hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10451.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MFN2 | Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2) | 5 | UniProt NCBI |
| OR12D3 | Olfactory receptor 12D3 (Hs6M1-27) (Olfactory receptor OR6-27) | 3 | UniProt NCBI |
| MARCHF5 | E3 ubiquitin-protein ligase MARCHF5 (EC 2.3.2.27) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) (Mitochondrial ubiquitin ligase) (MITOL) (RING finger protein 153) (RING-type E3 ubiquitin transferase MARCHF5) | 5 | UniProt NCBI |
| MFN1 | Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04137 | 5.19578118732e-05 | 0.75 | MARCHF5 MFN2 MFN1 | Mitophagy - animal |
| REAC:R-HSA-9013419 | 0.000215205765992 | 0.5 | MFN1 MFN2 | RHOT2 GTPase cycle |
| REAC:R-HSA-9715370 | 0.000286914834749 | 0.5 | MFN1 MFN2 | Miro GTPase Cycle |
| REAC:R-HSA-5205685 | 0.00214930898727 | 0.5 | MFN1 MFN2 | PINK1-PRKN Mediated Mitophagy |
| REAC:R-HSA-5205647 | 0.00332479301982 | 0.5 | MFN1 MFN2 | Mitophagy |
| KEGG:04621 | 0.02620193588 | 0.5 | MFN1 MFN2 | NOD-like receptor signaling pathway |
| REAC:R-HSA-9663891 | 0.0282617295192 | 0.5 | MFN1 MFN2 | Selective autophagy |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MFN1 | MFN2 | 0.994 | 0.286 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| OR12D3 | MARCHF5 | 0.973 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MFN2 | MARCHF5 | 0.963 | 0.172 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes