hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10433.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LMNB1 | Lamin-B1 | 5 | UniProt NCBI |
| PDE6D | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17) | 5 | UniProt NCBI |
| LMNB2 | Lamin-B2 | 5 | UniProt NCBI |
| LMNA | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | 5 | UniProt NCBI |
| INPP5E | Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6741 | 1.53774525569e-05 | 0.5 | PDE6D INPP5E | INPP5E-PDE6D-RPGR complex |
| REAC:R-HSA-5624958 | 3.07549051138e-05 | 0.5 | PDE6D INPP5E | ARL13B-mediated ciliary trafficking of INPP5E |
| WP:WP5104 | 9.18788843787e-05 | 0.5 | LMNB2 LMNA | Acquired partial lipodystrophy Barraquer Simons syndrome |
| HP:0009002 | 0.000100319571443 | 0.5 | LMNB2 LMNA | Loss of truncal subcutaneous adipose tissue |
| HP:0030809 | 0.000121313436134 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormal tongue morphology |
| HP:0000157 | 0.000276467736521 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormality of the tongue |
| WP:WP5103 | 0.000436026474737 | 0.5 | LMNB2 LMNA | Progeria associated lipodystrophy |
| HP:0030084 | 0.000672853608305 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Clinodactyly |
| WP:WP5102 | 0.000764539714508 | 0.5 | LMNB2 LMNA | Familial partial lipodystrophy |
| HP:0003635 | 0.000935888865729 | 0.5 | LMNB2 LMNA | Loss of subcutaneous adipose tissue in limbs |
| HP:0001651 | 0.00100965128821 | 0.75 | PDE6D LMNA INPP5E | Dextrocardia |
| HP:0004307 | 0.00103738630957 | 0.75 | PDE6D LMNA INPP5E | Abnormal anatomic location of the heart |
| HP:0000291 | 0.00150383256857 | 0.5 | LMNB2 LMNA | Abnormality of facial adipose tissue |
| WP:WP314 | 0.00178944501344 | 0.5 | LMNB2 LMNA | Fas ligand pathway and stress induction of heat shock proteins |
| HP:0040069 | 0.00232267152461 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormal lower limb bone morphology |
| HP:0002335 | 0.00260592941411 | 0.5 | PDE6D INPP5E | Agenesis of cerebellar vermis |
| WP:WP4656 | 0.0063063631888 | 0.5 | PDE6D INPP5E | Joubert syndrome |
| WP:WP5234 | 0.00722934152515 | 0.5 | PDE6D INPP5E | Bardet Biedl syndrome |
| HP:0005922 | 0.00850637899828 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormal hand morphology |
| HP:0007973 | 0.0092117244708 | 0.5 | PDE6D INPP5E | Retinal dysplasia |
| HP:0011040 | 0.0100118295947 | 0.5 | LMNA INPP5E | Abnormal intrahepatic bile duct morphology |
| HP:0002650 | 0.0102119274289 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Scoliosis |
| REAC:R-HSA-5620920 | 0.0105688559686 | 0.5 | PDE6D INPP5E | Cargo trafficking to the periciliary membrane |
| HP:0012210 | 0.0108336870716 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormal renal morphology |
| HP:0000032 | 0.0112948770693 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormal male external genitalia morphology |
| HP:0005328 | 0.0126114492305 | 0.5 | LMNB2 LMNA | Progeroid facial appearance |
| HP:0000811 | 0.013341386737 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormal external genitalia |
| HP:0010461 | 0.0133945396722 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormality of the male genitalia |
| HP:0010674 | 0.0139897634326 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormal curvature of the vertebral column |
| HP:0001288 | 0.0140448412414 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Gait disturbance |
| HP:0100820 | 0.0155098335254 | 0.5 | LMNB2 LMNA | Glomerulopathy |
| HP:0001167 | 0.0157140772861 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormal finger morphology |
| HP:0008887 | 0.0165423111708 | 0.5 | LMNB2 LMNA | Adipose tissue loss |
| KEGG:04210 | 0.0177164397058 | 0.5 | LMNB2 LMNA | Apoptosis |
| HP:0002419 | 0.018706736024 | 0.5 | PDE6D INPP5E | Molar tooth sign on MRI |
| HP:0001595 | 0.0214696885277 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormal hair morphology |
| HP:0000818 | 0.0230269631822 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormality of the endocrine system |
| CORUM:6091 | 0.0249718442456 | 0.25 | LMNA | NF-YA-LaminA complex |
| HP:0012243 | 0.0257797800958 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormal reproductive system morphology |
| HP:0000077 | 0.0275639757698 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormality of the kidney |
| GO:0051664 | 0.0280843539964 | 0.5 | LMNB2 LMNA | nuclear pore localization |
| HP:0002536 | 0.0297221025438 | 0.75 | PDE6D INPP5E LMNB2 | Abnormal cortical gyration |
| HP:0010935 | 0.0300200005964 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormality of the upper urinary tract |
| WP:WP4803 | 0.030443565418 | 0.5 | PDE6D INPP5E | Ciliopathies |
| HP:0011138 | 0.0329491688919 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormal skin adnexa morphology |
| HP:0005339 | 0.034474601612 | 0.5 | LMNB2 LMNA | Abnormality of complement system |
| HP:0040063 | 0.036003514982 | 0.5 | LMNB2 LMNA | Decreased adipose tissue |
| HP:0011297 | 0.0360876399144 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormal digit morphology |
| HP:0001760 | 0.0361997133303 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormal foot morphology |
| WP:WP4299 | 0.0373138951921 | 0.25 | LMNA | Lamin A processing pathway |
| HP:0002876 | 0.0391604009626 | 0.5 | PDE6D INPP5E | Episodic tachypnea |
| HP:0000925 | 0.0393256235707 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormality of the vertebral column |
| HP:0040019 | 0.0410470782574 | 0.75 | PDE6D LMNA LMNB2 | Finger clinodactyly |
| HP:0410008 | 0.0416942448541 | 0.75 | PDE6D LMNA INPP5E | Abnormality of the peripheral nervous system |
| HP:0001155 | 0.0440627140919 | 1.0 | PDE6D INPP5E LMNA LMNB2 | Abnormality of the hand |
| HP:0000190 | 0.0441432413831 | 0.5 | PDE6D LMNA | Abnormal oral frenulum morphology |
| CORUM:6740 | 0.049938562206 | 0.25 | INPP5E | AURKA-INPP5E complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LMNB1 | LMNA | 1.0 | 0.45 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM |
| LMNB1 | LMNB2 | 0.999 | 0.636 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| LMNB2 | LMNA | 0.998 | 0.538 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| PDE6D | INPP5E | 0.998 | bioplex3_HEK293 bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| LMNB1 | PDE6D | 0.978 | 0.174255319149 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| LMNB2 | PDE6D | 0.974 | 0.108 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| LMNA | PDE6D | 0.459 | 0.088 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| LMNB2 | INPP5E | 0.244 | bioplex3_WMM WMM_only | |
| LMNB1 | INPP5E | 0.159 | bioplex3_WMM WMM_only | |
| LMNA | INPP5E | 0.053 | bioplex3_WMM WMM_only |
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