hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10422.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CAMSAP1 | Calmodulin-regulated spectrin-associated protein 1 | 5 | UniProt NCBI |
| KIFAP3 | Kinesin-associated protein 3 (KAP-3) (KAP3) (Smg GDS-associated protein) | 5 | UniProt NCBI |
| KIF3C | Kinesin-like protein KIF3C | 5 | UniProt NCBI |
| KIF3A | Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A) | 5 | UniProt NCBI |
| KIF3B | Kinesin-like protein KIF3B (HH0048) (Microtubule plus end-directed kinesin motor 3B) [Cleaved into: Kinesin-like protein KIF3B, N-terminally processed] | 5 | UniProt NCBI |
| MFHAS1 | Malignant fibrous histiocytoma-amplified sequence 1 (Malignant fibrous histiocytoma-amplified sequence with leucine-rich tandem repeats 1) | 5 | UniProt NCBI |
| LYG1 | Lysozyme g-like protein 1 (EC 3.2.1.-) | 3 | UniProt NCBI |
| NCKAP5 | Nck-associated protein 5 (NAP-5) (Peripheral clock protein) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5620924 | 1.93858490754e-06 | 0.5 | KIF3C KIF3B KIFAP3 KIF3A | Intraflagellar transport |
| REAC:R-HSA-983189 | 2.45168370971e-06 | 0.5 | KIF3C KIF3B KIFAP3 KIF3A | Kinesins |
| GO:0016939 | 5.38272230028e-06 | 0.375 | KIF3A KIFAP3 KIF3B | kinesin II complex |
| REAC:R-HSA-6811434 | 2.24415957957e-05 | 0.5 | KIF3C KIF3B KIFAP3 KIF3A | COPI-dependent Golgi-to-ER retrograde traffic |
| KEGG:04814 | 4.86968585877e-05 | 0.5 | KIF3C KIF3B KIFAP3 KIF3A | Motor proteins |
| GO:0005874 | 5.33851245406e-05 | 0.75 | KIF3C CAMSAP1 NCKAP5 KIFAP3 KIF3A KIF3B | microtubule |
| GO:0072383 | 5.37995977657e-05 | 0.375 | KIF3A KIFAP3 KIF3B | plus-end-directed vesicle transport along microtubule |
| REAC:R-HSA-2132295 | 5.66828303964e-05 | 0.5 | KIF3C KIF3B KIFAP3 KIF3A | MHC class II antigen presentation |
| REAC:R-HSA-8856688 | 7.63750276844e-05 | 0.5 | KIF3C KIF3B KIFAP3 KIF3A | Golgi-to-ER retrograde transport |
| GO:0072386 | 0.00010757157937 | 0.375 | KIF3A KIFAP3 KIF3B | plus-end-directed organelle transport along microtubule |
| GO:0005871 | 0.000120770447162 | 0.5 | KIF3C KIF3B KIFAP3 KIF3A | kinesin complex |
| REAC:R-HSA-983231 | 0.000184608764319 | 0.5 | KIF3C KIF3B KIFAP3 KIF3A | Factors involved in megakaryocyte development and platelet production |
| CORUM:905 | 0.000239030245992 | 0.25 | KIF3A KIF3B | KIF3A/B-PAR-3-aPKC-PAR-6 complex |
| GO:0097542 | 0.000271975684832 | 0.5 | KIF3C KIF3B KIFAP3 KIF3A | ciliary tip |
| REAC:R-HSA-5617833 | 0.000387508352921 | 0.5 | KIF3C KIF3B KIFAP3 KIF3A | Cilium Assembly |
| REAC:R-HSA-6811442 | 0.000421277670154 | 0.5 | KIF3C KIF3B KIFAP3 KIF3A | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0099513 | 0.000714738930825 | 0.75 | KIF3C CAMSAP1 NCKAP5 KIFAP3 KIF3A KIF3B | polymeric cytoskeletal fiber |
| REAC:R-HSA-1445148 | 0.00117991190651 | 0.375 | KIF3A KIFAP3 KIF3B | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| WP:WP4536 | 0.00145791004127 | 0.375 | KIF3A KIFAP3 KIF3B | Genes related to primary cilium development based on CRISPR |
| REAC:R-HSA-1852241 | 0.0017212773113 | 0.5 | KIF3C KIF3B KIFAP3 KIF3A | Organelle biogenesis and maintenance |
| GO:0099512 | 0.00391420051165 | 0.75 | KIF3C CAMSAP1 NCKAP5 KIFAP3 KIF3A KIF3B | supramolecular fiber |
| GO:0099081 | 0.0042166170581 | 0.75 | KIF3C CAMSAP1 NCKAP5 KIFAP3 KIF3A KIF3B | supramolecular polymer |
| GO:0007017 | 0.0144794406787 | 0.75 | KIF3C CAMSAP1 NCKAP5 KIFAP3 KIF3A KIF3B | microtubule-based process |
| GO:0005875 | 0.0162903522249 | 0.5 | KIF3C KIF3B KIFAP3 KIF3A | microtubule associated complex |
| REAC:R-HSA-109582 | 0.0218504105027 | 0.5 | KIF3C KIF3B KIFAP3 KIF3A | Hemostasis |
| REAC:R-HSA-199991 | 0.0307022914608 | 0.5 | KIF3C KIF3B KIFAP3 KIF3A | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0379039189287 | 0.5 | KIF3C KIF3B KIFAP3 KIF3A | Vesicle-mediated transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| KIFAP3 | KIF3A | 1.0 | 0.47 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| KIF3B | KIF3A | 1.0 | 0.448 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| KIFAP3 | KIF3B | 1.0 | 0.376 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| KIFAP3 | KIF3C | 0.997 | 0.116 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| KIF3C | KIF3A | 0.994 | 0.202 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM |
| KIF3A | MFHAS1 | 0.985 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| LYG1 | KIF3A | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MFHAS1 | CAMSAP1 | 0.983 | 0.12 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| KIF3C | KIF3B | 0.983 | 0.178 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| KIFAP3 | MFHAS1 | 0.979 | 0.126 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| KIFAP3 | NCKAP5 | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| KIF3C | NCKAP5 | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| KIF3A | CAMSAP1 | 0.947 | 0.054 | bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| NCKAP5 | KIF3B | 0.884 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| KIF3B | MFHAS1 | 0.653 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only |
| KIF3C | MFHAS1 | 0.635 | 0.166 | bioplex_WMM bioplex3_WMM WMM_only |
| KIF3B | LYG1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| KIFAP3 | LYG1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| KIF3C | LYG1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| KIFAP3 | CAMSAP1 | 0.491 | 0.07 | bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| LYG1 | MFHAS1 | 0.476 | bioplex_WMM bioplex3_WMM WMM_only | |
| KIF3B | CAMSAP1 | 0.384 | 0.082 | bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| LYG1 | CAMSAP1 | 0.214 | bioplex3_WMM WMM_only | |
| KIF3C | CAMSAP1 | 0.108 | 0.094 | bioplex3_WMM WMM_only |
Related Complexes