hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10412.1

Complex Portal: CPX-17227

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
PDK1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)	5	UniProt NCBI
FOXD4L1	Forkhead box protein D4-like 1 (FOXD4-like 1)	5	UniProt NCBI
PDHX	Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)	5	UniProt NCBI
PDK3	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)	5	UniProt NCBI
TLR2	Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)	5	UniProt NCBI
PDK2	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)	5	UniProt NCBI
STAT5A	Signal transducer and activator of transcription 5A	5	UniProt NCBI
PDHA1	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)	5	UniProt NCBI
STAT5B	Signal transducer and activator of transcription 5B	5	UniProt NCBI
PDHB	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)	5	UniProt NCBI
FOXD4	Forkhead box protein D4 (Forkhead-related protein FKHL9) (Forkhead-related transcription factor 5) (FREAC-5) (Myeloid factor-alpha)	4	UniProt NCBI
DLAT	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-204174	4.77314020354e-11	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	Regulation of pyruvate dehydrogenase (PDH) complex
GO:0006086	5.70999833311e-10	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	acetyl-CoA biosynthetic process from pyruvate
REAC:R-HSA-70268	1.5510254452e-09	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	Pyruvate metabolism
REAC:R-HSA-5362517	4.73479627591e-09	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	Signaling by Retinoic Acid
GO:0006085	1.39932395176e-08	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	acetyl-CoA biosynthetic process
REAC:R-HSA-71406	2.81096356116e-08	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	Pyruvate metabolism and Citric Acid (TCA) cycle
GO:0006084	1.48369984827e-07	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	acetyl-CoA metabolic process
GO:0035384	1.12828086728e-06	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	thioester biosynthetic process
GO:0071616	1.12828086728e-06	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	acyl-CoA biosynthetic process
GO:0006790	1.80051044163e-06	0.7	PDK1 PDK2 PDK3 PDHX STAT5B PDHA1 STAT5A	sulfur compound metabolic process
GO:0034033	3.83798660243e-06	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	purine nucleoside bisphosphate biosynthetic process
GO:0034030	3.83798660243e-06	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	ribonucleoside bisphosphate biosynthetic process
GO:0033866	3.83798660243e-06	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	nucleoside bisphosphate biosynthetic process
REAC:R-HSA-1428517	1.13190038247e-05	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	The citric acid (TCA) cycle and respiratory electron transport
WP:WP581	3.47285060937e-05	0.3	PDK1 STAT5A STAT5B	EPO receptor signaling
GO:0006637	4.39196371931e-05	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	acyl-CoA metabolic process
GO:0035383	4.39196371931e-05	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	thioester metabolic process
GO:0010510	4.61210427592e-05	0.3	PDK1 PDK2 PDK3	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0050812	4.61210427592e-05	0.3	PDK1 PDK2 PDK3	regulation of acyl-CoA biosynthetic process
REAC:R-HSA-9006931	7.52204654284e-05	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	Signaling by Nuclear Receptors
GO:0006090	8.68098938149e-05	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	pyruvate metabolic process
GO:0004740	0.000115261178119	0.3	PDK1 PDK2 PDK3	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0034032	0.000142438770554	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	purine nucleoside bisphosphate metabolic process
GO:0033865	0.000142438770554	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	nucleoside bisphosphate metabolic process
GO:0033875	0.000142438770554	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	ribonucleoside bisphosphate metabolic process
GO:0005967	0.00040312426486	0.3	PDHX PDK2 PDHA1	mitochondrial pyruvate dehydrogenase complex
GO:0045254	0.00040312426486	0.3	PDHX PDK2 PDHA1	pyruvate dehydrogenase complex
REAC:R-HSA-9645135	0.000610250897391	0.2	STAT5A STAT5B	STAT5 Activation
GO:0044272	0.00065137928064	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	sulfur compound biosynthetic process
REAC:R-HSA-9027283	0.00101671361746	0.2	STAT5A STAT5B	Erythropoietin activates STAT5
WP:WP4255	0.00106295369076	0.3	PDK1 STAT5A STAT5B	Non small cell lung cancer
GO:0006082	0.00137210164184	0.7	PDK1 PDK2 PDK3 PDHX STAT5B PDHA1 STAT5A	organic acid metabolic process
GO:0042762	0.00138065085968	0.3	PDK1 PDK2 PDK3	regulation of sulfur metabolic process
GO:0009152	0.00161934942174	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	purine ribonucleotide biosynthetic process
WP:WP5050	0.00186090881862	0.2	PDK1 PDHA1	TCA cycle in senescence
REAC:R-HSA-9020958	0.00213354034849	0.2	STAT5A STAT5B	Interleukin-21 signaling
GO:0009260	0.00214184110524	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	ribonucleotide biosynthetic process
GO:0046390	0.00255899114378	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	ribose phosphate biosynthetic process
WP:WP5063	0.00272734094269	0.2	STAT5A STAT5B	FOXP3 in COVID 19
REAC:R-HSA-8985947	0.00284368219242	0.2	STAT5A STAT5B	Interleukin-9 signaling
REAC:R-HSA-9702518	0.00284368219242	0.2	STAT5A STAT5B	STAT5 activation downstream of FLT3 ITD mutants
GO:0034654	0.00300537391933	1.0	PDK1 PDK2 PDK3 TLR2 STAT5B PDHA1 PDHX FOXD4L1 FOXD4 STAT5A	nucleobase-containing compound biosynthetic process
KEGG:05162	0.00344875538076	0.3	TLR2 STAT5A STAT5B	Measles
GO:0018130	0.00360676293504	1.0	PDK1 PDK2 PDK3 TLR2 STAT5B PDHA1 PDHX FOXD4L1 FOXD4 STAT5A	heterocycle biosynthetic process
GO:0019438	0.00364529640625	1.0	PDK1 PDK2 PDK3 TLR2 STAT5B PDHA1 PDHX FOXD4L1 FOXD4 STAT5A	aromatic compound biosynthetic process
REAC:R-HSA-9020558	0.0036548283771	0.2	STAT5A STAT5B	Interleukin-2 signaling
REAC:R-HSA-2586552	0.0036548283771	0.2	STAT5A STAT5B	Signaling by Leptin
WP:WP22	0.00375768007348	0.2	STAT5A STAT5B	IL 9 signaling pathway
GO:0006164	0.00388883870534	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	purine nucleotide biosynthetic process
GO:0072522	0.00443718373016	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	purine-containing compound biosynthetic process
GO:1901362	0.0048698369109	1.0	PDK1 PDK2 PDK3 TLR2 STAT5B PDHA1 PDHX FOXD4L1 FOXD4 STAT5A	organic cyclic compound biosynthetic process
GO:0030808	0.00522556754165	0.3	PDK1 PDK2 PDK3	regulation of nucleotide biosynthetic process
GO:1900371	0.00522556754165	0.3	PDK1 PDK2 PDK3	regulation of purine nucleotide biosynthetic process
WP:WP205	0.00560972640403	0.2	STAT5A STAT5B	IL 7 signaling pathway
KEGG:05161	0.00583642418014	0.3	TLR2 STAT5A STAT5B	Hepatitis B
HP:0500231	0.0061877325188	0.2	PDHX PDHA1	Abnormal CSF pyruvate family amino acid concentration
WP:WP4630	0.00658064183178	0.3	TLR2 STAT5A STAT5B	Measles virus infection
GO:0009165	0.00661733096538	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	nucleotide biosynthetic process
REAC:R-HSA-1170546	0.00669318453569	0.2	STAT5A STAT5B	Prolactin receptor signaling
GO:1901293	0.00727686798611	0.5	PDK1 PDHA1 PDK2 PDK3 PDHX	nucleoside phosphate biosynthetic process
WP:WP4206	0.00782853915012	0.2	PDK1 PDHA1	Hereditary leiomyomatosis and renal cell carcinoma pathway
REAC:R-HSA-9703648	0.00790724004214	0.2	STAT5A STAT5B	Signaling by FLT3 ITD and TKD mutants
REAC:R-HSA-8983432	0.00790724004214	0.2	STAT5A STAT5B	Interleukin-15 signaling
WP:WP4666	0.00907021898379	0.3	TLR2 STAT5A STAT5B	Hepatitis B infection
KEGG:05415	0.0107622950615	0.3	PDK3 PDK2 PDHA1	Diabetic cardiomyopathy
REAC:R-HSA-9703465	0.0121516690115	0.2	STAT5A STAT5B	Signaling by FLT3 fusion proteins
REAC:R-HSA-1839117	0.0121516690115	0.2	STAT5A STAT5B	Signaling by cytosolic FGFR1 fusion mutants
WP:WP4149	0.0123383084162	0.2	STAT5A STAT5B	White fat cell differentiation
WP:WP3972	0.0133616217617	0.2	STAT5A STAT5B	PDGFR beta pathway
REAC:R-HSA-9669938	0.0137668647983	0.2	STAT5A STAT5B	Signaling by KIT in disease
REAC:R-HSA-9670439	0.0137668647983	0.2	STAT5A STAT5B	Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
WP:WP5358	0.0166734771023	0.2	STAT5A STAT5B	JAK STAT signaling in the regulation of Beta cells
REAC:R-HSA-9006335	0.0172971739669	0.2	STAT5A STAT5B	Signaling by Erythropoietin
HP:0002928	0.0185361113698	0.2	PDHX PDHA1	Decreased activity of the pyruvate dehydrogenase complex
WP:WP127	0.0190825311458	0.2	STAT5A STAT5B	IL 5 signaling pathway
REAC:R-HSA-162582	0.0190896791054	0.7	PDK1 PDK2 PDK3 PDHX STAT5B PDHA1 STAT5A	Signal Transduction
GO:0097411	0.0210690324038	0.2	PDK1 PDK3	hypoxia-inducible factor-1alpha signaling pathway
REAC:R-HSA-982772	0.0212266392091	0.2	STAT5A STAT5B	Growth hormone receptor signaling
WP:WP49	0.0216520902792	0.2	STAT5A STAT5B	IL 2 signaling pathway
GO:0044271	0.0220501553308	1.0	PDK1 PDK2 PDK3 TLR2 STAT5B PDHA1 PDHX FOXD4L1 FOXD4 STAT5A	cellular nitrogen compound biosynthetic process
WP:WP2203	0.0229969481751	0.2	STAT5A STAT5B	Thymic stromal lymphopoietin TSLP signaling pathway
REAC:R-HSA-8854691	0.0233407803855	0.2	STAT5A STAT5B	Interleukin-20 family signaling
REAC:R-HSA-9705462	0.0255543807721	0.2	STAT5A STAT5B	Inactivation of CSF3 (G-CSF) signaling
REAC:R-HSA-9682385	0.0278673305979	0.2	STAT5A STAT5B	FLT3 signaling in disease
REAC:R-HSA-1839124	0.0278673305979	0.2	STAT5A STAT5B	FGFR1 mutant receptor activation
REAC:R-HSA-389661	0.0302795201711	0.2	PDHX PDHA1	Glyoxylate metabolism and glycine degradation
WP:WP5220	0.030320246882	0.2	PDHX PDHA1	Metabolic reprogramming in pancreatic cancer
REAC:R-HSA-186763	0.032790839879	0.2	STAT5A STAT5B	Downstream signal transduction
WP:WP286	0.0351918400012	0.2	STAT5A STAT5B	IL 3 signaling pathway
KEGG:05221	0.0355555587532	0.2	STAT5A STAT5B	Acute myeloid leukemia
REAC:R-HSA-9674555	0.0381104316433	0.2	STAT5A STAT5B	Signaling by CSF3 (G-CSF)
KEGG:04917	0.0392530380302	0.2	STAT5A STAT5B	Prolactin signaling pathway
REAC:R-HSA-5655302	0.0409184848695	0.2	STAT5A STAT5B	Signaling by FGFR1 in disease
WP:WP395	0.0441033585523	0.2	STAT5A STAT5B	IL 4 signaling pathway
KEGG:05230	0.0458118206891	0.2	PDK1 PDHA1	Central carbon metabolism in cancer
KEGG:05223	0.047182824951	0.2	STAT5A STAT5B	Non-small cell lung cancer
HP:0500184	0.0493214801054	0.2	PDHX PDHA1	Abnormal CSF amino acid concentration
REAC:R-HSA-1266695	0.0499343626014	0.2	STAT5A STAT5B	Interleukin-7 signaling
REAC:R-HSA-9607240	0.0499343626014	0.2	STAT5A STAT5B	FLT3 Signaling
CORUM:2023	0.0499436884912	0.1	STAT5A	STAT5A homodimer complex
CORUM:2013	0.0499436884912	0.1	STAT5B	STAT5B homodimer complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PDHA1	PDHB	1.0	0.958	structurally_consistent (dimer)
STAT5A	PDHA1	1.0	0.158
STAT5A	DLAT	1.0	0.086
PDK3	STAT5A	1.0	0.03
PDK3	FOXD4	1.0		structurally_consistent (Q15119) structurally_consistent (dimer)
PDHA1	DLAT	1.0	0.718
PDHB	DLAT	1.0	0.694
PDK3	DLAT	0.999	0.118	structurally_consistent (dimer)
STAT5A	PDHB	0.999	0.124
PDK1	PDK2	0.999	0.058	structurally_consistent (dimer)
PDK3	PDK1	0.999	0.278	structurally_consistent (dimer)
STAT5A	PDHX	0.999	0.04
PDK3	PDHB	0.999	0.124	structurally_consistent (dimer)
STAT5A	STAT5B	0.999	0.768	structurally_consistent (dimer)
PDHX	PDHA1	0.998	0.684
PDK3	PDHX	0.998	0.06	structurally_consistent (dimer)
PDHX	DLAT	0.997	0.652
PDK3	PDHA1	0.997	0.18	structurally_consistent (dimer)
FOXD4	FOXD4L1	0.997
PDHA1	PDK2	0.996	0.204
PDK3	PDK2	0.996	0.088	structurally_consistent (dimer)
FOXD4	PDHA1	0.996
PDK1	PDHA1	0.996	0.29
STAT5A	TLR2	0.994	0.26	structurally_consistent (dimer)
PDK2	DLAT	0.994	0.236	structurally_consistent (dimer)
PDHX	PDK2	0.994	0.07
FOXD4	PDK2	0.994		structurally_consistent (P11177) structurally_consistent (dimer)
STAT5B	PDHX	0.993	0.078
PDHX	PDHB	0.991	0.568
STAT5B	PDHA1	0.989	0.11
FOXD4	PDHX	0.986		mutually_exclusive (Q15120)
FOXD4	PDHB	0.984		structurally_consistent (Q15119) structurally_consistent (dimer)
PDK1	PDHX	0.984	0.218
FOXD4	DLAT	0.982		structurally_consistent (Q15119)
STAT5B	PDHB	0.981	0.086
FOXD4	PDK1	0.977		structurally_consistent (Q15119)
PDK1	PDHB	0.964	0.429538461538
PDHB	PDK2	0.957	0.354	structurally_consistent (dimer)
PDK1	DLAT	0.924	0.3708
STAT5B	DLAT	0.88	0.092
PDK3	STAT5B	0.789	0.024
FOXD4L1	DLAT	0.508
FOXD4L1	PDHA1	0.384
FOXD4L1	PDHX	0.31
FOXD4L1	PDHB	0.294
PDK3	FOXD4L1	0.252
STAT5A	PDK2	0.239	0.110288
FOXD4L1	PDK1	0.213
FOXD4L1	PDK2	0.172
STAT5B	PDK2	0.143	0.06
TLR2	PDHA1	0.007	0.24
TLR2	PDHB	0.005	0.184
TLR2	DLAT	0.003	0.316

Related Complexes

Genename	Complexes
PDK1	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
FOXD4L1	huMAP3_01427.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_11665.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_13510.1
PDHX	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDK3	huMAP3_00016.1 huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
TLR2	huMAP3_03752.1 huMAP3_05442.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11975.1
PDK2	huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
STAT5A	huMAP3_03752.1 huMAP3_05442.1 huMAP3_07514.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHA1	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
STAT5B	huMAP3_03752.1 huMAP3_04704.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHB	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
FOXD4	huMAP3_01427.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1
DLAT	huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10412.1

Complex Portal: CPX-17227