List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_10527.1

Confidence: Medium High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
ENSA	Alpha-endosulfine (ARPP-19e)	5	UniProt   NCBI
XPA	DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein)	5	UniProt   NCBI
SLX4	Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)	5	UniProt   NCBI
ERCC1	DNA excision repair protein ERCC-1	5	UniProt   NCBI
ERCC4	DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:531	2.80233355908e-09	0.6	ERCC1 XPA ERCC4	XPA-ERCC1-ERCC4 complex
GO:0000109	4.33992010508e-08	0.8	ERCC4 ERCC1 XPA SLX4	nucleotide-excision repair complex
WP:WP5114	1.79216443484e-07	0.8	ERCC4 ERCC1 XPA SLX4	Nucleotide excision repair in xeroderma pigmentosum
GO:0000110	9.61200410764e-07	0.6	ERCC1 XPA ERCC4	nucleotide-excision repair factor 1 complex
GO:0070522	9.61200410764e-07	0.6	ERCC1 SLX4 ERCC4	ERCC4-ERCC1 complex
CORUM:2220	1.36501667663e-05	0.4	ERCC1 ERCC4	RAD52-ERCC4-ERCC1 complex
WP:WP4753	1.48411025729e-05	0.6	ERCC1 XPA ERCC4	Nucleotide excision repair
KEGG:03460	1.71122661794e-05	0.6	ERCC1 SLX4 ERCC4	Fanconi anemia pathway
REAC:R-HSA-6783310	2.03584684634e-05	0.6	ERCC1 SLX4 ERCC4	Fanconi Anemia Pathway
KEGG:03420	2.86326141069e-05	0.6	ERCC1 XPA ERCC4	Nucleotide excision repair
REAC:R-HSA-5696400	3.31378787787e-05	0.6	ERCC1 XPA ERCC4	Dual Incision in GG-NER
REAC:R-HSA-5696395	3.5683276241e-05	0.6	ERCC1 XPA ERCC4	Formation of Incision Complex in GG-NER
CORUM:368	4.09448956317e-05	0.4	ERCC1 ERCC4	ERCC1-ERCC4-MSH2 complex
CORUM:7295	4.09448956317e-05	0.4	ERCC1 XPA	ERCC1-RPA1-XPA complex
HP:0001034	6.43550146138e-05	0.8	ERCC4 ERCC1 XPA SLX4	Hypermelanotic macule
HP:0007400	0.000115326413283	0.8	ERCC4 ERCC1 XPA SLX4	Irregular hyperpigmentation
HP:0012733	0.000122437834659	0.8	ERCC4 ERCC1 XPA SLX4	Macule
REAC:R-HSA-6782135	0.000129211329951	0.6	ERCC1 XPA ERCC4	Dual incision in TC-NER
REAC:R-HSA-73894	0.000150476434856	0.8	ERCC4 ERCC1 XPA SLX4	DNA Repair
GO:0006289	0.000186904603412	0.8	ERCC4 ERCC1 XPA SLX4	nucleotide-excision repair
REAC:R-HSA-6781827	0.000226554396442	0.6	ERCC1 XPA ERCC4	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
WP:WP4946	0.00027954510039	0.6	ERCC1 XPA ERCC4	DNA repair pathways full network
REAC:R-HSA-5696399	0.000284390695808	0.6	ERCC1 XPA ERCC4	Global Genome Nucleotide Excision Repair (GG-NER)
HP:0000953	0.0003677422453	0.8	ERCC4 ERCC1 XPA SLX4	Hyperpigmentation of the skin
HP:0002860	0.000447946694857	0.6	ERCC4 XPA SLX4	Squamous cell carcinoma
REAC:R-HSA-5696398	0.000630278165562	0.6	ERCC1 XPA ERCC4	Nucleotide Excision Repair
REAC:R-HSA-5693567	0.000932817738425	0.6	ERCC1 SLX4 ERCC4	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
HP:0006313	0.000961529670085	0.4	ERCC1 ERCC4	Widely spaced primary teeth
REAC:R-HSA-5693538	0.00107666549853	0.6	ERCC1 SLX4 ERCC4	Homology Directed Repair
HP:0000135	0.00116306653983	0.8	ERCC4 ERCC1 XPA SLX4	Hypogonadism
HP:0006334	0.001345957274	0.4	ERCC1 ERCC4	Hypoplasia of the primary teeth
HP:0000509	0.00153309167261	0.6	ERCC1 XPA ERCC4	Conjunctivitis
HP:0000992	0.00169289796817	0.6	ERCC1 XPA ERCC4	Cutaneous photosensitivity
HP:0025337	0.00174852750004	0.6	ERCC1 XPA ERCC4	Red eye
HP:0010649	0.00179436403841	0.4	XPA ERCC4	Flat nasal alae
REAC:R-HSA-5693532	0.0019808748776	0.6	ERCC1 SLX4 ERCC4	DNA Double-Strand Break Repair
HP:0001000	0.00229405005158	0.8	ERCC4 ERCC1 XPA SLX4	Abnormality of skin pigmentation
HP:0001053	0.00258565436429	0.6	ERCC4 XPA SLX4	Hypopigmented skin patches
GO:1990599	0.00468200720083	0.4	ERCC1 ERCC4	3' overhang single-stranded DNA endodeoxyribonuclease activity
GO:0061819	0.00468200720083	0.4	ERCC1 ERCC4	telomeric DNA-containing double minutes formation
GO:1901255	0.00468200720083	0.4	XPA ERCC4	nucleotide-excision repair involved in interstrand cross-link repair
GO:1905764	0.00468200720083	0.4	ERCC1 ERCC4	regulation of protection from non-homologous end joining at telomere
GO:1905765	0.00468200720083	0.4	ERCC1 ERCC4	negative regulation of protection from non-homologous end joining at telomere
HP:0009755	0.00582689447108	0.4	XPA ERCC4	Ankyloblepharon
HP:0008373	0.00590636383162	0.8	ERCC4 ERCC1 XPA SLX4	Puberty and gonadal disorders
HP:0000502	0.00593647702079	0.6	ERCC1 XPA ERCC4	Abnormal conjunctiva morphology
HP:0000674	0.00672241921037	0.4	ERCC1 ERCC4	Anodontia
HP:0003079	0.00672241921037	0.4	XPA ERCC4	Defective DNA repair after ultraviolet radiation damage
GO:0032205	0.00683974211741	0.6	ERCC1 SLX4 ERCC4	negative regulation of telomere maintenance
HP:0000680	0.00768171284681	0.4	ERCC1 ERCC4	Delayed eruption of primary teeth
HP:0010468	0.00819982205473	0.6	ERCC4 XPA SLX4	Aplasia/Hypoplasia of the testes
HP:0006739	0.00870474912182	0.4	XPA ERCC4	Squamous cell carcinoma of the skin
REAC:R-HSA-5685938	0.00900400267976	0.4	ERCC1 ERCC4	HDR through Single Strand Annealing (SSA)
HP:0045058	0.0105962255115	0.6	ERCC4 XPA SLX4	Abnormality of the testis size
KEGG:01524	0.0108758996329	0.4	ERCC1 XPA	Platinum drug resistance
HP:0003254	0.0109419445801	0.4	XPA ERCC4	Abnormality of DNA repair
HP:0100533	0.0115529971699	0.6	ERCC1 XPA ERCC4	Inflammatory abnormality of the eye
HP:0000621	0.0121560512731	0.4	XPA ERCC4	Entropion
HP:0000524	0.0121560512731	0.4	XPA ERCC4	Conjunctival telangiectasia
HP:0008069	0.0127746024565	0.6	ERCC4 XPA SLX4	Neoplasm of the skin
HP:0002818	0.0132000411118	0.6	ERCC1 SLX4 ERCC4	Abnormal morphology of the radius
HP:0000028	0.0133683046288	0.8	ERCC4 ERCC1 XPA SLX4	Cryptorchidism
HP:0001010	0.0134162347773	0.6	ERCC4 XPA SLX4	Hypopigmentation of the skin
HP:0001029	0.0134337956242	0.4	XPA ERCC4	Poikiloderma
GO:1904506	0.0140440992017	0.4	ERCC1 ERCC4	negative regulation of telomere maintenance in response to DNA damage
HP:0000080	0.014110537422	0.8	ERCC4 ERCC1 XPA SLX4	Abnormality of reproductive system physiology
HP:0004493	0.0147751514018	0.4	XPA ERCC4	Craniofacial hyperostosis
HP:0005522	0.0147751514018	0.4	SLX4 ERCC4	Pyridoxine-responsive sideroblastic anemia
HP:0000025	0.015708466597	0.6	ERCC1 SLX4 ERCC4	Functional abnormality of male internal genitalia
HP:0010469	0.0161800923797	0.4	SLX4 ERCC4	Absent testis
HP:0040072	0.0164434381168	0.6	ERCC1 SLX4 ERCC4	Abnormal forearm bone morphology
HP:0002973	0.0166933934022	0.6	ERCC1 SLX4 ERCC4	Abnormal forearm morphology
HP:0000518	0.0170972280008	0.8	ERCC4 ERCC1 XPA SLX4	Cataract
HP:0008054	0.0176485923371	0.4	XPA ERCC4	Abnormal morphology of the conjunctival vasculature
HP:0000517	0.0189122123602	0.8	ERCC4 ERCC1 XPA SLX4	Abnormal lens morphology
HP:0011355	0.0220157972203	0.8	ERCC4 ERCC1 XPA SLX4	Localized skin lesion
HP:0010293	0.0224351839587	0.4	SLX4 ERCC4	Aplasia/Hypoplasia of the uvula
HP:0012848	0.0224351839587	0.4	SLX4 ERCC4	Small intestinal stenosis
HP:0100867	0.0224351839587	0.4	SLX4 ERCC4	Duodenal stenosis
HP:0002827	0.0228469664256	0.6	ERCC1 SLX4 ERCC4	Hip dislocation
HP:0000613	0.0241059715815	0.6	ERCC1 XPA ERCC4	Photophobia
HP:0100760	0.0241576577336	0.4	SLX4 ERCC4	Clubbing of toes
HP:0002245	0.0241576577336	0.4	SLX4 ERCC4	Meckel diverticulum
HP:0005328	0.0241576577336	0.4	ERCC1 ERCC4	Progeroid facial appearance
GO:0003684	0.0250826699056	0.6	ERCC1 XPA ERCC4	damaged DNA binding
HP:0100587	0.0277928629638	0.4	SLX4 ERCC4	Abnormal preputium morphology
GO:1904431	0.0280843539964	0.4	ERCC1 SLX4	positive regulation of t-circle formation
HP:0012874	0.0307145475304	0.6	ERCC1 SLX4 ERCC4	Abnormal male reproductive system physiology
HP:0000568	0.0314726608058	0.6	ERCC1 SLX4 ERCC4	Microphthalmia
HP:0001924	0.0316815705386	0.4	SLX4 ERCC4	Sideroblastic anemia
HP:0000026	0.0316815705386	0.4	ERCC1 ERCC4	Male hypogonadism
HP:0000035	0.0329820764126	0.8	ERCC4 ERCC1 XPA SLX4	Abnormal testis morphology
HP:0200007	0.0362822138687	0.6	ERCC1 SLX4 ERCC4	Abnormal size of the palpebral fissures
HP:5200058	0.0362822138687	0.6	ERCC1 XPA ERCC4	Sensory hypersensitivity
HP:0006887	0.0379894907585	0.4	XPA ERCC4	Intellectual disability, progressive
HP:0001059	0.0402186552091	0.4	XPA ERCC4	Pterygium
HP:5200046	0.0415537333882	0.6	ERCC1 XPA ERCC4	Sensory behavioral abnormality
HP:0100579	0.0425110382594	0.4	XPA ERCC4	Mucosal telangiectasiae
HP:0040012	0.0425110382594	0.4	SLX4 ERCC4	Chromosome breakage
HP:0001549	0.0425110382594	0.4	SLX4 ERCC4	Abnormal ileum morphology
HP:0030311	0.043417085174	0.6	ERCC1 SLX4 ERCC4	Lower extremity joint dislocation
HP:0100887	0.043417085174	0.6	ERCC1 SLX4 ERCC4	Abnormality of globe size
HP:0004437	0.0472853555832	0.4	XPA ERCC4	Cranial hyperostosis
HP:0000554	0.0472853555832	0.4	ERCC1 ERCC4	Uveitis
HP:0007700	0.0488237559993	0.6	ERCC1 SLX4 ERCC4	Ocular anterior segment dysgenesis



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?	Evidence ?
ERCC4	ERCC1	0.999	0.24	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     youn_WMM     Malo     fraction
ERCC4	XPA	0.994	0.158	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
ERCC1	XPA	0.991	0.2	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
ERCC4	SLX4	0.968	0.166	hein_WMM     bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     WMM_only
ENSA	XPA	0.968	0.136	bioplex3_WMM     bioplex3_HCT116     WMM_only
SLX4	ERCC1	0.682	0.184	bioplex ()     bioplex_WMM     bioplex3_WMM
ERCC4	ENSA	0.02	0.062	bioplex3_WMM     gupta_WMM     WMM_only
ERCC1	ENSA	0.012	0.1	bioplex3_WMM     youn_WMM     WMM_only





Related Complexes

Genename	Complexes
ENSA	huMAP3_01917.1 huMAP3_10527.1 huMAP3_13638.1 huMAP3_14163.1
XPA	huMAP3_01917.1 huMAP3_03121.1 huMAP3_09920.1 huMAP3_10527.1 huMAP3_11825.1 huMAP3_13432.1 huMAP3_13854.1 huMAP3_14846.1
SLX4	huMAP3_01069.1 huMAP3_03121.1 huMAP3_08597.1 huMAP3_09920.1 huMAP3_10527.1 huMAP3_13147.1
ERCC1	huMAP3_01069.1 huMAP3_09920.1 huMAP3_10527.1 huMAP3_11825.1
ERCC4	huMAP3_01069.1 huMAP3_03121.1 huMAP3_08597.1 huMAP3_09920.1 huMAP3_10527.1 huMAP3_11825.1