hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10410.1
Complex Portal: CPX-13974
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ABHD11 | sn-1-specific diacylglycerol lipase ABHD11 (EC 3.1.1.116) (Alpha/beta hydrolase domain-containing protein 11) (Abhydrolase domain-containing protein 11) (Williams-Beuren syndrome chromosomal region 21 protein) | 5 | UniProt NCBI |
| MRM2 | rRNA methyltransferase 2, mitochondrial (EC 2.1.1.-) (16S rRNA (uridine(1369)-2'-O)-methyltransferase) (16S rRNA [Um1369] 2'-O-methyltransferase) (Protein ftsJ homolog 2) | 5 | UniProt NCBI |
| COQ6 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (EC 1.14.13.-) (Coenzyme Q10 monooxygenase 6) | 5 | UniProt NCBI |
| TATDN1 | Deoxyribonuclease TATDN1 (EC 3.1.21.-) (Hepatocarcinoma high expression protein) | 3 | UniProt NCBI |
| QRSL1 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (Glu-AdT subunit A) (EC 6.3.5.7) (Glutaminyl-tRNA synthase-like protein 1) | 5 | UniProt NCBI |
| GUF1 | Translation factor GUF1, mitochondrial (EC 3.6.5.-) (Elongation factor 4 homolog) (EF-4) (GTPase GUF1) (Ribosomal back-translocase) | 4 | UniProt NCBI |
| VWA8 | von Willebrand factor A domain-containing protein 8 (PEX7-binding protein 2) (P7BP2) | 5 | UniProt NCBI |
| GATC | Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (Glu-AdT subunit C) (EC 6.3.5.-) (Protein 15E1.2) | 5 | UniProt NCBI |
| GATB | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome c oxidase assembly factor PET112 homolog) | 5 | UniProt NCBI |
| ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6959 | 1.31072783286e-08 | 0.333333333333 | QRSL1 GATC GATB | GATB-GATC-QRSL1 complex |
| GO:0050567 | 8.07408345042e-06 | 0.333333333333 | QRSL1 GATC GATB | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity |
| GO:0030956 | 8.07408345042e-06 | 0.333333333333 | QRSL1 GATC GATB | glutamyl-tRNA(Gln) amidotransferase complex |
| GO:0070681 | 8.07408345042e-06 | 0.333333333333 | QRSL1 GATC GATB | glutaminyl-tRNAGln biosynthesis via transamidation |
| KEGG:00970 | 9.95160164508e-05 | 0.333333333333 | QRSL1 GATC GATB | Aminoacyl-tRNA biosynthesis |
| HP:0008163 | 0.000378988522417 | 0.333333333333 | QRSL1 GATC GATB | Decreased circulating cortisol level |
| GO:0016884 | 0.000676970649307 | 0.333333333333 | QRSL1 GATC GATB | carbon-nitrogen ligase activity, with glutamine as amido-N-donor |
| GO:0005739 | 0.00141748309457 | 0.888888888889 | QRSL1 GUF1 GATB ABHD11 COQ6 MRM2 GATC VWA8 | mitochondrion |
| HP:0008207 | 0.00219910586189 | 0.333333333333 | QRSL1 GATC GATB | Primary adrenal insufficiency |
| HP:0011731 | 0.00266659082239 | 0.333333333333 | QRSL1 GATC GATB | Abnormality of circulating cortisol level |
| HP:0012111 | 0.00283592373541 | 0.333333333333 | QRSL1 GATC GATB | Abnormality of circulating glucocorticoid level |
| HP:0008347 | 0.00379009050824 | 0.333333333333 | MRM2 GATC QRSL1 | Decreased activity of mitochondrial complex IV |
| HP:0001790 | 0.0046906828491 | 0.333333333333 | QRSL1 GATC GATB | Nonimmune hydrops fetalis |
| HP:0000846 | 0.0100904083719 | 0.333333333333 | QRSL1 GATC GATB | Adrenal insufficiency |
| HP:0011923 | 0.0162349296719 | 0.333333333333 | MRM2 GATC QRSL1 | Decreased activity of mitochondrial complex I |
| HP:0011733 | 0.0251732083318 | 0.333333333333 | QRSL1 GATC GATB | Abnormality of adrenal physiology |
| HP:0001789 | 0.0298269199151 | 0.333333333333 | QRSL1 GATC GATB | Hydrops fetalis |
| HP:0001941 | 0.0363911312067 | 0.444444444444 | MRM2 GATB GATC QRSL1 | Acidosis |
| HP:0004360 | 0.0459881595419 | 0.444444444444 | MRM2 GATB GATC QRSL1 | Abnormality of acid-base homeostasis |
| HP:0008972 | 0.0482177591518 | 0.333333333333 | MRM2 GATC QRSL1 | Decreased activity of mitochondrial respiratory chain |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GATC | QRSL1 | 1.0 | 0.68 |
mutually_exclusive (O75879)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GATC | GATB | 0.999 | 0.764 |
mutually_exclusive (Q9H0R6)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| QRSL1 | GATB | 0.999 | 0.296 |
mutually_exclusive (O43716)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| QRSL1 | COQ6 | 0.99 | 0.014 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only |
| GUF1 | MRM2 | 0.989 | 0.27 | bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| ABHD11 | MRM2 | 0.983 | 0.162 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MRM2 | GATB | 0.979 | 0.276 | bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| VWA8 | MRM2 | 0.977 | 0.172 | bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| MRM2 | ALDH4A1 | 0.976 | 0.086 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| QRSL1 | ALDH4A1 | 0.968 | 0.02 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only |
| VWA8 | QRSL1 | 0.964 | 0.108 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| TATDN1 | MRM2 | 0.962 | 0.11 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GUF1 | COQ6 | 0.76 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only | |
| GUF1 | GATB | 0.682 | 0.416 | bioplex3_WMM youn_WMM WMM_only | |
| VWA8 | GUF1 | 0.654 | 0.072 | bioplex3_WMM youn_WMM WMM_only | |
| COQ6 | GATB | 0.613 | 0.028 | bioplex3_WMM WMM_only | |
| GUF1 | ABHD11 | 0.58 | 0.012 | bioplex3_WMM WMM_only | |
| VWA8 | GATB | 0.512 | 0.052 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| VWA8 | COQ6 | 0.455 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only | |
| GATB | ALDH4A1 | 0.448 | 0.046 | bioplex3_WMM WMM_only | |
| TATDN1 | GUF1 | 0.371 | 0.026 | bioplex3_WMM WMM_only | |
| COQ6 | ALDH4A1 | 0.348 | 0.07 | bioplex3_WMM WMM_only | |
| GUF1 | ALDH4A1 | 0.328 | 0.02 | bioplex3_WMM WMM_only treiber_WMM | |
| TATDN1 | COQ6 | 0.263 | 0.014 | bioplex3_WMM WMM_only | |
| VWA8 | TATDN1 | 0.244 | 0.046 | bioplex3_WMM fraction | |
| VWA8 | ABHD11 | 0.222 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only | |
| GATC | COQ6 | 0.22 | 0.044 |
mutually_exclusive (Q9H0R6)
|
bioplex3_WMM WMM_only |
| VWA8 | GATC | 0.215 | 0.078 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| VWA8 | ALDH4A1 | 0.211 | 0.102 | bioplex3_WMM WMM_only | |
| ABHD11 | ALDH4A1 | 0.189 | 0.064 | bioplex3_WMM fraction | |
| GATC | ALDH4A1 | 0.188 | 0.03 |
mutually_exclusive (Q9H0R6)
|
bioplex3_WMM WMM_only |
| MRM2 | COQ6 | 0.153 | 0.138 | bioplex3_WMM WMM_only | |
| TATDN1 | ALDH4A1 | 0.153 | 0.04 | bioplex3_WMM WMM_only | |
| ABHD11 | GATB | 0.134 | 0.016 | bioplex3_WMM WMM_only | |
| TATDN1 | GATB | 0.067 | 0.052 | bioplex3_WMM WMM_only | |
| TATDN1 | ABHD11 | 0.048 | 0.032 | bioplex3_WMM WMM_only | |
| MRM2 | QRSL1 | 0.02 | 0.358 | bioplex3_WMM youn_WMM WMM_only | |
| GUF1 | QRSL1 | 0.02 | 0.124 | bioplex3_WMM youn_WMM WMM_only | |
| ABHD11 | COQ6 | 0.02 | 0.066 | bioplex3_WMM WMM_only | |
| TATDN1 | GATC | 0.016 | 0.072 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TATDN1 | QRSL1 | 0.014 | 0.042 | bioplex3_WMM WMM_only | |
| ABHD11 | QRSL1 | 0.013 | 0.024 | bioplex3_WMM WMM_only |
Related Complexes