hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10496.1
Complex Portal: CPX-23448
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SRGAP1 | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | 5 | UniProt NCBI |
| AFDN | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | 5 | UniProt NCBI |
| SIPA1 | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | 5 | UniProt NCBI |
| MAP7D3 | MAP7 domain-containing protein 3 | 5 | UniProt NCBI |
| SRGAP2 | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-428543 | 0.000425287580531 | 0.4 | SRGAP1 SRGAP2 | Inactivation of CDC42 and RAC1 |
| KEGG:04670 | 0.0164241113683 | 0.4 | AFDN SIPA1 | Leukocyte transendothelial migration |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SRGAP1 | SRGAP2 | 0.98 | 0.202 | hein_WMM bioplex3_WMM WMM_only | |
| SRGAP2 | SIPA1 | 0.974 | 0.028 | hein_WMM bioplex3_WMM WMM_only | |
| AFDN | SIPA1 | 0.973 | 0.06 | hein_WMM bioplex3_WMM WMM_only | |
| MAP7D3 | SIPA1 | 0.964 | 0.016 | hein_WMM bioplex3_WMM WMM_only | |
| SRGAP2 | AFDN | 0.458 | 0.138 | bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| SRGAP1 | SIPA1 | 0.35 | 0.066 | hein_WMM bioplex3_WMM WMM_only | |
| SRGAP2 | MAP7D3 | 0.241 | 0.08 | bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| SRGAP1 | MAP7D3 | 0.196 | 0.126 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SRGAP1 | AFDN | 0.165 | 0.202 | bioplex3_WMM youn_WMM WMM_only | |
| MAP7D3 | AFDN | 0.071 | 0.026 | bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
Related Complexes