hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10458.1

Complex Portal: CPX-22747

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
MRM2	rRNA methyltransferase 2, mitochondrial (EC 2.1.1.-) (16S rRNA (uridine(1369)-2'-O)-methyltransferase) (16S rRNA [Um1369] 2'-O-methyltransferase) (Protein ftsJ homolog 2)	5	UniProt NCBI
PNPT1	Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein)	5	UniProt NCBI
PUS1	Pseudouridylate synthase 1 homolog (EC 5.4.99.-) (tRNA pseudouridine synthase 1) (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I)	5	UniProt NCBI
PRORP	Mitochondrial ribonuclease P catalytic subunit (EC 3.1.26.5) (Mitochondrial ribonuclease P protein 3) (Mitochondrial RNase P protein 3) (Protein only RNase P catalytic subunit)	5	UniProt NCBI
TATDN1	Deoxyribonuclease TATDN1 (EC 3.1.21.-) (Hepatocarcinoma high expression protein)	3	UniProt NCBI
MTG2	Mitochondrial ribosome-associated GTPase 2 (GTP-binding protein 5) (Protein obg homolog 1) (ObgH1)	5	UniProt NCBI
ATPAF1	ATP synthase mitochondrial F1 complex assembly factor 1 (ATP11 homolog)	3	UniProt NCBI
GLS	Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2) (K-glutaminase) (L-glutamine amidohydrolase) [Cleaved into: Glutaminase kidney isoform, mitochondrial 68 kDa chain; Glutaminase kidney isoform, mitochondrial 65 kDa chain]	5	UniProt NCBI
MTIF2	Translation initiation factor IF-2, mitochondrial (IF-2(Mt)) (IF-2Mt) (IF2(mt))	5	UniProt NCBI
UQCRFS1	Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 7.1.1.8) (Complex III subunit 5) (Cytochrome b-c1 complex subunit 5) (Rieske iron-sulfur protein) (RISP) (Rieske protein UQCRFS1) (Ubiquinol-cytochrome c reductase iron-sulfur subunit) [Cleaved into: Cytochrome b-c1 complex subunit 9 (Su9) (Subunit 9) (8 kDa subunit 9) (Complex III subunit IX) (Cytochrome b-c1 complex subunit 11) (UQCRFS1 mitochondrial targeting sequence) (UQCRFS1 MTS) (Ubiquinol-cytochrome c reductase 8 kDa protein)]	5	UniProt NCBI
PCCA	Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)	5	UniProt NCBI
NUDT19	Acyl-coenzyme A diphosphatase NUDT19 (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 19) (Nudix motif 19)	5	UniProt NCBI
ACAA2	3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1)	5	UniProt NCBI
ACSM5	Acyl-coenzyme A synthetase ACSM5, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 5)	5	UniProt NCBI
PCCB	Propionyl-CoA carboxylase beta chain, mitochondrial (PCCase subunit beta) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta)	5	UniProt NCBI
ELAC2	Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Heredity prostate cancer protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005739	7.49986203612e-09	0.875	ATPAF1 UQCRFS1 MRM2 MTIF2 ACSM5 PCCB GLS PUS1 PRORP MTG2 ELAC2 PCCA ACAA2 PNPT1	mitochondrion
HP:0001941	2.99585513113e-08	0.5625	ATPAF1 UQCRFS1 MRM2 ELAC2 PCCB PUS1 PRORP PCCA PNPT1	Acidosis
HP:0004360	5.11249132127e-08	0.5625	ATPAF1 UQCRFS1 MRM2 ELAC2 PCCB PUS1 PRORP PCCA PNPT1	Abnormality of acid-base homeostasis
GO:0005759	7.86143956089e-08	0.625	GLS MTG2 ACSM5 PCCB PUS1 PRORP MRM2 PCCA ACAA2 ELAC2	mitochondrial matrix
HP:0003128	2.28178377254e-05	0.375	UQCRFS1 ATPAF1 PCCB PUS1 ELAC2 PCCA	Lactic acidosis
GO:0090646	3.40386572815e-05	0.25	PUS1 ELAC2 PNPT1 PRORP	mitochondrial tRNA processing
REAC:R-HSA-8868766	3.75974041182e-05	0.1875	MRM2 PRORP ELAC2	rRNA processing in the mitochondrion
CORUM:7057	5.10764421909e-05	0.125	PCCA PCCB	Propionyl-CoA carboxylase
GO:0000963	0.000229594433106	0.25	PUS1 ELAC2 PNPT1 PRORP	mitochondrial RNA processing
HP:0003112	0.000431886675606	0.3125	GLS MRM2 PCCA PCCB ATPAF1	Abnormal circulating amino acid concentration
GO:0140053	0.000438126345452	0.375	MTIF2 PRORP PUS1 ELAC2 MTG2 PNPT1	mitochondrial gene expression
KEGG:00280	0.000941843029782	0.1875	PCCA ACAA2 PCCB	Valine, leucine and isoleucine degradation
HP:0001987	0.00108283689511	0.25	MRM2 PCCA PCCB ATPAF1	Hyperammonemia
REAC:R-HSA-77289	0.0018450565582	0.1875	PCCA ACAA2 PCCB	Mitochondrial Fatty Acid Beta-Oxidation
REAC:R-HSA-71032	0.00196885406049	0.125	PCCA PCCB	Propionyl-CoA catabolism
REAC:R-HSA-6785470	0.00327932770653	0.125	PRORP ELAC2	tRNA processing in the mitochondrion
HP:0003353	0.00366183923443	0.125	PCCA PCCB	Propionyl-CoA carboxylase deficiency
WP:WP5031	0.00448463745996	0.125	PCCA PCCB	Biotin metabolism including IMDs
REAC:R-HSA-8978868	0.00463266497689	0.25	PCCA PCCB NUDT19 ACAA2	Fatty acid metabolism
HP:0003808	0.00494491710919	0.625	ATPAF1 UQCRFS1 MRM2 ELAC2 PCCB PUS1 PRORP GLS PCCA PNPT1	Abnormal muscle tone
HP:0012337	0.0058842436769	0.5625	ATPAF1 UQCRFS1 MRM2 ELAC2 PCCB PUS1 PRORP PCCA PNPT1	Abnormal homeostasis
GO:0000959	0.00633219709228	0.25	PUS1 ELAC2 PNPT1 PRORP	mitochondrial RNA metabolic process
REAC:R-HSA-3371599	0.00687779493591	0.125	PCCA PCCB	Defective HLCS causes multiple carboxylase deficiency
HP:0004354	0.00895141290893	0.3125	GLS MRM2 PCCA PCCB ATPAF1	Abnormal circulating carboxylic acid concentration
REAC:R-HSA-3323169	0.00916453694962	0.125	PCCA PCCB	Defects in biotin (Btn) metabolism
HP:0001298	0.00943809821284	0.3125	ATPAF1 PCCA PCCB PNPT1 GLS	Encephalopathy
HP:0001939	0.0172632620753	0.625	ATPAF1 UQCRFS1 MRM2 ELAC2 PCCB PUS1 PRORP GLS PCCA PNPT1	Abnormality of metabolism/homeostasis
REAC:R-HSA-196780	0.017967304716	0.125	PCCA PCCB	Biotin transport and metabolism
HP:0410066	0.0182741382889	0.125	PCCA PCCB	Increased level of hippuric acid in urine
HP:0011695	0.0182741382889	0.125	PCCA PCCB	Cerebellar hemorrhage
HP:0002157	0.0186598457537	0.25	MRM2 PCCA PCCB ATPAF1	Azotemia
HP:0011804	0.0190176701119	0.625	ATPAF1 UQCRFS1 MRM2 ELAC2 PCCB PUS1 PRORP GLS PCCA PNPT1	Abnormal muscle physiology
HPA:0570733	0.0196944530151	0.5	UQCRFS1 MTG2 ELAC2 PCCB PUS1 PNPT1 PCCA PRORP	testis; Leydig cells[High]
KEGG:00630	0.021331036809	0.125	PCCA PCCB	Glyoxylate and dicarboxylate metabolism
HP:0004364	0.0240991338902	0.25	MRM2 PCCA PCCB ATPAF1	Abnormal circulating nitrogen compound concentration
KEGG:00640	0.0304225234928	0.125	PCCA PCCB	Propanoate metabolism
WP:WP4686	0.0312364916034	0.125	PCCA PCCB	Leucine isoleucine and valine metabolism
HP:0002060	0.0341479903518	0.5625	ATPAF1 MRM2 ELAC2 PCCB PUS1 PRORP GLS PCCA PNPT1	Abnormal cerebral morphology
HP:0003287	0.0351152743702	0.25	MRM2 ELAC2 PNPT1 PUS1	Abnormality of mitochondrial metabolism
HP:0100547	0.0387453136948	0.5625	ATPAF1 MRM2 ELAC2 PCCB PUS1 PRORP GLS PCCA PNPT1	Abnormal forebrain morphology
GO:0016054	0.0395276205262	0.3125	GLS ACAA2 PCCB NUDT19 PCCA	organic acid catabolic process
GO:0046395	0.0395276205262	0.3125	GLS ACAA2 PCCB NUDT19 PCCA	carboxylic acid catabolic process
REAC:R-HSA-3296482	0.0497588156052	0.125	PCCA PCCB	Defects in vitamin and cofactor metabolism

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PCCB	PCCA	1.0	0.626	structurally_consistent (dimer)
MTG2	MTIF2	0.997	0.23	mutually_exclusive (P43897)
MTG2	ATPAF1	0.995	0.106	mutually_exclusive (P43897)
MTG2	PUS1	0.995	0.24
PCCA	ACSM5	0.992
MTG2	GLS	0.991	0.14
MTG2	PNPT1	0.991	0.284
MRM2	ATPAF1	0.99	0.214
MRM2	PNPT1	0.986	0.27
MTG2	PCCA	0.985	0.056
MTIF2	GLS	0.984	0.138
MTG2	PRORP	0.983	0.25
PRORP	NUDT19	0.982	0.114
GLS	NUDT19	0.981	0.062
ELAC2	UQCRFS1	0.98	0.044
MTIF2	PUS1	0.979	0.246
UQCRFS1	MTIF2	0.977	0.494
MTG2	ACSM5	0.977
PUS1	GLS	0.976	0.064
MRM2	MTIF2	0.974	0.274
UQCRFS1	NUDT19	0.974	0.098
ELAC2	NUDT19	0.973	0.066
ELAC2	PRORP	0.973	0.304
MRM2	PRORP	0.968	0.356
PRORP	GLS	0.967	0.118
PUS1	PNPT1	0.966	0.342
UQCRFS1	GLS	0.964	0.084
MTG2	MRM2	0.964	0.254	structurally_consistent (dimer)
MTIF2	PCCA	0.964	0.068
ELAC2	MTG2	0.963	0.152
ELAC2	MRM2	0.963	0.306
ACAA2	PNPT1	0.962	0.092
TATDN1	MRM2	0.962	0.11
MTG2	TATDN1	0.959	0.064
MTIF2	ATPAF1	0.959	0.158
PUS1	ACSM5	0.958
ELAC2	PNPT1	0.956	0.22
PNPT1	GLS	0.955	0.154
PRORP	MTIF2	0.955	0.07
PUS1	NUDT19	0.954	0.118
PRORP	PUS1	0.953	0.11
ELAC2	PUS1	0.951	0.126
MRM2	GLS	0.95	0.08
MTG2	NUDT19	0.948	0.16
MRM2	PUS1	0.94	0.212
PRORP	ATPAF1	0.936	0.078
ACAA2	GLS	0.935	0.15
MRM2	PCCA	0.934	0.054	mutually_exclusive (P05166)
PCCB	PUS1	0.932	0.062
ATPAF1	PCCA	0.928	0.038
MTIF2	ACAA2	0.927	0.098
ELAC2	GLS	0.923	0.124
NUDT19	ACSM5	0.918
MTIF2	PNPT1	0.918	0.41
ACAA2	PUS1	0.909	0.13
ATPAF1	PNPT1	0.908	0.338
PNPT1	NUDT19	0.904	0.294
MTIF2	NUDT19	0.902	0.156
ATPAF1	ACSM5	0.899
ELAC2	MTIF2	0.893	0.056
UQCRFS1	PUS1	0.891	0.1
ATPAF1	GLS	0.89	0.086
ELAC2	ATPAF1	0.883	0.114
PRORP	ACSM5	0.877
PCCA	GLS	0.864	0.09
MTG2	PCCB	0.855	0.116
PRORP	PCCA	0.839	0.048
PCCA	PNPT1	0.837	0.066
MRM2	PCCB	0.816	0.184	structurally_consistent (dimer)
PCCB	ATPAF1	0.79	0.108
PCCB	NUDT19	0.775	0.072
GLS	ACSM5	0.728
UQCRFS1	PRORP	0.72	0.046
PCCB	PNPT1	0.704	0.086
PRORP	PNPT1	0.703	0.36
TATDN1	ACAA2	0.692	0.06
PCCB	MTIF2	0.683	0.092
PCCB	GLS	0.678	0.062
ELAC2	PCCA	0.675	0.0572307692308
PCCA	PUS1	0.672	0.142
PRORP	ACAA2	0.637	0.036
PCCB	ACAA2	0.631	0.314
ATPAF1	PUS1	0.622	0.096	mutually_exclusive (P43897)
ATPAF1	NUDT19	0.615	0.098
TATDN1	ACSM5	0.615
UQCRFS1	ACAA2	0.608	0.208
TATDN1	PRORP	0.604	0.028
PCCA	NUDT19	0.588	0.073
ACAA2	PCCA	0.539	0.354
PCCB	ACSM5	0.463
ACAA2	ATPAF1	0.456	0.024
UQCRFS1	PCCA	0.454	0.156
UQCRFS1	ATPAF1	0.449	0.074
TATDN1	ATPAF1	0.394	0.082
ELAC2	ACSM5	0.342
MTG2	UQCRFS1	0.323	0.286	mutually_exclusive (Q9UI43)
MTG2	ACAA2	0.301	0.124
MRM2	UQCRFS1	0.299	0.068	structurally_consistent (dimer)
TATDN1	MTIF2	0.259	0.068
UQCRFS1	PCCB	0.249	0.258	mutually_exclusive (Q9UI43)
MRM2	NUDT19	0.225	0.318	mutually_exclusive (P43155)
PCCB	PRORP	0.184	0.0300983606557
ELAC2	ACAA2	0.173	0.062
TATDN1	GLS	0.165	0.046
TATDN1	PUS1	0.134	0.11
TATDN1	PNPT1	0.128	0.17
TATDN1	UQCRFS1	0.124	0.042
UQCRFS1	PNPT1	0.123	0.148
TATDN1	PCCA	0.119	0.062
TATDN1	NUDT19	0.119	0.028
ACAA2	NUDT19	0.118	0.146
TATDN1	PCCB	0.103	0.024
ELAC2	TATDN1	0.092	0.072
PNPT1	ACSM5	0.087
ELAC2	PCCB	0.067	0.076
MRM2	ACAA2	0.049	0.064
ACAA2	ACSM5	0.019

Related Complexes

Genename	Complexes
MRM2	huMAP3_01763.1 huMAP3_03168.1 huMAP3_05744.1 huMAP3_08655.1 huMAP3_09897.1 huMAP3_10410.1 huMAP3_10458.1 huMAP3_13468.1
PNPT1	huMAP3_10458.1 huMAP3_13468.1
PUS1	huMAP3_09437.1 huMAP3_10458.1 huMAP3_12552.1 huMAP3_13468.1
PRORP	huMAP3_03877.1 huMAP3_09897.1 huMAP3_10458.1 huMAP3_13468.1
TATDN1	huMAP3_01279.1 huMAP3_01763.1 huMAP3_03168.1 huMAP3_05744.1 huMAP3_06941.1 huMAP3_08655.1 huMAP3_09897.1 huMAP3_10410.1 huMAP3_10458.1 huMAP3_13468.1
MTG2	huMAP3_01279.1 huMAP3_06941.1 huMAP3_08696.1 huMAP3_09437.1 huMAP3_10458.1 huMAP3_13468.1
ATPAF1	huMAP3_06941.1 huMAP3_08655.1 huMAP3_09897.1 huMAP3_10458.1 huMAP3_13399.1 huMAP3_13468.1
GLS	huMAP3_10458.1 huMAP3_13468.1
MTIF2	huMAP3_06099.1 huMAP3_10458.1 huMAP3_13202.1 huMAP3_13468.1
UQCRFS1	huMAP3_01826.1 huMAP3_04728.1 huMAP3_07021.1 huMAP3_07870.1 huMAP3_07890.1 huMAP3_09982.1 huMAP3_10294.1 huMAP3_10458.1 huMAP3_10623.1 huMAP3_12170.1 huMAP3_12457.1 huMAP3_12621.1 huMAP3_14018.1 huMAP3_14580.1
PCCA	huMAP3_07028.1 huMAP3_08696.1 huMAP3_09437.1 huMAP3_10458.1 huMAP3_13468.1
NUDT19	huMAP3_10458.1 huMAP3_13468.1
ACAA2	huMAP3_06682.1 huMAP3_10458.1 huMAP3_13468.1
ACSM5	huMAP3_10458.1 huMAP3_13468.1
PCCB	huMAP3_02917.1 huMAP3_07028.1 huMAP3_08047.1 huMAP3_10458.1 huMAP3_13468.1
ELAC2	huMAP3_00934.1 huMAP3_06761.1 huMAP3_10458.1 huMAP3_10599.1 huMAP3_13468.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10458.1

Complex Portal: CPX-22747