG2 SZT2 KPTN KICS2 | KICSTOR complex |
| GO:0009991 | 7.29757329537e-09 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | response to extracellular stimulus |
| CORUM:6215 | 1.68385473419e-08 | 0.3 | NPRL2 NPRL3 DEPDC5 | GATOR1 complex |
| GO:1990130 | 2.76191861336e-08 | 0.4 | NPRL2 DEPDC5 NPRL3 SZT2 | GATOR1 complex |
| REAC:R-HSA-2262752 | 3.4375826258e-07 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | Cellular responses to stress |
| REAC:R-HSA-8953897 | 3.71112301679e-07 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | Cellular responses to stimuli |
| GO:1902532 | 5.25116562605e-07 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | negative regulation of intracellular signal transduction |
| CORUM:6753 | 9.41265768188e-07 | 0.3 | NPRL2 NPRL3 SZT2 | SOG complex |
| CORUM:6217 | 9.41265768188e-07 | 0.3 | NPRL2 NPRL3 DEPDC5 | GATOR complex |
| GO:0035859 | 3.93917350423e-06 | 0.4 | NPRL2 DEPDC5 NPRL3 SZT2 | Seh1-associated complex |
| HP:0012004 | 4.51842207648e-06 | 0.3 | NPRL2 NPRL3 DEPDC5 | Focal cognitive seizure with deja vu/jamais vu |
| HP:0012005 | 4.51842207648e-06 | 0.3 | NPRL2 NPRL3 DEPDC5 | Deja vu aura |
| HP:0032680 | 4.51842207648e-06 | 0.3 | NPRL2 NPRL3 DEPDC5 | Focal cognitive seizure |
| HP:0008765 | 7.9043973502e-06 | 0.3 | NPRL2 NPRL3 DEPDC5 | Auditory hallucination |
| GO:0005765 | 1.46020331027e-05 | 0.7 | NPRL2 KICS2 SZT2 ITFG2 NPRL3 DEPDC5 KPTN | lysosomal membrane |
| GO:0098852 | 1.46020331027e-05 | 0.7 | NPRL2 KICS2 SZT2 ITFG2 NPRL3 DEPDC5 KPTN | lytic vacuole membrane |
| HP:0012002 | 1.89569221999e-05 | 0.3 | NPRL2 NPRL3 DEPDC5 | Experiential epileptic aura |
| HP:0033346 | 1.89569221999e-05 | 0.3 | NPRL2 NPRL3 DEPDC5 | Psychic epileptic aura |
| GO:0005774 | 2.49869369338e-05 | 0.7 | NPRL2 KICS2 SZT2 ITFG2 NPRL3 DEPDC5 KPTN | vacuolar membrane |
| HP:0002427 | 3.72100530138e-05 | 0.3 | NPRL2 NPRL3 DEPDC5 | Expressive aphasia |
| HP:0033259 | 4.87316989048e-05 | 0.5 | NPRL2 SZT2 DEPDC5 KPTN NPRL3 | Non-motor seizure |
| HP:0007206 | 8.19991586848e-05 | 0.3 | NPRL2 NPRL3 DEPDC5 | Hemimegalencephaly |
| HP:0031951 | 8.19991586848e-05 | 0.3 | NPRL2 NPRL3 DEPDC5 | Nocturnal seizures |
| HP:0032046 | 8.19991586848e-05 | 0.3 | NPRL2 NPRL3 DEPDC5 | Focal cortical dysplasia |
| HP:0002367 | 0.00010246210866 | 0.3 | NPRL2 NPRL3 DEPDC5 | Visual hallucination |
| HP:0011146 | 0.000139358665834 | 0.5 | NPRL2 SZT2 DEPDC5 KPTN NPRL3 | Dialeptic seizure |
| HP:0033348 | 0.000217896944891 | 0.3 | NPRL2 NPRL3 DEPDC5 | Epileptic aura |
| HP:0011171 | 0.000298859256632 | 0.3 | NPRL2 NPRL3 DEPDC5 | Simple febrile seizure |
| HP:0002349 | 0.000298859256632 | 0.3 | NPRL2 NPRL3 DEPDC5 | Focal aware seizure |
| GO:0009968 | 0.000347526743185 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | negative regulation of signal transduction |
| HP:0032052 | 0.000413118282426 | 0.2 | DEPDC5 NPRL3 | Focal cortical dysplasia type IIa |
| GO:0010648 | 0.000448830415867 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | negative regulation of cell communication |
| GO:0023057 | 0.000472734426853 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | negative regulation of signaling |
| GO:0042149 | 0.000499046750281 | 0.4 | ITFG2 SZT2 KPTN KICS2 | cellular response to glucose starvation |
| GO:0000323 | 0.000743659836227 | 0.7 | NPRL2 KICS2 SZT2 ITFG2 NPRL3 DEPDC5 KPTN | lytic vacuole |
| GO:0005764 | 0.000743659836227 | 0.7 | NPRL2 KICS2 SZT2 ITFG2 NPRL3 DEPDC5 KPTN | lysosome |
| HP:0002069 | 0.00126286223816 | 0.5 | NPRL2 SZT2 DEPDC5 KPTN NPRL3 | Bilateral tonic-clonic seizure |
| HP:0032679 | 0.00133837027533 | 0.3 | NPRL2 NPRL3 DEPDC5 | Focal non-motor seizure |
| GO:0005773 | 0.00144971593383 | 0.7 | NPRL2 KICS2 SZT2 ITFG2 NPRL3 DEPDC5 KPTN | vacuole |
| HP:0001355 | 0.00173594936665 | 0.3 | NPRL2 NPRL3 DEPDC5 | Megalencephaly |
| GO:0048585 | 0.00204413009732 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | negative regulation of response to stimulus |
| HP:0002521 | 0.00244629836916 | 0.4 | NPRL2 DEPDC5 NPRL3 SZT2 | Hypsarrhythmia |
| HP:0031284 | 0.0029514912006 | 0.3 | NPRL2 NPRL3 DEPDC5 | Flushing |
| WP:WP4657 | 0.00354552579336 | 0.3 | NPRL2 NPRL3 DEPDC5 | 22q11 2 copy number variation syndrome |
| HP:0032051 | 0.00412666115323 | 0.2 | DEPDC5 NPRL3 | Focal cortical dysplasia type II |
| GO:1902531 | 0.00445655560981 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | regulation of intracellular signal transduction |
| HP:0002539 | 0.00462927927608 | 0.3 | NPRL2 NPRL3 DEPDC5 | Cortical dysplasia |
| KEGG:04150 | 0.00583642418014 | 0.3 | NPRL2 NPRL3 DEPDC5 | mTOR signaling pathway |
| HP:0002353 | 0.00634618382081 | 0.5 | NPRL2 SZT2 DEPDC5 KPTN NPRL3 | EEG abnormality |
| GO:0033554 | 0.00690847051977 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | cellular response to stress |
| HP:0010841 | 0.00797162805718 | 0.3 | NPRL2 NPRL3 DEPDC5 | Multifocal epileptiform discharges |
| HP:0030178 | 0.0085704797878 | 0.5 | NPRL2 SZT2 DEPDC5 KPTN NPRL3 | Abnormality of central nervous system electrophysiology |
| HP:0000729 | 0.0108404992928 | 0.5 | NPRL2 SZT2 DEPDC5 KPTN NPRL3 | Autistic behavior |
| HP:0011198 | 0.0120211535719 | 0.4 | NPRL2 DEPDC5 NPRL3 SZT2 | EEG with generalized epileptiform discharges |
| HP:0001311 | 0.0187727844149 | 0.5 | NPRL2 SZT2 DEPDC5 KPTN NPRL3 | Abnormal nervous system electrophysiology |
| HP:0002381 | 0.0209309049474 | 0.3 | NPRL2 NPRL3 DEPDC5 | Aphasia |
| GO:0009605 | 0.0213745095283 | 0.8 | NPRL2 KICS2 ITFG2 NPRL3 BMT2 DEPDC5 SZT2 KPTN | response to external stimulus |
| HP:0011182 | 0.0227666835885 | 0.4 | NPRL2 DEPDC5 NPRL3 SZT2 | Interictal epileptiform activity |
| HP:0025373 | 0.0237622371958 | 0.4 | NPRL2 DEPDC5 NPRL3 SZT2 | Interictal EEG abnormality |
| HP:0007359 | 0.0265741037586 | 0.4 | NPRL2 DEPDC5 NPRL3 SZT2 | Focal-onset seizure |
| HP:0002384 | 0.0342690801014 | 0.3 | NPRL2 NPRL3 DEPDC5 | Focal impaired awareness seizure |
| HP:0011185 | 0.0408686292444 | 0.3 | NPRL2 NPRL3 DEPDC5 | EEG with focal epileptiform discharges |
| HP:0003401 | 0.049564177707 | 0.3 | NPRL2 NPRL3 DEPDC5 | Paresthesia |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| KPTN | ITFG2 | 1.0 | 0.234 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NPRL2 | DEPDC5 | 1.0 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SZT2 | ITFG2 | 1.0 | 0.156 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KPTN | SZT2 | 1.0 | 0.17 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KICS2 | ITFG2 | 0.999 | 0.134 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NPRL2 | NPRL3 | 0.999 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KPTN | TMCO4 | 0.999 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KPTN | KICS2 | 0.999 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| BMT2 | DEPDC5 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| BMT2 | SZT2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| BMT2 | KICS2 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DEPDC5 | NPRL3 | 0.996 | 0.118 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| NPRL2 | BMT2 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KICS2 | SZT2 | 0.989 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only |
| BMT2 | ITFG2 | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| OGA | BMT2 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BMT2 | NPRL3 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KPTN | NPRL3 | 0.978 | 0.222 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| NPRL2 | ITFG2 | 0.978 | 0.15 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ITFG2 | TMCO4 | 0.967 | 0.124 | bioplex_WMM bioplex3_WMM WMM_only |
| SZT2 | TMCO4 | 0.962 | 0.132 | bioplex_WMM bioplex3_WMM WMM_only |
| KICS2 | TMCO4 | 0.961 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only |
| DEPDC5 | ITFG2 | 0.959 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KPTN | BMT2 | 0.933 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ITFG2 | NPRL3 | 0.92 | 0.178 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| KPTN | NPRL2 | 0.657 | 0.142 | bioplex_WMM bioplex3_WMM WMM_only |
| NPRL2 | SZT2 | 0.65 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only |
| NPRL2 | KICS2 | 0.648 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only |
| KICS2 | NPRL3 | 0.636 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only |
| KPTN | DEPDC5 | 0.606 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SZT2 | NPRL3 | 0.6 | 0.156 | bioplex_WMM bioplex3_WMM WMM_only |
| DEPDC5 | KICS2 | 0.576 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| OGA | DEPDC5 | 0.345 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only |
| NPRL2 | OGA | 0.254 | 0.05 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| DEPDC5 | SZT2 | 0.247 | 0.202 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| OGA | KICS2 | 0.124 | 0.1 | bioplex_WMM bioplex3_WMM WMM_only |
| OGA | SZT2 | 0.099 | 0.064 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| OGA | NPRL3 | 0.063 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only |
| KPTN | OGA | 0.026 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only |
| OGA | ITFG2 | 0.026 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only |
| TMCO4 | NPRL3 | 0.016 | 0.134 | bioplex3_WMM WMM_only |
Related Complexes