hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10476.1
Complex Portal: CPX-18896
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TNFRSF10A | Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261) | 5 | UniProt NCBI |
| PROKR1 | Prokineticin receptor 1 (PK-R1) (G-protein coupled receptor 73) (G-protein coupled receptor ZAQ) (GPR73a) | 4 | UniProt NCBI |
| PCDHAC1 | Protocadherin alpha-C1 (PCDH-alpha-C1) | 4 | UniProt NCBI |
| GPR3 | G-protein coupled receptor 3 (ACCA orphan receptor) | 5 | UniProt NCBI |
| CASP8 | Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] | 5 | UniProt NCBI |
| CFLAR | CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12] | 5 | UniProt NCBI |
| TNFRSF10B | Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-75158 | 1.24872445941e-10 | 0.571428571429 | CASP8 TNFRSF10A TNFRSF10B CFLAR | TRAIL signaling |
| REAC:R-HSA-3371378 | 1.56249715062e-06 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | Regulation by c-FLIP |
| REAC:R-HSA-5218900 | 1.56249715062e-06 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | CASP8 activity is inhibited |
| REAC:R-HSA-69416 | 1.56249715062e-06 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | Dimerization of procaspase-8 |
| WP:WP1772 | 2.35100260282e-06 | 0.571428571429 | CASP8 TNFRSF10A TNFRSF10B CFLAR | Apoptosis modulation and signaling |
| REAC:R-HSA-140534 | 3.72165755864e-06 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | Caspase activation via Death Receptors in the presence of ligand |
| KEGG:04210 | 7.74732710295e-06 | 0.571428571429 | CASP8 TNFRSF10A TNFRSF10B CFLAR | Apoptosis |
| REAC:R-HSA-5357769 | 1.25938591632e-05 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | Caspase activation via extrinsic apoptotic signalling pathway |
| KEGG:04217 | 1.32078898316e-05 | 0.571428571429 | CASP8 TNFRSF10A TNFRSF10B CFLAR | Necroptosis |
| REAC:R-HSA-73887 | 3.61497405074e-05 | 0.571428571429 | CASP8 TNFRSF10A TNFRSF10B CFLAR | Death Receptor Signaling |
| REAC:R-HSA-5675482 | 5.26476903505e-05 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | Regulation of necroptotic cell death |
| REAC:R-HSA-5213460 | 5.26476903505e-05 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | RIPK1-mediated regulated necrosis |
| CORUM:5749 | 6.1565588648e-05 | 0.285714285714 | CASP8 CFLAR | MRIT complex |
| CORUM:5799 | 6.1565588648e-05 | 0.285714285714 | CASP8 CFLAR | DISC complex (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced |
| CORUM:5798 | 6.1565588648e-05 | 0.285714285714 | CASP8 CFLAR | Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced |
| KEGG:04115 | 0.000144487772681 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | p53 signaling pathway |
| GO:0036462 | 0.0001882019462 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | TRAIL-activated apoptotic signaling pathway |
| GO:0008625 | 0.000288863510592 | 0.571428571429 | CASP8 TNFRSF10A TNFRSF10B CFLAR | extrinsic apoptotic signaling pathway via death domain receptors |
| REAC:R-HSA-5218859 | 0.00030234111687 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | Regulated Necrosis |
| WP:WP254 | 0.000373640809752 | 0.428571428571 | CASP8 TNFRSF10B CFLAR | Apoptosis |
| WP:WP5322 | 0.000937232194939 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | CKAP4 signaling pathway map |
| KEGG:05164 | 0.00166242587361 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | Influenza A |
| KEGG:05130 | 0.0024968157629 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | Pathogenic Escherichia coli infection |
| REAC:R-HSA-6803211 | 0.00250948572249 | 0.285714285714 | TNFRSF10A TNFRSF10B | TP53 Regulates Transcription of Death Receptors and Ligands |
| WP:WP2507 | 0.00303405736115 | 0.285714285714 | CASP8 CFLAR | Nanomaterial induced apoptosis |
| WP:WP3982 | 0.00303405736115 | 0.285714285714 | CASP8 TNFRSF10B | miRNA regulation of p53 pathway in prostate cancer |
| KEGG:05417 | 0.0032364559788 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | Lipid and atherosclerosis |
| KEGG:05132 | 0.00620117831779 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | Salmonella infection |
| REAC:R-HSA-109581 | 0.00943980481067 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | Apoptosis |
| GO:0045569 | 0.00983221512175 | 0.285714285714 | TNFRSF10A TNFRSF10B | TRAIL binding |
| WP:WP314 | 0.0124193659106 | 0.285714285714 | CASP8 CFLAR | Fas ligand pathway and stress induction of heat shock proteins |
| GO:0097191 | 0.0146147722157 | 0.571428571429 | CASP8 TNFRSF10A TNFRSF10B CFLAR | extrinsic apoptotic signaling pathway |
| REAC:R-HSA-5357801 | 0.0150200835391 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | Programmed Cell Death |
| KEGG:04061 | 0.0167496959508 | 0.285714285714 | TNFRSF10A TNFRSF10B | Viral protein interaction with cytokine and cytokine receptor |
| WP:WP4754 | 0.0242608328425 | 0.285714285714 | CASP8 CFLAR | IL 18 signaling pathway |
| GO:0071260 | 0.0259578682575 | 0.428571428571 | CASP8 TNFRSF10A TNFRSF10B | cellular response to mechanical stimulus |
| REAC:R-HSA-5633008 | 0.0265716665994 | 0.285714285714 | TNFRSF10A TNFRSF10B | TP53 Regulates Transcription of Cell Death Genes |
| WP:WP1530 | 0.0365198824686 | 0.285714285714 | CASP8 TNFRSF10B | miRNA regulation of DNA damage response |
| WP:WP707 | 0.0365198824686 | 0.285714285714 | CASP8 TNFRSF10B | DNA damage response |
| KEGG:05142 | 0.0385237834173 | 0.285714285714 | CASP8 CFLAR | Chagas disease |
| KEGG:04668 | 0.0448625057456 | 0.285714285714 | CASP8 CFLAR | TNF signaling pathway |
| CORUM:1062 | 0.0499958217778 | 0.142857142857 | CASP8 | BAR-BCL2-CASP8 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CASP8 | CFLAR | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TNFRSF10B | TNFRSF10A | 0.986 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TNFRSF10B | CASP8 | 0.978 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TNFRSF10A | CASP8 | 0.967 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TNFRSF10B | PROKR1 | 0.963 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GPR3 | TNFRSF10B | 0.962 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TNFRSF10B | PCDHAC1 | 0.954 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes