hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10449.1

Complex Portal: CPX-21602

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
SIVA1	Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP)	5	UniProt NCBI
PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase)	5	UniProt NCBI
CDK3	Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)	5	UniProt NCBI
CCNB3	G2/mitotic-specific cyclin-B3	5	UniProt NCBI
TRIM49	Tripartite motif-containing protein 49 (RING finger protein 18) (Testis-specific RING-finger protein)	4	UniProt NCBI
SKP2	S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)	5	UniProt NCBI
GMNN	Geminin	5	UniProt NCBI
CCNB1	G2/mitotic-specific cyclin-B1	5	UniProt NCBI
E2F4	Transcription factor E2F4 (E2F-4)	5	UniProt NCBI
CDKN1C	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2)	5	UniProt NCBI
CKS1B	Cyclin-dependent kinases regulatory subunit 1 (CKS-1)	5	UniProt NCBI
CCND2	G1/S-specific cyclin-D2	5	UniProt NCBI
PCNA	Proliferating cell nuclear antigen (PCNA) (Cyclin)	5	UniProt NCBI
RBL1	Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)	5	UniProt NCBI
CDK1	Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)	5	UniProt NCBI
FGR	Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)	5	UniProt NCBI
CDK2	Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)	5	UniProt NCBI
CCNE1	G1/S-specific cyclin-E1	5	UniProt NCBI
SCAPER	S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291)	5	UniProt NCBI
CDKN2D	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d)	5	UniProt NCBI
CCNI	Cyclin-I	4	UniProt NCBI
MIDEAS	Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1)	4	UniProt NCBI
E2F5	Transcription factor E2F5 (E2F-5)	5	UniProt NCBI
CDT1	DNA replication factor Cdt1 (Double parked homolog) (DUP)	5	UniProt NCBI
CDK6	Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)	5	UniProt NCBI
CCND3	G1/S-specific cyclin-D3	5	UniProt NCBI
CDKN1B	Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1)	5	UniProt NCBI
CREBBP	CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)	5	UniProt NCBI
CDK5R1	Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)]	5	UniProt NCBI
CCNB2	G2/mitotic-specific cyclin-B2	5	UniProt NCBI
CKS2	Cyclin-dependent kinases regulatory subunit 2 (CKS-2)	4	UniProt NCBI
CDKN2B	Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B)	5	UniProt NCBI
RBL2	Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)	5	UniProt NCBI
CDKN2A	Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p14ARF)	5	UniProt NCBI
CCNA2	Cyclin-A2 (Cyclin-A) (Cyclin A)	5	UniProt NCBI
CDK4	Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)	5	UniProt NCBI
CDKN2C	Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)	5	UniProt NCBI
CCNA1	Cyclin-A1	5	UniProt NCBI
CCND1	G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene)	5	UniProt NCBI
EP300	Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)	5	UniProt NCBI
CDK5	Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)	5	UniProt NCBI
CCNE2	G1/S-specific cyclin-E2	5	UniProt NCBI
CCNO	Cyclin-O	5	UniProt NCBI
CDKN1A	Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04110	2.41230883205e-38	0.666666666667	CCNA1 RBL2 EP300 CDKN2A CDKN1C E2F5 CDT1 CCNE2 CDK6 E2F4 CCND1 CDK1 CDKN2D RBL1 CDKN2B CREBBP CDKN1A CCNB3 CDKN1B CCNA2 CCNB2 PKMYT1 SKP2 CDKN2C	Cell cycle
WP:WP179	3.38584807364e-36	0.611111111111	CCNA1 RBL2 EP300 CDKN2A CDKN1C CDKN1A CCNE2 CDK6 E2F4 CCND1 CDK1 CDKN2D RBL1 CDKN2B E2F5 CCNB3 CDKN1B CCNA2 CCNB2 PKMYT1 SKP2 CDKN2C	Cell cycle
REAC:R-HSA-453279	3.95378109711e-31	0.583333333333	CDT1 CDKN2C E2F5 CDKN1A CDK6 E2F4 CCND1 CCNE2 RBL2 CCNA2 GMNN CDK1 CDKN2D CKS1B RBL1 CCNA1 CDKN1C CDKN2B SKP2 CDKN1B CDKN2A	Mitotic G1 phase and G1/S transition
REAC:R-HSA-69236	1.06717322635e-29	0.444444444444	CDKN1A CDKN2C E2F5 CDKN1B E2F4 CCND1 CCNE2 RBL2 CDKN2B CDK6 CDKN1C CDKN2D RBL1 CKS1B SKP2 CDKN2A	G1 Phase
REAC:R-HSA-69231	1.06717322635e-29	0.444444444444	CDKN1A CDKN2C E2F5 CDKN1B E2F4 CCND1 CCNE2 RBL2 CDKN2B CDK6 CDKN1C CDKN2D RBL1 CKS1B SKP2 CDKN2A	Cyclin D associated events in G1
GO:0016538	2.86435371084e-28	0.444444444444	CCNI CCNB2 CDKN1A CDKN2C CCNB3 CCNE2 CCND1 CDKN1B CCNO CDKN2A CDK5R1 CCNA2 CCNA1 CKS1B CDKN2B CDKN2D	cyclin-dependent protein serine/threonine kinase regulator activity
REAC:R-HSA-69278	3.51041549094e-24	0.666666666667	CCNA1 RBL2 EP300 CDKN2A CKS1B CDKN1C GMNN CDT1 CCNE2 CDK6 E2F4 CCND1 CDK1 CDKN2D SKP2 E2F5 CDKN1A RBL1 CDKN1B CCNA2 CCNB2 PKMYT1 CDKN2B CDKN2C	Cell Cycle, Mitotic
GO:0000307	1.39433818401e-23	0.416666666667	CCNI CCNB2 CDK1 CCNB3 CCNE2 CDK3 CCND1 CDK6 CCNO CDK5R1 CDK5 CCNA2 CKS1B CDKN1A CCNA1	cyclin-dependent protein kinase holoenzyme complex
REAC:R-HSA-1640170	5.05985814687e-22	0.666666666667	CCNA1 RBL2 EP300 CDKN2A CKS1B CDKN1C GMNN CDT1 CCNE2 CDK6 E2F4 CCND1 CDK1 CDKN2D SKP2 E2F5 CDKN1A RBL1 CDKN1B CCNA2 CCNB2 PKMYT1 CDKN2B CDKN2C	Cell Cycle
GO:0044772	4.84636130081e-21	0.583333333333	CCNI CDKN2C PKMYT1 CDKN1A CDK6 RBL2 CCNB3 CCND1 CCNE2 CDK3 CDKN2B CDK1 CCNO CDKN2A CDKN2D RBL1 CCNA1 CCNA2 SKP2 CDKN1B CCNB2	mitotic cell cycle phase transition
GO:0044770	9.7774714905e-21	0.611111111111	CCNA1 RBL2 CDKN2A CCNA2 CDKN1A CCNE2 CDK6 CCND1 CDK1 CDKN2D RBL1 CDKN2B CDT1 CCNB3 CDK3 CDKN1B CCNO CCNB2 CCNI PKMYT1 SKP2 CDKN2C	cell cycle phase transition
GO:0000278	2.74074834257e-20	0.694444444444	CCNA1 RBL2 CDKN2A CKS1B CDKN1C GMNN CDT1 CCNE2 CDK6 CCND1 CDK1 CCNO CDKN2D RBL1 SKP2 CDKN1A CCNB3 CDK3 CDKN1B CCNA2 CCNB2 CCNI PKMYT1 CDKN2B CDKN2C	mitotic cell cycle
KEGG:04218	7.5226347501e-20	0.416666666667	CDKN1A E2F5 CDK1 CCNB3 CCNE2 RBL2 CCND1 CDK6 CDKN2A E2F4 RBL1 CCNA1 CCNA2 CDKN2B CCNB2	Cellular senescence
REAC:R-HSA-69206	1.12547487565e-19	0.416666666667	CDT1 E2F5 CDKN1A CDKN1B E2F4 CCND1 CCNE2 RBL2 CCNA2 GMNN CDK1 RBL1 CKS1B SKP2 CCNA1	G1/S Transition
GO:0019887	3.09140826322e-19	0.472222222222	CCNI CCNB2 CDKN1A CDKN2C CCNB3 CCNE2 CCND1 CCNA2 CDKN1B CCNO CDKN2A CDKN2D CDKN1C CCNA1 CKS1B CDKN2B CDK5R1	protein kinase regulator activity
WP:WP45	2.49278756907e-18	0.333333333333	CDK1 CDKN2C CCNA1 CDKN1A CDKN1B CCNE2 CCND1 CDK6 CDKN2D CDKN1C CDKN2B CDKN2A	G1 to S cell cycle control
GO:0019207	4.61465232482e-18	0.472222222222	CCNI CCNB2 CDKN1A CDKN2C CCNB3 CCNE2 CCND1 CCNA2 CDKN1B CCNO CDKN2A CDKN2D CDKN1C CCNA1 CKS1B CDKN2B CDK5R1	kinase regulator activity
KEGG:05203	6.10574335844e-18	0.416666666667	CDK1 CREBBP CDKN1A CDKN1B RBL1 CCND1 CCNE2 RBL2 CDKN2B CDK6 CDKN2A CCNA2 EP300 SKP2 CCNA1	Viral carcinogenesis
GO:1902554	1.09507817749e-17	0.416666666667	CCNI CCNB2 CDK1 CCNB3 CCNE2 CDK3 CCND1 CDK6 CCNO CDK5R1 CDK5 CCNA2 CKS1B CDKN1A CCNA1	serine/threonine protein kinase complex
GO:1903047	2.20422133493e-17	0.611111111111	CCNA1 RBL2 CDKN2A CCNA2 CDKN1A CCNE2 CDK6 CCND1 CDK1 CDKN2D RBL1 CDKN2B CDT1 CCNB3 CDK3 CDKN1B CCNO CCNB2 CCNI PKMYT1 SKP2 CDKN2C	mitotic cell cycle process
GO:0007049	2.8379856738e-17	0.75	CCNA1 RBL2 CDKN2A CKS1B CDKN1C GMNN CDT1 CCNE2 CDK6 CCND1 CDK1 CCNO CDKN2D RBL1 SKP2 CDKN1A CCNB3 CDK3 CDKN1B CDK5R1 CCNA2 CCNB2 CCNI PKMYT1 CDKN2B CDKN2C CDK5	cell cycle
GO:1902911	7.94876661911e-17	0.416666666667	CCNI CCNB2 CDK1 CCNB3 CCNE2 CDK3 CCND1 CDK6 CCNO CDK5R1 CDK5 CCNA2 CKS1B CDKN1A CCNA1	protein kinase complex
GO:0000082	8.82567629963e-16	0.416666666667	CDKN1A CDKN2C CCND1 CDK1 RBL2 RBL1 CCNE2 CDK3 CDKN2B CDK6 CDKN2D CCNA2 SKP2 CDKN1B CDKN2A	G1/S transition of mitotic cell cycle
REAC:R-HSA-6791312	1.97248690772e-15	0.277777777778	CDKN1A CCNA1 CDKN1B E2F4 RBL2 CDK1 RBL1 CCNA2 EP300 CCNE2	TP53 Regulates Transcription of Cell Cycle Genes
GO:0044843	5.92299904025e-15	0.416666666667	CDKN1A CDKN2C CCND1 CDK1 RBL2 RBL1 CCNE2 CDK3 CDKN2B CDK6 CDKN2D CCNA2 SKP2 CDKN1B CDKN2A	cell cycle G1/S phase transition
REAC:R-HSA-69242	1.06506791146e-14	0.361111111111	CDT1 E2F5 CDKN1A CCND1 E2F4 CCNE2 RBL2 GMNN CDKN1B CCNA2 CKS1B SKP2 CCNA1	S Phase
REAC:R-HSA-69202	1.45882989565e-14	0.305555555556	CDKN1A E2F5 E2F4 CCNE2 RBL2 CCND1 CDKN1B CCNA2 CKS1B SKP2 CCNA1	Cyclin E associated events during G1/S transition
REAC:R-HSA-69656	1.92902345995e-14	0.305555555556	CDKN1A E2F5 E2F4 CCNE2 RBL2 CCND1 CDKN1B CCNA2 CKS1B SKP2 CCNA1	Cyclin A:Cdk2-associated events at S phase entry
GO:0022402	3.96939672091e-14	0.638888888889	CCNA1 RBL2 CDKN2A CCNA2 GMNN CDT1 CCNE2 CDK6 CCND1 CDK1 CDKN2D RBL1 SKP2 CDKN1A CCNB3 CDK3 CDKN1B CCNO CCNB2 CCNI PKMYT1 CDKN2B CDKN2C	cell cycle process
GO:1904029	7.15873046411e-14	0.305555555556	CDKN1A PKMYT1 CDKN2C CCNE2 CCND1 CDKN1B CDKN2A CDK5R1 CDKN1C CDKN2B CDKN2D	regulation of cyclin-dependent protein kinase activity
KEGG:04068	1.20828817886e-13	0.305555555556	CDKN1A CCNB2 CCND1 CCNB3 RBL2 CDKN2B CDKN1B CDKN2D EP300 SKP2 CREBBP	FoxO signaling pathway
REAC:R-HSA-1538133	2.79788898514e-13	0.222222222222	E2F5 E2F4 CCNE2 RBL2 CDK1 RBL1 CCNA2 CCNA1	G0 and Early G1
WP:WP366	4.2678846009e-13	0.305555555556	CDKN1A CCNB2 EP300 E2F4 RBL2 CCND1 CDK1 E2F5 RBL1 CDKN2B CREBBP	TGF beta signaling pathway
GO:0051726	4.97596278959e-13	0.583333333333	CDT1 CDKN2C PKMYT1 CDKN1A CDK6 RBL2 RBL1 CCND1 CCNE2 CDK3 GMNN CDK1 CDKN2A CDKN2D CDK5 CKS1B CDKN1C CDKN2B SKP2 CDKN1B CDK5R1	regulation of cell cycle
WP:WP2446	8.43727752417e-13	0.277777777778	CDT1 CCNB2 CDKN1A CDK6 CCND1 CDK1 CCNA2 SKP2 CDKN1B CCNE2	Retinoblastoma gene in cancer
GO:0061695	1.849716268e-12	0.416666666667	CCNI CCNB2 CDK1 CCNB3 CCNE2 CDK3 CCND1 CDK6 CCNO CDK5R1 CDK5 CCNA2 CKS1B CDKN1A CCNA1	transferase complex, transferring phosphorus-containing groups
GO:0000079	4.16341962939e-12	0.277777777778	CDKN1A PKMYT1 CDKN2C CCNE2 CCND1 CDKN1B CDKN2A CDKN2D CDKN2B CDK5R1	regulation of cyclin-dependent protein serine/threonine kinase activity
WP:WP1530	4.24588164556e-12	0.25	CDK1 CCNB2 CDKN1B CCNB3 CCND1 CDK6 CDK5 CDKN1A CCNE2	miRNA regulation of DNA damage response
WP:WP707	4.24588164556e-12	0.25	CDK1 CCNB2 CDKN1B CCNB3 CCND1 CDK6 CDK5 CDKN1A CCNE2	DNA damage response
REAC:R-HSA-3700989	7.22574075055e-12	0.388888888889	CDKN1A CREBBP CDKN1B E2F4 CCNE2 RBL2 CDK1 CDK5R1 CDK5 RBL1 CCNA1 CCNA2 EP300 CDKN2A	Transcriptional Regulation by TP53
GO:0007346	1.05093987659e-11	0.444444444444	CDKN1A CDKN2C PKMYT1 CDK6 RBL2 RBL1 CCND1 CDK3 CDKN2B CDK1 CDKN2D CKS1B CDKN1C GMNN CDKN1B CDKN2A	regulation of mitotic cell cycle
KEGG:05166	6.28981037233e-11	0.305555555556	CDKN1A CREBBP EP300 CCNE2 CCND1 CDKN2C CDKN2A CCNA1 CCNA2 CDKN2B CCNB2	Human T-cell leukemia virus 1 infection
WP:WP5180	7.31723186122e-11	0.222222222222	E2F5 CDK6 E2F4 RBL2 CCND1 CDKN1B RBL1 GMNN	DYRK1A involvement regarding cell proliferation in brain development
REAC:R-HSA-69205	7.97853991021e-11	0.194444444444	CDT1 E2F5 E2F4 RBL2 CDK1 RBL1 CCNA1	G1/S-Specific Transcription
REAC:R-HSA-212436	8.6541400904e-11	0.527777777778	CDKN1A E2F5 CDK1 E2F4 CCND1 CCNE2 RBL2 CDKN2B CDK6 CDKN2A CDK5R1 CDK5 RBL1 CCNA1 CCNA2 EP300 SKP2 CDKN1B CREBBP	Generic Transcription Pathway
GO:1990234	9.02764424611e-11	0.527777777778	CCNI CREBBP CDKN1A CDK6 CCNB3 CCNE2 CDK3 CCND1 CDK1 CCNO CDK5R1 CDK5 CCNA2 CCNA1 CKS1B EP300 SKP2 CDKN1B CCNB2	transferase complex
KEGG:04115	1.55621963266e-10	0.222222222222	CDKN1A CCNB2 CDK1 SIVA1 CCND1 CDK6 CDKN2A CCNE2	p53 signaling pathway
REAC:R-HSA-1362300	2.23161016436e-10	0.166666666667	E2F5 E2F4 RBL2 CDK1 RBL1 CCNA2	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
REAC:R-HSA-187577	4.32377125165e-10	0.222222222222	CDKN1A CCNA1 CCND1 CDKN1B CCNA2 CKS1B SKP2 CCNE2	SCF(Skp2)-mediated degradation of p27/p21
REAC:R-HSA-2559582	4.36837803727e-10	0.25	CDKN1A CDKN2C CCNA1 CDKN1B CDK6 CDKN2A CCNA2 CDKN2B CDKN2D	Senescence-Associated Secretory Phenotype (SASP)
REAC:R-HSA-9659787	5.49875037828e-10	0.166666666667	CDKN1A CCNE2 CDK6 CCND1 CDKN1B CDKN1C	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
REAC:R-HSA-9661069	5.49875037828e-10	0.166666666667	CDKN1A CCNE2 CDK6 CCND1 CDKN1B CDKN1C	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
REAC:R-HSA-9687139	5.95815711678e-10	0.194444444444	CDKN1A CCNE2 CDK6 CCND1 CDKN1B CDKN1C SKP2	Aberrant regulation of mitotic cell cycle due to RB1 defects
GO:0004861	6.01841138773e-10	0.166666666667	CDKN1A CDKN2C CDKN1B CDKN2A CDKN2B CDKN2D	cyclin-dependent protein serine/threonine kinase inhibitor activity
REAC:R-HSA-73857	6.16477372629e-10	0.527777777778	CDKN1A E2F5 CDK1 E2F4 CCND1 CCNE2 RBL2 CDKN2B CDK6 CDKN2A CDK5R1 CDK5 RBL1 CCNA1 CCNA2 EP300 SKP2 CDKN1B CREBBP	RNA Polymerase II Transcription
REAC:R-HSA-9675126	9.09045023944e-10	0.194444444444	CDKN1A CCNE2 CDK6 CCND1 CDKN1B CDKN1C SKP2	Diseases of mitotic cell cycle
GO:1901987	1.29776252121e-09	0.388888888889	CDT1 CDKN2C PKMYT1 CDKN1A CDK6 RBL1 CCND1 CDK3 RBL2 CDK1 CDKN2D CDKN2B CDKN1B CDKN2A	regulation of cell cycle phase transition
KEGG:05200	1.34420565425e-09	0.361111111111	CDKN1A CREBBP CDK6 CCNE2 CCND1 SKP2 CDKN1B CDKN2A CCNA2 CKS1B EP300 CDKN2B CCNA1	Pathways in cancer
WP:WP2261	1.42276819186e-09	0.222222222222	CDKN1A CDKN2C CCND1 CDK6 CDKN2A EP300 CDKN2B CDKN1B	Glioblastoma signaling pathways
KEGG:05222	1.79670254725e-09	0.222222222222	CDKN1A CCNE2 CDK6 CCND1 SKP2 CDKN1B CKS1B CDKN2B	Small cell lung cancer
HP:0006744	2.42861475041e-09	0.166666666667	CDKN1A CDKN1B CDKN2C CDKN2A CDKN1C CDKN2B	Adrenocortical carcinoma
REAC:R-HSA-2559583	2.858703733e-09	0.277777777778	CDKN1A CDKN2C CCNA1 CDKN1B CCNE2 CDK6 CDKN2A CCNA2 CDKN2B CDKN2D	Cellular Senescence
KEGG:05165	4.58625525135e-09	0.305555555556	CDKN1A CREBBP CDK6 RBL1 CCNE2 RBL2 CCND1 CDKN1B CCNA2 EP300 CCNA1	Human papillomavirus infection
WP:WP4658	4.67833776175e-09	0.222222222222	CDKN1A CCNE2 CDKN1B CCND1 CDK6 CKS1B CDKN1C CDKN2B	Small cell lung cancer
GO:0043549	5.15605946097e-09	0.388888888889	CDKN1A CDKN2C PKMYT1 CDKN1B RBL1 CCNE2 RBL2 CCND1 FGR CDKN2A CDKN2D CDKN1C CDKN2B CDK5R1	regulation of kinase activity
HP:0008261	5.25250155407e-09	0.138888888889	CDKN1B CCND1 CDKN2B CDKN1A CDKN2C	Pancreatic islet cell adenoma
REAC:R-HSA-74160	5.67448196129e-09	0.527777777778	CDKN1A E2F5 CDK1 E2F4 CCND1 CCNE2 RBL2 CDKN2B CDK6 CDKN2A CDK5R1 CDK5 RBL1 CCNA1 CCNA2 EP300 SKP2 CDKN1B CREBBP	Gene expression (Transcription)
CORUM:310	5.89332900986e-09	0.111111111111	CDK1 CCNB2 CDKN1A CCND1	Cell cycle kinase complex CDC2
HP:0100631	7.23261119236e-09	0.194444444444	CDKN1A CDKN1B CCND1 CDKN2C CDKN2A CDKN1C CDKN2B	Neoplasm of the adrenal gland
HP:0100641	1.96010658679e-08	0.166666666667	CDKN1A CDKN1B CDKN2C CDKN2A CDKN1C CDKN2B	Neoplasm of the adrenal cortex
HP:0002588	2.35527415167e-08	0.138888888889	CDKN1B EP300 CDKN2B CDKN1A CDKN2C	Duodenal ulcer
REAC:R-HSA-6804116	2.70906201256e-08	0.138888888889	CDKN1B CCNE2 CCNA1 CDKN1A CCNA2	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
GO:1901990	3.65973732352e-08	0.333333333333	CDK1 CDKN2C CCND1 CDKN1A CDKN1B RBL1 CDK3 RBL2 CDK6 CDKN2D CDKN2B CDKN2A	regulation of mitotic cell cycle phase transition
KEGG:04934	3.72547034035e-08	0.222222222222	CDKN1A CCNE2 CDKN2C CCND1 CDK6 CDKN2A CDKN2B CDKN1B	Cushing syndrome
HP:0030405	7.37613479773e-08	0.138888888889	CDKN1B CCND1 CDKN2B CDKN1A CDKN2C	Pancreatic endocrine tumor
GO:0005634	7.38754071466e-08	0.944444444444	CCNA1 CDK3 EP300 E2F4 CKS1B CDKN1C GMNN CREBBP CDT1 CCNE2 CDKN2C SIVA1 CCND1 CCNA2 CDK1 CCNO CDKN2D CDK5 RBL1 SKP2 E2F5 CDKN1A CCNB3 RBL2 CDKN1B CDK5R1 MIDEAS CCNB2 CCNI PKMYT1 CDKN2B CDK6 SCAPER CDKN2A	nucleus
CORUM:5118	8.80904371543e-08	0.111111111111	E2F4 EP300 E2F5 RBL2	RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2)
GO:0051338	1.26662904401e-07	0.388888888889	CDKN1A CDKN2C PKMYT1 CDKN1B RBL1 CCNE2 RBL2 CCND1 FGR CDKN2A CDKN2D CDKN1C CDKN2B CDK5R1	regulation of transferase activity
REAC:R-HSA-6804114	1.29335004987e-07	0.138888888889	E2F4 EP300 CDK1 RBL2 RBL1	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
KEGG:05206	1.43407964613e-07	0.222222222222	CDKN1A CREBBP EP300 CCND1 CDK6 CDKN2A CDKN1B CCNE2	MicroRNAs in cancer
GO:0045786	1.95907649368e-07	0.333333333333	CDT1 PKMYT1 CDKN1A CDK6 RBL1 RBL2 CCND1 CDK1 CDKN2A CDKN1C GMNN CDKN1B	negative regulation of cell cycle
GO:0000086	2.03088392851e-07	0.25	CDKN1A PKMYT1 CDK1 CDK3 CCND1 CDK6 CDKN2A CCNA2 SKP2	G2/M transition of mitotic cell cycle
HP:0040306	2.14893036519e-07	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Decreased male libido
HP:0012197	2.14893036519e-07	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Insulinoma
HP:0011762	2.14893036519e-07	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Pituitary thyrotropic cell adenoma
HP:0005605	2.14893036519e-07	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Large cafe-au-lait macules with irregular margins
HP:0011761	2.14893036519e-07	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Pituitary null cell adenoma
HP:0100522	2.14893036519e-07	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Thymoma
HP:0011759	2.14893036519e-07	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Pituitary gonadotropic cell adenoma
GO:0030234	3.90272680373e-07	0.472222222222	CCNI CCNB2 CDKN1A CDKN2C CCNB3 CCNE2 CCND1 CCNA2 CDKN1B CCNO CDKN2A CDKN2D CDKN1C CCNA1 CKS1B CDKN2B CDK5R1	enzyme regulator activity
GO:0044839	4.53099029656e-07	0.25	CDKN1A PKMYT1 CDK1 CDK3 CCND1 CDK6 CDKN2A CCNA2 SKP2	cell cycle G2/M phase transition
HP:0500166	6.43549582544e-07	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Abnormal circulating gastrin concentration
HP:0500167	6.43549582544e-07	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Hypergastrinemia
HP:0030404	6.43549582544e-07	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Glucagonoma
HP:0006723	6.43549582544e-07	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Intestinal carcinoid
HP:0006780	6.43549582544e-07	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Parathyroid carcinoma
KEGG:05169	6.72798922129e-07	0.222222222222	CDKN1A CCNA1 CDKN1B CCND1 CDK6 CCNA2 SKP2 CCNE2	Epstein-Barr virus infection
HP:0002888	7.89534642672e-07	0.138888888889	CDKN1B CDKN2C CDKN2B CDKN1A CDKN2A	Ependymoma
GO:2000045	8.19158250488e-07	0.25	CDKN1A CDKN2C RBL1 RBL2 CCND1 CDKN1B CDKN2A CDKN2B CDKN2D	regulation of G1/S transition of mitotic cell cycle
HP:0002858	8.45804727262e-07	0.166666666667	CDKN1A CREBBP CDKN2C CDKN1B EP300 CDKN2B	Meningioma
GO:0016310	8.84308166402e-07	0.472222222222	CDKN1A CDKN2C PKMYT1 CDK1 RBL1 CCNE2 RBL2 CCND1 FGR CDKN2A CDKN2D CDK5R1 CDKN1C CDK5 CDKN2B CDKN1B CDK6	phosphorylation
GO:0010564	9.2322748769e-07	0.388888888889	CDT1 CDKN2C PKMYT1 CDKN1A CDK6 RBL1 CCND1 CDK3 RBL2 CDK1 CDKN2D CDKN2B CDKN1B CDKN2A	regulation of cell cycle process
GO:0045859	1.030191771e-06	0.333333333333	CDKN1A CDKN2C PKMYT1 FGR CCNE2 CCND1 CDKN1B CDKN2A CDK5R1 CDKN1C CDKN2B CDKN2D	regulation of protein kinase activity
REAC:R-HSA-69273	1.09485364687e-06	0.138888888889	CCNA1 CDK1 PKMYT1 CCNA2 CCNB2	Cyclin A/B1/B2 associated events during G2/M transition
GO:0071900	1.26780481391e-06	0.277777777778	CDKN1A PKMYT1 CDKN2C CCNE2 CCND1 CDKN1B CDKN2A CDKN2D CDKN2B CDK5R1	regulation of protein serine/threonine kinase activity
HP:0031094	1.4989847898e-06	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Abnormal breast physiology
HP:0040085	1.4989847898e-06	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Abnormal circulating aldosterone
HP:0006767	1.4989847898e-06	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Pituitary prolactin cell adenoma
HP:0100829	1.4989847898e-06	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Galactorrhea
HP:0100521	1.4989847898e-06	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Neoplasm of the thymus
GO:1902494	1.52044645254e-06	0.555555555556	CCNI CREBBP CDKN1A CDK6 CCNB3 CCNE2 CDK3 CCNA2 CCND1 CDK1 CCNO CDK5R1 CDK5 MIDEAS CCNA1 CKS1B EP300 SKP2 CDKN1B CCNB2	catalytic complex
REAC:R-HSA-2262752	2.4122678881e-06	0.361111111111	CDKN1A CDKN2C CREBBP CDKN1B CCNE2 SKP2 CDK6 CDKN2D CCNA1 CCNA2 EP300 CDKN2B CDKN2A	Cellular responses to stress
CORUM:1661	2.60949465128e-06	0.0833333333333	E2F4 CCNA2 RBL1	E2F4-p107-cyclinA complex
CORUM:313	2.60949465128e-06	0.0833333333333	CDKN1A CCND1 CDK5	Cell cycle kinase complex CDK5
GO:0030291	2.61037745369e-06	0.166666666667	CDKN1A CDKN2C CDKN1B CDKN2A CDKN2B CDKN2D	protein serine/threonine kinase inhibitor activity
REAC:R-HSA-8953897	2.70798318021e-06	0.361111111111	CDKN1A CDKN2C CREBBP CDKN1B CCNE2 SKP2 CDK6 CDKN2D CCNA1 CCNA2 EP300 CDKN2B CDKN2A	Cellular responses to stimuli
WP:WP2877	2.77813774049e-06	0.194444444444	CDKN1A CDKN2C CCND1 CDKN1B CDKN2A CDKN2B CDKN2D	Vitamin D receptor pathway
HP:0011732	2.87307988898e-06	0.194444444444	CDKN1A CDKN1B CCND1 CDKN2C CDKN2A CDKN1C CDKN2B	Abnormal adrenal morphology
HP:0031071	2.87307988898e-06	0.194444444444	CDKN1A CDKN1B CCND1 CDKN2C CDKN2A CDKN1C CDKN2B	Abnormal endocrine morphology
KEGG:04914	2.90621268088e-06	0.166666666667	PKMYT1 CCNA1 CCNB3 CDK1 CCNA2 CCNB2	Progesterone-mediated oocyte maturation
HP:0001579	2.99271707805e-06	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Primary hypercortisolism
REAC:R-HSA-69563	3.06625783192e-06	0.166666666667	CDKN1A CCNA1 CDKN1B CDKN2A CCNA2 CCNE2	p53-Dependent G1 DNA Damage Response
REAC:R-HSA-69580	3.06625783192e-06	0.166666666667	CDKN1A CCNA1 CDKN1B CDKN2A CCNA2 CCNE2	p53-Dependent G1/S DNA damage checkpoint
GO:1902806	3.2692138701e-06	0.25	CDKN1A CDKN2C RBL1 RBL2 CCND1 CDKN1B CDKN2A CDKN2B CDKN2D	regulation of cell cycle G1/S phase transition
REAC:R-HSA-69615	3.70280175395e-06	0.166666666667	CDKN1A CCNA1 CDKN1B CDKN2A CCNA2 CCNE2	G1/S DNA Damage Checkpoints
HP:0003118	3.87533625281e-06	0.138888888889	CDKN1B CDKN2C CDKN2B CDKN1A CDKN2A	Increased circulating cortisol level
WP:WP1545	3.94955165305e-06	0.111111111111	CDK6 CCND1 CDKN1A CDKN1B	miRNAs involved in DNA damage response
KEGG:04350	4.15433709991e-06	0.166666666667	CREBBP E2F4 EP300 RBL1 CDKN2B E2F5	TGF-beta signaling pathway
REAC:R-HSA-170145	4.31633392004e-06	0.0833333333333	CDK1 CCNA1 CCNA2	Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
WP:000000	4.32530923444e-06	0.888888888889	CCNA1 RBL2 FGR CDKN2A CDKN1C SIVA1 GMNN E2F5 CDT1 CCNE2 CDKN2C E2F4 CCND1 CCNA2 CDK1 CCNO CDKN2D RBL1 SKP2 CREBBP CDKN1A CCNB3 CDKN1B CDK5R1 CKS1B CCNB2 PKMYT1 EP300 CDKN2B CDK6 SCAPER CDK5	WIKIPATHWAYS
GO:0004860	4.60943338853e-06	0.194444444444	CDKN1A CDKN1B CDKN2C CDKN2A CDKN1C CDKN2B CDKN2D	protein kinase inhibitor activity
REAC:R-HSA-2559585	4.82203074708e-06	0.138888888889	CDK6 CDKN2C CDKN2A CDKN2D CDKN2B	Oncogene Induced Senescence
KEGG:05215	5.09502296351e-06	0.166666666667	CDKN1A CCNE2 EP300 CCND1 CDKN1B CREBBP	Prostate cancer
HP:0100006	5.33677053973e-06	0.222222222222	CDKN1A CREBBP CDKN2C CCND1 CDKN1B CDKN2A EP300 CDKN2B	Neoplasm of the central nervous system
HP:0030445	5.3774529555e-06	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Pulmonary carcinoid tumor
HP:0008208	5.3774529555e-06	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Parathyroid hyperplasia
HP:0032044	5.3774529555e-06	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Decreased vigilance
HP:0007449	5.3774529555e-06	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Confetti-like hypopigmented macules
HP:0046504	5.3774529555e-06	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Decreased libido
HP:0002044	5.3774529555e-06	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Zollinger-Ellison syndrome
HP:0000849	5.3774529555e-06	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Adrenocortical abnormality
REAC:R-HSA-69620	5.57994697143e-06	0.25	CDKN1A CCNB2 CDKN1B CCNE2 CDK1 CDKN2A CCNA1 CCNA2 PKMYT1	Cell Cycle Checkpoints
HP:0100835	5.59364754987e-06	0.194444444444	CDKN1A CREBBP CDKN2C CCND1 CDKN1B EP300 CDKN2B	Benign neoplasm of the central nervous system
HP:0002666	5.97635007471e-06	0.138888888889	CDKN1B CCND1 CDKN2B CDKN1A CDKN2C	Pheochromocytoma
GO:0019220	6.43206541928e-06	0.416666666667	CDKN1A CDKN2C PKMYT1 CDKN1B RBL1 CCNE2 RBL2 CCND1 FGR CDKN2A CDKN2D CDKN1C EP300 CDKN2B CDK5R1	regulation of phosphate metabolic process
GO:0051174	6.54942394588e-06	0.416666666667	CDKN1A CDKN2C PKMYT1 CDKN1B RBL1 CCNE2 RBL2 CCND1 FGR CDKN2A CDKN2D CDKN1C EP300 CDKN2B CDK5R1	regulation of phosphorus metabolic process
HP:0006476	7.32164031206e-06	0.138888888889	CDKN1B CCND1 CDKN2B CDKN1A CDKN2C	Abnormality of the pancreatic islet cells
HP:0003072	7.38886089902e-06	0.166666666667	CDKN1A CDKN1B CCND1 CDKN2C CDKN1C CDKN2B	Hypercalcemia
GO:0019210	7.42360717054e-06	0.194444444444	CDKN1A CDKN1B CDKN2C CDKN2A CDKN1C CDKN2B CDKN2D	kinase inhibitor activity
REAC:R-HSA-2173796	7.61889847096e-06	0.138888888889	E2F4 CDKN2B EP300 E2F5 RBL1	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
GO:0031981	8.6671523513e-06	0.777777777778	CCNA1 RBL2 EP300 CDKN2A MIDEAS SIVA1 GMNN E2F5 CDT1 CCNE2 E2F4 CCND1 CDK1 CCNO CDKN2D CKS1B RBL1 SKP2 CREBBP CDKN1A CCNB3 CDKN1B CDK5R1 CCNA2 PKMYT1 CDK6 SCAPER CDK5	nuclear lumen
HP:0012093	8.89753810059e-06	0.138888888889	CDKN1B CCND1 CDKN2B CDKN1A CDKN2C	Abnormality of endocrine pancreas physiology
HP:0008200	8.94671976481e-06	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Primary hyperparathyroidism
HP:0012232	8.94671976481e-06	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Shortened QT interval
GO:0042325	9.46586927738e-06	0.388888888889	CDKN1A CDKN2C PKMYT1 CDKN1B RBL1 CCNE2 RBL2 CCND1 FGR CDKN2A CDKN2D CDKN1C CDKN2B CDK5R1	regulation of phosphorylation
HP:0004375	1.08671223748e-05	0.222222222222	CDKN1A CREBBP CDKN2C CCND1 CDKN1B CDKN2A EP300 CDKN2B	Neoplasm of the nervous system
HP:0000787	1.09274790538e-05	0.194444444444	CDKN1A CREBBP EP300 CDKN2C CDKN1C CDKN2B CDKN1B	Nephrolithiasis
HP:0030448	1.23971862518e-05	0.194444444444	CDKN1A CDKN2C CCND1 CDKN1B CDKN2A EP300 CDKN2B	Soft tissue sarcoma
HP:0000845	1.40345003891e-05	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Elevated circulating growth hormone concentration
GO:0005654	1.6205536621e-05	0.75	CCNA1 RBL2 EP300 CDKN2A MIDEAS SIVA1 GMNN E2F5 CDT1 CCNE2 E2F4 CCND1 CDK1 CDKN2D CKS1B RBL1 SKP2 CREBBP CDKN1A CCNB3 CDKN1B CDK5R1 CCNA2 PKMYT1 CDK6 SCAPER CDK5	nucleoplasm
HP:0007378	1.7957576179e-05	0.25	CDKN1A CREBBP CDKN1B CCND1 CDKN2C CDKN2A CDKN1C EP300 CDKN2B	Neoplasm of the gastrointestinal tract
HP:0034930	1.7957576179e-05	0.25	CDKN1A CREBBP CDKN1B CCND1 CDKN2C CDKN2A CDKN1C EP300 CDKN2B	Digestive system neoplasm
GO:0098772	1.88593365675e-05	0.5	CCNI CCNB2 CDKN1A CDKN2C CCNB3 CCNE2 CCND1 CCNA2 CDKN1B CCNO CDKN2A CDKN2D CDK5 CDKN1C CCNA1 CKS1B CDKN2B CDK5R1	molecular function regulator activity
HP:0003144	2.10148699096e-05	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Increased serum serotonin
HP:0008291	2.10148699096e-05	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Pituitary corticotropic cell adenoma
REAC:R-HSA-5633007	2.33593187673e-05	0.194444444444	CCNA1 EP300 CDK1 CDK5R1 CDK5 CCNA2 CDKN2A	Regulation of TP53 Activity
REAC:R-HSA-69052	2.43215247126e-05	0.166666666667	CDT1 CCNA1 GMNN CCNA2 SKP2 CCNE2	Switching of origins to a post-replicative state
HP:0100634	2.4925091158e-05	0.138888888889	CDKN1B CCND1 CDKN2B CDKN1A CDKN2C	Neuroendocrine neoplasm
HP:0002717	2.4925091158e-05	0.138888888889	CDKN1B CDKN2C CDKN2B CDKN1A CDKN2A	Adrenal overactivity
CORUM:5117	2.60066240206e-05	0.0833333333333	E2F4 E2F5 RBL2	RBL2 complex (DNMT1, E2F4, E2F5, HDAC1, SUV39H1, RBL2)
CORUM:2975	2.60066240206e-05	0.0833333333333	E2F4 E2F5 RBL1	SMAD3-E2F4/5-p107-DP1 complex
CORUM:1471	2.60066240206e-05	0.0833333333333	EP300 E2F5 RBL2	pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300)
REAC:R-HSA-1362277	2.91057981686e-05	0.111111111111	RBL2 E2F4 E2F5 RBL1	Transcription of E2F targets under negative control by DREAM complex
HP:0100570	3.03016342077e-05	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Carcinoid tumor
HP:0011151	3.03016342077e-05	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Atypical absence status epilepticus
GO:0006468	3.66310448131e-05	0.416666666667	CDK1 CDKN2C PKMYT1 CDKN1A CDK6 CCNE2 CCND1 FGR CDKN2A CDKN2D CDK5 CDKN1C CDKN2B CDKN1B CDK5R1	protein phosphorylation
REAC:R-HSA-2173793	4.17713400699e-05	0.138888888889	E2F4 CDKN2B EP300 E2F5 RBL1	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
HP:0032860	4.23479705021e-05	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Generalized non-convulsive status epilepticus without coma
GO:0065009	4.26542520115e-05	0.5	CDT1 CDKN2C PKMYT1 CDKN1A CDKN1B SIVA1 CCND1 CCNE2 RBL2 CDKN2B FGR CDKN2A CDKN2D RBL1 CDKN1C EP300 GMNN CDK5R1	regulation of molecular function
REAC:R-HSA-69478	4.30172460215e-05	0.0833333333333	CDK1 PKMYT1 CCNB2	G2/M DNA replication checkpoint
HP:0100568	4.32235491477e-05	0.194444444444	CDKN1A CDKN1B CCND1 CDKN2C CDKN2A CDKN1C CDKN2B	Neoplasm of the endocrine system
HP:0002894	4.88971481379e-05	0.166666666667	CDKN1A CDKN2C CCND1 CDKN1B CDKN2A CDKN2B	Neoplasm of the pancreas
CORUM:1474	5.1925157604e-05	0.0833333333333	E2F4 E2F5 RBL1	SMAD3/4-E2F4/5-p107-DP1 complex
CORUM:3015	5.1925157604e-05	0.0833333333333	CKS1B SKP2 CDKN1B	p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex
HP:0011407	5.76460698142e-05	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Proportionate tall stature
HP:0100733	5.76460698142e-05	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Neoplasm of the parathyroid gland
HP:0011760	5.76460698142e-05	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Pituitary growth hormone cell adenoma
GO:0019901	5.95722942471e-05	0.333333333333	TRIM49 CDKN2C CDKN1A CDKN1B CCND1 FGR CDKN2A CDK5R1 CCNA2 CKS1B CDKN2B CDKN2D	protein kinase binding
KEGG:05220	6.3761757335e-05	0.138888888889	CDK6 CCND1 CDKN2A CDKN1A CDKN1B	Chronic myeloid leukemia
HP:0410266	7.61260704598e-05	0.0833333333333	EP300 CREBBP CCND1	Visceral hemangioma
HP:0031207	7.61260704598e-05	0.0833333333333	EP300 CREBBP CCND1	Hepatic hemangioma
HP:0002248	7.67267813535e-05	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Hematemesis
HP:0032671	7.67267813535e-05	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Non-convulsive status epilepticus without coma
HP:0010785	8.16908203535e-05	0.166666666667	CREBBP CDKN1B CCND1 EP300 CDKN2A CDKN1C	Gonadal neoplasm
WP:WP3981	9.12798405277e-05	0.111111111111	CDKN1B CREBBP CDKN1A CCND1	miRNA regulation of prostate cancer signaling pathways
GO:1902749	9.56412418811e-05	0.194444444444	CDKN1A PKMYT1 CDK6 CCND1 CDK3 CDK1 CDKN2A	regulation of cell cycle G2/M phase transition
KEGG:05161	9.72984402159e-05	0.166666666667	CDKN1A CCNE2 EP300 CCNA1 CCNA2 CREBBP	Hepatitis B
GO:0031323	9.73870577508e-05	0.777777777778	TRIM49 RBL2 FGR CDKN2A MIDEAS CDKN1C GMNN E2F5 CDT1 CCNE2 CDKN2C SIVA1 CCND1 CDK1 CDKN2D CDKN2B CREBBP CDKN1A RBL1 CDK3 CDKN1B CDK5R1 CCNA2 PKMYT1 EP300 CDK6 E2F4 CDK5	regulation of cellular metabolic process
HP:0000169	0.000100159258815	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Gingival fibromatosis
REAC:R-HSA-69275	0.000103457158412	0.194444444444	CDKN1A CCNA1 EP300 CDK1 CCNB2 CCNA2 PKMYT1	G2/M Transition
REAC:R-HSA-9614085	0.000105784186167	0.138888888889	CDKN1B EP300 CREBBP CDKN1A RBL2	FOXO-mediated transcription
KEGG:01522	0.000106481811264	0.138888888889	CDKN1B CCND1 CDKN2A CDKN1A CDKN2C	Endocrine resistance
HP:0009733	0.000107329970416	0.138888888889	CDKN1B CDKN2C CDKN2B CDKN1A CDKN2A	Glioma
HP:0034274	0.000107329970416	0.138888888889	CDKN1B EP300 CDKN2B CDKN1A CDKN2C	Gastrointestinal ulcer
REAC:R-HSA-453274	0.000111111649239	0.194444444444	CDKN1A CCNA1 EP300 CDK1 CCNB2 CCNA2 PKMYT1	Mitotic G2-G2/M phases
HP:0100242	0.000123330497021	0.194444444444	CDKN1A CDKN2C CCND1 CDKN1B CDKN2A EP300 CDKN2B	Sarcoma
HP:0002249	0.000128550608578	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Melena
HP:0032367	0.000128550608578	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Abnormal growth hormone level
HP:0011766	0.000128550608578	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Abnormal parathyroid morphology
REAC:R-HSA-69239	0.000128788735759	0.166666666667	CDT1 CCNA1 GMNN CCNA2 SKP2 CCNE2	Synthesis of DNA
HP:0000847	0.000162545539808	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Abnormality of renin-angiotensin system
HP:0031475	0.000162545539808	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Status epilepticus without prominent motor symptoms
HP:0002890	0.000166335286676	0.138888888889	CDKN1B CDKN2C CDKN2B CDKN1A CDKN2A	Thyroid carcinoma
HP:0011731	0.000166335286676	0.138888888889	CDKN1B CDKN2C CDKN2B CDKN1A CDKN2A	Abnormality of circulating cortisol level
HP:0012111	0.000184490085309	0.138888888889	CDKN1B CDKN2C CDKN2B CDKN1A CDKN2A	Abnormality of circulating glucocorticoid level
REAC:R-HSA-2559586	0.00018475524509	0.138888888889	CDKN1B CCNE2 CCNA1 CDKN1A CCNA2	DNA Damage/Telomere Stress Induced Senescence
HP:0030421	0.000189992836595	0.0833333333333	EP300 CREBBP CCND1	Epididymal neoplasm
HP:0009715	0.000189992836595	0.0833333333333	EP300 CREBBP CCND1	Papillary cystadenoma of the epididymis
HP:0002039	0.000190278520077	0.166666666667	CDKN1A CDKN2C CCND1 CDKN1B CDKN2A CDKN2B	Anorexia
HP:0003528	0.000202826016438	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Elevated circulating calcitonin concentration
HP:0034902	0.000202826016438	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Abnormal circulating calcitonin concentration
GO:0030332	0.00021514860269	0.138888888889	CDK1 CDKN1A CDK3 CDKN1B CDK6	cyclin binding
HP:0000834	0.000222158751496	0.194444444444	CDKN1A CDKN1B CCND1 CDKN2C CDKN2A CDKN1C CDKN2B	Abnormality of the adrenal glands
WP:WP3998	0.000222404913645	0.138888888889	CDK6 CCND1 CDKN2C CDKN2B CDKN2A	Prader Willi and Angelman syndrome
HP:0002150	0.00022550342694	0.138888888889	CDKN1C CDKN2C CDKN2B CDKN1A CDKN1B	Hypercalciuria
GO:0043233	0.000239517484451	0.805555555556	CCNA1 RBL2 FGR CDKN2A MIDEAS SIVA1 GMNN E2F5 CDT1 CCNE2 E2F4 CCND1 CDK1 CCNO CDKN2D CKS1B RBL1 SKP2 CREBBP CDKN1A CCNB3 CDKN1B CDK5R1 CCNA2 PKMYT1 EP300 CDK6 SCAPER CDK5	organelle lumen
GO:0070013	0.000239517484451	0.805555555556	CCNA1 RBL2 FGR CDKN2A MIDEAS SIVA1 GMNN E2F5 CDT1 CCNE2 E2F4 CCND1 CDK1 CCNO CDKN2D CKS1B RBL1 SKP2 CREBBP CDKN1A CCNB3 CDKN1B CDK5R1 CCNA2 PKMYT1 EP300 CDK6 SCAPER CDK5	intracellular organelle lumen
GO:0031974	0.000239517484451	0.805555555556	CCNA1 RBL2 FGR CDKN2A MIDEAS SIVA1 GMNN E2F5 CDT1 CCNE2 E2F4 CCND1 CDK1 CCNO CDKN2D CKS1B RBL1 SKP2 CREBBP CDKN1A CCNB3 CDKN1B CDK5R1 CCNA2 PKMYT1 EP300 CDK6 SCAPER CDK5	membrane-enclosed lumen
GO:0019900	0.000245182934472	0.333333333333	TRIM49 CDKN2C CDKN1A CDKN1B CCND1 FGR CDKN2A CDK5R1 CCNA2 CKS1B CDKN2B CDKN2D	kinase binding
HP:0000843	0.000250110911036	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Hyperparathyroidism
HP:0001034	0.00025033467586	0.194444444444	CDKN1A CREBBP EP300 CDKN2C CDKN1C CDKN2B CDKN1B	Hypermelanotic macule
HP:0011280	0.000329094406161	0.138888888889	CDKN1C CDKN2C CDKN2B CDKN1A CDKN1B	Abnormality of urine calcium concentration
WP:WP1971	0.000344523061426	0.111111111111	CDK1 CDKN2B CDKN1A CDKN1B	Integrated cancer pathway
GO:0036211	0.000345112105872	0.555555555556	TRIM49 CDKN2C PKMYT1 CDKN1A CDK1 CCNE2 CCND1 CDKN2B FGR CDK5 CDKN2A CDKN2D CDK5R1 CCNA2 CDKN1C CREBBP EP300 SKP2 CDKN1B CDK6	protein modification process
WP:WP3611	0.000462792818609	0.111111111111	CCNA2 CDKN2A CDKN1A CCND1	Photodynamic therapy induced AP 1 survival signaling
REAC:R-HSA-6804757	0.000483409642775	0.111111111111	CCNA1 CDK1 CDKN2A CCNA2	Regulation of TP53 Degradation
HP:0100007	0.000508028730979	0.138888888889	CDKN1B CCND1 CDKN2B CDKN1A CDKN2C	Neoplasm of the peripheral nervous system
HP:0020073	0.000524944696229	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Hypopigmented macule
REAC:R-HSA-6806003	0.000542883485813	0.111111111111	CCNA1 CDK1 CDKN2A CCNA2	Regulation of TP53 Expression and Degradation
WP:WP710	0.000587708161822	0.138888888889	CDKN1B CCND1 RBL2 CDKN1A CDKN2A	DNA damage response only ATM dependent
HP:0007400	0.000670180082285	0.194444444444	CDKN1A CREBBP EP300 CDKN2C CDKN1C CDKN2B CDKN1B	Irregular hyperpigmentation
REAC:R-HSA-170834	0.000682273381027	0.138888888889	E2F4 CDKN2B EP300 E2F5 RBL1	Signaling by TGF-beta Receptor Complex
GO:0001932	0.000685869876174	0.333333333333	CDKN1A CDKN2C PKMYT1 FGR CCNE2 CCND1 CDKN1B CDKN2A CDK5R1 CDKN1C CDKN2B CDKN2D	regulation of protein phosphorylation
GO:0060255	0.000718111858574	0.75	TRIM49 RBL2 FGR CDKN2A MIDEAS CDKN1C GMNN E2F5 CDT1 CCNE2 CDK6 SIVA1 CCND1 CDKN2D CDKN2B CREBBP CDKN1A RBL1 CDK3 CDKN1B CDK5R1 CCNA2 PKMYT1 EP300 CDKN2C E2F4 CDK5	regulation of macromolecule metabolic process
REAC:R-HSA-8878159	0.000722094391495	0.138888888889	EP300 CCND1 CREBBP CDKN1A CDKN2A	Transcriptional regulation by RUNX3
HP:0012733	0.000741076845187	0.194444444444	CDKN1A CREBBP EP300 CDKN2C CDKN1C CDKN2B CDKN1B	Macule
HP:0011792	0.000750780513638	0.222222222222	CDKN1A CDKN1B CCND1 CDKN2C CDKN2A CDKN1C EP300 CDKN2B	Neoplasm by histology
GO:0019222	0.000756153118706	0.777777777778	TRIM49 RBL2 FGR CDKN2A MIDEAS CDKN1C GMNN E2F5 CDT1 CCNE2 CDKN2C SIVA1 CCND1 CDK1 CDKN2D CDKN2B CREBBP CDKN1A RBL1 CDK3 CDKN1B CDK5R1 CCNA2 PKMYT1 EP300 CDK6 E2F4 CDK5	regulation of metabolic process
HP:0004363	0.000760777839173	0.166666666667	CDKN1A CDKN1B CCND1 CDKN2C CDKN1C CDKN2B	Abnormal circulating calcium concentration
WP:WP4970	0.000792691593342	0.0833333333333	CDKN1C CDKN1A CDKN1B	Galanin receptor pathway
GO:0090398	0.000843629388003	0.166666666667	CDKN1A CDK6 RBL1 CDKN1B CDKN2A CDKN2B	cellular senescence
HP:0001012	0.000845206795751	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Multiple lipomas
HP:0010787	0.00091607631336	0.166666666667	CREBBP CDKN1B CCND1 EP300 CDKN2A CDKN1C	Genital neoplasm
GO:0050790	0.00100722317732	0.388888888889	CDKN1A CDKN2C PKMYT1 CDKN1B RBL1 CCNE2 RBL2 CCND1 FGR CDKN2A CDKN2D CDKN1C CDKN2B CDK5R1	regulation of catalytic activity
KEGG:05218	0.00102905101746	0.111111111111	CDK6 CDKN2A CDKN1A CCND1	Melanoma
KEGG:05226	0.00106486932673	0.138888888889	CDKN1B CCNE2 CDKN2B CDKN1A CCND1	Gastric cancer
CORUM:5160	0.00112154545115	0.0555555555556	E2F4 RBL2	E2F4-p130 complex
CORUM:6140	0.00112154545115	0.0555555555556	CDT1 GMNN	Cdt1-Geminin complex
CORUM:5159	0.00112154545115	0.0555555555556	E2F4 RBL1	E2F4-p107-cyclinE complex
CORUM:5542	0.00112154545115	0.0555555555556	CDK1 CCNB2	CCNB2-CDC2 complex
CORUM:312	0.00112154545115	0.0555555555556	CDKN1A CCND1	Cell cycle kinase complex CDK4
CORUM:5101	0.00112154545115	0.0555555555556	CDK6 CDKN1A	CyclinD3-CDK4-CDK6-p21 complex
CORUM:311	0.00112154545115	0.0555555555556	CDKN1A CCND1	Cell cycle kinase complex CDK2
CORUM:5557	0.00112154545115	0.0555555555556	CDK1 CCNA2	CDC2-CCNA2 complex
CORUM:3087	0.00112154545115	0.0555555555556	CDK6 CCND1	CCND1-CDK6 complex
CORUM:1634	0.00112154545115	0.0555555555556	CDKN1A CCND1	CyclinD1-CDK4-p21 complex
CORUM:5559	0.00112154545115	0.0555555555556	CDK1 CCNA2	CDC2-CCNA2-CDK2 complex
CORUM:1633	0.00112154545115	0.0555555555556	CDK6 CCND1	CyclinD1-CDK4-CDK6 complex
REAC:R-HSA-69306	0.00118972821933	0.166666666667	CDT1 CCNA1 GMNN CCNA2 SKP2 CCNE2	DNA Replication
GO:0006796	0.00123096031759	0.5	CDKN1A CDKN2C PKMYT1 CDK1 RBL1 CCNE2 RBL2 CCND1 FGR CDK5 CDKN2A CDKN2D CDK5R1 CDKN1C EP300 CDKN2B CDKN1B CDK6	phosphate-containing compound metabolic process
HP:0010615	0.00129206084704	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Angiofibromas
GO:1901988	0.00130803025886	0.222222222222	CDT1 PKMYT1 CDK1 RBL1 RBL2 CCND1 CDKN1B CDKN1A	negative regulation of cell cycle phase transition
HP:0010927	0.00136191347611	0.166666666667	CDKN1A CDKN1B CCND1 CDKN2C CDKN1C CDKN2B	Abnormal blood inorganic cation concentration
GO:0006793	0.00143436701117	0.5	CDKN1A CDKN2C PKMYT1 CDK1 RBL1 CCNE2 RBL2 CCND1 FGR CDK5 CDKN2A CDKN2D CDK5R1 CDKN1C EP300 CDKN2B CDKN1B CDK6	phosphorus metabolic process
GO:0043412	0.0014548290467	0.555555555556	TRIM49 CDKN2C PKMYT1 CDKN1A CDK1 CCNE2 CCND1 CDKN2B FGR CDK5 CDKN2A CDKN2D CDK5R1 CCNA2 CDKN1C CREBBP EP300 SKP2 CDKN1B CDK6	macromolecule modification
KEGG:05223	0.0014865802528	0.111111111111	CDK6 CDKN2A CDKN1A CCND1	Non-small cell lung cancer
KEGG:05214	0.0014865802528	0.111111111111	CDK6 CDKN2A CDKN1A CCND1	Glioma
REAC:R-HSA-9755511	0.00164771590158	0.138888888889	EP300 CDKN2A SKP2 CDKN1A CREBBP	KEAP1-NFE2L2 pathway
HP:0031845	0.00167443526194	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Abnormal libido
HP:0100530	0.00167443526194	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Abnormal circulating calcium-phosphate regulating hormone concentration
HP:0012091	0.00174769378495	0.166666666667	CDKN1A CDKN2C CCND1 CDKN1B CDKN2A CDKN2B	Abnormality of pancreas physiology
WP:WP4685	0.00177498384736	0.111111111111	CDK6 CDKN2A CDKN1A CCND1	Melanoma
HP:0002246	0.00186422547535	0.138888888889	CDKN1B EP300 CDKN2B CDKN1A CDKN2C	Abnormal duodenum morphology
KEGG:05212	0.00186484369183	0.111111111111	CDK6 CDKN2A CDKN1A CCND1	Pancreatic cancer
REAC:R-HSA-2559580	0.00189466482207	0.138888888889	CDK6 CDKN2C CDKN2A CDKN2D CDKN2B	Oxidative Stress Induced Senescence
REAC:R-HSA-156711	0.00192439594359	0.0833333333333	EP300 PKMYT1 CCNB2	Polo-like kinase mediated events
REAC:R-HSA-9006936	0.00198312368648	0.138888888889	E2F4 CDKN2B EP300 E2F5 RBL1	Signaling by TGFB family members
HP:0100031	0.00198498926817	0.138888888889	CDKN1B CDKN2C CDKN2B CDKN1A CDKN2A	Neoplasm of the thyroid gland
GO:0010389	0.00204802525358	0.166666666667	CDKN1A CDK6 CCND1 CDK3 CDK1 CDKN2A	regulation of G2/M transition of mitotic cell cycle
HP:0030063	0.00211183793118	0.138888888889	CDKN1B CDKN2C CDKN2B CDKN1A CDKN2A	Neuroepithelial neoplasm
HP:0000098	0.00221865182942	0.166666666667	CDKN1A CDKN1B CCND1 CDKN2C CDKN1C CDKN2B	Tall stature
HP:0030061	0.00224499152082	0.138888888889	CDKN1B CDKN2C CDKN2B CDKN1A CDKN2A	Neuroectodermal neoplasm
HP:0030060	0.00224499152082	0.138888888889	CDKN1B CDKN2C CDKN2B CDKN1A CDKN2A	Nervous tissue neoplasm
HP:0009714	0.00226067508393	0.0833333333333	EP300 CREBBP CCND1	Abnormal epididymis morphology
REAC:R-HSA-9617828	0.0023644783687	0.0833333333333	CDKN1B RBL2 CDKN1A	FOXO-mediated transcription of cell cycle genes
KEGG:05202	0.00239541441125	0.138888888889	CDKN1B CDKN2C CCNA1 CDKN1A CCNA2	Transcriptional misregulation in cancer
HP:0004398	0.00239773539568	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Peptic ulcer
GO:0031324	0.00271376290373	0.5	CDT1 CDKN2C CREBBP CDKN1A CDKN1B RBL1 CCND1 RBL2 CDKN2B CDK6 CDKN2A CDKN2D CDK5 MIDEAS CDKN1C EP300 GMNN CDK5R1	negative regulation of cellular metabolic process
WP:WP4255	0.00275597104831	0.111111111111	CDK6 CDKN2A CDKN1A CCND1	Non small cell lung cancer
GO:0097472	0.00276216412873	0.111111111111	CDK1 CDK3 CDK5 CDK6	cyclin-dependent protein kinase activity
GO:0004693	0.00276216412873	0.111111111111	CDK1 CDK3 CDK5 CDK6	cyclin-dependent protein serine/threonine kinase activity
HP:0025085	0.00299413485231	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Bloody diarrhea
GO:0031399	0.00314650063973	0.361111111111	CDKN1A CDKN2C PKMYT1 FGR CCNE2 CCND1 CDKN1B CDKN2A CDK5R1 CDKN1C EP300 CDKN2B CDKN2D	regulation of protein modification process
HP:0100836	0.0031892502291	0.138888888889	CDKN1B CDKN2C CDKN2B CDKN1A CDKN2A	Malignant neoplasm of the central nervous system
HP:0012591	0.0031892502291	0.138888888889	CDKN1C CDKN2C CDKN2B CDKN1A CDKN1B	Abnormal urinary electrolyte concentration
WP:WP4674	0.00327952687684	0.111111111111	CDK6 CDKN2A CDKN1A CCND1	Head and neck squamous cell carcinoma
CORUM:5144	0.00335941736415	0.0555555555556	RBL1 CCNA2	E2F1-p107-cyclinA complex
CORUM:6954	0.00335941736415	0.0555555555556	CDT1 GMNN	Idas-Geminin-Cdt1 complex
CORUM:571	0.00335941736415	0.0555555555556	EP300 CREBBP	p300-CBP-p270 complex
CORUM:4	0.00335941736415	0.0555555555556	EP300 CREBBP	Multisubunit ACTR coactivator complex
CORUM:1473	0.00335941736415	0.0555555555556	E2F5 RBL2	E2F5-RB2-DP1 complex
CORUM:6300	0.00335941736415	0.0555555555556	CDK1 CDKN1A	CDKN1A-TP53-CDK1-PCNA complex
REAC:R-HSA-9768919	0.00343373023154	0.0833333333333	CREBBP CDK5 CDK5R1	NPAS4 regulates expression of target genes
KEGG:05167	0.00351946718412	0.138888888889	CDK6 EP300 CREBBP CDKN1A CCND1	Kaposi sarcoma-associated herpesvirus infection
HP:0002242	0.00384223732936	0.277777777778	CDKN1A CREBBP CDKN1B SCAPER CCND1 CDKN2C CDKN2A CCNO EP300 CDKN2B	Abnormal intestine morphology
HP:0200013	0.00408624215942	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Neoplasm of fatty tissue
HP:0012031	0.00408624215942	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Lipomatous tumor
KEGG:04151	0.00417177966827	0.166666666667	CDKN1A CCNE2 CDKN1B CCND1 RBL2 CDK6	PI3K-Akt signaling pathway
HP:0010929	0.0041869536936	0.194444444444	CDKN1A CDKN1B CCND1 CDKN2C CDKN2A CDKN1C CDKN2B	Abnormal blood cation concentration
GO:0010948	0.00434549094588	0.222222222222	CDT1 PKMYT1 CDK1 RBL1 RBL2 CCND1 CDKN1B CDKN1A	negative regulation of cell cycle process
HP:0011747	0.00440222943284	0.194444444444	CDKN1A CDKN1B GMNN CDKN2C CDKN2A CDKN1C CDKN2B	Abnormality of the anterior pituitary
HP:0000953	0.00462668477392	0.194444444444	CDKN1A CREBBP EP300 CDKN2C CDKN1C CDKN2B CDKN1B	Hyperpigmentation of the skin
HP:0001732	0.00462668477392	0.194444444444	CDKN1A CDKN1B CCND1 CDKN2C CDKN2A CDKN1C CDKN2B	Abnormality of the pancreas
GO:1904030	0.0046278219088	0.111111111111	CDKN1C CDKN2A CDKN1A CDKN1B	negative regulation of cyclin-dependent protein kinase activity
HP:0000802	0.00496216744398	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Impotence
HP:0001293	0.00496216744398	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Cranial nerve compression
HP:0010651	0.00543157565137	0.166666666667	CDKN1A CREBBP CDKN2C CDKN1B EP300 CDKN2B	Abnormal meningeal morphology
HP:0031547	0.00544882684234	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Abnormal QT interval
REAC:R-HSA-9632700	0.00555677211806	0.0555555555556	CDK6 CDKN2A	Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
REAC:R-HSA-9630794	0.00555677211806	0.0555555555556	CDK6 CDKN2A	Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
REAC:R-HSA-9675132	0.00555677211806	0.0555555555556	CDK6 CDKN2A	Diseases of cellular response to stress
REAC:R-HSA-9632693	0.00555677211806	0.0555555555556	CDK6 CDKN2A	Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects
REAC:R-HSA-9630750	0.00555677211806	0.0555555555556	CDK6 CDKN2A	Evasion of Oncogene Induced Senescence Due to p16INK4A Defects
REAC:R-HSA-9630747	0.00555677211806	0.0555555555556	CDK6 CDKN2A	Diseases of Cellular Senescence
WP:WP4263	0.00583727259422	0.111111111111	CDK6 CDKN2A CDKN1A CCND1	Pancreatic adenocarcinoma pathway
HP:0000853	0.00596994848838	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Goiter
HP:0003111	0.00603952061578	0.194444444444	CDKN1A CDKN1B CCND1 CDKN2C CDKN2A CDKN1C CDKN2B	Abnormal blood ion concentration
HP:0012503	0.00603952061578	0.194444444444	CDKN1A CDKN1B GMNN CDKN2C CDKN2A CDKN1C CDKN2B	Abnormal pituitary gland morphology
WP:WP4172	0.00607937824212	0.166666666667	CDKN1A CCNE2 CDKN1B CCND1 RBL2 CDK6	PI3K Akt signaling pathway
KEGG:05219	0.00610514169358	0.0833333333333	CDKN1A CDKN2A CCND1	Bladder cancer
KEGG:04066	0.0065084166582	0.111111111111	CDKN1B CREBBP CDKN1A EP300	HIF-1 signaling pathway
HP:0011733	0.00693981536574	0.138888888889	CDKN1B CDKN2C CDKN2B CDKN1A CDKN2A	Abnormality of adrenal physiology
GO:0005667	0.00771790917986	0.25	E2F5 E2F4 RBL2 CCND1 EP300 RBL1 MIDEAS GMNN CREBBP	transcription regulator complex
KEGG:04114	0.00788064855095	0.111111111111	CDK1 CCNE2 PKMYT1 CCNB2	Oocyte meiosis
REAC:R-HSA-68949	0.00796161870731	0.111111111111	CCNA1 CDT1 SKP2 CCNA2	Orc1 removal from chromatin
GO:2000134	0.00811812336983	0.138888888889	RBL1 CCND1 RBL2 CDKN1A CDKN1B	negative regulation of G1/S transition of mitotic cell cycle
HP:0001042	0.00819351260146	0.0555555555556	EP300 CREBBP	High axial triradius
HP:0034227	0.00819351260146	0.0555555555556	EP300 CREBBP	Aortic isthmus hypoplasia
HP:0008107	0.00819351260146	0.0555555555556	EP300 CREBBP	Plantar crease between first and second toes
HP:0005895	0.00819351260146	0.0555555555556	EP300 CREBBP	Radial deviation of thumb terminal phalanx
WP:WP4241	0.00839601672092	0.0833333333333	EP300 CREBBP CDKN1A	Type 2 papillary renal cell carcinoma
REAC:R-HSA-9734009	0.00843089456081	0.0833333333333	CDK5R1 CDK5 CDKN2A	Defective Intrinsic Pathway for Apoptosis
WP:WP2431	0.00882476720852	0.111111111111	CDK1 CCND1 E2F5 CDKN1B	Spinal cord injury
REAC:R-HSA-1643685	0.00901469421049	0.361111111111	FGR CDKN1A CREBBP CDKN1B CCNE2 CCND1 CDK6 CDK5R1 CDK5 CDKN1C EP300 SKP2 CDKN2A	Disease
HP:0002893	0.00914718856795	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Pituitary adenoma
HP:0001000	0.00934061492226	0.222222222222	CDKN1A CREBBP CDKN1B CDKN2C CDKN2A CDKN1C EP300 CDKN2B	Abnormality of skin pigmentation
WP:WP2828	0.0110229159054	0.0833333333333	CDKN1A CDKN2A CCND1	Bladder cancer
HP:0000736	0.0110890320342	0.222222222222	CDKN1A CREBBP CDKN1B SCAPER CDKN2C CDKN1C EP300 CDKN2B	Short attention span
CORUM:2638	0.0111633529668	0.0555555555556	EP300 CREBBP	HES1 promoter corepressor complex
CORUM:3036	0.0111633529668	0.0555555555556	CKS1B SKP2	Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1)
HP:0007379	0.01137526992	0.166666666667	CREBBP CDKN1B CCND1 EP300 CDKN2A CDKN1C	Neoplasm of the genitourinary tract
HP:5200241	0.0116024531936	0.305555555556	CDKN1A CREBBP CDKN2C SCAPER RBL2 CCND1 CDKN1B CDKN2A CDKN1C EP300 CDKN2B	Recurrent maladaptive behavior
GO:1902807	0.0118473986218	0.138888888889	RBL1 CCND1 RBL2 CDKN1A CDKN1B	negative regulation of cell cycle G1/S phase transition
HP:0009726	0.0119109545792	0.138888888889	CDKN1C CCND1 EP300 CDKN2A CDKN1B	Renal neoplasm
WP:WP3941	0.0120046698068	0.0833333333333	CDKN1C CDKN1A CDKN1B	Oxidative damage response
GO:0009892	0.0122261405868	0.5	CDT1 CDKN2C CREBBP CDKN1A CDKN1B RBL1 CCND1 RBL2 CDKN2B CDK6 CDKN2A CDKN2D CDK5 MIDEAS CDKN1C EP300 GMNN CDK5R1	negative regulation of metabolic process
HP:5200044	0.0122656062557	0.222222222222	CDKN1A CREBBP CDKN1B SCAPER CDKN2C CDKN1C EP300 CDKN2B	Reduced attention regulation
HP:0100639	0.012473309334	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Erectile dysfunction
HP:0000777	0.012473309334	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Abnormal thymus morphology
GO:0045930	0.0127303411045	0.194444444444	CDKN1A CDKN1B RBL1 CCND1 RBL2 CDK1 CDKN1C	negative regulation of mitotic cell cycle
WP:WP5322	0.0127976379367	0.111111111111	CDK1 CCND1 CCNB2 CDKN1B	CKAP4 signaling pathway map
HPA:0570781	0.0130803117891	0.361111111111	CDKN1A CREBBP CDK1 RBL1 RBL2 CDK6 CDKN2A CDK5 SCAPER CCNA1 CCNE2 GMNN CCNB2	testis; preleptotene spermatocytes[>=Low]
HP:0002896	0.0135065836691	0.138888888889	CDKN1C CCND1 EP300 CREBBP CDKN2A	Neoplasm of the liver
REAC:R-HSA-9634815	0.0135539541919	0.0833333333333	CREBBP CDK5 CDK5R1	Transcriptional Regulation by NPAS4
HP:0010786	0.0146599570351	0.138888888889	CDKN1C CCND1 EP300 CDKN2A CDKN1B	Urinary tract neoplasm
KEGG:05162	0.015525326546	0.111111111111	CDK6 CCNE2 CCND1 CDKN1B	Measles
GO:0030511	0.0159021806907	0.111111111111	CDKN1C EP300 CREBBP CDKN2B	positive regulation of transforming growth factor beta receptor signaling pathway
GO:1903846	0.0159021806907	0.111111111111	CDKN1C EP300 CREBBP CDKN2B	positive regulation of cellular response to transforming growth factor beta stimulus
WP:WP5342	0.0159233605947	0.0555555555556	EP300 CDKN1A	Pathophysiological roles of DUX4 in FSHD1
WP:WP4659	0.016081410981	0.111111111111	CDKN1B CDKN2A CDKN1A CCND1	Gastrin signaling pathway
WP:WP5300	0.0164994723172	0.0833333333333	CDKN1B CDKN2A CCND1	TROP2 regulatory signaling
WP:WP2586	0.0164994723172	0.0833333333333	CDKN1B CDKN1A EP300	Aryl hydrocarbon receptor pathway
HP:0011767	0.0166168394163	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Abnormality of the parathyroid physiology
CORUM:6444	0.0167190668714	0.0555555555556	RBL1 RBL2	SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex
CORUM:5596	0.0167190668714	0.0555555555556	E2F4 RBL2	LINC complex, quiescent cells
HP:0040202	0.0172240906334	0.166666666667	CDKN1A CDKN2C CCND1 CDKN1B CDKN2A CDKN2B	Abnormal consumption behavior
WP:WP236	0.0173003955788	0.111111111111	E2F4 RBL2 CDKN1A RBL1	Adipogenesis
WP:WP3878	0.0177719753707	0.0833333333333	CDK1 CDK5R1 CDK5	ATM signaling in development and disease
HP:0030956	0.0178064579409	0.222222222222	CDKN1A CREBBP CDKN2C CCND1 CDKN1B CDKN2A EP300 CDKN2B	Abnormality of cardiovascular system electrophysiology
REAC:R-HSA-453276	0.0179298057541	0.111111111111	CCNA1 CDK1 SKP2 CCNA2	Regulation of mitotic cell cycle
REAC:R-HSA-174143	0.0179298057541	0.111111111111	CCNA1 CDK1 SKP2 CCNA2	APC/C-mediated degradation of cell cycle proteins
REAC:R-HSA-68911	0.0184651687438	0.0555555555556	CCNA2 CCNA1	G2 Phase
REAC:R-HSA-9032845	0.0184651687438	0.0555555555556	CDK5R1 CDK5	Activated NTRK2 signals through CDK5
REAC:R-HSA-3134973	0.0184651687438	0.0555555555556	EP300 CREBBP	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
REAC:R-HSA-9754119	0.0184651687438	0.0555555555556	CDK6 CCND1	Drug-mediated inhibition of CDK4/CDK6 activity
HP:0000864	0.0188982021572	0.194444444444	CDKN1A CDKN1B GMNN CDKN2C CDKN2A CDKN1C CDKN2B	Abnormality of the hypothalamus-pituitary axis
KEGG:04630	0.019154208453	0.111111111111	EP300 CREBBP CDKN1A CCND1	JAK-STAT signaling pathway
HP:0001291	0.0203316830081	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Abnormal cranial nerve morphology
HP:0001289	0.0203316830081	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Confusion
REAC:R-HSA-9031628	0.0203827827313	0.0833333333333	EP300 CDK5R1 CDK5	NGF-stimulated transcription
HP:0100763	0.020389569012	0.25	CDKN1A CREBBP CDKN2C CCND1 CDKN1B CDKN2A CCNO EP300 CDKN2B	Abnormality of the lymphatic system
REAC:R-HSA-6804756	0.0205073628329	0.111111111111	CCNA2 CDK5R1 CDK5 CCNA1	Regulation of TP53 Activity through Phosphorylation
HP:0000822	0.0212301953737	0.194444444444	CDKN1A CDKN1B SCAPER CCND1 CDKN2C CDKN2A CDKN2B	Hypertension
REAC:R-HSA-8864260	0.0223831492626	0.0833333333333	EP300 CREBBP CDKN1A	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
HP:0000022	0.023126179334	0.111111111111	EP300 CCND1 CREBBP CDKN2A	Abnormal male internal genitalia morphology
HP:0011750	0.023126179334	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Neoplasm of the anterior pituitary
HP:0040277	0.023126179334	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Neoplasm of the pituitary gland
CORUM:570	0.0233704075649	0.0555555555556	EP300 CREBBP	p300-CBP-p270-SWI/SNF complex
HP:0000078	0.0240553652532	0.361111111111	CDT1 CREBBP CDKN1A CDKN2C SCAPER CCND1 CDKN2B CDKN1B CDKN2A CCNO CDKN1C EP300 GMNN	Abnormality of the genital system
HP:0002244	0.0240763129185	0.166666666667	CDKN1A EP300 SCAPER CDKN2C CDKN2B CDKN1B	Abnormal small intestine morphology
HP:5200232	0.0245424101881	0.0555555555556	EP300 CREBBP	Phobia
HP:0008752	0.0245424101881	0.0555555555556	EP300 CREBBP	Laryngeal cartilage malformation
HP:0005322	0.0245424101881	0.0555555555556	EP300 CREBBP	Prominent nasal septum
HP:0006200	0.0245424101881	0.0555555555556	EP300 CREBBP	Widened distal phalanges
HP:0000756	0.0245424101881	0.0555555555556	EP300 CREBBP	Agoraphobia
HP:0005363	0.0245424101881	0.0555555555556	EP300 CREBBP	Humoral immunodeficiency
HP:0003117	0.0251723391182	0.194444444444	CDKN1A CDKN1B SCAPER CCND1 CDKN2C CDKN2A CDKN2B	Abnormal circulating hormone concentration
REAC:R-HSA-9711123	0.0252142680657	0.138888888889	EP300 CDKN2A SKP2 CDKN1A CREBBP	Cellular response to chemical stress
GO:0043231	0.0256646702116	0.972222222222	CCNA1 CDK3 FGR E2F4 CKS1B CDKN1C GMNN CREBBP CDT1 CCNE2 CDKN2C SIVA1 CCND1 CCNA2 CDK1 CCNO CDKN2D CDK5 RBL1 SKP2 E2F5 CDKN1A CCNB3 RBL2 CDKN1B CDK5R1 MIDEAS CCNB2 CCNI PKMYT1 EP300 CDKN2B CDK6 SCAPER CDKN2A	intracellular membrane-bounded organelle
KEGG:05221	0.0267369791991	0.0833333333333	CCNA2 CCNA1 CCND1	Acute myeloid leukemia
REAC:R-HSA-8849470	0.0276548087243	0.0555555555556	CDKN1B CCND1	PTK6 Regulates Cell Cycle
HP:0000828	0.029550134018	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Abnormality of the parathyroid gland
WP:WP4630	0.0295947502074	0.111111111111	CDK6 CCNE2 CCND1 CDKN1B	Measles virus infection
HP:0012718	0.0301924102439	0.277777777778	CDKN1A CREBBP CDKN1B SCAPER CCND1 CDKN2C CDKN2A CCNO EP300 CDKN2B	Abnormal gastrointestinal tract morphology
HP:0100705	0.0309582151852	0.138888888889	CDKN1B CDKN2C CDKN2B CDKN1A CDKN2A	Abnormal glial cell morphology
HP:0010614	0.0313420669965	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Fibroma
GO:0042326	0.0324695119547	0.194444444444	CDKN1A CDKN1B CDKN2C CDKN2A CDKN1C CDKN2B CDKN2D	negative regulation of phosphorylation
HP:0003042	0.0332125808096	0.111111111111	CDT1 EP300 GMNN CREBBP	Elbow dislocation
HP:0012316	0.0351638159573	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Fibrous tissue neoplasm
KEGG:05211	0.0355622752986	0.0833333333333	EP300 CREBBP CDKN1A	Renal cell carcinoma
REAC:R-HSA-8878166	0.0362354361593	0.111111111111	CDK1 SKP2 CDKN1A CCND1	Transcriptional regulation by RUNX2
HP:0040307	0.0371979347742	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Male sexual dysfunction
REAC:R-HSA-1234158	0.038656711884	0.0555555555556	EP300 CREBBP	Regulation of gene expression by Hypoxia-inducible Factor
REAC:R-HSA-2980767	0.038656711884	0.0555555555556	CDK1 CCNB2	Activation of NIMA Kinases NEK9, NEK6, NEK7
KEGG:05225	0.039908103539	0.111111111111	CDK6 CDKN2A CDKN1A CCND1	Hepatocellular carcinoma
HP:0000140	0.042443517941	0.166666666667	CDKN1A CDKN1B SCAPER CDKN2C CDKN1C CDKN2B	Abnormality of the menstrual cycle
WP:WP2882	0.0453701734652	0.138888888889	CDKN1C EP300 CCND1 CDKN1B CDK1	Nuclear receptors meta pathway
HP:0011772	0.0459857396416	0.138888888889	CDKN1B CDKN2C CDKN2B CDKN1A CDKN2A	Abnormal thyroid morphology
HP:0006753	0.0462072431108	0.111111111111	EP300 CCND1 CDKN2B CDKN2A	Neoplasm of the stomach
HP:0001944	0.0462072431108	0.111111111111	CDKN1B CDKN2B CDKN1A CDKN2C	Dehydration
HP:0011087	0.0490086943057	0.0555555555556	EP300 CREBBP	Talon cusp
HP:0010775	0.0490086943057	0.0555555555556	EP300 CREBBP	Vascular ring
HP:0001128	0.0490086943057	0.0555555555556	EP300 CREBBP	Trichiasis
HP:0000769	0.0491288318855	0.194444444444	CDT1 CDKN1A CDKN1B GMNN CDKN2C CDKN2A CDKN2B	Abnormality of the breast
WP:WP4790	0.0496583061355	0.0555555555556	CDKN1A CCND1	FGF23 signaling in hypophosphatemic rickets and related disorders
WP:WP53	0.0496583061355	0.0555555555556	RBL1 RBL2	ID signaling pathway
CORUM:1005	0.049846966401	0.0555555555556	CDK1 CCNA2	RC complex during G2/M-phase of cell cycle

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
CDKN1B	CCNA2	1.0	0.124	structurally_consistent (dimer)
CCNA2	CDKN1A	1.0	0.308	structurally_consistent (dimer)
SKP2	CKS1B	1.0	0.138	structurally_consistent (dimer)
CCNB1	CKS1B	1.0	0.22	structurally_consistent (dimer)
CCNB1	CDKN1B	1.0	0.26236
SKP2	CCNA2	1.0	0.284	mutually_exclusive (P11802) structurally_consistent (dimer)
CCNA2	CKS1B	1.0	0.222
RBL2	CCNA2	1.0	0.118
CCNB1	CKS2	1.0	0.152
CDK4	CDKN2C	1.0	0.138483660131	structurally_consistent (dimer)
PKMYT1	CCNB2	1.0	0.214	structurally_consistent (dimer)
CCNA2	CDK2	1.0	0.224	structurally_consistent (dimer)
CDKN1B	CKS1B	1.0	0.072
CCNA2	GMNN	1.0	0.358
RBL1	CDK2	1.0	0.184	structurally_consistent (dimer)
CDKN1B	CCNE1	1.0	0.102
RBL2	CDK2	1.0	0.126	mutually_exclusive (P24385) structurally_consistent (dimer)
CDKN1B	CCND1	1.0	0.264
CCNB2	CKS2	1.0	0.134
RBL1	CCNA2	1.0	0.296	structurally_consistent (dimer)
CDKN1B	CKS2	1.0	0.036
CDK1	CKS2	1.0	0.23	structurally_consistent (dimer)
CDT1	CCNA2	1.0	0.128
CDK6	CDKN2C	1.0	0.120941176471	structurally_consistent (dimer)
CDKN1B	CDK1	1.0	0.158	structurally_consistent (P20248)
CKS1B	CDK2	0.999	0.112	structurally_consistent (dimer)
CDKN2C	CCND1	0.999	0.176725274725
CDT1	GMNN	0.999	0.204
CCNB1	CDK2	0.999	0.161	structurally_consistent (dimer)
CKS2	CDKN1A	0.999	0.096
CDKN1A	CCND3	0.999	0.218	structurally_consistent (dimer)
CDK1	CCNA2	0.999	0.258	structurally_consistent (dimer)
CDK2	CCNE2	0.999		structurally_consistent (dimer)
CCND2	CDKN1A	0.999	0.226
CDK2	CDKN1A	0.999	0.274	structurally_consistent (P20248)
CCNA2	CDKN1C	0.999	0.096
CCND2	CDKN1B	0.999	0.168	structurally_consistent (dimer)
CDKN2C	CCND3	0.999	0.084	structurally_consistent (dimer)
SCAPER	CCNA2	0.999	0.176	structurally_consistent (dimer)
CCNB2	CDKN1B	0.999	0.182
CKS1B	CDKN1A	0.999	0.12
SKP2	CDK2	0.999	0.278
CDKN1B	CDK2	0.999	0.1424	structurally_consistent (P20248) structurally_consistent (dimer)
PCNA	CDKN1A	0.999	0.31	structurally_consistent (dimer)
CCNB2	CCNB1	0.999	0.274
CCNA2	CCNE2	0.999
CDKN1B	CDKN1C	0.999	0.158	mutually_exclusive (P30281)
CDK1	CDKN1A	0.999	0.306859813084	structurally_consistent (P20248)
CDK5	CDK5R1	0.999		structurally_consistent (dimer)
CCNE2	CDKN1A	0.999
CCNE1	CDKN1A	0.999	0.156
CKS2	CCNA2	0.999	0.206	structurally_consistent (dimer)
CDK1	CKS1B	0.999	0.452	structurally_consistent (dimer)
CCNB1	CDKN1A	0.999	0.240685714286
CDKN1B	CDK5	0.999	0.114
CKS2	CDK2	0.999	0.062	structurally_consistent (dimer)
PKMYT1	CCNB1	0.999	0.276	mutually_exclusive (P61024) structurally_consistent (dimer)
CCNB2	CKS1B	0.999	0.22
CDK5	CCND1	0.999	0.154	structurally_consistent (dimer)
CCNE1	CCNE2	0.999
EP300	CREBBP	0.999	0.476
CKS1B	CDKN1C	0.999	0.068
CDK6	CCND3	0.999	0.251541475535
CDKN1B	CDKN1A	0.999	0.192	mutually_exclusive (P30281)
CCNB1	CDK1	0.999	0.3
CCNB1	CCNE1	0.998	0.102
SKP2	CDKN1C	0.998	0.086
CDK4	CCND1	0.998	0.308596685083	structurally_consistent (dimer)
CDKN1A	CDKN1C	0.998	0.176	mutually_exclusive (P30281)
CKS2	CKS1B	0.998	0.584	structurally_consistent (dimer)
CCND2	CDKN1C	0.998	0.1
CCNA2	CCNE1	0.998	0.126	mutually_exclusive (P24941)
CDKN1B	SKP2	0.998	0.174	mutually_exclusive (P11802)
CDK2	CDKN1C	0.998	0.172	structurally_consistent (dimer)
CKS2	SKP2	0.998	0.098
PKMYT1	CCNA2	0.998	0.12
CDK4	CDKN2A	0.998	0.182
GMNN	CKS1B	0.998	0.138
CCND1	CDKN1C	0.998	0.15
CKS1B	CDK3	0.998		structurally_consistent (dimer)
CCNB2	CDK1	0.998	0.35
CDKN1B	CCND3	0.998	0.144	structurally_consistent (dimer)
CDKN1A	CCND1	0.998	0.2396
SKP2	CDT1	0.998	0.21
CCNB1	CCNA2	0.998	0.348	structurally_consistent (dimer)
CDK2	CCND1	0.998	0.1498	structurally_consistent (dimer)
CDK2	CCNE1	0.998	0.15	structurally_consistent (dimer)
CDK6	CDKN1C	0.998	0.076	mutually_exclusive (O95067)
PKMYT1	CDKN1B	0.998	0.08
PCNA	CCND3	0.998	0.183555555556
CDKN1B	CDK4	0.998	0.178	structurally_consistent (dimer)
CDK1	CDK2	0.998	0.288	mutually_exclusive (P20248)
CDKN2D	CDK6	0.997
CDKN1B	CCNE2	0.997
CCND2	CDK5	0.997	0.164
CKS2	CDKN1C	0.997	0.026
CDK3	CDK2	0.997		structurally_consistent (dimer)
CDK5	CCND3	0.997	0.156
SKP2	GMNN	0.997	0.27
CREBBP	CDK2	0.997	0.134
CCNA2	CDK3	0.996
RBL2	RBL1	0.996	0.118
CDK4	CCND3	0.996	0.406	structurally_consistent (dimer)
CDKN2B	CDK4	0.996		structurally_consistent (dimer)
RBL2	CDKN1A	0.996	0.156
CCNB2	CCNA2	0.996	0.28	structurally_consistent (dimer)
CDT1	CDK2	0.996	0.256
CREBBP	CCNA2	0.996	0.236473684211
SKP2	CDK3	0.996
CDK5	CDKN1A	0.996	0.225037037037
CDK1	CDKN1C	0.996	0.298
CDK1	CCND3	0.996	0.360930232558	mutually_exclusive (P20248)
PKMYT1	CKS1B	0.996	0.064	structurally_consistent (dimer)
GMNN	CDK2	0.996	0.193555555556
CCNO	CDKN1A	0.996
CDK1	SKP2	0.996	0.372
SKP2	CDKN1A	0.995	0.182	mutually_exclusive (P11802)
EP300	CCNA2	0.995	0.266809384164
MIDEAS	CCNA2	0.995	0.06
CCND2	CDK4	0.995	0.294	structurally_consistent (dimer)
CDK4	CDKN1A	0.995	0.308	structurally_consistent (dimer)
CDT1	CKS1B	0.995	0.19
CDKN2D	CDK4	0.995		structurally_consistent (P42772)
CKS2	CDK3	0.995		structurally_consistent (dimer)
CCNB1	SKP2	0.994	0.354	mutually_exclusive (P20248)
CDK2	CDK5	0.994	0.158
PCNA	CCNE2	0.994
CDKN2B	CDK6	0.994
CCNB2	SKP2	0.994	0.322	mutually_exclusive (P20248)
CDK5	CCNI	0.993		structurally_consistent (dimer)
CCNA2	CCNA1	0.993		structurally_consistent (dimer)
PKMYT1	CDK1	0.993	0.206885714286	structurally_consistent (dimer)
CDKN1B	CDK6	0.993	0.154
CCNB1	CCNE2	0.992
CDKN1B	CDT1	0.992	0.066
CDK2	CCND3	0.992	0.272	structurally_consistent (dimer)
CKS2	CCNE2	0.992
PCNA	CCNE1	0.992	0.124
CKS2	CCNE1	0.992	0.126
CDKN1B	GMNN	0.992	0.148
CDK3	CCNE2	0.991		structurally_consistent (dimer)
CCNB3	CDKN1A	0.991
CCNB2	CDKN1A	0.991	0.238
CCNB2	CDK2	0.991	0.214	structurally_consistent (dimer)
RBL2	CCND3	0.991	0.102	structurally_consistent (dimer)
CCND2	CDK2	0.99	0.1824	structurally_consistent (dimer)
CDK1	CCND1	0.99	0.242	structurally_consistent (dimer)
CDKN1B	CDK3	0.99		structurally_consistent (dimer)
RBL2	CDKN1C	0.989	0.052
CCND2	CDK1	0.988	0.25
CDK6	CDKN1A	0.988	0.281278688525	structurally_consistent (dimer)
CDK3	CDKN1A	0.988
CDKN2A	CCND1	0.987	0.206
SIVA1	PCNA	0.987		structurally_consistent (dimer)
MIDEAS	CDKN1C	0.987	0.06
CDK4	CDKN1C	0.987	0.136
RBL2	CDKN1B	0.987	0.147076923077
CDKN2A	CCND3	0.984	0.134
CCNB1	CDK3	0.984
CCNE2	CCND3	0.984
CDK2	CDK5R1	0.984		structurally_consistent (dimer)
PKMYT1	CKS2	0.984	0.056
CDKN1B	MIDEAS	0.983	0.094
CDK3	CDKN1C	0.982		structurally_consistent (dimer)
CDK5	CDKN1C	0.982	0.132
CDK3	CCNE1	0.982
CKS1B	CCNE2	0.981		structurally_consistent (dimer)
E2F5	CDKN1A	0.981
FGR	CDKN1A	0.981	0.138
CDK4	CDK6	0.981	0.084
SKP2	CCNE2	0.98
CKS2	CCND3	0.98	0.082
CDK6	CDKN2A	0.979	0.08
CKS1B	CCNE1	0.979	0.084	structurally_consistent (dimer)
RBL2	CDK1	0.979	0.230961538462
CDK4	FGR	0.979	0.2
CDT1	CDK3	0.977		mutually_exclusive (P06493) structurally_consistent (dimer)
SKP2	CCNE1	0.977	0.158
CCNA2	CCND3	0.977	0.184	structurally_consistent (dimer)
CDK1	GMNN	0.976	0.142
E2F4	GMNN	0.974	0.072
CCNB1	CDK5	0.974	0.066
E2F4	E2F5	0.974
CKS2	GMNN	0.974	0.084
CCNA2	PCNA	0.973	0.310958333333
CCNB1	CDKN1C	0.973	0.12	structurally_consistent (dimer)
CDT1	CDKN1A	0.971	0.208
PKMYT1	SKP2	0.969	0.184	mutually_exclusive (P61024)
CKS1B	CCND3	0.969	0.062
CDKN1B	CDKN2C	0.968	0.108
CCND2	CDK6	0.968	0.184
CKS1B	TRIM49	0.968		structurally_consistent (dimer)
EP300	CDK2	0.967	0.144578947368
CDKN2C	CDKN1A	0.967	0.15
GMNN	CDK3	0.967
MIDEAS	CDK2	0.966	0.038
CDK5	CCNE2	0.965
E2F5	CDK2	0.965
CCNO	CDK3	0.963
E2F4	CDK2	0.962	0.284
CCNE1	CCND3	0.962	0.124
CDK6	CCND1	0.961	0.272	structurally_consistent (dimer)
GMNN	E2F5	0.961
E2F4	CDKN1A	0.961	0.216
SKP2	CCND3	0.96	0.124988764045	mutually_exclusive (P11802)
CCNO	CDK2	0.96
CCNE1	CCND1	0.96	0.234
CCNE2	CCND1	0.96
CCND3	CDKN1C	0.96	0.068	structurally_consistent (dimer)
CDKN2D	CDKN2B	0.96		structurally_consistent (dimer)
E2F4	CCNA2	0.96	0.138
PKMYT1	CDKN1C	0.959	0.182
PKMYT1	CDT1	0.958	0.116	mutually_exclusive (P14635)
CCNB1	CCND3	0.956	0.216
CDKN2C	CDKN1C	0.956	0.088
CDK1	CCNE1	0.955	0.254946428571
CDK1	CDT1	0.954	0.386741935484	mutually_exclusive (Q00526) structurally_consistent (dimer)
RBL2	CKS2	0.953	0.046	mutually_exclusive (P24941)
CDKN2B	CDKN1C	0.952
CDK2	PCNA	0.951	0.414	structurally_consistent (dimer)
CDK6	CDK2	0.951	0.084
RBL2	CCNB1	0.95	0.251449636552	mutually_exclusive (P24941)
CCND1	CCND3	0.95	0.168
CDKN2D	CDKN2C	0.95		structurally_consistent (P42772)
RBL2	CKS1B	0.949	0.052	mutually_exclusive (P24941)
CCNB2	CCNE1	0.949	0.114
RBL2	SKP2	0.947	0.098
CDKN2D	CDKN1A	0.945
CDKN2D	CCND3	0.944		structurally_consistent (dimer)
CDKN1B	CDKN2D	0.944
SKP2	TRIM49	0.943
CDKN1B	CCNA1	0.942
CCNB2	CCND3	0.941	0.146
CCNB2	CCNE2	0.938
MIDEAS	SKP2	0.937	0.056
CKS2	CCNO	0.937
CDK1	CCNE2	0.936
CDK1	CDK6	0.936	0.244
CCNO	CKS1B	0.936
RBL1	CCNE1	0.934	0.15	mutually_exclusive (P24941)
CDKN2D	CDKN1C	0.933
MIDEAS	CKS1B	0.932	0.012
CKS2	CDT1	0.93	0.088	mutually_exclusive (P06493)
CCNA2	CDK5	0.93	0.237875
RBL2	CCNE1	0.93	0.09
CDKN2A	CDKN2C	0.924	0.084
GMNN	CDKN1C	0.92	0.126
CCNE2	CDKN1C	0.92
CDK5	CCNE1	0.916	0.176
CDK1	CCNO	0.914
RBL1	CCNE2	0.914		mutually_exclusive (P24941)
SIVA1	CDKN1A	0.911		mutually_exclusive (P12004)
CDKN2B	CDKN2C	0.911		structurally_consistent (dimer)
PCNA	CCND1	0.91	0.276
CDKN2B	CCND3	0.905
SIVA1	CCNE2	0.904
CCNO	CCNB3	0.902
RBL2	CCNE2	0.901
SKP2	CCND1	0.898	0.23900952381
CDKN1B	CDKN2B	0.896
CDKN2B	CDKN1A	0.896
CDK6	CDK5	0.894	0.092
E2F5	CCNB3	0.892
CCNO	E2F5	0.892
CDKN1B	CCNO	0.887
SKP2	CCNO	0.882
CKS1B	CCND1	0.88	0.112
SCAPER	CDKN1C	0.878	0.096
EP300	RBL1	0.877	0.323130434783
CKS2	CCND1	0.873	0.1
CDK4	CDK2	0.869	0.162
FGR	CCNB3	0.869
CCNO	FGR	0.869
CDKN2B	CDKN2A	0.866
CCNB1	PCNA	0.863	0.19	structurally_consistent (dimer)
GMNN	CCNE1	0.855	0.099
CCNB2	CDKN1C	0.851	0.118	structurally_consistent (dimer)
CCNO	CDK5	0.848
RBL2	CREBBP	0.846	0.362
PKMYT1	CDK2	0.835	0.184	mutually_exclusive (O95067)
RBL1	CREBBP	0.828	0.307536384977
CDK1	CDK4	0.824	0.213294117647
CCNB1	CCND1	0.821	0.130210526316
SCAPER	GMNN	0.82	0.058
CDT1	SCAPER	0.809	0.178
CCNA2	CCND1	0.809	0.19
CCNB2	CCND1	0.805	0.144
CCNB3	CCNE2	0.804
CCNB2	CCNB3	0.804
RBL1	CKS1B	0.798	0.112
RBL1	CKS2	0.798	0.142	structurally_consistent (P20248)
RBL2	CCND1	0.796	0.2	mutually_exclusive (P24941) structurally_consistent (dimer)
RBL2	CDK5	0.793	0.11	mutually_exclusive (P24385)
MIDEAS	CDKN1A	0.79	0.12
SKP2	SCAPER	0.788	0.154
RBL1	SKP2	0.784	0.136
RBL1	CDKN1B	0.781	0.076
MIDEAS	SCAPER	0.774	0.076
CDT1	CDKN1C	0.773	0.048	mutually_exclusive (P14635)
CDT1	CCNE1	0.771	0.136
MIDEAS	GMNN	0.77	0.024
CDKN1B	SCAPER	0.769	0.12	mutually_exclusive (P20248)
CCNO	CCNE2	0.768
CKS1B	E2F5	0.763
RBL2	CDK3	0.761
RBL1	CDKN1A	0.759	0.3198
CCNA2	E2F5	0.757
E2F4	CDK1	0.752	0.286385542169
CKS2	MIDEAS	0.749	0.012
CKS2	E2F5	0.746
RBL1	CDKN1C	0.738	0.182
CDKN1B	CCNB3	0.736
PKMYT1	GMNN	0.73	0.14
CDK4	CDK5	0.724	0.058
CCNB2	CCNO	0.715
PKMYT1	SCAPER	0.704	0.118
SIVA1	CCNE1	0.703
SIVA1	CCND1	0.703
RBL2	CCND2	0.702	0.132	structurally_consistent (dimer)
E2F4	SKP2	0.702	0.302
RBL1	CDK3	0.702
E2F4	CKS1B	0.702	0.032
CDK1	SCAPER	0.699	0.2368
SIVA1	CCND3	0.698
CDK1	PCNA	0.69	0.434	structurally_consistent (Q9H211)
PCNA	CDK5	0.685	0.126142857143
E2F4	CKS2	0.681	0.102
CCNB1	SIVA1	0.676		mutually_exclusive (P12004)
CCNO	CCND3	0.676
CDK3	E2F5	0.675
RBL2	CDK4	0.66	0.204
RBL2	PCNA	0.65	0.19	structurally_consistent (P30279)
CDKN2B	FGR	0.647
CCNB2	CDK3	0.646
RBL1	GMNN	0.638	0.13
CREBBP	CDKN1A	0.635	0.4008
E2F4	CDKN1C	0.634	0.074
E2F5	CCND1	0.634		structurally_consistent (Q08999)
CCNB1	E2F5	0.634
CDKN2D	CCND1	0.634
E2F4	CCND1	0.634	0.184
FGR	CCND1	0.634
FGR	CCND3	0.633
CDKN2B	CCND1	0.633		structurally_consistent (dimer)
GMNN	CDKN1A	0.631	0.316
CDK6	SIVA1	0.626		mutually_exclusive (P12004)
RBL2	GMNN	0.625	0.094
RBL1	SCAPER	0.625	0.112
CCNB3	CCND3	0.622
CCNB1	CDT1	0.621	0.338	mutually_exclusive (P12004) structurally_consistent (dimer)
RBL2	SCAPER	0.611	0.15
CCNB2	CDK4	0.6	0.268	structurally_consistent (dimer)
CKS1B	CDK5	0.597	0.046
CCND2	CCND3	0.594	0.118
E2F4	CDT1	0.592	0.164
PCNA	CDKN1C	0.59	0.098
CDK4	CCNE2	0.589
E2F4	CDKN1B	0.587	0.178
CCNB2	CDK6	0.587	0.293480701754	structurally_consistent (dimer)
CKS2	CDK6	0.587	0.004
CDK6	CKS1B	0.587	0.018
CREBBP	CCND3	0.573	0.294
RBL1	CDT1	0.572	0.134
RBL2	CDT1	0.572	0.062
CKS2	SCAPER	0.563	0.032
SCAPER	CDKN1A	0.563	0.164
CCNB1	CCNB3	0.561
CCNB3	CCNE1	0.561
CDK4	CCNE1	0.559	0.140610619469	structurally_consistent (dimer)
CKS2	CCNB3	0.553
CCNA2	CCNB3	0.553
SCAPER	CKS1B	0.548	0.114
PKMYT1	MIDEAS	0.541	0.0384117647059
CKS1B	CCNB3	0.539
CDK5	CCNB3	0.539
CDK4	CKS1B	0.539	0.06
CCNA2	CDK4	0.535	0.360610619469	structurally_consistent (dimer)
CDK6	PCNA	0.533	0.105333333333	structurally_consistent (dimer)
E2F4	RBL1	0.526	0.154
E2F4	RBL2	0.524	0.09	structurally_consistent (dimer)
CDK2	CCNB3	0.519
CCND2	PCNA	0.515	0.19	structurally_consistent (dimer)
CCND2	CDKN2B	0.513		structurally_consistent (P11802)
CKS2	CDK5	0.509	0.022
MIDEAS	CCNA1	0.502
EP300	GMNN	0.5	0.343443566096
RBL2	CCNB3	0.499
CDK4	CCNB3	0.49
CDKN1B	CDKN2A	0.489	0.092
SCAPER	CCNA1	0.487
EP300	RBL2	0.482	0.226
CCNB3	CCND1	0.477
CKS2	CDK4	0.475	0.088
CDK1	MIDEAS	0.466	0.0484553571429
CCNO	PCNA	0.455
E2F5	CCNE1	0.455
CCNO	CCNE1	0.455
CCNO	CCND1	0.455
CDK4	PCNA	0.453	0.196	structurally_consistent (dimer)
CDKN1B	CREBBP	0.431	0.388
CDK1	CCNB3	0.427
CCNA2	SIVA1	0.418
E2F4	CCNB1	0.416	0.164
CDK6	CCNE1	0.415	0.278
CDK6	CCNE2	0.415
CCNA1	CCNB3	0.415
CCND2	CCNA1	0.415
CCNE1	CDKN1C	0.413	0.056
FGR	PCNA	0.409	0.1532
RBL2	CCNO	0.405
E2F4	CCNB3	0.405
E2F4	CCNO	0.405
RBL2	E2F5	0.404		structurally_consistent (dimer)
CDK1	CREBBP	0.404	0.222
CDK2	SIVA1	0.401		mutually_exclusive (P12004)
MIDEAS	CDT1	0.396	0.072
CDK4	SIVA1	0.389		mutually_exclusive (P12004)
CCNB1	CCNO	0.388
SIVA1	CDK5	0.388
E2F4	SCAPER	0.388	0.116
CDK6	CCNO	0.388
E2F5	CCNE2	0.384
RBL1	E2F5	0.384
E2F4	CCNE2	0.384
CCNB1	CDK6	0.376	0.05
GMNN	CCNE2	0.367
CCNB2	GMNN	0.367	0.192
CREBBP	CDKN1C	0.367	0.198
E2F4	CCNE1	0.362	0.124
PCNA	CCNB3	0.361
CCNB2	CDK5	0.36	0.142
CCNB1	GMNN	0.358	0.246
FGR	E2F5	0.356
CCNA2	CCNO	0.356
FGR	CCNE2	0.356
CCNB2	FGR	0.356	0.114
CDT1	CCNA1	0.35
CCNA2	CDK6	0.348	0.198941176471
CDKN2D	FGR	0.343
CDKN2A	CDKN1A	0.341	0.218
CDK1	SIVA1	0.336
CCNB1	FGR	0.334	0.078
FGR	CCNE1	0.334
CREBBP	CCNA1	0.333
CDK4	CCNO	0.332
CDKN2B	PCNA	0.327
E2F4	CDK3	0.325
CDK6	CCNB3	0.325
CDK3	CCND1	0.325
CDKN2C	FGR	0.323	0.1
CDK1	CDK3	0.32		structurally_consistent (dimer)
CDK3	CDK5	0.318
CDKN1B	PCNA	0.308	0.148	structurally_consistent (P30279)
CDKN2D	CDKN2A	0.295
RBL2	CDK6	0.293	0.162215962441
CCNB2	CDT1	0.291	0.208695652174
CCNB2	E2F5	0.288
SCAPER	CDK2	0.284	0.14
CDT1	CCNE2	0.281
E2F5	PCNA	0.274
CREBBP	CDK3	0.266
CCNA1	CDK3	0.265
EP300	CDKN1C	0.264	0.088
CCNA1	CKS1B	0.262
CDK1	CCNA1	0.262
RBL1	CCNB1	0.258	0.224	mutually_exclusive (P24941)
CKS1B	PCNA	0.254	0.114	structurally_consistent (P24941)
SKP2	E2F5	0.251
CCNA1	CCND3	0.25
CCND2	CDKN2D	0.248
CDKN2A	CDKN1C	0.243	0.066
EP300	CCNE2	0.242
MIDEAS	CCNE1	0.232	0.152
E2F4	PCNA	0.229	0.228
FGR	CKS1B	0.229	0.052
E2F4	FGR	0.22	0.086
E2F5	CCND3	0.22
FGR	CDKN1C	0.22
RBL2	FGR	0.22	0.054
CKS2	CCNA1	0.218
CCNA1	CDK2	0.218		mutually_exclusive (P20248) structurally_consistent (dimer)
EP300	CDK3	0.217
CCND2	CCNO	0.214
E2F4	CCNB2	0.214	0.17
EP300	CCNE1	0.213	0.218
CCNA1	CDK5	0.211
EP300	CCNB2	0.208	0.232
PKMYT1	CDK3	0.207		mutually_exclusive (P06493)
CDK6	FGR	0.206	0.13
CDKN1B	FGR	0.205	0.072
CCND2	CDKN2C	0.196	0.178
RBL1	CDK1	0.193	0.26446031746
RBL2	CCNB2	0.19	0.088	mutually_exclusive (P24941)
CDK4	E2F5	0.19
E2F4	CCND3	0.188	0.134
CDK6	E2F5	0.188
CDKN1B	E2F5	0.188
E2F5	CDKN1C	0.188
RBL1	CCND1	0.188	0.212
MIDEAS	CREBBP	0.185	0.132
CCNA2	FGR	0.184	0.08
CKS2	FGR	0.184	0.042
EP300	MIDEAS	0.178	0.258
EP300	CKS1B	0.177	0.022
CCND2	CCND1	0.175	0.192
SCAPER	CREBBP	0.172	0.208
EP300	CCNA1	0.172
RBL2	CCNA1	0.172
CCNA1	CDKN1C	0.172
RBL1	CCNA1	0.172
MIDEAS	CDKN2A	0.165	0.092
CREBBP	GMNN	0.164	0.204
PKMYT1	CCNA1	0.164
EP300	SCAPER	0.164	0.27
PKMYT1	CDKN1A	0.162	0.146666666667
RBL1	PKMYT1	0.16	0.178
EP300	CKS2	0.16	0.024
E2F4	CDK5	0.159	0.194
RBL1	CCNB2	0.158	0.314
FGR	CDK5	0.157	0.088
SKP2	CCNA1	0.156
CDKN2C	CDK5	0.154	0.098
PKMYT1	CREBBP	0.15	0.146
E2F4	CDK6	0.145	0.25
CDK1	CDK5	0.145	0.07
PKMYT1	CCNE2	0.143		mutually_exclusive (P61024)
CDKN2D	PCNA	0.143
EP300	CDT1	0.143	0.26
RBL2	MIDEAS	0.143	0.112
RBL1	MIDEAS	0.143	0.064
CDT1	CREBBP	0.143	0.248
CCNA1	CDKN1A	0.143
CDT1	E2F5	0.143
CCNA1	GMNN	0.143
EP300	CDKN1A	0.141	0.352
EP300	CDKN1B	0.141	0.362
CREBBP	CCNE2	0.141
CREBBP	CCNE1	0.136	0.37
CCND2	CCNB3	0.135
E2F5	CDK5	0.133
FGR	CDK2	0.129	0.13
PKMYT1	CCNE1	0.124	0.106	mutually_exclusive (P61024)
EP300	SKP2	0.12	0.280075471698
CREBBP	CKS1B	0.12	0.048
CKS2	CREBBP	0.12	0.016
CDK1	CDKN2A	0.119	0.141261538462
CDK1	E2F5	0.118
RBL2	PKMYT1	0.114	0.062
CCNA1	CCNE1	0.113
CCNA1	CCNE2	0.113
CDK3	CCNB3	0.113
CKS2	PCNA	0.112	0.062	structurally_consistent (P24941)
SKP2	CREBBP	0.111	0.260784313725
SCAPER	CDK3	0.108
E2F4	CDK4	0.097	0.18
RBL1	CDK5	0.097	0.188
CCND2	CCNA2	0.095	0.134
CCNB1	CDK4	0.094	0.106
EP300	CDK1	0.092	0.257333333333
CDKN2C	PCNA	0.089	0.126
CDK2	CCNI	0.087		mutually_exclusive (Q00526)
CDKN2A	CDK5	0.083	0.074
CREBBP	CCND1	0.08	0.2463
CCND2	SKP2	0.08	0.076
CCND2	CDKN2A	0.08	0.116
CCNB1	CCND2	0.079	0.16
CCND2	CKS2	0.079	0.104	structurally_consistent (P24941)
CCNB2	CCND2	0.079	0.084
CCND2	CKS1B	0.079	0.124	structurally_consistent (P24941)
CCND2	CCNE1	0.079	0.072
CCND2	CCNE2	0.079
CCNB1	CCNA1	0.078
CCND2	CDK3	0.078
CCNB2	CCNA1	0.078
CDK3	CCND3	0.076		structurally_consistent (dimer)
MIDEAS	CDK5	0.076	0.006
E2F4	PKMYT1	0.074	0.09
CCNB2	CREBBP	0.074	0.376
SKP2	CCNB3	0.071
CDKN2C	CDK2	0.071	0.062
CCNA1	CDK4	0.068
SKP2	PCNA	0.067	0.186
CDK1	FGR	0.067	0.104
CDK1	CDKN2C	0.067	0.134405405405
CREBBP	CDK5	0.067	0.046
EP300	PKMYT1	0.066	0.154
MIDEAS	CCNE2	0.063
MIDEAS	CCND1	0.063	0.104
PKMYT1	CCND3	0.063	0.082
CDT1	CDK5	0.063	0.124
MIDEAS	CDK3	0.06
RBL2	CDKN2C	0.058	0.08
CDK3	CDK5R1	0.055
CCNA1	CCND1	0.055
CKS2	CDKN2A	0.053	0.078
CKS2	CDKN2C	0.05	0.044
SKP2	CDK5	0.05	0.144
CCNB1	CREBBP	0.048	0.148
MIDEAS	CCND3	0.048	0.082
EP300	CCND1	0.048	0.376
CDK6	CDK3	0.046
E2F4	EP300	0.046	0.212
E2F4	CREBBP	0.046	0.294
CCND2	FGR	0.046	0.09
E2F4	CCNA1	0.046
CCND2	E2F5	0.046		mutually_exclusive (Q08999)
RBL2	CDKN2A	0.045	0.14
SCAPER	CDK5	0.044	0.118
SKP2	CDK4	0.044	0.238	structurally_consistent (dimer)
CDKN2A	CKS1B	0.043	0.068
CREBBP	E2F5	0.043
CCNB1	CDK5R1	0.043
CCNA1	CDK6	0.043
CDKN1B	CDK5R1	0.043		mutually_exclusive (P24941)
E2F4	MIDEAS	0.042	0.088
EP300	E2F5	0.042
E2F4	CCND2	0.042	0.206	mutually_exclusive (Q08999)
GMNN	CDK5	0.039	0.15
SKP2	CDK6	0.037	0.12
PKMYT1	CDKN2A	0.036	0.124
EP300	CCNB1	0.036	0.09
RBL1	PCNA	0.034	0.274
CDKN2A	CDK2	0.034	0.17
CCNB1	CDKN2C	0.033	0.148
CREBBP	CDK6	0.031	0.122
CDK3	PCNA	0.03
CCNB1	MIDEAS	0.028	0.06
CREBBP	CCNB3	0.027
CCND2	CREBBP	0.027	0.24
SKP2	FGR	0.026
GMNN	CCND1	0.026	0.216
CDKN2A	FGR	0.024
CREBBP	PCNA	0.024	0.262
CDKN2A	CDK3	0.021
CCNA2	CDKN2C	0.021	0.11
PKMYT1	CDK4	0.02	0.167537861553	mutually_exclusive (O95067)
PKMYT1	CDK5	0.019	0.104
CREBBP	CDKN2C	0.019	0.2025
CREBBP	CDK4	0.019	0.148
CCNB2	PCNA	0.018	0.218
SKP2	CDKN2A	0.016	0.156
CDK1	CDK5R1	0.016
CDKN2A	E2F5	0.015
PKMYT1	PCNA	0.014	0.26
CDK4	CDK3	0.014
CREBBP	FGR	0.013	0.222
CREBBP	CCNO	0.013
MIDEAS	PCNA	0.013	0.064
EP300	CDK5	0.011	0.098
CCNA1	PCNA	0.011
CCNB2	SCAPER	0.011	0.13
CDT1	PCNA	0.01	0.206	structurally_consistent (dimer)
CCNB1	SCAPER	0.01	0.186
CDKN2A	PCNA	0.009	0.158
CREBBP	CDKN2A	0.009	0.154842465753
CCNA2	CDKN2A	0.008	0.188
EP300	CDKN2A	0.008	0.112
SCAPER	CDKN2A	0.007	0.078
EP300	PCNA	0.007	0.286
CCNB2	MIDEAS	0.006	0.052
TRIM49	PCNA	0.006
CDKN2A	CDK5R1	0.006
CCNB1	CDKN2A	0.005	0.148
PCNA	CDK5R1	0.004
CDKN2A	GMNN	0.004	0.132
CCNB2	CDKN2A	0.004	0.298
CDK4	GMNN	0.003	0.351
PCNA	CCNI	0.003
GMNN	PCNA	0.002	0.178
SCAPER	PCNA	0.002	0.162

Related Complexes

Genename	Complexes
SIVA1	huMAP3_03604.1 huMAP3_05320.1 huMAP3_10449.1 huMAP3_11068.1 huMAP3_13863.1 huMAP3_14546.1 huMAP3_14722.1
PKMYT1	huMAP3_00736.1 huMAP3_01356.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1
CDK3	huMAP3_03477.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CCNB3	huMAP3_04688.1 huMAP3_06121.1 huMAP3_09229.1 huMAP3_10449.1 huMAP3_13863.1 huMAP3_14722.1
TRIM49	huMAP3_03425.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10328.1 huMAP3_10449.1 huMAP3_11918.1 huMAP3_12012.1 huMAP3_12140.1 huMAP3_14115.1 huMAP3_14134.1 huMAP3_14163.1 huMAP3_14336.1 huMAP3_14632.1 huMAP3_14722.1 huMAP3_14816.1
SKP2	huMAP3_01026.1 huMAP3_04611.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14632.1 huMAP3_14722.1
GMNN	huMAP3_02716.1 huMAP3_03477.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CCNB1	huMAP3_00736.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
E2F4	huMAP3_00125.1 huMAP3_03477.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_10910.1 huMAP3_11168.1
CDKN1C	huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CKS1B	huMAP3_03425.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10328.1 huMAP3_10449.1 huMAP3_14134.1 huMAP3_14722.1
CCND2	huMAP3_00736.1 huMAP3_06121.1 huMAP3_09229.1 huMAP3_10449.1 huMAP3_14722.1
PCNA	huMAP3_03604.1 huMAP3_05320.1 huMAP3_05530.1 huMAP3_06587.1 huMAP3_10449.1 huMAP3_11068.1 huMAP3_14546.1 huMAP3_14722.1
RBL1	huMAP3_00487.1 huMAP3_03164.1 huMAP3_03477.1 huMAP3_05269.1 huMAP3_05947.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_12894.1 huMAP3_12923.1 huMAP3_14722.1
CDK1	huMAP3_00736.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
FGR	huMAP3_03055.1 huMAP3_04688.1 huMAP3_06121.1 huMAP3_07971.1 huMAP3_09622.1 huMAP3_10449.1 huMAP3_13863.1 huMAP3_14722.1
CDK2	huMAP3_03477.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CCNE1	huMAP3_04688.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
SCAPER	huMAP3_01026.1 huMAP3_05269.1 huMAP3_07430.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_14365.1 huMAP3_14722.1
CDKN2D	huMAP3_01523.1 huMAP3_09622.1 huMAP3_10449.1 huMAP3_14722.1
CCNI	huMAP3_04028.1 huMAP3_04468.1 huMAP3_06311.1 huMAP3_09793.1 huMAP3_10253.1 huMAP3_10449.1 huMAP3_11987.1 huMAP3_14722.1 huMAP3_15344.1
MIDEAS	huMAP3_01026.1 huMAP3_01287.1 huMAP3_05396.1 huMAP3_06334.1 huMAP3_06587.1 huMAP3_07709.1 huMAP3_08377.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09319.1 huMAP3_09513.1 huMAP3_10311.1 huMAP3_10449.1 huMAP3_14722.1
E2F5	huMAP3_03477.1 huMAP3_04355.1 huMAP3_05947.1 huMAP3_06412.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_13863.1 huMAP3_14722.1
CDT1	huMAP3_01026.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_14722.1
CDK6	huMAP3_01523.1 huMAP3_09622.1 huMAP3_10449.1 huMAP3_14722.1
CCND3	huMAP3_06121.1 huMAP3_09229.1 huMAP3_10449.1 huMAP3_14722.1
CDKN1B	huMAP3_00736.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CREBBP	huMAP3_01026.1 huMAP3_02340.1 huMAP3_04432.1 huMAP3_06547.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_10958.1 huMAP3_12894.1 huMAP3_12923.1 huMAP3_14722.1
CDK5R1	huMAP3_04028.1 huMAP3_04468.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_09793.1 huMAP3_10253.1 huMAP3_10449.1 huMAP3_15344.1
CCNB2	huMAP3_00736.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_14722.1
CKS2	huMAP3_01026.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CDKN2B	huMAP3_01523.1 huMAP3_09622.1 huMAP3_10449.1 huMAP3_14722.1
RBL2	huMAP3_00487.1 huMAP3_03477.1 huMAP3_05947.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_12923.1 huMAP3_14722.1
CDKN2A	huMAP3_01523.1 huMAP3_02172.1 huMAP3_09622.1 huMAP3_10449.1 huMAP3_14722.1 huMAP3_14892.1
CCNA2	huMAP3_01026.1 huMAP3_05269.1 huMAP3_06587.1 huMAP3_07430.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_14722.1
CDK4	huMAP3_01523.1 huMAP3_09622.1 huMAP3_10449.1 huMAP3_13837.1 huMAP3_14722.1
CDKN2C	huMAP3_01523.1 huMAP3_09622.1 huMAP3_10449.1 huMAP3_14722.1
CCNA1	huMAP3_01026.1 huMAP3_05269.1 huMAP3_07430.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_14722.1
CCND1	huMAP3_06121.1 huMAP3_09229.1 huMAP3_10449.1 huMAP3_14722.1
EP300	huMAP3_00314.1 huMAP3_01026.1 huMAP3_04432.1 huMAP3_06547.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_10958.1 huMAP3_12894.1 huMAP3_12923.1 huMAP3_14722.1
CDK5	huMAP3_04028.1 huMAP3_04468.1 huMAP3_06311.1 huMAP3_06587.1 huMAP3_09793.1 huMAP3_10253.1 huMAP3_10449.1 huMAP3_11987.1 huMAP3_14722.1 huMAP3_15344.1
CCNE2	huMAP3_04688.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CCNO	huMAP3_02428.1 huMAP3_04688.1 huMAP3_05982.1 huMAP3_06121.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_13863.1 huMAP3_14722.1
CDKN1A	huMAP3_04688.1 huMAP3_06121.1 huMAP3_09229.1 huMAP3_10449.1 huMAP3_13863.1 huMAP3_14722.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10449.1

Complex Portal: CPX-21602