hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10437.1
Complex Portal: CPX-17775
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RTL9 | Retrotransposon Gag-like protein 9 (Retrotransposon gag domain-containing protein 1) (Tumor antigen BJ-HCC-23) | 2 | UniProt NCBI |
| UGT1A8 | UDP-glucuronosyltransferase 1A8 (UGT1A8) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-8) (UDPGT 1-8) (UGT1*8) (UGT1-08) (UGT1.8) (UDP-glucuronosyltransferase 1-H) (UGT-1H) (UGT1H) | 5 | UniProt NCBI |
| ST8SIA3 | Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3 (EC 2.4.3.-) (Alpha-2,8-sialyltransferase 8C) (Alpha-2,8-sialyltransferase III) (Ganglioside GD3 synthase ST8SIA3) (EC 2.4.3.8) (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3) (Sia-a2,3-Gal-b1,4-Glc-NAc-R:a2,8-sialyltransferase) (hST8Sia III) (Sialyltransferase 8C) (SIAT8-C) (Sialyltransferase St8Sia III) (ST8SiaIII) | 5 | UniProt NCBI |
| SUSD2 | Sushi domain-containing protein 2 | 5 | UniProt NCBI |
| UGT1A7 | UDP-glucuronosyltransferase 1A7 (UGT1A7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-7) (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP698 | 0.00089796435942 | 0.4 | UGT1A8 UGT1A7 | Glucuronidation |
| KEGG:00053 | 0.00104717092459 | 0.4 | UGT1A8 UGT1A7 | Ascorbate and aldarate metabolism |
| KEGG:00040 | 0.00135940352356 | 0.4 | UGT1A8 UGT1A7 | Pentose and glucuronate interconversions |
| REAC:R-HSA-156588 | 0.0018206657072 | 0.4 | UGT1A8 UGT1A7 | Glucuronidation |
| KEGG:00860 | 0.00238992944204 | 0.4 | UGT1A8 UGT1A7 | Porphyrin metabolism |
| KEGG:00140 | 0.00352719256651 | 0.4 | UGT1A8 UGT1A7 | Steroid hormone biosynthesis |
| KEGG:00830 | 0.0057569162449 | 0.4 | UGT1A8 UGT1A7 | Retinol metabolism |
| KEGG:05204 | 0.00622027886669 | 0.4 | UGT1A8 UGT1A7 | Chemical carcinogenesis - DNA adducts |
| KEGG:00982 | 0.00645863473927 | 0.4 | UGT1A8 UGT1A7 | Drug metabolism - cytochrome P450 |
| REAC:R-HSA-9749641 | 0.0065872694687 | 0.4 | UGT1A8 UGT1A7 | Aspirin ADME |
| KEGG:04976 | 0.0074565122263 | 0.4 | UGT1A8 UGT1A7 | Bile secretion |
| KEGG:00980 | 0.00771708586936 | 0.4 | UGT1A8 UGT1A7 | Metabolism of xenobiotics by cytochrome P450 |
| KEGG:00983 | 0.00996128881886 | 0.4 | UGT1A8 UGT1A7 | Drug metabolism - other enzymes |
| GO:0051552 | 0.0280843539964 | 0.4 | UGT1A8 UGT1A7 | flavone metabolic process |
| GO:0052696 | 0.0280843539964 | 0.4 | UGT1A8 UGT1A7 | flavonoid glucuronidation |
| WP:WP5224 | 0.0316649111647 | 0.4 | UGT1A8 UGT1A7 | 2q37 copy number variation syndrome |
| KEGG:01240 | 0.0397793006284 | 0.4 | UGT1A8 UGT1A7 | Biosynthesis of cofactors |
| GO:0009804 | 0.0468008499735 | 0.4 | UGT1A8 UGT1A7 | coumarin metabolic process |
| GO:0009698 | 0.0468008499735 | 0.4 | UGT1A8 UGT1A7 | phenylpropanoid metabolic process |
| REAC:R-HSA-156580 | 0.0475253950332 | 0.4 | UGT1A8 UGT1A7 | Phase II - Conjugation of compounds |
| REAC:R-HSA-9748784 | 0.0487218825663 | 0.4 | UGT1A8 UGT1A7 | Drug ADME |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RTL9 | UGT1A7 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ST8SIA3 | SUSD2 | 0.994 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UGT1A8 | UGT1A7 | 0.972 |
mutually_exclusive (Q9HAW8)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UGT1A7 | SUSD2 | 0.959 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RTL9 | SUSD2 | 0.418 | bioplex3_WMM WMM_only | ||
| RTL9 | UGT1A8 | 0.415 | bioplex3_WMM WMM_only | ||
| UGT1A8 | SUSD2 | 0.046 | bioplex3_WMM WMM_only |
Related Complexes