hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10436.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RBCK1 | RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3) | 5 | UniProt NCBI |
| SHFL | Shiftless antiviral inhibitor of ribosomal frameshifting protein (SFL) (SHFL) (Interferon-regulated antiviral protein) (IRAV) (Repressor of yield of DENV protein) (RyDEN) | 5 | UniProt NCBI |
| RNF31 | E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) | 5 | UniProt NCBI |
| SHARPIN | Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6178 | 7.01606139244e-10 | 0.75 | RNF31 RBCK1 SHARPIN | LUBAC complex |
| GO:0071797 | 3.84480164306e-07 | 0.75 | RNF31 RBCK1 SHARPIN | LUBAC complex |
| REAC:R-HSA-5357786 | 2.8370403595e-06 | 0.75 | RNF31 RBCK1 SHARPIN | TNFR1-induced proapoptotic signaling |
| GO:0097039 | 3.84440695359e-06 | 0.75 | RNF31 RBCK1 SHARPIN | protein linear polyubiquitination |
| REAC:R-HSA-5357956 | 6.94957302308e-06 | 0.75 | RNF31 RBCK1 SHARPIN | TNFR1-induced NF-kappa-B signaling pathway |
| REAC:R-HSA-5357905 | 1.85450342998e-05 | 0.75 | RNF31 RBCK1 SHARPIN | Regulation of TNFR1 signaling |
| REAC:R-HSA-75893 | 3.27872895639e-05 | 0.75 | RNF31 RBCK1 SHARPIN | TNF signaling |
| KEGG:04217 | 0.000142922483011 | 0.75 | RNF31 RBCK1 SHARPIN | Necroptosis |
| KEGG:04621 | 0.000173136486645 | 0.75 | RNF31 RBCK1 SHARPIN | NOD-like receptor signaling pathway |
| REAC:R-HSA-73887 | 0.000464818544718 | 0.75 | RNF31 RBCK1 SHARPIN | Death Receptor Signaling |
| CORUM:6344 | 0.000465981333253 | 0.5 | RNF31 RBCK1 | TNF-R1-associated signaling complex |
| KEGG:05131 | 0.000652828786911 | 0.75 | RNF31 RBCK1 SHARPIN | Shigellosis |
| GO:0043130 | 0.0238272099283 | 0.75 | RNF31 RBCK1 SHARPIN | ubiquitin binding |
| GO:0032182 | 0.0449670283878 | 0.75 | RNF31 RBCK1 SHARPIN | ubiquitin-like protein binding |
| CORUM:7563 | 0.049938562206 | 0.25 | SHFL | LARP1-PABPC1-RYDEN complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RBCK1 | RNF31 | 1.0 | 0.276 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF31 | SHARPIN | 1.0 | 0.288 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RBCK1 | SHARPIN | 0.999 | 0.144 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RBCK1 | SHFL | 0.987 | 0.074 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| SHFL | RNF31 | 0.954 | 0.056 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes