hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10502.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
PCMTD1	Protein-L-isoaspartate O-methyltransferase domain-containing protein 1	5	UniProt NCBI
LRRC41	Leucine-rich repeat-containing protein 41 (Protein Muf1)	5	UniProt NCBI
TULP4	Tubby-related protein 4 (Tubby superfamily protein) (Tubby-like protein 4)	5	UniProt NCBI
SOCS2	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)	5	UniProt NCBI
ASB2	Ankyrin repeat and SOCS box protein 2 (ASB-2)	5	UniProt NCBI
PCMTD2	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2	5	UniProt NCBI
SOCS5	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2 protein 6) (CIS-6) (Cytokine-inducible SH2-containing protein 5)	5	UniProt NCBI
SOCS4	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7)	5	UniProt NCBI
RNF7	RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein)	5	UniProt NCBI
XIRP1	Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1)	5	UniProt NCBI
SOCS7	Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4)	5	UniProt NCBI
LRRC28	Leucine-rich repeat-containing protein 28	2	UniProt NCBI
ASB13	Ankyrin repeat and SOCS box protein 13 (ASB-13)	5	UniProt NCBI
WSB1	WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box-containing WD protein SWiP-1)	5	UniProt NCBI
CUL5	Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)	5	UniProt NCBI
CISH	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)	5	UniProt NCBI
ASB1	Ankyrin repeat and SOCS box protein 1 (ASB-1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-8951664	3.31883914552e-14	0.647058823529	ASB2 TULP4 SOCS5 WSB1 ASB13 CUL5 RNF7 CISH SOCS2 LRRC41 ASB1	Neddylation
GO:0046935	1.10864386311e-07	0.294117647059	CISH SOCS2 SOCS4 SOCS7 SOCS5	1-phosphatidylinositol-3-kinase regulator activity
KEGG:04917	4.1826697342e-07	0.294117647059	CISH SOCS2 SOCS4 SOCS7 SOCS5	Prolactin signaling pathway
CORUM:208	5.57843805733e-07	0.176470588235	RNF7 CUL5 ASB1	Ubiquitin E3 ligase (ASB1, TCEB1, TCEB2, CUL5, RNF7)
CORUM:207	5.57843805733e-07	0.176470588235	ASB2 CUL5 RNF7	Ubiquitin E3 ligase (ASB2, TCEB1, TCEB2, CUL5, RNF7)
GO:0005942	2.92008200567e-06	0.294117647059	CISH SOCS2 SOCS4 SOCS7 SOCS5	phosphatidylinositol 3-kinase complex
REAC:R-HSA-597592	3.62954077182e-06	0.647058823529	ASB2 TULP4 SOCS5 WSB1 ASB13 CUL5 RNF7 CISH SOCS2 LRRC41 ASB1	Post-translational protein modification
REAC:R-HSA-983168	4.91622213272e-06	0.411764705882	ASB2 WSB1 ASB13 CUL5 ASB1 RNF7 LRRC41	Antigen processing: Ubiquitination & Proteasome degradation
KEGG:04630	1.83454398018e-05	0.294117647059	CISH SOCS2 SOCS4 SOCS7 SOCS5	JAK-STAT signaling pathway
REAC:R-HSA-983169	2.0070993527e-05	0.411764705882	ASB2 WSB1 ASB13 CUL5 ASB1 RNF7 LRRC41	Class I MHC mediated antigen processing & presentation
GO:0046854	8.30450212052e-05	0.294117647059	CISH SOCS2 SOCS4 SOCS7 SOCS5	phosphatidylinositol phosphate biosynthetic process
REAC:R-HSA-392499	0.000109786181458	0.647058823529	ASB2 TULP4 SOCS5 WSB1 ASB13 CUL5 RNF7 CISH SOCS2 LRRC41 ASB1	Metabolism of proteins
GO:1990234	0.00011792235314	0.588235294118	ASB2 PCMTD1 SOCS5 SOCS4 CUL5 RNF7 CISH SOCS2 ASB1 SOCS7	transferase complex
CORUM:211	0.000326093232852	0.117647058824	RNF7 CUL5	Ubiquitin E3 ligase (ASB12, TCEB1, TCEB2, CUL5, RNF7)
CORUM:214	0.000543116825549	0.117647058824	WSB1 CUL5	Ubiquitin E3 ligase (WSB1, TCEB1, TCEB2, CUL5, RBX1)
CORUM:209	0.000543116825549	0.117647058824	RNF7 CUL5	Ubiquitin E3 ligase (ASB6, TCEB1, TCEB2, CUL5, RNF7)
CORUM:210	0.000543116825549	0.117647058824	RNF7 CUL5	Ubiquitin E3 ligase (ASB7, TCEB1, TCEB2, CUL5, RNF7)
REAC:R-HSA-168256	0.00119192973801	0.588235294118	ASB2 SOCS5 WSB1 ASB13 CUL5 RNF7 CISH SOCS2 LRRC41 ASB1	Immune System
REAC:R-HSA-1280218	0.0016295235782	0.411764705882	ASB2 WSB1 ASB13 CUL5 ASB1 RNF7 LRRC41	Adaptive Immune System
GO:0031466	0.00546674693619	0.176470588235	RNF7 PCMTD1 CUL5	Cul5-RING ubiquitin ligase complex
GO:0006661	0.00552309299639	0.294117647059	CISH SOCS2 SOCS4 SOCS7 SOCS5	phosphatidylinositol biosynthetic process
WP:WP2034	0.00710476910048	0.176470588235	SOCS2 SOCS7 CISH	Leptin signaling pathway
GO:0046488	0.0120348118424	0.294117647059	CISH SOCS2 SOCS4 SOCS7 SOCS5	phosphatidylinositol metabolic process
GO:0019898	0.0219400432254	0.294117647059	CISH SOCS2 SOCS4 SOCS7 SOCS5	extrinsic component of membrane

Edges

Protein 1	Protein 2	Score	ProteomeHD
CISH	CUL5	1.0
RNF7	CUL5	1.0	0.544
SOCS2	CUL5	0.999
TULP4	CUL5	0.999
LRRC41	CUL5	0.999	0.018
SOCS7	CUL5	0.998
SOCS5	CUL5	0.998
ASB1	CUL5	0.998	0.096
LRRC28	CUL5	0.998
WSB1	CUL5	0.997
SOCS4	CUL5	0.997
RNF7	SOCS2	0.997
SOCS5	RNF7	0.997
ASB1	RNF7	0.997	0.138
ASB13	RNF7	0.997
WSB1	RNF7	0.997
SOCS4	RNF7	0.997
SOCS7	RNF7	0.995
ASB13	CUL5	0.993
LRRC41	RNF7	0.992	0.03
RNF7	CISH	0.991
PCMTD1	CUL5	0.991	0.034
RNF7	PCMTD1	0.99	0.082
XIRP1	SOCS7	0.983
PCMTD2	RNF7	0.98	0.128
PCMTD2	CUL5	0.976	0.06
TULP4	RNF7	0.974
ASB2	CUL5	0.961
PCMTD2	PCMTD1	0.941	0.136
WSB1	SOCS2	0.925
ASB13	SOCS4	0.925
SOCS5	SOCS2	0.925
ASB13	WSB1	0.925
ASB13	SOCS5	0.925
SOCS4	SOCS2	0.925
ASB13	SOCS7	0.918
WSB1	SOCS4	0.913
WSB1	SOCS5	0.913
SOCS7	SOCS5	0.913
SOCS7	SOCS4	0.913
SOCS7	WSB1	0.913
SOCS5	SOCS4	0.913
ASB13	SOCS2	0.912
WSB1	CISH	0.907
SOCS4	CISH	0.907
SOCS5	CISH	0.907
SOCS4	LRRC28	0.877
WSB1	LRRC28	0.877
SOCS5	LRRC28	0.877
ASB13	CISH	0.873
LRRC28	SOCS2	0.868
ASB13	LRRC28	0.868
SOCS7	LRRC28	0.868
SOCS7	SOCS2	0.861
ASB13	ASB1	0.844
ASB1	SOCS4	0.841
ASB1	SOCS5	0.841
ASB1	WSB1	0.841
SOCS7	CISH	0.83
ASB1	SOCS2	0.823
SOCS5	TULP4	0.821
WSB1	TULP4	0.821
TULP4	SOCS4	0.821
ASB1	PCMTD2	0.816	0.076
LRRC41	SOCS4	0.812
LRRC41	SOCS5	0.812
LRRC41	WSB1	0.812
PCMTD1	SOCS2	0.802
ASB13	TULP4	0.8
ASB1	SOCS7	0.799
SOCS7	PCMTD1	0.795
LRRC41	LRRC28	0.788
CISH	SOCS2	0.787
TULP4	SOCS2	0.786
ASB1	CISH	0.786
PCMTD2	SOCS5	0.785
PCMTD2	SOCS4	0.785
PCMTD2	WSB1	0.785
ASB13	PCMTD2	0.783
WSB1	PCMTD1	0.778
SOCS4	PCMTD1	0.778
SOCS5	PCMTD1	0.778
LRRC41	TULP4	0.777
SOCS7	TULP4	0.775
LRRC41	ASB13	0.765
LRRC41	SOCS7	0.765
ASB13	PCMTD1	0.763
LRRC41	SOCS2	0.759
LRRC41	ASB1	0.757	0.11
ASB1	TULP4	0.754
ASB1	PCMTD1	0.745	0.074
RNF7	LRRC28	0.741
ASB1	LRRC28	0.741
LRRC41	PCMTD2	0.728	0.07
TULP4	LRRC28	0.716
SOCS7	PCMTD2	0.714
PCMTD2	TULP4	0.685
PCMTD2	LRRC28	0.68
LRRC28	PCMTD1	0.644
LRRC41	PCMTD1	0.631	0.014
LRRC41	CISH	0.625
TULP4	PCMTD1	0.512
CISH	PCMTD1	0.459
PCMTD2	SOCS2	0.356
LRRC28	CISH	0.333
TULP4	CISH	0.265
PCMTD2	CISH	0.133
XIRP1	CUL5	0.049

Related Complexes

Genename	Complexes
PCMTD1	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1 huMAP3_14346.1
LRRC41	huMAP3_00145.1 huMAP3_02336.1 huMAP3_02504.1 huMAP3_04750.1 huMAP3_05263.1 huMAP3_06952.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_10962.1 huMAP3_13601.1
TULP4	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
SOCS2	huMAP3_04750.1 huMAP3_05263.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
ASB2	huMAP3_01110.1 huMAP3_05263.1 huMAP3_10502.1 huMAP3_14158.1
PCMTD2	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1 huMAP3_14346.1
SOCS5	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
SOCS4	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
RNF7	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
XIRP1	huMAP3_03653.1 huMAP3_04495.1 huMAP3_10502.1 huMAP3_13198.1
SOCS7	huMAP3_03653.1 huMAP3_04750.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
LRRC28	huMAP3_04750.1 huMAP3_05263.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
ASB13	huMAP3_01436.1 huMAP3_04750.1 huMAP3_05263.1 huMAP3_06301.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09431.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
WSB1	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
CUL5	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
CISH	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
ASB1	huMAP3_01555.1 huMAP3_02310.1 huMAP3_04750.1 huMAP3_05263.1 huMAP3_05980.1 huMAP3_06706.1 huMAP3_07874.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_12652.1 huMAP3_13601.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10502.1