hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10464.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RNF14 | E3 ubiquitin-protein ligase RNF14 (EC 2.3.2.31) (Androgen receptor-associated protein 54) (HFB30) (RING finger protein 14) | 5 | UniProt NCBI |
| OSBPL3 | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | 5 | UniProt NCBI |
| ZFPL1 | Zinc finger protein-like 1 (Zinc finger protein MCG4) | 5 | UniProt NCBI |
| PITPNM1 | Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) | 5 | UniProt NCBI |
| OSBP | Oxysterol-binding protein 1 | 5 | UniProt NCBI |
| PITPNM3 | Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1) | 5 | UniProt NCBI |
| OSBPL2 | Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2) | 5 | UniProt NCBI |
| VAPA | Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33) | 5 | UniProt NCBI |
| OSBPL6 | Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) | 5 | UniProt NCBI |
| KLRD1 | Natural killer cells antigen CD94 (KP43) (Killer cell lectin-like receptor subfamily D member 1) (NK cell receptor) (CD antigen CD94) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-192105 | 1.58873212508e-07 | 0.4 | OSBPL3 OSBPL6 OSBPL2 OSBP | Synthesis of bile acids and bile salts |
| REAC:R-HSA-194068 | 6.28819246487e-07 | 0.4 | OSBPL3 OSBPL6 OSBPL2 OSBP | Bile acid and bile salt metabolism |
| GO:0005319 | 2.12967255275e-06 | 0.6 | PITPNM1 OSBPL6 OSBP OSBPL3 PITPNM3 OSBPL2 | lipid transporter activity |
| REAC:R-HSA-556833 | 5.66829866813e-06 | 0.7 | PITPNM1 VAPA OSBP OSBPL3 PITPNM3 OSBPL2 OSBPL6 | Metabolism of lipids |
| GO:0097038 | 1.30949840786e-05 | 0.4 | OSBPL3 OSBPL6 OSBPL2 OSBP | perinuclear endoplasmic reticulum |
| GO:0006699 | 4.01817082119e-05 | 0.4 | OSBPL3 OSBPL6 OSBPL2 OSBP | bile acid biosynthetic process |
| GO:0015248 | 8.20132428287e-05 | 0.4 | OSBPL3 OSBPL6 OSBPL2 OSBP | sterol transporter activity |
| GO:0008206 | 0.000112248624614 | 0.4 | OSBPL3 OSBPL6 OSBPL2 OSBP | bile acid metabolic process |
| REAC:R-HSA-8957322 | 0.000225524796323 | 0.4 | OSBPL3 OSBPL6 OSBPL2 OSBP | Metabolism of steroids |
| GO:0008610 | 0.00033141724834 | 0.7 | PITPNM1 VAPA OSBP OSBPL3 PITPNM3 OSBPL2 OSBPL6 | lipid biosynthetic process |
| GO:0120013 | 0.000449289899845 | 0.4 | PITPNM1 PITPNM3 OSBPL2 OSBP | lipid transfer activity |
| GO:0008526 | 0.000644767051209 | 0.3 | PITPNM1 OSBPL2 PITPNM3 | phosphatidylinositol transfer activity |
| GO:0032934 | 0.000971743443131 | 0.4 | OSBPL3 OSBPL6 OSBPL2 OSBP | sterol binding |
| REAC:R-HSA-1483226 | 0.00101671361746 | 0.2 | PITPNM1 PITPNM3 | Synthesis of PI |
| GO:0015914 | 0.00185320096161 | 0.4 | PITPNM1 VAPA OSBPL2 OSBP | phospholipid transport |
| GO:0005496 | 0.00344224325698 | 0.4 | OSBPL3 OSBPL6 OSBPL2 OSBP | steroid binding |
| GO:0030301 | 0.00769229904439 | 0.4 | OSBP OSBPL6 VAPA OSBPL2 | cholesterol transport |
| REAC:R-HSA-1430728 | 0.00790690859643 | 0.7 | PITPNM1 VAPA OSBP OSBPL3 PITPNM3 OSBPL2 OSBPL6 | Metabolism |
| GO:0006869 | 0.00836311927428 | 0.5 | PITPNM1 OSBPL6 VAPA OSBPL2 OSBP | lipid transport |
| GO:0015918 | 0.00896320209978 | 0.4 | OSBP OSBPL6 VAPA OSBPL2 | sterol transport |
| GO:0015748 | 0.0103846818546 | 0.4 | PITPNM1 VAPA OSBPL2 OSBP | organophosphate ester transport |
| GO:0120014 | 0.0130691170406 | 0.3 | PITPNM1 OSBPL2 PITPNM3 | phospholipid transfer activity |
| GO:0006629 | 0.0154846744626 | 0.7 | PITPNM1 VAPA OSBP OSBPL3 PITPNM3 OSBPL2 OSBPL6 | lipid metabolic process |
| GO:0010876 | 0.0172008666431 | 0.5 | PITPNM1 OSBPL6 VAPA OSBPL2 OSBP | lipid localization |
| GO:0006694 | 0.0201600977054 | 0.4 | OSBPL3 OSBPL6 OSBPL2 OSBP | steroid biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| VAPA | OSBPL3 | 0.999 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| VAPA | ZFPL1 | 0.999 | 0.17 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM |
| VAPA | OSBPL6 | 0.999 | 0.140194444444 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| VAPA | OSBPL2 | 0.999 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| ZFPL1 | OSBPL3 | 0.996 | 0.086 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| VAPA | OSBP | 0.992 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| VAPA | PITPNM3 | 0.992 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| OSBPL6 | KLRD1 | 0.99 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| OSBPL6 | OSBPL3 | 0.985 | 0.082 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| VAPA | PITPNM1 | 0.983 | 0.11 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ZFPL1 | OSBPL2 | 0.983 | 0.026 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ZFPL1 | PITPNM3 | 0.979 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| OSBPL3 | KLRD1 | 0.978 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| OSBPL2 | RNF14 | 0.976 | 0.07 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| VAPA | KLRD1 | 0.976 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZFPL1 | OSBPL6 | 0.96 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PITPNM3 | OSBPL3 | 0.909 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PITPNM1 | PITPNM3 | 0.843 | bioplex_WMM bioplex3_WMM WMM_only | |
| PITPNM1 | OSBPL2 | 0.797 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only |
| PITPNM3 | OSBPL2 | 0.793 | bioplex_WMM bioplex3_WMM WMM_only | |
| PITPNM1 | OSBPL6 | 0.737 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only |
| PITPNM1 | OSBP | 0.731 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only |
| PITPNM1 | OSBPL3 | 0.72 | 0.028 | bioplex_WMM bioplex3_WMM WMM_only |
| OSBP | PITPNM3 | 0.677 | bioplex_WMM bioplex3_WMM WMM_only | |
| OSBP | OSBPL6 | 0.653 | 0.148 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PITPNM3 | OSBPL6 | 0.644 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZFPL1 | KLRD1 | 0.637 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PITPNM1 | ZFPL1 | 0.563 | 0.034 | bioplex_WMM bioplex3_WMM WMM_only |
| OSBPL6 | OSBPL2 | 0.551 | 0.122 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| OSBPL3 | OSBPL2 | 0.543 | 0.036 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| OSBP | OSBPL3 | 0.509 | 0.082 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM |
| OSBP | OSBPL2 | 0.477 | 0.052 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| OSBP | ZFPL1 | 0.227 | 0.11 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| ZFPL1 | RNF14 | 0.097 | 0.0222558139535 | bioplex3_WMM WMM_only |
| VAPA | RNF14 | 0.054 | 0.072 | bioplex3_WMM WMM_only |
Related Complexes