hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10482.1
Complex Portal: CPX-13930
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TNS3 | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | 5 | UniProt NCBI |
| BABAM1 | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | 5 | UniProt NCBI |
| ABRAXAS1 | BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A) | 5 | UniProt NCBI |
| DEF6 | Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) | 5 | UniProt NCBI |
| SHMT2 | Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | 5 | UniProt NCBI |
| C9orf85 | Uncharacterized protein C9orf85 | 2 | UniProt NCBI |
| BRCC3 | Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36) | 5 | UniProt NCBI |
| BABAM2 | BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein) | 5 | UniProt NCBI |
| ABRAXAS2 | BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0070552 | 6.80576638125e-12 | 0.555555555556 | BABAM1 BRCC3 ABRAXAS2 BABAM2 SHMT2 | BRISC complex |
| REAC:R-HSA-5689901 | 5.25686745994e-10 | 0.555555555556 | BABAM1 BABAM2 ABRAXAS2 ABRAXAS1 BRCC3 | Metalloprotease DUBs |
| GO:0070531 | 2.31823352537e-07 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | BRCA1-A complex |
| KEGG:03440 | 3.0335626748e-07 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | Homologous recombination |
| REAC:R-HSA-5693571 | 8.07264008546e-06 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | Nonhomologous End-Joining (NHEJ) |
| REAC:R-HSA-5693565 | 1.49891302637e-05 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 1.58664855984e-05 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | DNA Double Strand Break Response |
| WP:WP5380 | 1.95968401753e-05 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | 5q35 copy number variation |
| CORUM:7114 | 2.73623797451e-05 | 0.222222222222 | SHMT2 ABRAXAS2 | ABRAXAS2-SHMT2 complex |
| GO:0070536 | 2.92053987194e-05 | 0.444444444444 | SHMT2 ABRAXAS2 BABAM2 BRCC3 | protein K63-linked deubiquitination |
| REAC:R-HSA-69473 | 3.41876218612e-05 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | G2/M DNA damage checkpoint |
| REAC:R-HSA-5688426 | 3.89471992676e-05 | 0.555555555556 | BABAM1 BABAM2 ABRAXAS2 ABRAXAS1 BRCC3 | Deubiquitination |
| REAC:R-HSA-5693607 | 3.92129315961e-05 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | Processing of DNA double-strand break ends |
| GO:0007095 | 9.02134234826e-05 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | mitotic G2 DNA damage checkpoint signaling |
| REAC:R-HSA-5693567 | 0.000138065138157 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.000167151000677 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | Homology Directed Repair |
| CORUM:5400 | 0.000273361732609 | 0.222222222222 | BRCC3 BABAM2 | BRCC complex |
| REAC:R-HSA-5693532 | 0.000376424321897 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | DNA Double-Strand Break Repair |
| REAC:R-HSA-69481 | 0.000386032040152 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | G2/M Checkpoints |
| GO:0044818 | 0.000534830416832 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | mitotic G2/M transition checkpoint |
| GO:0031593 | 0.00103422373522 | 0.444444444444 | BRCC3 ABRAXAS2 ABRAXAS1 BABAM2 | polyubiquitin modification-dependent protein binding |
| GO:0010972 | 0.00111503328238 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | negative regulation of G2/M transition of mitotic cell cycle |
| GO:1902750 | 0.0012907232035 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | negative regulation of cell cycle G2/M phase transition |
| GO:0044773 | 0.00298534559142 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | mitotic DNA damage checkpoint signaling |
| GO:0016579 | 0.00334782846127 | 0.444444444444 | SHMT2 ABRAXAS2 BABAM2 BRCC3 | protein deubiquitination |
| REAC:R-HSA-69620 | 0.00359892505584 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | Cell Cycle Checkpoints |
| GO:0044774 | 0.00374224380784 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | mitotic DNA integrity checkpoint signaling |
| REAC:R-HSA-73894 | 0.00517868236837 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | DNA Repair |
| GO:0010389 | 0.00540067687882 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | regulation of G2/M transition of mitotic cell cycle |
| GO:0010212 | 0.00656544696377 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | response to ionizing radiation |
| GO:0070646 | 0.00755501568248 | 0.444444444444 | SHMT2 ABRAXAS2 BABAM2 BRCC3 | protein modification by small protein removal |
| GO:1902749 | 0.00827392856677 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | regulation of cell cycle G2/M phase transition |
| GO:0000077 | 0.0160151987026 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | DNA damage checkpoint signaling |
| GO:0000086 | 0.0179204158456 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | G2/M transition of mitotic cell cycle |
| GO:0031570 | 0.0222326056689 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | DNA integrity checkpoint signaling |
| GO:0044839 | 0.0255085593346 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | cell cycle G2/M phase transition |
| GO:0045739 | 0.0263809026071 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | positive regulation of DNA repair |
| GO:0007093 | 0.0300945162572 | 0.444444444444 | BABAM1 BABAM2 ABRAXAS1 BRCC3 | mitotic cell cycle checkpoint signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| BABAM1 | BABAM2 | 1.0 | 0.45 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM |
| BABAM1 | ABRAXAS2 | 1.0 | 0.334 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| BABAM1 | BRCC3 | 1.0 | 0.316 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM | |
| BABAM1 | SHMT2 | 1.0 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| BRCC3 | ABRAXAS2 | 1.0 | 0.372 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM | |
| SHMT2 | BRCC3 | 0.999 | 0.122482269504 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| BRCC3 | BABAM2 | 0.998 | 0.802 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only | |
| BABAM1 | ABRAXAS1 | 0.998 | 0.304 |
structurally_consistent (Q9NXR7)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TNS3 | DEF6 | 0.996 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SHMT2 | ABRAXAS2 | 0.996 | 0.096 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| BABAM2 | ABRAXAS2 | 0.99 | 0.282 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| C9orf85 | ABRAXAS2 | 0.989 | 0.194 |
structurally_consistent (Q9NXR7)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| BABAM1 | DEF6 | 0.986 | 0.02 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SHMT2 | BABAM2 | 0.985 | 0.136 |
structurally_consistent (Q15018)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| ABRAXAS2 | DEF6 | 0.982 | 0.042 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ABRAXAS1 | BRCC3 | 0.981 | 0.32 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| C9orf85 | BABAM1 | 0.981 | 0.08 |
mutually_exclusive (Q9NXR7)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| BABAM2 | DEF6 | 0.98 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| C9orf85 | BABAM2 | 0.959 | 0.116 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| BRCC3 | DEF6 | 0.959 | 0.056 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ABRAXAS1 | SHMT2 | 0.929 | 0.16 |
structurally_consistent (Q9NXR7)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ABRAXAS1 | BABAM2 | 0.867 | 0.17 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only |
| ABRAXAS1 | ABRAXAS2 | 0.4 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only | |
| C9orf85 | BRCC3 | 0.39 | 0.114 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ABRAXAS2 | TNS3 | 0.18 | 0.058 | bioplex_WMM bioplex3_WMM WMM_only | |
| BABAM1 | TNS3 | 0.172 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only | |
| BABAM2 | TNS3 | 0.164 | 0.032 | bioplex_WMM bioplex3_WMM WMM_only | |
| BRCC3 | TNS3 | 0.163 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only | |
| C9orf85 | SHMT2 | 0.019 | 0.116 |
structurally_consistent (Q9NXR7)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| SHMT2 | DEF6 | 0.001 | 0.084 | bioplex3_HEK293 bioplex () bioplex3_HCT116 |
Related Complexes