hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10522.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
RBMXL3	RNA-binding motif protein, X-linked-like-3	2	UniProt NCBI
CBARP	Voltage-dependent calcium channel beta subunit-associated regulatory protein	5	UniProt NCBI
CACNB4	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4)	5	UniProt NCBI
CACNB2	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB)	5	UniProt NCBI
CACNB1	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1)	5	UniProt NCBI
CACNB3	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-112308	5.07705636973e-11	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	Presynaptic depolarization and calcium channel opening
REAC:R-HSA-419037	2.5402076735e-08	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	NCAM1 interactions
REAC:R-HSA-375165	1.61742470164e-07	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	NCAM signaling for neurite out-growth
WP:WP2118	2.56173883411e-07	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	Arrhythmogenic right ventricular cardiomyopathy
KEGG:05412	3.30414614276e-07	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	Arrhythmogenic right ventricular cardiomyopathy
GO:0008331	3.94651622678e-07	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	high voltage-gated calcium channel activity
KEGG:04260	4.17220190946e-07	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	Cardiac muscle contraction
KEGG:05410	5.20074832828e-07	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	Hypertrophic cardiomyopathy
KEGG:05414	5.20074832828e-07	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	Dilated cardiomyopathy
GO:1901385	1.52730449682e-06	0.666666666667	CACNB4 CACNB3 CBARP CACNB2	regulation of voltage-gated calcium channel activity
GO:0007528	2.88146527749e-06	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	neuromuscular junction development
KEGG:04921	3.09636971273e-06	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	Oxytocin signaling pathway
KEGG:04261	3.20371655146e-06	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	Adrenergic signaling in cardiomyocytes
GO:1903169	3.28516911608e-06	0.833333333333	CACNB4 CACNB1 CACNB3 CBARP CACNB2	regulation of calcium ion transmembrane transport
GO:0005245	1.23822125661e-05	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	voltage-gated calcium channel activity
GO:0005891	1.60994442835e-05	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	voltage-gated calcium channel complex
GO:0051924	2.07823329526e-05	0.833333333333	CACNB4 CACNB1 CACNB3 CBARP CACNB2	regulation of calcium ion transport
WP:WP382	3.65710878533e-05	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	MAPK signaling pathway
KEGG:04010	5.63999263147e-05	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	MAPK signaling pathway
GO:1904062	8.18917029697e-05	0.833333333333	CACNB4 CACNB1 CACNB3 CBARP CACNB2	regulation of monoatomic cation transmembrane transport
GO:0070588	8.18917029697e-05	0.833333333333	CACNB4 CACNB1 CACNB3 CBARP CACNB2	calcium ion transmembrane transport
REAC:R-HSA-112315	9.75067714909e-05	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	Transmission across Chemical Synapses
GO:0034704	9.81259188038e-05	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	calcium channel complex
GO:1901019	0.000124138457674	0.666666666667	CACNB4 CACNB3 CBARP CACNB2	regulation of calcium ion transmembrane transporter activity
GO:0034765	0.000132089122668	0.833333333333	CACNB4 CACNB1 CACNB3 CBARP CACNB2	regulation of monoatomic ion transmembrane transport
GO:1990454	0.000161332517231	0.5	CACNB1 CACNB2 CACNB3	L-type voltage-gated calcium channel complex
GO:0010959	0.000234372796223	0.833333333333	CACNB4 CACNB1 CACNB3 CBARP CACNB2	regulation of metal ion transport
GO:0006816	0.000339164286609	0.833333333333	CACNB4 CACNB1 CACNB3 CBARP CACNB2	calcium ion transport
GO:0005262	0.000450665620324	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	calcium channel activity
REAC:R-HSA-112316	0.000452345664425	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	Neuronal System
GO:0043269	0.000487840865747	0.833333333333	CACNB4 CACNB1 CACNB3 CBARP CACNB2	regulation of monoatomic ion transport
GO:2001257	0.000502392288512	0.666666666667	CACNB4 CACNB3 CBARP CACNB2	regulation of cation channel activity
GO:0034762	0.000672152924128	0.833333333333	CACNB4 CACNB1 CACNB3 CBARP CACNB2	regulation of transmembrane transport
GO:0022843	0.000684451996602	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	voltage-gated monoatomic cation channel activity
GO:0061577	0.000698569295426	0.5	CACNB1 CACNB2 CACNB3	calcium ion transmembrane transport via high voltage-gated calcium channel
GO:0015085	0.000999031924798	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	calcium ion transmembrane transporter activity
REAC:R-HSA-5576893	0.00116019984728	0.333333333333	CACNB1 CACNB2	Phase 2 - plateau phase
GO:0005244	0.00147034444981	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	voltage-gated monoatomic ion channel activity
GO:0022832	0.00147034444981	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	voltage-gated channel activity
REAC:R-HSA-422475	0.0030564769327	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	Axon guidance
REAC:R-HSA-9675108	0.00353370301704	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	Nervous system development
GO:0034703	0.00442159197262	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	cation channel complex
GO:0098662	0.00485223565793	0.833333333333	CACNB4 CACNB1 CACNB3 CBARP CACNB2	inorganic cation transmembrane transport
GO:0098655	0.00509483152423	0.833333333333	CACNB4 CACNB1 CACNB3 CBARP CACNB2	monoatomic cation transmembrane transport
REAC:R-HSA-400042	0.00594265866298	0.333333333333	CACNB3 CACNB2	Adrenaline,noradrenaline inhibits insulin secretion
GO:0032412	0.00686543980196	0.666666666667	CACNB4 CACNB3 CBARP CACNB2	regulation of monoatomic ion transmembrane transporter activity
REAC:R-HSA-5576892	0.0070977267476	0.333333333333	CACNB1 CACNB2	Phase 0 - rapid depolarisation
GO:0098660	0.00732180844953	0.833333333333	CACNB4 CACNB1 CACNB3 CBARP CACNB2	inorganic ion transmembrane transport
GO:0022898	0.0082999617565	0.666666666667	CACNB4 CACNB3 CBARP CACNB2	regulation of transmembrane transporter activity
GO:0030315	0.00949259421943	0.5	CACNB1 CACNB2 CACNB3	T-tubule
GO:0034220	0.0102647533522	0.833333333333	CACNB4 CACNB1 CACNB3 CBARP CACNB2	monoatomic ion transmembrane transport
GO:0032409	0.0109925666122	0.666666666667	CACNB4 CACNB3 CBARP CACNB2	regulation of transporter activity
GO:0030001	0.0112754825257	0.833333333333	CACNB4 CACNB1 CACNB3 CBARP CACNB2	metal ion transport
GO:0034702	0.0121174468054	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	monoatomic ion channel complex
GO:0022836	0.0156557881857	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	gated channel activity
WP:WP5356	0.0159206501541	0.333333333333	CACNB1 CACNB2	Affected pathways in Duchenne muscular dystrophy
GO:0006812	0.018956843244	0.833333333333	CACNB4 CACNB1 CACNB3 CBARP CACNB2	monoatomic cation transport
GO:0005261	0.0249855480901	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	monoatomic cation channel activity
REAC:R-HSA-1266738	0.02903341132	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	Developmental Biology
GO:0050808	0.0372717918379	0.666666666667	CACNB4 CACNB3 CACNB2 CACNB1	synapse organization
GO:0006811	0.0394764540724	0.833333333333	CACNB4 CACNB1 CACNB3 CBARP CACNB2	monoatomic ion transport
GO:1901843	0.042122686785	0.333333333333	CACNB3 CACNB2	positive regulation of high voltage-gated calcium channel activity

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
CACNB3	CACNB2	0.999		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CACNB3	CACNB1	0.999		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CBARP	CACNB3	0.999		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
RBMXL3	CACNB1	0.998		bioplex3_WMM bioplex3_HCT116 WMM_only
CACNB2	CACNB1	0.997		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CBARP	CACNB1	0.997		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CACNB4	CACNB3	0.995		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CACNB3	RBMXL3	0.904		bioplex3_WMM WMM_only
CACNB4	CACNB2	0.902		bioplex3_WMM WMM_only
CACNB4	CBARP	0.768		bioplex3_WMM WMM_only
CBARP	CACNB2	0.754	0.09	bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
CBARP	RBMXL3	0.478		bioplex3_WMM WMM_only
CACNB2	RBMXL3	0.214		bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
RBMXL3	huMAP3_01863.1 huMAP3_02609.1 huMAP3_06519.1 huMAP3_08329.1 huMAP3_09033.1 huMAP3_09809.1 huMAP3_10522.1 huMAP3_10586.1 huMAP3_11209.1 huMAP3_13029.1 huMAP3_13440.1 huMAP3_13920.1 huMAP3_14403.1
CBARP	huMAP3_00355.1 huMAP3_08329.1 huMAP3_09809.1 huMAP3_10522.1 huMAP3_12693.1 huMAP3_12897.1 huMAP3_14403.1
CACNB4	huMAP3_00355.1 huMAP3_00599.1 huMAP3_09795.1 huMAP3_10193.1 huMAP3_10522.1 huMAP3_10929.1 huMAP3_10945.1 huMAP3_11209.1 huMAP3_12625.1 huMAP3_14403.1
CACNB2	huMAP3_00355.1 huMAP3_08329.1 huMAP3_09809.1 huMAP3_10522.1 huMAP3_11209.1 huMAP3_12625.1 huMAP3_14403.1
CACNB1	huMAP3_01863.1 huMAP3_08329.1 huMAP3_09809.1 huMAP3_10522.1 huMAP3_11209.1 huMAP3_12625.1 huMAP3_14403.1
CACNB3	huMAP3_00355.1 huMAP3_09809.1 huMAP3_10522.1 huMAP3_11209.1 huMAP3_12625.1 huMAP3_14403.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10522.1